The association of preterm birth and small for gestational age with recurrent multisite musculoskeletal pain during early and middle adulthood — The Northern Finland Birth Cohort 1966 Study

IF 3 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Annals of Epidemiology Pub Date : 2025-09-19 DOI:10.1016/j.annepidem.2025.09.011

Sandra-Sofia Nieminen , Jaro Karppinen , Eero Kajantie , Paulo Ferreira , Eveliina Heikkala

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引用次数: 0

Abstract

Purpose

Musculoskeletal (MSK) pain is a leading cause of disability and commonly affects multiple locations. Identifying early-life risk factors could enable targeted prevention of multisite MSK pain. This study investigated associations of preterm birth (<37 weeks) and small for gestational age (SGA) with recurrent multisite MSK pain during early and middle adulthood.

Methods

Participants in the NFBC1966 were prospectively followed from gestation to 46 years. Exposure data were based on delivery records; the outcome was self-reported. Multinomial logistic regression estimated odds ratios (ORs) and 95 % confidence intervals (CIs) both unadjusted and adjusted [a] for sex, maternal age at birth, pregnancy disorder, maternal smoking, family socioeconomic status, and parity.

Results

Among participants, 12 % born prematurely and 16 % born at term reported recurrent multisite MSK pain between 31 and 46 years (aOR 0.79, 95 % CI 0.43–1.46). Using continuous gestational age, a statistically significant association was observed (aOR 1.07, 95 % CI 1.00–1.14). SGA showed no association (aOR 0.94, 95 % CI 0.84–1.04). No associations were found for onset or resolved multisite MSK pain.

Conclusion

Preterm birth and SGA were not negatively associated with adult multisite MSK pain. A protective association appeared with continuous gestational age, but small sample sizes warrant cautious interpretation.

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1966年芬兰北部出生队列研究：早产和小于胎龄与成年早期和中期复发性多部位肌肉骨骼疼痛的关系

目的：肌肉骨骼（MSK）疼痛是残疾的主要原因，通常影响多个位置。识别早期生活风险因素可以有针对性地预防多部位MSK疼痛。本研究调查了早产的相关性(方法：NFBC1966的参与者从妊娠到46岁进行前瞻性随访。暴露数据基于分娩记录；结果是自我报告的。多项逻辑回归估计了性别、产妇出生年龄、妊娠障碍、产妇吸烟、家庭社会经济地位和胎次的未调整和调整的比值比（ORs）和95%置信区间（ci）。结果：在参与者中，12%的早产儿和16%的足月新生儿报告在31至46岁期间复发性多部位MSK疼痛（aOR 0.79, 95% CI 0.43-1.46）。使用连续胎龄，观察到有统计学意义的关联（aOR 1.07, 95% CI 1.00-1.14）。SGA无相关性（aOR 0.94, 95% CI 0.84-1.04）。没有发现与多部位MSK疼痛的发作或消退有关。结论：早产和SGA与成人多部位MSK疼痛无负相关。连续胎龄出现保护性关联，但样本量小需要谨慎解释。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Epidemiology 医学-公共卫生、环境卫生与职业卫生

CiteScore

7.40

自引率

1.80%

发文量

207

审稿时长

59 days

期刊介绍： The journal emphasizes the application of epidemiologic methods to issues that affect the distribution and determinants of human illness in diverse contexts. Its primary focus is on chronic and acute conditions of diverse etiologies and of major importance to clinical medicine, public health, and health care delivery.