Annals of Human Biology最新文献_第4页

Increased prevalence of the COVID-19 associated Neanderthal mutations in the Central European Roma population. 中欧罗姆人中与 COVID-19 相关的尼安德特人基因突变发生率增加。

IF 1.7 4区医学

Annals of Human Biology Pub Date : 2024-02-01 Epub Date: 2024-05-21 DOI: 10.1080/03014460.2024.2341727

Jaroslav A Hubáček, Lenka Šedová, Věra Hellerová, Věra Adámková, Valérie Tóthová

{"title":"Increased prevalence of the COVID-19 associated Neanderthal mutations in the Central European Roma population.","authors":"Jaroslav A Hubáček, Lenka Šedová, Věra Hellerová, Věra Adámková, Valérie Tóthová","doi":"10.1080/03014460.2024.2341727","DOIUrl":"https://doi.org/10.1080/03014460.2024.2341727","url":null,"abstract":"Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and subsequent COVID-19 has spread world-wide and become pandemic with about 7 million deaths reported so far. Interethnic variability of the disease has been described, but a significant part of the differences remain unexplained and may be attributable to genetic factors.Aim: To analyse genetic factors potentially influencing COVID-19 susceptibility and severity in European Roma minority.Subjects and methods: Two genetic determinants, within OAS-1 (2-prime,5-prime-oligoadenylate synthetase 1, a key protein in the defence against viral infection; it activates RNases that degrade viral RNAs; rs4767027 has been analysed) and LZTFL1 (leucine zipper transcription factor-like 1, expressed in the lung respiratory epithelium; rs35044562 has been analysed) genes were screened in a population-sample of Czech Roma (N = 302) and majority population (N = 2,559).Results: For both polymorphisms, Roma subjects were more likely carriers of at least one risky allele for both rs4767027-C (p < 0.001) and rs35044562-G (p < 0.00001) polymorphism. There were only 5.3% Roma subjects without at least one risky allele in comparison with 10.1% in the majority population (p < 0.01).Conclusions: It is possible that different genetic background plays an important role in increased prevalence of COVID-19 in the Roma minority.","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141077301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic polymorphism of 27 Y-STR loci in Kazakh populations from Central Kazakhstan. 哈萨克斯坦中部哈萨克族 27 个 Y-STR 位点的遗传多态性。

IF 1.2 4区医学

Annals of Human Biology Pub Date : 2024-02-01 Epub Date: 2024-07-25 DOI: 10.1080/03014460.2024.2377571

Yeldar Ashirbekov, Aigul Zhunussova, Arman Abaildayev, Ayagoz Bukayeva, Zhaxylyk Sabitov, Maxat Zhabagin

{"title":"Genetic polymorphism of 27 Y-STR loci in Kazakh populations from Central Kazakhstan.","authors":"Yeldar Ashirbekov, Aigul Zhunussova, Arman Abaildayev, Ayagoz Bukayeva, Zhaxylyk Sabitov, Maxat Zhabagin","doi":"10.1080/03014460.2024.2377571","DOIUrl":"https://doi.org/10.1080/03014460.2024.2377571","url":null,"abstract":"Background: The haplotypes from Northern, Southern, Eastern, and Western Kazakhstan, analysed for 27 Y-STR loci, have been contributed to the Y-Chromosome STR Haplotype Reference Database, while the genetic profile of Central Kazakhstan remains inadequately explored.Aim: To investigate the genetic diversity of 27 Y-STR loci in the Kazakh populations from Central Kazakhstan.Subjects and methods: A total of 112 unrelated Central Kazakh males were genotyped via the Yfiler Plus kit. Data analysis yielded haplotype and allele frequencies, and forensic parameters. Genetic distances were graphically represented by a multidimensional scaling plot, with genetic linkages further elucidated through Nei's distance dendrograms and Median-joining networks.Results: A total of 102 haplotypes were detected, of which 96 were unique. The haplotype diversity and discrimination capacity were 0.997 and 0.91, respectively. Central Kazakhstan displays a unique cluster in analyses, underscoring its distinct Y-chromosome diversity compared to other Kazakh regions. The analysis of the Naiman tribe, predominantly residing in Central, Southern and Eastern Kazakhstan, revealed three genetic clusters of distinct haplogroups associated with their clans.Conclusions: The identified haplotypes will enhance the existing reference database for Y-chromosomal studies in Kazakhstan, offering a robust tool for future research in population genetics, forensic science and genetic genealogy.","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141762423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary to the article: an estimation of the number of cells in the human body. 文章评论：对人体细胞数量的估计。

IF 1.2 4区医学

Annals of Human Biology Pub Date : 2024-02-01 Epub Date: 2024-10-02 DOI: 10.1080/03014460.2024.2407587

Pierluigi Strippoli, Raffaella Casadei, Flavia Frabetti, Lorenza Vitale, Silvia Canaider

引用次数: 0

Identification of mitophagy and ferroptosis-related hub genes associated with intracerebral haemorrhage through bioinformatics analysis. 通过生物信息学分析鉴定与脑内出血相关的有丝分裂和铁突变相关的枢纽基因。

IF 1.7 4区医学

Annals of Human Biology Pub Date : 2024-02-01 Epub Date: 2024-06-12 DOI: 10.1080/03014460.2024.2334719

Yan Wang, Rufeng Wang, Jianzhong Zhu, Ling Chen

{"title":"Identification of mitophagy and ferroptosis-related hub genes associated with intracerebral haemorrhage through bioinformatics analysis.","authors":"Yan Wang, Rufeng Wang, Jianzhong Zhu, Ling Chen","doi":"10.1080/03014460.2024.2334719","DOIUrl":"https://doi.org/10.1080/03014460.2024.2334719","url":null,"abstract":"Background: Mitophagy and ferroptosis occur in intracerebral haemorrhage (ICH) but our understanding of mitophagy and ferroptosis-related genes remains incomplete.Aim: This study aims to identify shared ICH genes for both processes.Methods: ICH differentially expressed mitophagy and ferroptosis-related genes (DEMFRGs) were sourced from the GEO database and literature. Enrichment analysis elucidated functions. Hub genes were selected via STRING, MCODE, and MCC algorithms in Cytoscape. miRNAs targeting hubs were predicted using miRWalk 3.0, forming a miRNA-hub gene network. Immune microenvironment variances were assessed with MCP and TIMER. Potential small molecules for ICH were forecasted via CMap database.Results: 64 DEMFRGs and ten hub genes potentially involved in various processes like ferroptosis, TNF signalling pathway, MAPK signalling pathway, and NF-kappa B signalling pathway were discovered. Several miRNAs were identified as shared targets of hub genes. The ICH group showed increased infiltration of monocytic lineage and myeloid dendritic cells compared to the Healthy group. Ten potential small molecule drugs (e.g. Zebularine, TWS-119, CG-930) were predicted via CMap.Conclusion: Several shared genes between mitophagy and ferroptosis potentially drive ICH progression via TNF, MAPK, and NF-kappa B pathways. These results offer valuable insights for further exploring the connection between mitophagy, ferroptosis, and ICH.","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the existence, strength, and independence of relative age and maturation selection biases: a case study in Gaelic football talent development programmes. 探索相对年龄和成熟度选择偏差的存在、强度和独立性：盖尔足球人才培养计划案例研究。

IF 1.7 4区医学

Annals of Human Biology Pub Date : 2024-02-01 Epub Date: 2024-05-29 DOI: 10.1080/03014460.2024.2349040

F Fitzgerald, M Campbell, P E Kearney, S Cumming

{"title":"Exploring the existence, strength, and independence of relative age and maturation selection biases: a case study in Gaelic football talent development programmes.","authors":"F Fitzgerald, M Campbell, P E Kearney, S Cumming","doi":"10.1080/03014460.2024.2349040","DOIUrl":"https://doi.org/10.1080/03014460.2024.2349040","url":null,"abstract":"Background: Biological maturity and relative age player selection biases are well documented in youth sports. However, there has been limited examination of the relationship between these biases.Aim: This study investigated the presence, strength, and independence of relative age and biological maturity selection biases in Gaelic football.Subjects and methods: A total of 247 male players from U14 to U16, from two talent academies were assessed for relative age (decimal age (DA)) and biological maturity (discrepancy between biological and chronological age (BA-CA)).Results: Relative age effects (RAE) were observed in the U14 (DA = 0.62, d = 0.40) and U15 squads (DA = 0.57. d = 0.26) only. A bias towards advanced maturity status was present at U14 (BA-CA = 0.60, d = 0.83), U15 (BA-CA = 0.78, d = 0.89), and U16 (BA-CA, d = 1.01). There was a trivial (U14, r(83) = -0.210; U15, r(88) = 0.060) and low (U16, r(76) = 0.352) correlation between relative age and maturity status.Conclusion: Substantial maturity selection biases and, to a lesser degree, relative age biases are evident in youth Gaelic football. Critically, these biases are independent constructs. Coaches and policy makers should be educated on the distinct influences of relative age and maturation, and on strategies to address these biases.","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photoanthropometric study: are non-professional photographs suitable for objective and reliable analysis of facial features? 照片人类测量学研究：非专业照片是否适合用于客观可靠的面部特征分析？

IF 1.2 4区医学

Annals of Human Biology Pub Date : 2024-02-01 Epub Date: 2024-10-21 DOI: 10.1080/03014460.2024.2414991

Egle Stukaite-Ruibiene, Stefanie Ritz-Timme, Cristina Cattaneo, Zuzana Obertova, Renata Simkunaite-Rizgeliene, Arunas Barkus, Janina Tutkuviene

{"title":"Photoanthropometric study: are non-professional photographs suitable for objective and reliable analysis of facial features?","authors":"Egle Stukaite-Ruibiene, Stefanie Ritz-Timme, Cristina Cattaneo, Zuzana Obertova, Renata Simkunaite-Rizgeliene, Arunas Barkus, Janina Tutkuviene","doi":"10.1080/03014460.2024.2414991","DOIUrl":"https://doi.org/10.1080/03014460.2024.2414991","url":null,"abstract":"Background: The face has been widely investigated using professionally taken frontal and lateral photographs, however, there is a lack of studies of non-professional facial photographs. It is not known if they could be suitable for facial analysis. The analysis of non-professional photographs could allow the performance of cost- effective longitudinal studies.Aim: To determine if non-professional photographs could be used for a reliable analysis of facial features.Subjects and methods: The frontal profiles of 18-21-year-olds (35 males, 39 females) were measured by direct anthropometry, in addition, professional photographs were taken and non-professional photographs were obtained. Anthropometric landmarks were superimposed on those photographs. The indices calculated on the basis of the measurements of direct anthropometry and both types of photographs were compared.Results: The comparison of the measurements of direct anthropometry and professional photographs showed no difference between 14 out of 25 male and 10 out of 25 female facial indices (p > 0.05) after comparing the results of direct anthropometry with those of non-professional photographs, no difference was found in 8 out of 25 male and 7 out of 25 female indices. These indices were mostly composed of vertical parameters and eye measurements.Conclusion: Vertical facial dimensions and eye measurements may not only be used interchangeably for both facial photographs and direct anthropometry, but may also be suitable for objective and reliable facial analyses.","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Molecular characterisation of sickle cell disease and classification of major haplotypes associated with the β-globin cluster (HBB gene) by means of SNP marker sequencing in a group of samples from Bolívar, Colombia. 通过对哥伦比亚玻利瓦尔的一组样本进行 SNP 标记测序，确定镰状细胞病的分子特征，并对与β-球蛋白簇（HBB 基因）相关的主要单倍型进行分类。

IF 1.7 4区医学

Annals of Human Biology Pub Date : 2024-02-01 Epub Date: 2024-02-20 DOI: 10.1080/03014460.2024.2308714

Marcela Díaz-Matallana, Ignacio Briceño, Escilda Benavides-Benítez, Jaime E Bernal, Julio C Martínez-Lozano

{"title":"Molecular characterisation of sickle cell disease and classification of major haplotypes associated with the β-globin cluster (HBB gene) by means of SNP marker sequencing in a group of samples from Bolívar, Colombia.","authors":"Marcela Díaz-Matallana, Ignacio Briceño, Escilda Benavides-Benítez, Jaime E Bernal, Julio C Martínez-Lozano","doi":"10.1080/03014460.2024.2308714","DOIUrl":"10.1080/03014460.2024.2308714","url":null,"abstract":"Background: Colombia has a mestizo population and the prevalence of haemoglobin variants varies according to each region, but heterozygous carriers can be found in all of them.Aim: To characterise sickle cell disease (SCD) haematologically, biochemically, and molecularly, and detect classic haplotypes by DNA sequencing in a group of samples from Bolívar, Colombia.Subjects and methods: Blood samples were collected after informed consent from volunteers from eight communities in the Bolívar department, plus samples from the Pacific region, Providencia Island, and Bogotá were included. Data were obtained from: (1) haematological analyses; (2) biochemical tests: dHPLC was used to determine haemoglobin (Hb); and (3) DNA sequencing data through five SNPs.Results: 101 samples were identified by rs334 through Sanger's Sequencing, structural haemoglobinopathies HbAS (34.65%), HbSS (2.97%) and HbAC (1.98%) were found. When contrasting the Hb identification results between SNP rs334 Vs. dHPLC/Isoelectric Focusing (IEF), a coincidence was found in 39/43 samples analysed, therefore, when comparing these techniques, a significant correlation was found (Pearson's correlation coefficient r = 0.998). 26 samples previously analysed by rs334 were classified into classical haplotypes CAR (50.0%), BEN (30.76%), CAM (7.69%), SEN (3.84%), and ATP-I (7.69%).Conclusions: SCD characterisation and SNPs-based classification through Sanger's DNA sequencing have not been performed before in Colombia. The results of this work will make it possible to expand the data or records of carriers and those affected, which will benefit patients and their families.","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139914007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary on "new systems for dental maturity based on seven and four teeth" Demirjian and Goldstein, Annals of Human Biology, 1976,3,411-421. 对 "基于七齿和四齿的牙齿成熟新系统 "的评论，Demirjian 和 Goldstein，《人类生物学年鉴》，1976 年，3,411-421。

IF 1.2 4区医学

Annals of Human Biology Pub Date : 2024-02-01 Epub Date: 2024-10-08 DOI: 10.1080/03014460.2024.2401026

Helen M Liversidge

引用次数: 0

Cross-sectional associations between patterns of cultural engagement and indicators of biological dysregulation. 文化参与模式与生物失调指标之间的横截面关联。

IF 1.2 4区医学

Annals of Human Biology Pub Date : 2024-02-01 Epub Date: 2024-09-25 DOI: 10.1080/03014460.2024.2399276

Emma S Walker, Daisy Fancourt, Meena Kumari, Anne McMunn

{"title":"Cross-sectional associations between patterns of cultural engagement and indicators of biological dysregulation.","authors":"Emma S Walker, Daisy Fancourt, Meena Kumari, Anne McMunn","doi":"10.1080/03014460.2024.2399276","DOIUrl":"https://doi.org/10.1080/03014460.2024.2399276","url":null,"abstract":"Background: Research has shown that cultural activities may bring about improved health. However, large-scale quantitative analyses on cultural engagement and biomarkers are lacking to date. As a result, the mechanisms through which cultural activities may be associated with health are unclear.Aim: Test quantitative associations between cultural engagement pattern (including active and passive engagement in arts, sports, and heritage activities) and indicators of biological dysregulation in a large dataset.Subjects and methods: Understanding Society data were used to conduct cross-sectional linear regression analyses between a data-driven latent class model of cultural engagement and indicators of anthropometric, cardiovascular, metabolic, immune, and neuroendocrine function. Analyses were adjusted for age, gender, ethnicity, childcare responsibility, urbanicity, leisure time satisfaction, capacity-related factors, socioeconomic position, social and economic capital indicators, physical activity, and medication use.Results: More culturally participants had better indicators of biological health, such as lower waist circumference and fibrinogen blood concentration. Specific associations between cultural engagement pattern and the different biological outcomes were also observed. The associations were explained in part by correlated factors (accounting for around half of the association).Conclusions: Cultural engagement is cross-sectionally associated with biomarkers, although the characteristics of people who engage with culture are an important consideration when interpreting these findings.","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Professor Donald A. Bailey Jan 5^th 1934 to June 3^rd 2023. 唐纳德-贝利（Donald A. Bailey）教授，1934 年 1 月 5 日至 2023 年 6 月 3 日。

IF 1.7 4区医学

Annals of Human Biology Pub Date : 2024-02-01 Epub Date: 2024-06-07 DOI: 10.1080/03014460.2024.2356950

Adam D G Baxter-Jones

引用次数: 0