David R. Holtgrave PhD , James V. McDonald MD, MPH
{"title":"Benefits of reaching the national 2025 goal for reduction in fatal drug overdoses, AEP-D-25-00208 R2","authors":"David R. Holtgrave PhD , James V. McDonald MD, MPH","doi":"10.1016/j.annepidem.2025.05.015","DOIUrl":"10.1016/j.annepidem.2025.05.015","url":null,"abstract":"<div><h3>Purpose</h3><div>Centers for Disease Control and Prevention (CDC) provisional data on drug fatalities for year ending December 2024 indicates that the 2025 national goal of reducing drug fatalities to 81,000 or fewer was met one year early. We estimate the 2024 public health impacts of meeting that goal and analyze the impacts of three scenarios for 2025: continued downward trajectory of drug fatalities, stagnation, or regression of progress.</div></div><div><h3>Methods</h3><div>CDC 2024 data was compared to 2023 data to estimate lives saved, years of life saved, and valuation of statistical lives saved. Three scenarios for year ending December 2025 were compared to 2024 data to estimate the impact on the same metrics.</div></div><div><h3>Results</h3><div>Drug fatality progress in 2024 relative to 2023 resulted in 29,646 lives saved, 928,916 years of life saved, and valuation of statistical lives saved ranging from $180 billion to $584 billion. If similar percentage declines in drug fatalities occur in 2025, another 21,659 lives would be saved. However, if drug fatalities flatten or rise in 2025, opportunities to save lives be lost.</div></div><div><h3>Conclusion</h3><div>Meeting the national goal one year early resulted in substantial public health benefits in 2024. Now, programmatic and policy efforts must prevent stagnation or backsliding.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"107 ","pages":"Pages 51-53"},"PeriodicalIF":3.3,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mihret Melaku, Diana L Juvinao-Quintero, Sixto E Sanchez, Marta B Rondon, Clemens Kirschbaum, Michelle A Williams, Bizu Gelaye
{"title":"Association of preconception maternal glucocorticoid concentrations with sex ratio at birth: Evidence from a prospective cohort study.","authors":"Mihret Melaku, Diana L Juvinao-Quintero, Sixto E Sanchez, Marta B Rondon, Clemens Kirschbaum, Michelle A Williams, Bizu Gelaye","doi":"10.1016/j.annepidem.2025.05.011","DOIUrl":"https://doi.org/10.1016/j.annepidem.2025.05.011","url":null,"abstract":"<p><strong>Purpose: </strong>To examine the association between maternal preconception glucocorticoid concentrations and the sex ratio at birth (SRB).</p><p><strong>Methods: </strong>We analyzed data from 1,106 pregnant women in a birth cohort study in Lima, Peru, focusing on singleton live births with complete data for preconception glucocorticoids, newborn sex, and covariates. Hair samples of 6 cm were collected in the first trimester and analyzed using LC-MS/MS to extract cortisol (HCC) and cortisone concentrations (HCNC) from the 3-6 cm hair segment. Baseline maternal characteristics were described using descriptive statistics. Unadjusted and adjusted Poisson regressions assessed associations between preconception glucocorticoids and newborn sex.</p><p><strong>Results: </strong>Most of the samples were Mestizos, multiparous, and married women. The observed SRB was 0.52 (576 males out of 1,106 total births). Adjusted regressions revealed an association between higher preconception HCC and an 8% reduction in male births (95% CI = 0.85, 0.99). Quartile comparisons showed a 13% decline in male births in the highest versus the lowest quartile of preconception HCC, with similar trends seen for HCNC.</p><p><strong>Conclusion: </strong>The observed SRB aligns with global averages, and the inverse relationship between preconception cortisol levels and male births supports prior evidence linking maternal stress to SRB variation. This study underscores the potential role of maternal stress and hypothalamic-pituitary-adrenal axis function in influencing reproductive outcomes.</p>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":" ","pages":""},"PeriodicalIF":3.3,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association of sleep duration, bedtime regularity, and weekend catch-up sleep with age-related hearing loss: A population-based cross-sectional study","authors":"Juyeon Lee , Bong Jik Kim , Bo Ram Yang","doi":"10.1016/j.annepidem.2025.05.009","DOIUrl":"10.1016/j.annepidem.2025.05.009","url":null,"abstract":"<div><h3>Purpose</h3><div>Age-related hearing loss (ARHL) impacts quality of life and cognition in older adults, but its link to sleep patterns remains unclear. This study explores associations between ARHL and sleep duration, weekend catch-up sleep (WCS), and bedtime regularity in a Korean population.</div></div><div><h3>Methods</h3><div>Data from 6797 adults aged ≥ 40 years were analyzed using the Korea National Health and Nutrition Examination Survey (KNHANES, 2021–2022). Sleep patterns were assessed via self-reported questionnaires. ARHL was classified as mild (26–41 dB) or moderate and above (>41 dB) using audiometry. Poisson regression models examined associations between sleep characteristics and ARHL, adjusting for confounders.</div></div><div><h3>Results</h3><div>WCS (≥1 h) was significantly associated with a lower prevalence of both mild (adjusted prevalence ratio = 0.58, 95 % CI: 0.44–0.76) and moderate ARHL (aPR = 0.79, 95 % CI: 0.63–0.98). These associations remained robust in stratified analyses among middle-aged adults and men (p-interaction < 0.01). In contrast, sleep duration and bedtime regularity showed no significant associations with ARHL after adjustment.</div></div><div><h3>Conclusion</h3><div>Our findings indicate that WCS may be associated with a lower prevalence of ARHL, particularly in middle-aged adults and men, highlighting the potential role of sleep behavior in auditory health promotion.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"107 ","pages":"Pages 37-43"},"PeriodicalIF":3.3,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dougie Zubizarreta , Sari L. Reisner , Jarvis T. Chen , Merrily E. LeBlanc , Nykesha R. Johnson , Nancy Krieger
{"title":"Context matters: Validity and reliability of a sociopolitical concerns measure for use in population health research on discrimination and health","authors":"Dougie Zubizarreta , Sari L. Reisner , Jarvis T. Chen , Merrily E. LeBlanc , Nykesha R. Johnson , Nancy Krieger","doi":"10.1016/j.annepidem.2025.05.008","DOIUrl":"10.1016/j.annepidem.2025.05.008","url":null,"abstract":"<div><h3>Background</h3><div>Sociopolitical contexts shape both experiences of discrimination and health, yet limited research has included sociopolitical concerns metrics, as an exposure, confounder, or effect modifier.</div></div><div><h3>Objective</h3><div>To assess psychometric properties of a self-report measure of sociopolitical concerns.</div></div><div><h3>Methods</h3><div>We assessed a 15-item sociopolitical concerns scale, based on Gallup poll questions, in a cross-sectional sample of 699 US-born adults ages 25–64 years recruited from three community health centers in Boston, Massachusetts, between May 2020-July 2022. We conducted exploratory factor analysis (EFA) to assess construct validity and multi-group confirmatory factor analysis (CFA) to assess measurement invariance across groups for 6 types of discrimination, involving age, racialized group, gender modality, gender identity, sexual orientation, and weight.</div></div><div><h3>Results</h3><div>Inter-item correlations ranged from 0.04 to 0.50 (36 % of correlations were <span><math><mo>≥</mo></math></span>0.40), with a high Cronbach’s alpha (0.87). EFA revealed three underlying factors, all related to a single construct. Multi-group CFA indicated that configural and metric invariance held for 5 of the 6 discrimination groups (for age, only configural invariance held). Self-reported experiences of discrimination were positively associated with sociopolitical concerns for each type of discrimination.</div></div><div><h3>Conclusion</h3><div>The sociopolitical concerns scale is a reliable measure with strong construct validity, potentially useful for future research on discrimination and health.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"107 ","pages":"Pages 24-28"},"PeriodicalIF":3.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144137841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Saad Ahmed Waqas , Sonia Hurjkaliani , Hussain Salim , Peter Collins , Raheel Ahmed
{"title":"Post-COVID shifts and disparities in hypertension-related mortality in the United States","authors":"Saad Ahmed Waqas , Sonia Hurjkaliani , Hussain Salim , Peter Collins , Raheel Ahmed","doi":"10.1016/j.annepidem.2025.05.010","DOIUrl":"10.1016/j.annepidem.2025.05.010","url":null,"abstract":"<div><h3>Purpose</h3><div>This study examines trends in hypertension-related mortality in the U.S. before, during, and after the COVID-19 pandemic, assessing demographic and regional disparities.</div></div><div><h3>Methods</h3><div>We used CDC WONDER’s Provisional Multiple Cause of Death database (2018–2023) to analyze age-adjusted mortality rates (AAMRs) for hypertension (ICD-10: I10–I15). We calculated percentage changes across three periods: pre-COVID (2018–2019), during COVID (2020–2021), and post-COVID (2022–2023), stratifying by age, sex, race/ethnicity, and region.</div></div><div><h3>Results</h3><div>Hypertension-related AAMRs increased by 33.4 % from pre- to during COVID (193.5–258.2 per 100,000) and remained 28.1 % above pre-pandemic levels post-COVID. Mortality rose across all demographics, with men experiencing a 34.1 % increase and younger adults (25–44 years) experiencing the highest rise (42.1 %). Hispanic individuals saw the largest increase (49.8 %) but also the sharpest post-pandemic decline (17.8 %). Regional disparities persisted, with the South having the highest increase (37.2 %) and the smallest drop (1.5 %).</div></div><div><h3>Conclusions</h3><div>Despite a modest decline post-pandemic, hypertension-related mortality remains elevated, with persistent disparities by sex, age, race, and region. Targeted interventions are needed to address hypertension management and reduce mortality in high-risk populations.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"107 ","pages":"Pages 20-23"},"PeriodicalIF":3.3,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144130868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Danping Liu , Martha S. Linet , Paul S. Albert , Cato M. Milder , Annelie M. Landgren , Allison Iwan , Lynn Penberthy , Bruce H. Alexander , Amy Berrington de González , Cari M. Kitahara
{"title":"Examining bias due to method of follow-up for cancer incidence in a large U.S. cohort: Self-report versus registry linkage","authors":"Danping Liu , Martha S. Linet , Paul S. Albert , Cato M. Milder , Annelie M. Landgren , Allison Iwan , Lynn Penberthy , Bruce H. Alexander , Amy Berrington de González , Cari M. Kitahara","doi":"10.1016/j.annepidem.2025.05.006","DOIUrl":"10.1016/j.annepidem.2025.05.006","url":null,"abstract":"<div><h3>Background</h3><div>Cancer incidence follow-up of many U.S. cohort studies relies on self-report due to the lack of a national cancer registry.</div></div><div><h3>Methods</h3><div>In the U.S. Radiologic Technologists (USRT) Study, cancer incidence has been captured via self-report approximately every 10 years between the mid-1980s and mid-2010s and via linkages with state cancer registries during 1999–2012. We compared associations of smoking and lung cancer (rapidly fatal) and body mass index and thyroid cancer (rarely fatal) according to method of cancer incidence follow-up: self-report versus registry-based. Simulation studies were performed to quantify bias and assess relative efficiency of cancer ascertainment methods.</div></div><div><h3>Results</h3><div>During 1999–2012, hazard ratio (HR) estimates were similar regardless of cancer follow-up method, although self-reported data yielded the widest confidence intervals (CIs). Simulation studies showed that registry data yielded the least-biased HRs. The usefulness of self-reported data depends mostly on its specificity: with perfect specificity, self-reported data led to nearly unbiased inference. However, with imperfect specificity, self-reported data resulted in 3–9 % bias and lower than nominal CI coverage.</div></div><div><h3>Conclusions</h3><div>These findings highlight the benefits of registry-based cancer incidence follow-up compared to self-report in contemporary U.S. cohort studies assuming high coverage by registries of the study population.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"107 ","pages":"Pages 44-50"},"PeriodicalIF":3.3,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Joint associations of physical activity and body mass index on the prevalence of hypertension among a nationally representative sample of 1.9 million U.S. adults: A cross-sectional study","authors":"David Abernethy , Jason Bennie , Toby Pavey","doi":"10.1016/j.annepidem.2025.05.002","DOIUrl":"10.1016/j.annepidem.2025.05.002","url":null,"abstract":"<div><h3>Purpose</h3><div>This study examines the joint associations of physical activity (PA) and body mass index (BMI) on the prevalence of hypertension in a nationally representative sample of 1.9 million U.S. adults.</div></div><div><h3>Methods</h3><div>Data were pooled from five U.S. Behavioural Risk Factor Surveillance System surveys from 2011 to 2019. Cross-sectional associations between self-reported PA and BMI status (independent variables) and hypertension (dependent variable) were analysed using Poisson log-linear regression with a robust-error variance, reported by adjusted prevalence ratios (APRs).</div></div><div><h3>Results</h3><div>Data was available for 1,909,597 individuals (≥18 years). Compared to normal weight, highly active individuals (reference category), there was an association with decreased PA, increased BMI and prevalence of hypertension. Adjusted prevalence ratios (APRs) ranged from APR= 1.05, 95 % CI= 1.05–1.05 (Non-Active, Normal Weight) to APR= 1.83, 95 % CI= 1.82–1.83 (Non-Active, Obesity Class III).</div></div><div><h3>Conclusion</h3><div>A high body mass and low levels of PA were associated with a substantially increased prevalence of hypertension. Being highly active was associated with minor differences in the prevalence of hypertension for individuals who were living with obesity; however, this association was not observed among those who were living with normal weight or overweight. Due to likely bias in this cross-sectional study, findings regarding PA should be replicated in longitudinal studies with objective measures. These findings nonetheless highlight the public health relevance of maintaining a healthy body weight in relation to hypertension prevalence and the importance of PA for weight loss and management.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"107 ","pages":"Pages 29-36"},"PeriodicalIF":3.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144095690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Samuel C.O. Opara , Caitlin A. Moran , Shivani A. Patel , Anandi N. Sheth , Sophia A. Hussen , Jithin Sam Varghese
{"title":"Within-partner concordance of hypertension and overweight/obesity among sexual minority couples","authors":"Samuel C.O. Opara , Caitlin A. Moran , Shivani A. Patel , Anandi N. Sheth , Sophia A. Hussen , Jithin Sam Varghese","doi":"10.1016/j.annepidem.2025.05.004","DOIUrl":"10.1016/j.annepidem.2025.05.004","url":null,"abstract":"<div><h3>Purpose</h3><div>The role of partners on an individual's cardiometabolic risk status in same-sex relationships is underexplored to date, despite significant health disparities impacting sexual minority individuals. This study investigated cardiometabolic risk concordance in same-sex older adult couples in the United States.</div></div><div><h3>Methods</h3><div>We conducted a pooled analysis of seven study waves of the University of Michigan Health and Retirement Survey (2006–2019) and estimated concordance of hypertension and overweight/obesity among same-sex couples.</div></div><div><h3>Results</h3><div>Among 81 same-sex couples, we observed high concordance of hypertension and overweight/obesity among sexual minority male couples (39 couples, hypertension: 72.4 %, overweight/obesity: 64.2 %) and sexual minority female couples (42 couples, hypertension: 61.0 %, overweight/obesity: 35.6 %).</div></div><div><h3>Conclusions</h3><div>Our findings signify a need for longitudinal studies among same-sex couples to better characterize mechanisms of influence on partners’ cardiometabolic health, as well as a potential role for couple-level interventions targeting cardiometabolic risk.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"107 ","pages":"Pages 8-12"},"PeriodicalIF":3.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144086597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rajib Dey , Federico Roncarolo , Geneviève Mercille , Mylene Riva , Elsury J. Perez , Rosanne Blanchet , Mabel Carabali , Caroline Adam , Louise Potvin , Marie-Pierre Sylvestre
{"title":"Trajectories of food bank use among new users in Quebec, Canada: Evidence from the pathways study","authors":"Rajib Dey , Federico Roncarolo , Geneviève Mercille , Mylene Riva , Elsury J. Perez , Rosanne Blanchet , Mabel Carabali , Caroline Adam , Louise Potvin , Marie-Pierre Sylvestre","doi":"10.1016/j.annepidem.2025.05.003","DOIUrl":"10.1016/j.annepidem.2025.05.003","url":null,"abstract":"<div><h3>Purpose</h3><div>This study describes trajectories of food bank (FB) use among new users in relation with change in food insecurity status.</div></div><div><h3>Methods</h3><div>The Pathways Study followed 1001 new FB users across four regions of Québec, Canada, over a two-year period, from September 2018 to January 2020. Participants reported past-month FB use in two consecutive interviews following a baseline assessment, leading to 24 consecutive measures of monthly FB use. Household food insecurity was measured using the Household Food Security Survey Module. Group-based trajectory analysis was used to identify trajectories of FB use.</div></div><div><h3>Results</h3><div>Six trajectories were identified, including chronic use (30 % of the sample), infrequent use (11 %), withdrawal after recruitment (22 %), fast withdrawal (14 %), slow withdrawal (15 %), and intermittent (8 %). Chronic FB usage was associated with lower education levels and rural residency, suggesting economic challenges and limited opportunities in such areas. About a third of FB users changed their status from food insecure at baseline to food secure at the end of follow-up.</div></div><div><h3>Conclusions</h3><div>These findings challenge the perception of FB users as a homogenous group and emphasize the need for tailored approaches to address food insecurity.</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"107 ","pages":"Pages 1-7"},"PeriodicalIF":3.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jessica Korona-Bailey MPH , Jenna Moses MPH , Mircea Lazar PhD , Kristi Hall MPH , Sutapa Mukhopadhyay PhD
{"title":"Examining potential bystander presence for overdose deaths in Tennessee, 2019–2022","authors":"Jessica Korona-Bailey MPH , Jenna Moses MPH , Mircea Lazar PhD , Kristi Hall MPH , Sutapa Mukhopadhyay PhD","doi":"10.1016/j.annepidem.2025.05.005","DOIUrl":"10.1016/j.annepidem.2025.05.005","url":null,"abstract":"<div><h3>Objective</h3><div>To examine potential bystander presence in fatal drug overdoses in Tennessee by assessing the type of potential bystander, type of responses carried out, reasons for lack of response, and the sociodemographic characteristics of overdose decedents in Tennessee.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study to examine potential bystander presence in overdose deaths in Tennessee using 2019–2022 data from the State Unintentional Drug Overdose Reporting System. Descriptive statistics were calculated to compare potential bystander presence by demographic breakdown of decedents, type of potential bystander, and reasons for no response.</div></div><div><h3>Results</h3><div>We identified 11,970 accidental and undetermined fatal drug overdoses in Tennessee from 2019 to 2022. A potential bystander was present in 24.8 % of deaths. Most potential bystanders were family members (27.4 %), intimate partners (26.5 %), or friends (21.1 %). Overall, potential bystanders called 911 or attempted another type of response in 94.5 % of overdose events. The most frequent reason for no response was being spatially separated from the decedent (34.2 %).</div></div><div><h3>Conclusions</h3><div>A quarter of drug overdose deaths in Tennessee had a potential bystander present who could have intervened. Continued education about how to identify and respond to an overdose as well as the availability of naloxone should be delivered to potential bystanders. Future qualitative studies should assess bystander knowledge and barriers to responding. Messaging should also encourage people who use substances to avoid using alone, given that most overdose deaths occurred without a bystander present</div></div>","PeriodicalId":50767,"journal":{"name":"Annals of Epidemiology","volume":"107 ","pages":"Pages 13-19"},"PeriodicalIF":3.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}