青少年早期有多动/注意力不集中问题的年轻人酒精使用障碍的风险：英国出生队列研究

IF 3.3 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Annals of Epidemiology Pub Date : 2025-07-15 DOI:10.1016/j.annepidem.2025.07.018

Dr Berihun Dachew, Getinet Ayano, Rosa Alati

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引用次数: 0

摘要

目的：本研究旨在探讨青少年早期多动/注意力不集中问题与成年早期AUDs风险之间的关系。方法：我们使用的数据来自雅芳父母和儿童纵向研究（ALSPAC），这是一项基于英国布里斯托尔的基于人群的前瞻性队列研究。Logistic回归分析用于检验相关性。计算E值(E)来估计未测量的混杂程度。结果：青春期早期的多动/注意力不集中问题与任何AUDs的风险增加1.75倍相关(OR = 1.75, 95% CI: 1.20-2.56；E= 2.90, CI: 1.69)， 24岁时严重酒精使用障碍的风险增加4倍(OR = 4.35, 95% CI: 2.00 - 9.47；E= 8.17, ci: 3.58)。我们还发现2.09 (OR = 2.09, 95% CI: 1.24-3.53；E= 3.60, CI: 1.79)和1.63倍(OR = 1.63, 95% CI: 1.07 - 2.49；E= 2.64, CI: 1.34)分别在11岁时出现多动问题的后代24岁时出现酒精依赖症状和酒精滥用症状的风险增加。这些相关性无性别差异（P < 0.05）。结论：青春期早期的多动/注意力不集中问题与成年期AUDs的风险增加有关。未测量的混杂因素不太可能改变观察到的关联。行为问题的早期识别和治疗可能有助于降低日后患AUDs的风险。

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The risk of alcohol use disorders in young adults with hyperactivity/inattention problems in early adolescence: UK birth cohort study.

Purpose: This study aimed to examine the association between hyperactivity/inattention problems in early adolescence and the risk of AUDs in young adulthood.

Methods: We used data from the Avon Longitudinal Study of Parents and Children (ALSPAC), a population-based prospective cohort based in Bristol, United Kingdom. Logistic regression analyses were used to examine associations. E-values (E) were calculated to estimate the extent of unmeasured confounding.

Results: Hyperactivity/ inattention problems in early adolescence were associated with a 1.75-fold increased risk of any AUDs (OR = 1.75, 95% CI: 1.20-2.56; E= 2.90, CI: 1.69) and a 4-fold increased risk of severe alcohol use disorders at age 24 (OR = 4.35, 95% CI: 2.00 - 9.47; E= 8.17, CI: 3.58). We also found a 2.09 (OR = 2.09, 95 % CI: 1.24-3.53; E= 3.60, CI: 1.79) and 1.63-fold (OR = 1.63, 95% CI: 1.07 - 2.49; E= 2.64, CI: 1.34) increased risk of alcohol dependence symptoms and alcohol abuse symptoms at age 24 in offspring who had hyperactivity problems at age 11, respectively. These associations did not differ by sex (P > 0.05).

Conclusions: Hyperactivity/ inattention problems in early adolescence were associated with an increased risk of AUDs in adulthood. Unmeasured confounders were unlikely to alter the observed associations. Early identification and treatment of behavioural problems may help reduce the risk of AUDs later in life.

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来源期刊

Annals of Epidemiology 医学-公共卫生、环境卫生与职业卫生

CiteScore

7.40

自引率

1.80%

发文量

207

审稿时长

59 days

期刊介绍： The journal emphasizes the application of epidemiologic methods to issues that affect the distribution and determinants of human illness in diverse contexts. Its primary focus is on chronic and acute conditions of diverse etiologies and of major importance to clinical medicine, public health, and health care delivery.