Annals of Human Biology最新文献

{"title":"Somatotype affects lean body mass estimation with bioelectrical impedance analysis in young athletes.","authors":"Katinka Utczás, Zsófia Tróznai, Gergely Pálinkás, Irina Kalabiska, Leonidas Petridis","doi":"10.1080/03014460.2025.2558939","DOIUrl":"https://doi.org/10.1080/03014460.2025.2558939","url":null,"abstract":"<p><strong>Background: </strong>The accuracy of body composition assessments with bioelectrical impedance (BIA) based devices may be affected, besides the well-known factors (e.g. hydration status), by factors which are related to anthropometric characteristics.</p><p><strong>Aim: </strong>The aim of this study was to investigate the effects of somatotype on body composition estimation, especially on lean body mass (LBM), using BIA.</p><p><strong>Methods: </strong>539 male (mean age: 15.8 ± 2.5 years) and 121 female young athletes (mean age: 16.5 ± 3.2 years) were included. Body composition was assessed by BIA and dual-energy X-ray absorptiometry (DXA). Somatotype was determined using the Heath-Carter method (endomorphy, mesomorphy, and ectomorphy). Intergroup differences were analysed with one-way and repeated measures analysis of variance.</p><p><strong>Results: </strong>On average, BIA underestimated percent body fat (PBF) by 7.6% and overestimated LBM by 3.9 kg compared to DXA. Significantly smaller bias between the two methods was found in mesomorphy for both LBM and PBF. The ectomorph group demonstrated the largest underestimation in PBF, while the endomorph group the largest overestimation in LBM. Segmental analysis revealed larger overestimation of LBM of the lower limbs in ectomorphy.</p><p><strong>Conclusions: </strong>Findings suggest that LBM estimates are affected by somatotype with mesomorphy reducing, while ectomorphy and endomorphy increase, the estimation bias between BIA and DXA.</p>","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"52 1","pages":"2558939"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145201615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of biomarkers related to iron death in diabetic kidney disease based on machine learning algorithms.","authors":"Wen Xiong, Hongxia Liu, Bo Xiang, Guangyu Shang","doi":"10.1080/03014460.2025.2477248","DOIUrl":"10.1080/03014460.2025.2477248","url":null,"abstract":"<p><strong>Background: </strong>While ferroptosis has been recognised for its key role in tumour development, its involvement in DKD is not well understood. Identifying differentially expressed ferroptosis-related genes (DEIRGs) could help improve early diagnosis and treatment strategies for DKD.</p><p><strong>Aim: </strong>Diabetic kidney disease (DKD) is a complication of diabetes that can progress to end-stage renal disease. Early diagnosis and identification of biomarkers related to its pathogenesis are crucial. This study aims to investigate the role of ferroptosis, a type of programmed cell death, in DKD, which remains largely unexplored.</p><p><strong>Objective: </strong>The objective of this study was to screen for diagnosis-related DEIRGs (DDEIRGs) in DKD and construct a diagnostic model with high accuracy.</p><p><strong>Method: </strong>We intersected differentially expressed genes in the DKD dataset with ferroptosis-related genes to obtain DEIRGs. Gene importance was ranked using the random forest and Adaboost algorithms, and DDEIRGs were identified by intersecting results. A diagnostic model was constructed using logistic regression, and its accuracy was evaluated. Additionally, the immune landscape of DDEIRGs was analysed, and RT-qPCR was used to validate gene expression levels.</p><p><strong>Results: </strong>The diagnostic model constructed with logistic regression demonstrated high diagnostic accuracy for DKD. Immune landscape analysis of DDEIRGs provided further insights into their potential roles. RT-qPCR confirmed the differential expression of diagnosis-related genes.</p><p><strong>Conclusion: </strong>This study successfully identified diagnosis-related ferroptosis genes in DKD and constructed an accurate diagnostic model. These findings enhance our understanding of the role of ferroptosis in DKD and may contribute to the development of new diagnostic and therapeutic approaches.</p>","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"52 1","pages":"2477248"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intergenerational effects of climate disasters: trimester of pregnancy when a hurricane hits predicts neonate body size.","authors":"Michaela Emily Howells, Jessica C Reich, Lenis P Chen-Edinboro, Alexandra Faith Ortiz Blair","doi":"10.1080/03014460.2025.2494570","DOIUrl":"https://doi.org/10.1080/03014460.2025.2494570","url":null,"abstract":"<p><strong>Context: </strong>Climate disasters have been tied to prenatal stress and pregnancy outcomes. However, it is unclear if these outcomes are influenced by the stage of foetal development when the disaster hits.</p><p><strong>Objective: </strong>To compare the birth outcomes by trimester for those pregnant during Hurricane Florence and those in the same community 1-2 years earlier. We further assessed the role of marital status and race.</p><p><strong>Methods: </strong>We included people who gave birth between 2016-2019 in one of the coastal communities impacted by Hurricane Florence (<i>n</i> = 7,240). We used multiple logistic regression to determine the effects of period (hurricane or pre-hurricane) and trimester and their respective interactions on birth outcomes controlling for key demographic variables.</p><p><strong>Results: </strong>Individuals in their first trimester during the hurricane had a greater likelihood of having low-birthweight, low-APGAR, or preterm babies compared to those in the same community a year earlier and those in later trimesters during the hurricane. Unmarried individuals in their first trimester during the hurricane were particularly at risk for low-birthweight neonates.</p><p><strong>Conclusion: </strong>Increased prenatal stress associated with disasters disrupts first trimester foetal development across all groups but is most pronounced in unmarried individuals. Differences in birthweight reflect intergenerational impacts in disaster events.</p>","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"52 1","pages":"2494570"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144081776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial shapes in Frankfurt Horizontal and natural head positions: a methodological study.","authors":"Anna A Mezentseva, Victoria V Rostovtseva, Anna V Komarova, Anna A Korotkova, Nadezhda B Dashieva, Marina L Butovskaya","doi":"10.1080/03014460.2025.2536162","DOIUrl":"10.1080/03014460.2025.2536162","url":null,"abstract":"<p><strong>Background: </strong>Head orientation during photography can distort facial shape, but this is rarely considered in cross-population studies focusing on facial morphology and its perception.</p><p><strong>Aim: </strong>To assess how head positioning (Frankfurt Horizontal [FH] vs. natural position [NP]) affects facial shape and trait perception across two ethnic populations.</p><p><strong>Subjects and methods: </strong>Facial photographs were collected from Buryats of Mongolian descent (<i>N</i> = 148) and Russians of European descent (<i>N</i> = 155). Geometric morphometrics were used to compare the facial shapes in the FH and NP positions. Independent rater groups with similar population origins, Kalmyks (<i>N</i> = 162) and Russians (<i>N</i> = 242), evaluated perceived aggressiveness and attractiveness based on these portraits.</p><p><strong>Results: </strong>Head orientation significantly altered facial shape, particularly among the Buryat group. Despite the larger facial sexual dimorphism in the Buryat group, sex differences were more pronounced in FH across both samples. Correlations between facial shape and body metrics (height, Body Mass Index, and body fat mass) were stronger in FH. Ratings of male aggressiveness and female attractiveness were consistently influenced by head position across both rater populations and sexes.</p><p><strong>Conclusion: </strong>Head positioning introduces systematic bias into facial shape analysis and perception. Failure to control for this factor may compromise study comparability and distort meta-analytic findings.</p>","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"52 1","pages":"2536162"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The changes in the prevalence of underweight and short stature among Polish youth from 1938 to 2020.","authors":"Łukasz Kryst, Magdalena Żegleń, Małgorzata Kowal, Agnieszka Woronkowicz","doi":"10.1080/03014460.2025.2495749","DOIUrl":"https://doi.org/10.1080/03014460.2025.2495749","url":null,"abstract":"<p><strong>Background: </strong>The issues of underweight and short stature are significant yet underrepresented in the literature.</p><p><strong>Aim: </strong>This study examines the prevalence of changes in underweight and short stature among Polish youth from 1938 to 2020.</p><p><strong>Subjects and methods: </strong>Utilising five cross-sectional data sets from Kraków, Poland, the study analysed 24,655 children and adolescents aged 3-18 years. Height and weight were measured, with BMI calculated. Underweight was determined using Cole's cut-off points, while short stature was defined as height below -2 standard deviations from the mean for age and sex.</p><p><strong>Results: </strong>For girls, the prevalence of underweight remained stable at approximately 9.5% from 1938 to 2020, peaking in 1983, particularly during puberty, before declining in subsequent cohorts. In boys, underweight prevalence varied more, from 5.6% in 1938 to 11.1% in 1983, with a steady decline thereafter. Short stature prevalence for both sexes remained low (1.5-2.5%) and unchanged over 85 years.</p><p><strong>Conclusion: </strong>Underweight prevalence increased significantly from 1938 to 1983, reflecting adverse environmental conditions, but has decreased in the last four decades, highlighting socioeconomic influences. Both underweight and short stature can significantly affect children's health.</p>","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"52 1","pages":"2495749"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High wet-bulb temperatures, time allocation, and diurnal patterns of breastfeeding in Bangladeshi fisher-traders.","authors":"Kathrine Starkweather, Haley Ragsdale, Margaret Butler, Fatema T Zohora, Nurul Alam","doi":"10.1080/03014460.2025.2461709","DOIUrl":"10.1080/03014460.2025.2461709","url":null,"abstract":"<p><strong>Background: </strong>Climate change is a growing threat to population health, with dangerous combinations of heat and humidity increasing in frequency, particularly in South Asia. Evidence suggests that high temperatures and heat stress influence breastfeeding behaviour and may lead to suboptimal infant and young child nutrition.</p><p><strong>Aim: </strong>Few studies have quantified the relationship between ambient heat and breastfeeding. Here we evaluate associations between wet-bulb temperature and daily breastfeeding patterns in a rural community in Bangladesh.</p><p><strong>Subjects and methods: </strong>We used 23 months of daily time-diary data from 68 maternal-child dyads and regional wet-bulb temperatures to test the hypothesis that increased heat and humidity negatively influence breastfeeding outcomes among Shodagor fisher-traders.</p><p><strong>Results: </strong>We found that higher wet-bulb temperatures predicted reduced daily breastfeeding time allocation, particularly among fishers, and drove shifts towards increased night-time and decreased mid/late morning feeding. Maternal occupation and the interaction of child age with heat strongly influenced diurnal breastfeeding patterns.</p><p><strong>Conclusion: </strong>These results highlight an important role of maternal work on infants' vulnerability to environmental stress. Dyads' ability to behaviourally compensate for extreme heat may be constrained by extended heatwaves, humidity, and economic circumstances, suggesting that climate change will likely exacerbate heat-related risks to global child health going forward.</p>","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"52 1","pages":"2461709"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactose in human milk is associated with lower rates of infection during a drought.","authors":"Masako Fujita, Katherine Wander","doi":"10.1080/03014460.2025.2455703","DOIUrl":"10.1080/03014460.2025.2455703","url":null,"abstract":"<p><strong>Background: </strong>Infants given mothers' milk have higher resistance against infections than formula-fed counterparts. This protection is likely multifactorial, with roles for both milk immune factors and nutrients, particularly under elevated nutritional and disease stress.</p><p><strong>Aim: </strong>This study evaluated several milk nutrients/immune factors to assess associations with infant infectious disease during a severe drought.</p><p><strong>Subjects and methods: </strong>The study analysed morbidity recall data from Kenyan mother-infant dyads surveyed during a historic drought (n 84). Predictors of interest in logistic regression models of infant infections included milk sIgA, lactoferrin, retinol, folate receptor-α, fat, protein, and lactose. Adjustment variables included dyadic demographic characteristics and maternal infection. Akaike Information Criterion guided model fit assessment. Interactions between variables were allowed in the best-fit model.</p><p><strong>Results: </strong>In the best-fit model, lactose was inversely (OR 0.93; 90% CI 0.89, 0.97), and maternal infection was positively (OR 2.80; 90% CI 1.04, 7.52) associated with infant infection. Milk immune factors (sIgA, lactoferrin) were not included in the final models.</p><p><strong>Conclusion: </strong>Mothers' milk may protect infants against infection through a broad range of immune and nutrient components. In the context of severe drought with heightened nutritional and disease stress, lactose may protect against infection or decrease in the presence of an infection.</p>","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"52 1","pages":"2455703"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiorespiratory fitness in Chinese children and adolescents: a systematic review and meta-analysis.","authors":"Yihan Meng, Yu Song, Hongjuan Li","doi":"10.1080/03014460.2025.2459141","DOIUrl":"10.1080/03014460.2025.2459141","url":null,"abstract":"<p><strong>Background: </strong>Cardiorespiratory fitness (CRF) has become a significant focus in the field of public health. CRF is considered a strong predictor of health outcomes. However, cardiorespiratory fitness levels of children and adolescents are declining.</p><p><strong>Aims: </strong>(1) To analyse the cardiorespiratory fitness levels of children and adolescents in China, focusing on maximum oxygen uptake (VO₂max), maximum heart rate (HRmax), peak oxygen uptake (Peak VO₂) and 20-metre shuttle run test (20 m-SRT). (2) To provide baseline data, with the goal of supporting the development of sports programs, intervention strategies, and public health decision-making.</p><p><strong>Subjects and methods: </strong>A meta-analysis was conducted using 30 studies selected from five databases.</p><p><strong>Results: </strong>The average performance on 20 m-SRT for Chinese children and adolescents was 34.67 laps, with a VO₂max of 46.47 ml/kg/min, HRmax of 195.02 bpm, and Peak VO₂ of 48.58 ml/kg/min. Boys outperformed girls in VO₂max, 20 m-SRT, and HRmax, although the differences in HRmax and Peak VO₂ were not statistically significant. Tibetan children showed better performance than Han children in three indicators with no significant differences found.</p><p><strong>Conclusion: </strong>Cardiorespiratory fitness in Chinese children and adolescents is within a healthy range but not optimal. Boys generally perform better than girls, and Tibetan children outperform Han children.</p>","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"52 1","pages":"2459141"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between MTHFR, MTRR gene polymorphisms and H-type hypertension: a systematic review and meta-analysis.","authors":"Lan Gao, Lisen Dong, Yixuan Niu, Meiyun Jian, Junli Yang, Gang Chen, Hailang Tang, Changhai Su, Lei Xu","doi":"10.1080/03014460.2025.2486165","DOIUrl":"10.1080/03014460.2025.2486165","url":null,"abstract":"<p><strong>Context: </strong>The relationship between methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) gene polymorphisms and H-type hypertension susceptibility has been deeply analysed, but the conclusions are not consistent. Therefore, we carried out a meta-analysis aimed at assessing the relationship exactly.</p><p><strong>Methods: </strong>Six English databases (PubMed, Embase, EBSCO, ScienceDirect, Cochrane Library, and Web of Science) and four Chinese databases (China Biological Medicine, WanFang, China Science and Technology Journal, and China National Knowledge Infrastructure) were used for searching studies from inception to August 2023. MTHFR C677T/A1298C and MTRR A66G genetic polymorphisms were evaluated.</p><p><strong>Results: </strong>A total of 24 papers were included in our research, including 3649 H-type hyperpietics, 2772 non-H-type hyperpietics, and 2149 healthy controls. Our analysis shows that MTHFR C677T polymorphism showed significant association with H-type hypertension in both healthy individuals and non-H-type hyperpietics (TT vs. CC: OR = 3.43, 95% CI = 2.48-4.75). Further subgroup analysis based on geography revealed that homocysteine levels in the southern Chinese population were more susceptible to MTHFR C677T polymorphism (<i>p</i> < 0.05). However, there was no significant association in all genetic models for the polymorphisms of MTHFR A1298C and MTRR A66G.</p><p><strong>Conclusion: </strong>MTHFR C677T polymorphisms are associated with H-type hypertension in non-H-type hyperpietics and healthy individuals.</p>","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"52 1","pages":"2486165"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of iodine and fluorine levels in the environment on thyroid function indicators in Hebei Province, China.","authors":"Yanguo Li, Ruixia Yan, Yuan Zhou, Wen Tang, Qiannan Li, Shuzhen Li, Liping Zhang","doi":"10.1080/03014460.2025.2540007","DOIUrl":"https://doi.org/10.1080/03014460.2025.2540007","url":null,"abstract":"<p><strong>Background: </strong>The impact of environmental iodine and fluorine levels on thyroid function indicators in a healthy population is of crucial significance for developing scientifically sound prevention and control strategies to safeguard residents' health.</p><p><strong>Aim: </strong>To investigate impacts of iodine and fluorine levels in the environment on thyroid function indicators among a healthy population in Hebei Province, China.</p><p><strong>Subjects and methods: </strong>Water samples were collected and the area was divided into six regions based on different iodine and fluorine levels: purely high-iodine area, purely low-iodine area, purely adequate-iodine area, high-iodine high-fluorine area, low-iodine high-fluorine area, and purely high-fluorine area. Probability proportionate sampling was used to select 1-2 administrative villages in each region. In each selected village, residents aged 8 and above who had lived there continuously for at least two years were examined. A thyroid survey was conducted, blood samples were taken to check thyroid function indicators, urinary iodine and fluorine levels were measured, and the proportion of residents consuming iodised salt was recorded.</p><p><strong>Results: </strong>A total of 2400 residents from six regions were included in the study. There was no significant difference in the general data of the six regions (<i>p</i> > 0.05). However, there were significant differences in the comparisons of Thyroid-Stimulating Hormone (TSH), Free Thyroxine (FT4) and Free Triiodothyronine (FT3) levels (<i>p</i> < 0.05). There was no significant difference in the comparison of the proportion of iodised salt consumption among the six regions (X2/F Value, <i>p</i> = 0.160). TSH was negatively correlated with water iodine levels (r = -0.543, <i>p</i> < 0.05), and positively correlated with water fluorine levels (<i>r</i> = 0.281, <i>p</i> < 0.05). FT4 and FT3 were positively correlated with water iodine levels (<i>r</i> = 0.595, <i>p</i> < 0.05; r = -0.117, <i>p</i> < 0.05), and negatively correlated with water fluorine levels (<i>r</i> = 0.543, <i>p</i> < 0.05; <i>r</i> = -0.486, <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>High environmental iodine levels significantly impact thyroid function indicators. Residents in areas with high iodine levels in water sources should take early measures to prevent and control thyroid diseases and undergo regular check-ups.</p>","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"52 1","pages":"2540007"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145126518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}