Shaohua Yin , Dan Li , Yingying Yang , Qin Wang , Lei Yuan , Keyi Si
{"title":"Association of birthweight with all-cause and cause-specific premature mortality in the UK: A prospective cohort study","authors":"Shaohua Yin , Dan Li , Yingying Yang , Qin Wang , Lei Yuan , Keyi Si","doi":"10.1016/j.annepidem.2025.03.010","DOIUrl":"10.1016/j.annepidem.2025.03.010","url":null,"abstract":"<div><h3>Purpose</h3><div>We investigated the association between birthweight and all-cause and cause-specific premature mortality, and evaluated the effect modification by lifestyle factors.</div></div><div><h3>Methods</h3><div>This prospective cohort study used data of participants aged 39–71 years from the UK Biobank in 2006–2010 and followed up till the end of 2022. Birthweight was classified into < 1.0 kg, 1.0–<1.5 kg, 1.5–<2.5 kg, 2.5–<4.0 kg, and ≥ 4.0 kg. Cox proportional-hazards models were used to estimate adjusted hazard ratios (aHR) and 95 % confidence intervals (CI) for premature mortality.</div></div><div><h3>Results</h3><div>Of 221 848 participants, there were 6336 premature deaths (2148 cardiovascular, 624 respiratory, 3040 cancers, 524 other causes). Birthweight was nonlinearly associated with risks of all-cause, cardiovascular, and cancer-related mortality but the association was linear for respiratory and other-cause mortality. Compared to birthweight of 2.5–<4.0 kg, birthweight< 1.0 kg (aHR 1.36, 95 %CI 1.00–1.85) and ≥ 4.0 kg (1.10, 1.02–1.17) were associated with increased risks of all-cause mortality. A similar pattern was observed for cardiovascular mortality, with corresponding aHRs of 1.54 (1.02–2.49) and 1.16 (1.03–1.31) for birthweight of 2.5–<4.0 kg, and ≥ 4.0 kg, respectively. Birthweight≥ 4.0 kg was associated with increased risk of cancer-related mortality (1.11, 1.00–1.22). The mortality risks did not differ significantly across lifestyle scores (all <em>P</em>-interaction>0.05).</div></div><div><h3>Conclusions</h3><div>Both lower and higher birthweight were associated with increased risks of premature mortality from all causes and cardiovascular diseases, and higher birthweight was associated with increased risk of cancer-related mortality.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"105 ","pages":"Pages 32-40"},"PeriodicalIF":3.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dylan B. Jackson , Alexander Testa , Reed DeAngelis , Odis Johnson Jr , Roland J. Thorpe Jr
{"title":"Historical redlining and criminal offending trajectories from adolescence to adulthood","authors":"Dylan B. Jackson , Alexander Testa , Reed DeAngelis , Odis Johnson Jr , Roland J. Thorpe Jr","doi":"10.1016/j.annepidem.2025.03.003","DOIUrl":"10.1016/j.annepidem.2025.03.003","url":null,"abstract":"<div><h3>Purpose</h3><div>Area-level research finds higher contemporary crime rates in historically redlined communities. However, there is a lack of multilevel research assessing the relationship between living in a historically redlined area, individual patterns of criminal offending over time, and whether this relationship varies for different racial-ethnic groups.</div></div><div><h3>Methods</h3><div>Data are from Waves I, III, IV, and V of the National Longitudinal Study of Adolescent to Adult Health (<em>n</em> = 7843; ages 11–44), including recently digitized 1930s redlining maps from the Home Owners’ Loan Corporation. Using age-based growth curve models, we estimate rates of criminal offending for non-Hispanic Black, Hispanic, and non-Hispanic White Americans who live inside (vs. outside) formerly redlined areas from adolescence to adulthood.</div></div><div><h3>Results</h3><div>Starting in adolescence, Black and Hispanic respondents typically report more criminal offenses than White peers, regardless of redlining. As respondents transition to adulthood, reports of criminal offenses approach zero at an exponential rate. However, declines in criminal offenses are lagged by two years, on average, for Black and Hispanic respondents who live in redlined areas, relative to White and non-redlined counterparts.</div></div><div><h3>Conclusions</h3><div>Findings suggest formerly redlined urban areas may still promote criminal behavior, particularly for Black and Hispanic adolescents transitioning to adulthood. Future research and policy should address the long-term consequences of institutionalized segregation for public safety and community well-being.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"105 ","pages":"Pages 20-25"},"PeriodicalIF":3.3,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143694010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emily M. D’Agostino , Cambey Mikush , Denise M. Nepveux , Barb Hooper
{"title":"Innovative epidemiology instruction for promoting population health thinking in occupational therapy doctoral students","authors":"Emily M. D’Agostino , Cambey Mikush , Denise M. Nepveux , Barb Hooper","doi":"10.1016/j.annepidem.2025.03.009","DOIUrl":"10.1016/j.annepidem.2025.03.009","url":null,"abstract":"<div><h3>Purpose</h3><div>Recent shifts toward population-based health care and research in health science training programs are vital to reducing health disparities, although students need stronger education in this area. This study aimed to determine if innovative epidemiology research instruction is associated with improved science literacy skills, a core objective of population health curricula, for occupational therapy doctoral students.</div></div><div><h3>Methods</h3><div>We used the Test of Scientific Literacy Skills (TOSLS) to determine change in student science literacy skills based on change in performance from baseline. Multilevel repeated measures models were run clustering by student and cohort, adjusted for demographics and prior research courses.</div></div><div><h3>Results</h3><div>The sample included 166 students (91 % female, 57 % Non-Hispanic White, 14 % Hispanic, 19 % Non-Hispanic Black, 10 % Asian; 83 % ≤25 years old). Model estimates showed improvements in science literacy skills (β=0.39 [95 %CI:0.10, 0.67]) relative to baseline. Interaction models showed greater improvements from baseline for students who identified as Hispanic (β=0.82 [95 %CI:0.10, 1.63]) and Non-Hispanic White (β=0.55 [95 %CI:0.16, 0.94]). Additional interaction models did not show differences in the time-TOSLS association by student characteristics.</div></div><div><h3>Conclusions</h3><div>Innovative epidemiology instruction may be an appropriate method for supporting health sciences student development of science literacy skills to foster population health thinking, research, and practice.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"105 ","pages":"Pages 26-31"},"PeriodicalIF":3.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Trends in cardiometabolic risk factors according to body mass index in Peru between 2015 and 2023","authors":"Rodrigo M. Carrillo-Larco , Antonio Bernabe-Ortiz","doi":"10.1016/j.annepidem.2025.03.006","DOIUrl":"10.1016/j.annepidem.2025.03.006","url":null,"abstract":"<div><h3>Background</h3><div>Global evidence has shown rising trends in the prevalence of cardiometabolic risk factors. Whether the same trends are observed according to body mass index (BMI) cut-offs is unknown, though critical to focus on specific BMI populations.</div></div><div><h3>Methods</h3><div>We conducted a pooled analysis of national health surveys in Peru, grouped into three-year periods (2015–17 [n = 97,079], 2018–20 [n = 98,540], 2021–23 [n = 94,850]). BMI (kg/m²) was classified into four categories: normal weight (18–24.9), overweight (25–29.9), obesity I (30–34.9), and obesity II (≥35). For each period-BMI category, we computed the age-sex-standardized prevalence of cardiometabolic risk factors: raised blood pressure with and without self-reported antihypertensive treatment, self-reported diabetes with and without treatment, daily smoking, alcohol consumption in the last month, and fruits/vegetables consumption in the last week.</div></div><div><h3>Results</h3><div>The proportion of people with raised blood pressure increased in the overweight and obesity groups, with the largest increase observed in the obesity II group (22 % relative increase). Diabetes prevalence rose substantially among normal weight (89 %) and overweight individuals (58 %). Smoking, alcohol, and fruit/vegetable consumption showed no major changes across BMI categories.</div></div><div><h3>Conclusions</h3><div>The prevalence of raised blood pressure has increased between 2015 and 17 and 2020–23, with greater increases observed in the overweight and obesity groups; conversely, the prevalence of self-reported diabetes has increased across BMI categories. These findings highlight the need for tailored interventions targeting both overweight/obese individuals and normal weight populations with diabetes risk.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"105 ","pages":"Pages 1-7"},"PeriodicalIF":3.3,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The influence of frailty: How the associations between modifiable risk factors and dementia vary","authors":"Lingyuan Gao , Junhan Tang , Michelle C. Odden, Chenkai Wu","doi":"10.1016/j.annepidem.2025.03.005","DOIUrl":"10.1016/j.annepidem.2025.03.005","url":null,"abstract":"","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"104 ","pages":"Page 79"},"PeriodicalIF":3.3,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143637166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Sousa , J.A. Fonseca-Moutinho , F. Gomes , F. Loureiro , A.R. Goes , P. Soares
{"title":"Spatial analysis of HPV infection and contextual factors associated with higher HPV prevalence","authors":"R. Sousa , J.A. Fonseca-Moutinho , F. Gomes , F. Loureiro , A.R. Goes , P. Soares","doi":"10.1016/j.annepidem.2025.03.002","DOIUrl":"10.1016/j.annepidem.2025.03.002","url":null,"abstract":"<div><h3>Objectives</h3><div>To identify areas with high rates of high-risk Papillomavirus (hrHPV) infection and associated contextual factors in the Centre Region of Portugal at the municipality level.</div></div><div><h3>Study design</h3><div>We conducted an ecological study in 78 municipalities located in the Central Region of Portugal from March 2019 to December 2022.</div></div><div><h3>Methods</h3><div>We used data from the cervical cancer screening (CCS) program database after switching to primary HPV testing. Demographic, socio-economic, and healthcare availability variables were extracted from official sources (<em>Statistics Portugal</em> and Central Region Health Administration Information Systems). Spatial analysis and logistic generalised linear models were used to identify areas of high hrHPV infection and associated contextual factors.</div></div><div><h3>Results</h3><div>The overall hrHPV infection prevalence was 9.9 %. We found three significant clusters, predominantly in municipalities near major urban centres. These clusters were characterised by higher population density, a greater proportion of younger women, higher median income per inhabitant, a larger proportion of residents with graduate degrees, and increased availability of healthcare units.</div></div><div><h3>Conclusions</h3><div>This study has uncovered the geographical distribution of hrHPV infection at the municipal level and highlights the contextual factors associated with higher prevalence. Identifying demographics and socio-economic predictors of high hrHPV infection could support public health programs by targeting interventions to specific populations and contexts. This might open up new scenarios for improving prevention and control strategies, offering more intensive screening in areas with the most urgent needs.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"105 ","pages":"Pages 8-14"},"PeriodicalIF":3.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143634054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lorenzo Blandi , Paola Bertuccio , Timo Clemens , Helmut Brand , Anna Odone
{"title":"Incidence and mortality trends of people living with dementia among 7 million individuals over 10 years in Italy: A retrospective cohort study using administrative linked data","authors":"Lorenzo Blandi , Paola Bertuccio , Timo Clemens , Helmut Brand , Anna Odone","doi":"10.1016/j.annepidem.2025.03.007","DOIUrl":"10.1016/j.annepidem.2025.03.007","url":null,"abstract":"<div><h3>Purpose</h3><div>We aimed to estimate trends of dementia incidence and to compute and compare all-cause mortality among people living with and without dementia, in a whole regional population, from 2013 to 2023.</div></div><div><h3>Methods</h3><div>Our retrospective population-wide cohort study included 7,030,374 people aged 50 years and older from regional administrative data, living in Lombardy, the most populous Italian region. We computed annual age-standardised dementia incidence estimated rates and age-standardised all-cause mortality estimated rates among people living with and without dementia, both overall and stratified by age and sex.</div></div><div><h3>Results</h3><div>Over the last decade, age-standardised dementia incidence estimated rates have decreased by 52.8 % for women and 53.1 % for males. In contrast, age-standardised all-cause mortality estimated rates among people living with dementia grew by 14.0 % for women and 21.8 % for males. Conversely, during the pandemic, there was a higher excess in mortality estimated rates in the female population living with dementia compared to the male, up to 60 % in older groups aged 80 or older. In the male population without dementia compared to the female, the higher excess was up to 50 % in age groups of 70–74 and 75–79.</div></div><div><h3>Conclusions</h3><div>Our study reported a reduction in dementia incidence and increase in all-cause mortality of people living with dementia over the last decade, indicating that dementia prevalence is declining. Moreover, previously under-investigated gender disparities in mortality estimated rates emerged across different age groups during the pandemic.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"104 ","pages":"Pages 72-78"},"PeriodicalIF":3.3,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of frailty on the associations between modifiable risk factors and dementia","authors":"Tomoyuki Kawada","doi":"10.1016/j.annepidem.2025.03.004","DOIUrl":"10.1016/j.annepidem.2025.03.004","url":null,"abstract":"","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"104 ","pages":"Page 71"},"PeriodicalIF":3.3,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Quang Vuong , Rebecca K. Metcalfe , Albee Ling , Benjamin Ackerman , Kosuke Inoue , Jay JH Park
{"title":"Systematic review of applied transportability and generalizability analyses: A landscape analysis","authors":"Quang Vuong , Rebecca K. Metcalfe , Albee Ling , Benjamin Ackerman , Kosuke Inoue , Jay JH Park","doi":"10.1016/j.annepidem.2025.03.001","DOIUrl":"10.1016/j.annepidem.2025.03.001","url":null,"abstract":"<div><div>Transportability and generalizability analysis are novel causal inference methods that quantitatively assess external validity. Currently, it is unclear how these analyses are applied in practice. To characterize applications and methods, we conducted a landscape analysis of applied transportability and generalizability analyses using a systematic literature search of PubMed, CINAHL and Embase supplemented with hand-searches. We identified 68 publications describing transportability and generalizability analyses conducted with 83 unique source-target dataset pairs and reporting 99 distinct analyses. The majority of source and target datasets were collected in the US (n = 63/83, 75.9 %; and n = 59/83, 71.1 %, respectively). These methods were most often applied to transport RCT findings to observational studies (n = 38/83; 45.8 %), or to another RCT (n = 20/83; 24.1 %). Several studies used transportability analysis outside the standard application, for example to identify effect modifiers or calibrate measurements within an RCT. Methods that used weights and individual-level patient data were most common (n = 56/99, 56.5 %; n = 80/83, 96.4 %, respectively). Reporting quality varied across studies. Transportability analysis has a wide range of applications including supporting decision-making by improving evidence relevance and improving trial design by identifying contextual effect modifiers and calibrating outcome measurements. Efforts are needed to standardize analysis and reporting of these methods to improve transparency and uptake.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"104 ","pages":"Pages 61-70"},"PeriodicalIF":3.3,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alexa Zimbalist, Kelly H. Radimer, Isaac J. Ergas, Janise M. Roh, Charles P. Quesenberry, Marilyn L. Kwan, Lawrence H. Kushi
{"title":"Utilization of locally estimated scatterplot smoothing (LOESS) regression to estimate missing weights in a longitudinal cohort of breast cancer patients","authors":"Alexa Zimbalist, Kelly H. Radimer, Isaac J. Ergas, Janise M. Roh, Charles P. Quesenberry, Marilyn L. Kwan, Lawrence H. Kushi","doi":"10.1016/j.annepidem.2025.02.013","DOIUrl":"10.1016/j.annepidem.2025.02.013","url":null,"abstract":"<div><h3>Introduction</h3><div>Traditional methods to handle missing data rely on making assumptions about missing data patterns. Locally estimated scatterplot smoothing (LOESS) regression models were explored as a data-driven option to minimize missing weight data in a longitudinal cohort of breast cancer patients.</div></div><div><h3>Methods</h3><div>Outpatient weights from 2 years prior to breast cancer diagnosis to 10 years post were extracted from electronic health records for 10,778 women with invasive breast cancer diagnosed from 2005‐2013 at Kaiser Permanente. LOESS regression models estimated weights at baseline (breast cancer diagnosis) and 6 follow-up time points (6, 12, 24, 48, 72, and 96 months post-baseline). The weights identified by the LOESS models were compared with those identified by the closest-available method, in which the weight measurement closest to each timepoint within a specified time window was selected.</div></div><div><h3>Results</h3><div>Compared with the closest-available method, LOESS models identified fewer weights at baseline and 6 months post, but significantly more weights at later follow-up periods. At all timepoints, more than 80% of the weights identified by both approaches differed by 2.50 kilograms or less.</div></div><div><h3>Conclusions</h3><div>LOESS regression makes effective use of available longitudinal data and may be a beneficial tool to minimize missing longitudinal data in future EHR-based studies.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"104 ","pages":"Pages 55-60"},"PeriodicalIF":3.3,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}