Annals of Epidemiology最新文献

{"title":"Chronic conditions, disability, and COVID-19 testing and vaccination: A national Rapid Acceleration of Diagnostics‐Underserved Populations analysis","authors":"Haley R. Fonseca ,&nbsp;Elizabeth Lydon ,&nbsp;Troy A. Stefano ,&nbsp;Eileen Fluney ,&nbsp;Lisa Wruck ,&nbsp;Susanna Stevens ,&nbsp;Krista M. Perreira ,&nbsp;David R. Brown ,&nbsp;Wensong Wu ,&nbsp;Marianna K. Baum","doi":"10.1016/j.annepidem.2025.09.019","DOIUrl":"10.1016/j.annepidem.2025.09.019","url":null,"abstract":"<div><h3>Purpose</h3><div>We investigated the impact of chronic conditions on COVID-19 testing, vaccination, and related challenges, with a focus on the interaction effect of disability.</div></div><div><h3>Methods</h3><div>This cross-sectional, cross-consortium analysis was conducted as part of the National Institutes of Health Rapid Acceleration of Diagnostics-Underserved Population (RADx-UP) initiative. Data were self-reported via standardized RADx-UP common data elements. Multivariable generalized estimating equation models with a logit link adjusted for sociodemographic variables, health insurance, health status, housing, and United States region were utilized.</div></div><div><h3>Results</h3><div>Participants were from 28 states (n = 8813), enrolled between February 2021-March 2022 with a mean age of 49 years, 60.4 % female, 30.8 % Hispanic, and 25.5 % Black, non-Hispanic. Over 30 % were living with three or more chronic conditions and 22.1 % reported some type of disability. Odds of COVID-19 testing (aOR:1.95; 95 %CI:1.75, 2.17), vaccination (aOR:1.63; 95 %CI:1.31, 2.03), food insecurity (aOR:1.43; 95 %CI:1.21, 1.68), housing insecurity (aOR:1.42; 95 %CI:1.10, 1.82), healthcare access challenges (aOR:1.60; 95 %CI:1.38, 1.86) and transportation challenges (aOR:1.48; 95 %CI:1.21, 1.81) increased as number of chronic conditions increased. The effect of chronic conditions on probability of COVID-19 testing (p = 0.157) and vaccination (p = 0.147) did not differ by disability, but the effect on probability of experiencing COVID-19-related challenges did differ by disability (p &lt; 0.001). For those with functional and employment disability, the more chronic conditions one had, the more likely they were to experience food insecurity (aOR:1.94; 95 %CI:1.33, 2.82) and issues accessing healthcare (aOR:2.21; 95 %CI:1.19, 4.14) and transportation (aOR:2.33; 95 %CI:1.11, 4.89).</div></div><div><h3>Conclusions</h3><div>Testing and vaccination sites may have been accessible to various populations and/or adults with chronic conditions may have had heightened awareness of potential vulnerability to COVID-19, which could have led to similar testing and vaccination behaviors across different disability statuses. However, disability may still exacerbate daily-life challenges in those living with chronic conditions during public health crises.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"111 ","pages":"Pages 107-115"},"PeriodicalIF":3.0,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145180233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term risk of all-cause mortality and major adverse cardiovascular events in hip osteoarthritis patients after total hip replacement","authors":"Nai-Chen Shih MD, PhD ,&nbsp;Han-Wei Yeh MD ,&nbsp;Shun-Fa Yang PhD ,&nbsp;Jing-Yang Huang PhD ,&nbsp;Ping-Kun Tsai MD, PhD ,&nbsp;Chao-Bin Yeh MD, PhD","doi":"10.1016/j.annepidem.2025.09.018","DOIUrl":"10.1016/j.annepidem.2025.09.018","url":null,"abstract":"<div><h3>Introduction</h3><div>To evaluate the long-term effects of total hip replacement (THR) on all-cause mortality and major adverse cardiovascular events (MACEs) among patients with hip osteoarthritis (OA).</div></div><div><h3>Methods</h3><div>A retrospective cohort study utilizing data from the TriNetX US Collaborative Network, a multicenter electronic health record database. We identified adult patients diagnosed with hip OA between January 1, 2012, and December 31, 2020. Propensity score matching (PSM) was employed to generate 16,893 matched pairs of patients who underwent THR and those who did not. Outcomes included all-cause mortality and incidence of MACEs, analyzed using Kaplan–Meier survival curves and Cox proportional hazards models. Subgroup analyses were conducted stratified by age, sex, race, and body mass index (BMI).</div></div><div><h3>Results</h3><div>Following PSM, patients receiving THR demonstrated a significantly 41 % lower risk of all-cause mortality (hazard ratio [HR], 0.59; 95 % confidence interval [CI], 0.54–0.64) and a 41 % lower risk of MACEs (HR, 0.59; 95 % CI, 0.56–0.62) compared with those not undergoing THR. Subgroup analysis revealed sex-based heterogeneity in mortality benefit (HR, 0.61; 95 % CI, 0.54–0.69 in males vs. HR, 0.75; 95 % CI, 0.66–0.87 in females). Age-stratified analyses for MACE risk showed a diminishing protective effect with increasing age (HR, 0.48 for 50–59 years; HR, 0.58 for 60–69 years; HR, 0.66 for 70–79 years).</div></div><div><h3>Conclusions</h3><div>Total hip replacement is associated with a substantial reduction in long-term all-cause mortality and cardiovascular events among patients with hip OA, corresponding to approximately 40 % lower risks compared with non-surgical patients. These associations appear to be modified by sex and age. The observed benefits may reflect improved mobility, enhanced physical activity, and better cardiovascular health following surgical intervention.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"111 ","pages":"Pages 65-73"},"PeriodicalIF":3.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implications of case definition selection on traumatic brain injury trends: A controlled interrupted time-series analysis of North Carolina emergency department data","authors":"Lucas M. Neuroth ,&nbsp;Yuni Tang ,&nbsp;Anna E. Waller ,&nbsp;Katherine J. Harmon","doi":"10.1016/j.annepidem.2025.09.017","DOIUrl":"10.1016/j.annepidem.2025.09.017","url":null,"abstract":"<div><h3>Background</h3><div>In 2015, the CDC removed unspecified head injuries from its TBI surveillance case definition, complicating the investigation of long-term morbidity trends. We examined the long-term impact of this change on quantifying statewide TBI incidence.</div></div><div><h3>Methods</h3><div>North Carolina emergency department (ED) visit records were obtained from 2012 to 2024 and classified based on the presence (S09.90+) or absence (S09.90-) of the ICD-10-CM code for \"head injury, unspecified\". Segmented Poisson regression was used to compare slope- and level-changes in monthly TBI visit counts.</div></div><div><h3>Results</h3><div>From January 2012 through September 2015, TBI visits increased at a rate of 14.9 visits per month. TBI visits dropped at the onset of COVID-19, and then rebounded after the relaxation of the state's stay-at-home-order; however, this trend was diminished under the S09.90- definition, with a difference of 75.9 (57.2–94.6) visits per month between the two definitions.</div></div><div><h3>Conclusions</h3><div>The presence of unspecified head injuries in the TBI surveillance case definition substantially altered statewide trends and their inclusion may better reflect injury burden.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"111 ","pages":"Pages 82-86"},"PeriodicalIF":3.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145151808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association of preterm birth and small for gestational age with recurrent multisite musculoskeletal pain during early and middle adulthood — The Northern Finland Birth Cohort 1966 Study","authors":"Sandra-Sofia Nieminen ,&nbsp;Jaro Karppinen ,&nbsp;Eero Kajantie ,&nbsp;Paulo Ferreira ,&nbsp;Eveliina Heikkala","doi":"10.1016/j.annepidem.2025.09.011","DOIUrl":"10.1016/j.annepidem.2025.09.011","url":null,"abstract":"<div><h3>Purpose</h3><div>Musculoskeletal (MSK) pain is a leading cause of disability and commonly affects multiple locations. Identifying early-life risk factors could enable targeted prevention of multisite MSK pain. This study investigated associations of preterm birth (&lt;37 weeks) and small for gestational age (SGA) with recurrent multisite MSK pain during early and middle adulthood.</div></div><div><h3>Methods</h3><div>Participants in the NFBC1966 were prospectively followed from gestation to 46 years. Exposure data were based on delivery records; the outcome was self-reported. Multinomial logistic regression estimated odds ratios (ORs) and 95 % confidence intervals (CIs) both unadjusted and adjusted [a] for sex, maternal age at birth, pregnancy disorder, maternal smoking, family socioeconomic status, and parity.</div></div><div><h3>Results</h3><div>Among participants, 12 % born prematurely and 16 % born at term reported recurrent multisite MSK pain between 31 and 46 years (aOR 0.79, 95 % CI 0.43–1.46). Using continuous gestational age, a statistically significant association was observed (aOR 1.07, 95 % CI 1.00–1.14). SGA showed no association (aOR 0.94, 95 % CI 0.84–1.04). No associations were found for onset or resolved multisite MSK pain.</div></div><div><h3>Conclusion</h3><div>Preterm birth and SGA were not negatively associated with adult multisite MSK pain. A protective association appeared with continuous gestational age, but small sample sizes warrant cautious interpretation.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"111 ","pages":"Pages 58-64"},"PeriodicalIF":3.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body mass index inequities among adults in Spain: An intersectional multilevel analysis of individual heterogeneity and discriminatory accuracy of age, sex/gender, immigration status, and education","authors":"Luisa N. Borrell ,&nbsp;Julia Díez ,&nbsp;Nerea Lanborena ,&nbsp;Sara Yago-Gonzalez ,&nbsp;Elena Rodriguez-Alvarez","doi":"10.1016/j.annepidem.2025.09.013","DOIUrl":"10.1016/j.annepidem.2025.09.013","url":null,"abstract":"<div><h3>Purpose</h3><div>We aimed to examine intersectional BMI inequities across age, sex/gender, immigration status, and education among adults in Spain.</div></div><div><h3>Methods</h3><div>We analyzed data from 61,844 adults aged ≥ 18 years from the 2014 and 2020 European Health Interview Surveys in Spain and the 2017 Spanish National Health Survey. Using intersectional multilevel analysis of individual heterogeneity and discriminatory accuracy (I-MAIHDA) via linear mixed models, we examined BMI inequities across 180 intersectional strata, defined by age, sex/gender, immigration status, education, and survey year, and quantified the contribution of their intersections to BMI inequities.</div></div><div><h3>Results</h3><div>The intersectional strata explained 9.6 % of BMI inequities, with 87.1 % of the between-strata variance explained by age, sex/gender, immigration status, education, and survey year. On average, BMI was higher in older adults, immigrants, and those with lower education but lower in women. Interaction effects revealed that immigrant women had a higher predicted BMI than Spanish-born women. BMI inequities between immigrant and Spanish-born women were greatest for those aged 55–64 with middle and high education.</div></div><div><h3>Conclusion</h3><div>Although most BMI inequities were explained by the social factors considered as inequity axes, interaction effects were present. The latter calls for a universal public health intervention proportionate to the needs of specific groups in the population. I-MAIHDA revealed complex patterns of BMI inequities in Spain, which may inform the interventions needed to address weight-related outcomes.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"111 ","pages":"Pages 74-81"},"PeriodicalIF":3.0,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145114859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in orofacial cleft prevalence and the effect of prenatal detection on pregnancy outcomes in Northern Netherlands","authors":"Sofia Anania MD ,&nbsp;Marian K. Bakker PhD ,&nbsp;Jorieke E.H. Bergman MD PhD ,&nbsp;Leonie K. Duin MD PhD ,&nbsp;Mike Ruettermann MD PhD ,&nbsp;Dieuwke C. Broekstra PhD","doi":"10.1016/j.annepidem.2025.09.012","DOIUrl":"10.1016/j.annepidem.2025.09.012","url":null,"abstract":"<div><h3>Objectives</h3><div>To describe trends in total and live birth (LB) prevalence of orofacial clefts (OFCs) and investigate the effect of prenatal diagnosis on its LB prevalence in the Northern Netherlands (NNL) over a 21-year period.</div></div><div><h3>Study design</h3><div>Cases with OFCs were selected from Eurocat NNL, a population-based registry of congenital anomalies. Aggregated denominator data (controls) was derived from Statistics Netherlands. We categorized OFCs into cleft lip with or without palate (CL±P) and cleft palate (CP). We analyzed trends in prevalence and temporal patterns in prenatal detection rates and birth type by calculating the annual percentage change (APC) using Joinpoint regression or the <em>X²</em> test for linear trends.</div></div><div><h3>Results</h3><div>The total prevalence of CL±P decreased non-significantly from 1.65/1000 births in 2001 to 1.17/1000 births in 2021 (APC=-0.82 [95 %CI: −2.18, 0.55]), whereas the LB prevalence decreased significantly from 1.57/1000 births in 2001 to 0.93/1000 births in 2021 (APC=-1.65 [95 %CI −3.03, −0.25]). The total and LB prevalence of CP did not show significant decreasing trends.</div><div>The prenatal detection rate of CL±P increased from 15 % to 71 % between 2001 and 2007 (APC=34.38 [95 %CI 24.27, 52.26]), followed by a slower increase, reaching 94 % in 2021 (APC=3.57 [95 %CI 0.59, 6.08]). The percentage of induced abortions increased from 3.2 % to 12.7 % between 2001 and 2021 (<em>X</em>^<em>2</em> for trend P &lt; 0.001), with most induced abortions occurring in the CL±P associated with genetic/syndromic or other congenital anomalies.</div></div><div><h3>Conclusions</h3><div>The LB prevalence of CL±P decreased, which may be associated with better prenatal detection and increasing pregnancy terminations due to unfavorable prognosis</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"111 ","pages":"Pages 44-50"},"PeriodicalIF":3.0,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145103189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methods for estimating public transit travel times to healthcare services as a measure of equitable healthcare access","authors":"Noah Mancuso ,&nbsp;Patrick S. Sullivan","doi":"10.1016/j.annepidem.2025.09.010","DOIUrl":"10.1016/j.annepidem.2025.09.010","url":null,"abstract":"<div><h3>Purpose</h3><div>To introduce an equity-based method for assessing public transit access to health services and apply it to pre-exposure prophylaxis (PrEP) clinics in metro-Atlanta.</div></div><div><h3>Methods</h3><div>Census block groups (CBGs) were analyzed with PrEP clinics identified via <em>PrEP Locator</em>. One-way public transit times were estimated using the <em>Google Maps Distance Matrix</em> API. CBGs were classified as public transit deserts if transit options were unavailable or if travel time was &gt; 30 min. T-tests compared sociodemographic characteristics of CBGs with and without public transit. Linear regression assessed the association of a 5 % increase in priority populations with transit times.</div></div><div><h3>Results</h3><div>Among 2466 CBGs, one-quarter lacked public transit access to PrEP and two-thirds were transit deserts. Median travel time was 32 min. CBGs with transit access had significantly higher proportions of Black, Hispanic/Latinx, young men (aged 25–34), and residents living below the poverty line (P &lt; .001). Increases in the proportion of Hispanic/Latinx residents, young men, and residents living under the poverty line were associated with shorter transit times, with no association for Black residents.</div></div><div><h3>Conclusions</h3><div>Public transit access to PrEP was low in Atlanta, and overall public transit times were long. Current PrEP locations are aligned with priority populations, but additional work is needed to ensure equity is met for Black and Hispanic/Latinx residents.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"111 ","pages":"Pages 24-29"},"PeriodicalIF":3.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between adverse childhood experiences and obesity among young US adults","authors":"Kiran Thapa PhD ,&nbsp;Ye Shen PhD ,&nbsp;José F. Cordero MD, MPH ,&nbsp;Emily Anne Vall PhD ,&nbsp;Janani Rajbhandari-Thapa PhD","doi":"10.1016/j.annepidem.2025.09.009","DOIUrl":"10.1016/j.annepidem.2025.09.009","url":null,"abstract":"<div><h3>Purpose</h3><div>We examined whether adverse childhood experiences (ACEs) are associated with obesity in young adulthood, and whether these associations differ by sex.</div></div><div><h3>Methods</h3><div>We used data from the National Longitudinal Study of Adolescent to Adult Health, a nationally representative cohort of U.S. adolescents followed into adulthood (age 33–43 years) across five waves. Our sample included 5193 participants with measured anthropometrics at wave V (2016–18). Modified Poisson regression estimated risk ratios (RR) for general obesity (body mass index ≥ 30 kg/m²) and abdominal obesity (waist circumference &gt;102 cm for males, &gt;88 cm for females) associated with individual and cumulative ACEs, adjusting for baseline BMI, co-occurring ACEs, and sociodemographic covariates. Sex-stratified models assessed heterogeneity in effects.</div></div><div><h3>Results</h3><div>Childhood physical abuse was independently associated with higher risk of general obesity, particularly among females (aRR: 1.23; 95 % CI: 1.05–1.45). Exposure to ≥ 4 ACEs was associated with increased risk of both general (aRR: 1.32; 95 % CI: 1.15–1.52) and abdominal obesity (aRR: 1.18; 95 % CI: 1.02–1.37), independent of childhood obesity.</div></div><div><h3>Conclusions</h3><div>ACEs, especially physical abuse and cumulative exposure, were linked to higher risk of obesity, suggesting that traumatic events may play an important role in young adulthood obesity, especially in females.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"111 ","pages":"Pages 51-57"},"PeriodicalIF":3.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145088071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence and natural language processing of patient narratives to evaluate semaglutide for weight loss","authors":"Akshaya Srikanth Bhagavathula PhD, FACE","doi":"10.1016/j.annepidem.2025.09.003","DOIUrl":"10.1016/j.annepidem.2025.09.003","url":null,"abstract":"<div><h3>Purpose</h3><div>This study used artificial intelligence (AI) and natural language processing (NLP) to analyze patient reviews of semaglutide, with the goal of better understanding its real-world effectiveness and safety for weight management.</div></div><div><h3>Methods</h3><div>A retrospective, cross-sectional analysis was conducted on 772 user-generated reviews of semaglutide posted on Drugs.com (July 2021–March 2025). Sentiment analysis was performed using a transformer-based BERT model on a five-point scale. Topic modeling with Latent Dirichlet Allocation (LDA) and Latent Semantic Analysis (LSA) was used to identify dominant themes. Cluster analysis was applied to segment users based on weight loss outcomes and side effect severity. Reviewers (n = 95) that explicitly reporting both weight loss and treatment duration were analyzed for real-world efficacy and safety.</div></div><div><h3>Results</h3><div>Users who took semaglutide more than 60 days reported a mean weight loss of 32.2 ± 3.1 lbs (14.6 kg). Frequently mentioned side effects included nausea (46.9 %), headache (18.4 %), vomiting (14.3 %), fatigue (9.2 %), and dizziness (4.8 %). The highest sentiment scores were observed in the ≤ 30-day group (mean: 3.38). Topic modeling identified themes such as appetite suppression, medication cost and access, and long-term experiences. Clusters analysis revealed distinct user profile, including super-responder group with substantial weight loss and another with more side effects.</div></div><div><h3>Conclusions</h3><div>AI and NLP methods offer valuable tools for analyzing patient-reported outcomes, revealing semaglutide’s real-world efficacy and safety profile for weight management. These findings contribute to ongoing efforts to integrate patient-reported data into post-marketing surveillance and treatment decision-making.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"111 ","pages":"Pages 9-13"},"PeriodicalIF":3.0,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular disease burden attributable to estimated glomerular filtration rate: Insights from the ATTICA study (2002–2022)","authors":"Evangelia Damigou ,&nbsp;Matilda Florentin ,&nbsp;Christina Chrysohoou ,&nbsp;Costas Anastasiou ,&nbsp;Fotios Barkas ,&nbsp;Evangelos Liberopoulos ,&nbsp;Petros P. Sfikakis ,&nbsp;Costas Tsioufis ,&nbsp;Christos Pitsavos ,&nbsp;Demosthenes Panagiotakos","doi":"10.1016/j.annepidem.2025.09.007","DOIUrl":"10.1016/j.annepidem.2025.09.007","url":null,"abstract":"<div><h3>Purpose</h3><div>This study aimed to estimate cardiovascular disease (CVD) burden attributable to chronic kidney disease (CKD) and whether this burden varies in participants with different population characteristics.</div></div><div><h3>Methods</h3><div>Our sample included 1988 adults free-of-CVD at baseline who took part in the ATTICA study (2002–2022). Estimated glomerular filtration rate (eGFR) was calculated based on the Chronic Kidney Disease Epidemiology Collaboration equation. CKD was defined in 2002, according to Kidney Disease Improving Global Outcomes (KDIGO) guidelines, as an eGFR ≤ 60 mL/min/1.73 m². Combined fatal or non-fatal CVD events were assessed in 2006, 2012 and 2022 based on WHO-ICD-10. Population attributable fractions for multiadjusted models were computed based on Miettinen’s formula. Stratified analyses were also performed.</div></div><div><h3>Results</h3><div>At baseline, CKD prevalence was 4.7 % (n = 94). During the 20-year period, 36.1 % of participants developed CVD. A higher percentage of participants with CKD developed CVD compared to those without (77 % vs. 34 %). Approximately 6 out of a 100 new CVD cases (95 %CI: 1.7 %, 8.1 %) would have been prevented if CKD had been properly managed. Variations in these fractions were observed by sex and presence of comorbidities.</div></div><div><h3>Conclusions</h3><div>Albeit more research is warranted, our study supports that CKD should become a public health priority, and specifically a CVD priority.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"111 ","pages":"Pages 1-8"},"PeriodicalIF":3.0,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}