Annals of Human Biology最新文献

The wintertime brown adipose tissue thermogenesis of New York City residents amidst climate change.

IF 1.2 4区医学

Annals of Human Biology Pub Date : 2025-12-01 Epub Date: 2025-02-12 DOI: 10.1080/03014460.2025.2455685

Stephanie B Levy, Shelby Pirtle, Ruthbernick Bastien, Kandra Cruz, Jahnae Vernon

{"title":"The wintertime brown adipose tissue thermogenesis of New York City residents amidst climate change.","authors":"Stephanie B Levy, Shelby Pirtle, Ruthbernick Bastien, Kandra Cruz, Jahnae Vernon","doi":"10.1080/03014460.2025.2455685","DOIUrl":"https://doi.org/10.1080/03014460.2025.2455685","url":null,"abstract":"Background: The built environment buffers residents of large cities, such as New York (NYC), from exposure to low temperatures. Furthermore, average winter temperatures are rising in NYC due to climate change. The degree to which NYC residents exhibit metabolic adaptations to cold stress is currently unclear.Aim: This study quantified variation in brown adipose tissue (BAT), energy expenditure (EE), and ambient temperature among NYC residents.Subjects and methods: We recruited 46 adults (31 females; 15 males) and quantified anthropometrics, change in EE, and BAT thermogenesis after a cooling condition in the lab. A subsample of 21 participants wore temperature loggers for three days in order to quantify ambient temperature exposure.Results: BAT thermogenesis was not significantly associated with change in EE. Participants that were exposed to lower average temperatures exhibited greater BAT thermogenesis (p = 0.013). Change in EE, however, was not significantly associated with time spent outside nor average temperature exposure.Conclusion: Our study provides mixed evidence for the role of BAT thermogenesis in metabolic adaptations to cold stress among NYC residents. Many young adults in NYC are exposed to minimal amounts of cold stress, and this trend is likely to be exacerbated by climate change.","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"52 1","pages":"2455685"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pliocene climatic change and the origins of Homo at Ledi-Geraru, Ethiopia.

IF 1.2 4区医学

Annals of Human Biology Pub Date : 2025-12-01 Epub Date: 2025-02-27 DOI: 10.1080/03014460.2025.2462255

Irene E Smail, Amy L Rector, Joshua R Robinson, Kaye E Reed

{"title":"Pliocene climatic change and the origins of Homo at Ledi-Geraru, Ethiopia.","authors":"Irene E Smail, Amy L Rector, Joshua R Robinson, Kaye E Reed","doi":"10.1080/03014460.2025.2462255","DOIUrl":"https://doi.org/10.1080/03014460.2025.2462255","url":null,"abstract":"Background: Long-term cooling and aridification are associated with the spread of grassland habitats and the appearance of new hominin adaptations starting in the late Miocene. However, limited fossil data during critical periods limits our ability to examine these climatic correlations further.Aim: We set out to reconstruct potential habitat and climate conditions at the origin of our genus Homo.Subjects and methods: Mammalian faunal lists and species trait data were collected for Ledi-Geraru localities dated from ∼2.78 to <2.59 million years ago (Ma). These were compared to a modern comparative dataset of mammal communities across Africa with known habitat and climate conditions, as well as to other fossil mammal data from eastern Africa in the time period leading up to and following shortly after the earliest known appearance of Homo at ∼2.78 Ma.Results: Early Homo is associated with ongoing aridification and increasing seasonality in the Afar Depression. While climate trends in eastern Africa parallel global models, local environmental variation persisted across fossil-bearing regions.Conclusion: Climatic change (aridification and increasing seasonality) continues to be supported as a possible factor in the origins of our genus, although other fossil hominins continued to persist in these conditions.","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"52 1","pages":"2462255"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ambient temperature and wet bulb globe temperature outperform heat index in predicting hydration status and heat perception in a semi-arid environment.

IF 1.2 4区医学

Annals of Human Biology Pub Date : 2025-12-01 Epub Date: 2025-02-24 DOI: 10.1080/03014460.2025.2456152

Lilian Baker, Hannah Jacobson, Amanda McGrosky, Elena Hinz, Faith Wambua, Alison Sherwood, Tiffany-Chrissy Mbeng, Rosemary Nzunza, David R Braun, Emmanuel Ndiema, Herman Pontzer, Asher Y Rosinger

{"title":"Ambient temperature and wet bulb globe temperature outperform heat index in predicting hydration status and heat perception in a semi-arid environment.","authors":"Lilian Baker, Hannah Jacobson, Amanda McGrosky, Elena Hinz, Faith Wambua, Alison Sherwood, Tiffany-Chrissy Mbeng, Rosemary Nzunza, David R Braun, Emmanuel Ndiema, Herman Pontzer, Asher Y Rosinger","doi":"10.1080/03014460.2025.2456152","DOIUrl":"10.1080/03014460.2025.2456152","url":null,"abstract":"Background: Climate change is increasing temperatures, frequency of heatwaves, and erratic rainfall, which threatens human biology and health, particularly in already extreme environments. Therefore, it is important to understand how environmental heat stress measures are tied to human water needs and thermoregulation under increasingly hot conditions.Aim: To test how ambient temperature, heat index, and wet bulb globe temperature (WBGT) relate to hydration status and thermal heat perception in a hot, semi-arid environment.Subjects and methods: Urine samples, perceived heat stress, and anthropometrics were collected among Daasanach semi-nomadic pastoralists (n = 187 children, n = 231 adults) in northern Kenya. Environmental heat stress measures were recorded at sample collection; samples' urine specific gravity (USG) was measured.Results: Multiple linear and logistic regressions indicate that all environmental heat stress measures were associated with USG, odds of dehydration, and heat perception. Ambient temperature performed marginally better than WBGT, and both performed better than heat index. These associations were stronger among children than adults.Conclusion: In a hot, semi-arid climate, ambient temperature and WBGT accurately predict human water needs and heat stress, with children more vulnerable to dehydration. To mitigate consequences of extreme heat, local bioculturally-appropriate hydration (e.g. tea) and cooling (e.g. shade) strategies should be encouraged.","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"52 1","pages":"2456152"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143484577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Household storm damage limits use of and access to insecticide treated bednets in Mozambique. 在莫桑比克，暴风雨对家庭造成的损害限制了驱虫蚊帐的使用和获取。

IF 1.2 4区医学

Annals of Human Biology Pub Date : 2025-12-01 Epub Date: 2025-03-06 DOI: 10.1080/03014460.2025.2461145

Kelly M Searle, Dominique E Earland, Keeley Morris, Albino F Bibe, Vali Muhiro, Anísio Novela, João L Ferrão

{"title":"Household storm damage limits use of and access to insecticide treated bednets in Mozambique.","authors":"Kelly M Searle, Dominique E Earland, Keeley Morris, Albino F Bibe, Vali Muhiro, Anísio Novela, João L Ferrão","doi":"10.1080/03014460.2025.2461145","DOIUrl":"https://doi.org/10.1080/03014460.2025.2461145","url":null,"abstract":"Background: Cyclone Idai was one of the most destructive cyclones in the Southern Hemisphere. Malaria prevention is not part of cyclone response, but housing damage has been shown to increase malaria risk.Aim: To assess the extent to which housing damage led to insecticide treated net (ITN) damage, thus compounding malaria risk.Subjects and methods: A cross-sectional survey was conducted in Sussundenga village. This analysis focused on household damage and ITN use in the aftermath of Cyclone Idai. Generalised estimating equations logistic regression models were used to identify factors associated with ITN use.Results: Thirty-five percent (104 of 296) of participants reported not sleeping under an ITN the previous night. Sixty-one percent (64 of 104) of participants who reported not sleeping under an ITN indicated lack of access as the reason why. Minor household damage was associated with 0.34 (95% CI: 0.15-0.78) times lower odds of ITN use and destruction was associated with 0.23 (95% CI: 0.11-0.50) times lower odds of ITN use.Conclusion: We found that even minor household damage was associated with 70% decreased odds of ITN use. As severe storms become more frequent due to climate change, this is an area for further research to assist malaria control programs in their success.","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"52 1","pages":"2461145"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143568685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drought-compounded stress and immune function in Kenyan pastoralist boys and girls occupying contrasting climate zones.

IF 1.2 4区医学

Annals of Human Biology Pub Date : 2025-12-01 Epub Date: 2025-02-18 DOI: 10.1080/03014460.2025.2455698

Bilinda Straight, Charles E Hilton, Charles Owuor Olungah, Belinda L Needham, Erica Tyler, Lora Iannotti, Theodore Zava, Melanie A Martin, Eleanor Brindle

{"title":"Drought-compounded stress and immune function in Kenyan pastoralist boys and girls occupying contrasting climate zones.","authors":"Bilinda Straight, Charles E Hilton, Charles Owuor Olungah, Belinda L Needham, Erica Tyler, Lora Iannotti, Theodore Zava, Melanie A Martin, Eleanor Brindle","doi":"10.1080/03014460.2025.2455698","DOIUrl":"10.1080/03014460.2025.2455698","url":null,"abstract":"Background and aim: We provide ethnographic, photovoice, and psychosocial stress data (food and water insecurity, potentially traumatic events, stress biomarkers) documenting the joys, hazards, and stressors of adolescents engaging in climate-sensitive pastoralist livelihoods in a global climate change hot spot. We aim to holistically capture socio-environmental relationships characterised by climate sensitive livelihoods and forms of precarity exacerbated by climate change.Subjects and methods: Qualitative and quantitative methods were integrated to understand the embodied toll of hazards that Samburu pastoralists faced based on a sample of 161 young people. Quantitatively, we tested for associations of psychosocial stressors with both psychological distress and cell-mediated immune function (assessed through differences in IgG antibodies to Epstein-Barr virus).Results: Qualitatively, young Samburu reported drought, food and water insecurity, wildlife encounters, and war exposure. Girls overall endorsed more posttraumatic stress symptoms, although boys reported relatively more stressors; girls overall and young people in the hotter subregion manifested more immune dysregulation.Conclusion: In spite of important differences between climate subregions, the common elements throughout the Samburu pastoralist leanscape include food and water insecurity and overall precarity exacerbated by drought and climate change. Community-driven interventions are needed to reduce precarity for young people pursuing pastoralist livelihoods.","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"52 1","pages":"2455698"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839180/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of birth month on body height of Austrian conscripts varies according to educational level.

IF 1.2 4区医学

Annals of Human Biology Pub Date : 2025-12-01 Epub Date: 2025-03-31 DOI: 10.1080/03014460.2025.2482972

Thomas Waldhoer, Sylvia Kirchengast, Lin Yang

{"title":"The effect of birth month on body height of Austrian conscripts varies according to educational level.","authors":"Thomas Waldhoer, Sylvia Kirchengast, Lin Yang","doi":"10.1080/03014460.2025.2482972","DOIUrl":"https://doi.org/10.1080/03014460.2025.2482972","url":null,"abstract":"An association between birth month and height has been repeatedly described, but no consistent seasonal patterns can be observed. In this study, the significance of educational level as a modulating cofactor for the association between body height and birth month was analysed using an anonymous data set from 1,179,600 male conscripts born in Austria between 1971 and 2002. A distinct seasonal trend was observed. Conscripts born from June to December had shorter final body height than their counterparts born between January and May. In general, the effect of month of birth on final body height is very small. Considering socioeconomic co-factors, however, this effect was particularly noticeable for the highest and middle education classes, while the observed effect was small among the lowest education class. A low educational level seems to reduce the seasonal effect on growth and finally body height. Consequently, a clear seasonal effect in body height was observed in this Austrian population-based sample, socioeconomic stress factors, such as a low level of education, can reduce the seasonal effects.","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"52 1","pages":"2482972"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143754919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The associations of preterm birth and low birth weight with childhood growth curves between birth and 12 years: a SITAR-based longitudinal analysis.

IF 1.2 4区医学

Annals of Human Biology Pub Date : 2025-12-01 Epub Date: 2025-03-17 DOI: 10.1080/03014460.2025.2472757

Ruta Morkuniene, Tim J Cole, Ruta Levuliene, Andrej Suchomlinov, Janina Tutkuviene

{"title":"The associations of preterm birth and low birth weight with childhood growth curves between birth and 12 years: a SITAR-based longitudinal analysis.","authors":"Ruta Morkuniene, Tim J Cole, Ruta Levuliene, Andrej Suchomlinov, Janina Tutkuviene","doi":"10.1080/03014460.2025.2472757","DOIUrl":"https://doi.org/10.1080/03014460.2025.2472757","url":null,"abstract":"Background: Children born preterm grow differently from those born at term.Aim: To compare growth in length/height, weight, and BMI of preterm- and term-born children, grouped by birth weight (BW) and gestational age (GA).Subjects and methods: Longitudinal data of 950 children (birth to 12 years) were collected retrospectively. Growth trajectories were modelled using SITAR (Superimposition by Translation and Rotation) by sex, with three groups each for GA and BW.Results: SITAR summarised growth patterns from birth to 12 years and explained 76-79% of height variance, 90-92% for weight, and 72-75% for BMI. Early preterm and low BW groups were shorter, lighter and thinner on average than their term or normal BW peers, with late preterm and low-normal BW groups intermediate. Effects were larger for BW than GA, e.g. early preterm girls/boys were 0.3/0.8 kg lighter, 0.9/0.9 cm shorter and 0.8/0.8 kg/m2 thinner, while low BW girls/boys were 0.5/1.0 kg lighter, 1.5/1.4 cm shorter and 0.8/0.9 kg/m2 thinner. Moreover, faster growth rates were associated with lower BW.Conclusion: Both BW and GA significantly impacted growth, but low BW more so than early preterm birth. This underscores the need for targeted interventions for low BW children to address potential long-term growth challenges.","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"52 1","pages":"2472757"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unravelling the molecular mechanisms and immune landscape of vitiligo: a comprehensive bioinformatics study on melanogenesis-related genes.

IF 1.2 4区医学

Annals of Human Biology Pub Date : 2025-12-01 Epub Date: 2025-03-07 DOI: 10.1080/03014460.2025.2468692

Binxi Ma, Xiao Wang

{"title":"Unravelling the molecular mechanisms and immune landscape of vitiligo: a comprehensive bioinformatics study on melanogenesis-related genes.","authors":"Binxi Ma, Xiao Wang","doi":"10.1080/03014460.2025.2468692","DOIUrl":"https://doi.org/10.1080/03014460.2025.2468692","url":null,"abstract":"Background: Vitiligo is an autoimmune disorder marked by melanocyte destruction and skin depigmentation.Aim: To explore the molecular mechanisms underlying melanogenesis and their link to vitiligo.Subjects and methods: We analysed three vitiligo-related datasets, correcting for batch effects with ComBat. Key melanogenesis genes were pinpointed using LASSO and logistic regression, and a nomogram was developed. The immune microenvironment was evaluated by ssGSEA, and correlations between gene expression, melanogenesis pathways, and immune cell infiltration were examined.Results: We identified 2,405 DEGs, with 960 up-regulated and 1,445 down-regulated genes in vitiligo samples. GSVA indicated significant disturbances in melanogenesis pathways. ssGSEA revealed reduced activity in REACTOME_MELANIN_BIOSYNTHESIS and KEGG_MELANOGENESIS pathways. Three key diagnostic genes (CALM2, KIT, OCA2) were found and used to build a highly accurate predictive nomogram. Immune cell analysis showed increased T helper and Th2 cells in vitiligo, correlating with both diagnostic genes and melanogenic pathways.Conclusion: This study identifies crucial melanogenesis-related genes and provides a predictive model for vitiligo risk. It underscores the relationship between impaired melanogenesis and immune cell infiltration, suggesting potential therapeutic targets.","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"52 1","pages":"2468692"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of different Taekwondo practices on biomechanics of balance and control during kick technique.

IF 1.2 4区医学

Annals of Human Biology Pub Date : 2025-12-01 Epub Date: 2025-02-25 DOI: 10.1080/03014460.2025.2461132

Jinqian Zhang, Youngsuk Kim, Qingling Qu, Sukwon Kim

{"title":"Effects of different Taekwondo practices on biomechanics of balance and control during kick technique.","authors":"Jinqian Zhang, Youngsuk Kim, Qingling Qu, Sukwon Kim","doi":"10.1080/03014460.2025.2461132","DOIUrl":"https://doi.org/10.1080/03014460.2025.2461132","url":null,"abstract":"Background: Long-term training focused on specific skills significantly influences athletes' physical control abilities.Aim: To evaluate the balance control capabilities during kicking actions of different Taekwondo skill groups (kyorugi (K); poomsae (P); demonstration (D)), and long-term training effects of the different Taekwondo skills on body control.Subjects and methods: The present study utilised a motion capture system and a ground reaction force system to compare and analyse the balance control abilities of athletes across various Taekwondo practices (kyorugi, poomsae, demonstration) during the execution of an identical kicking motion. All participants' (23 male college athletes) kicks were aimed at nose height.Results: The results indicate that K exhibited distinct COM trajectories in left-right and front-back directions during front kicks, whereas differences of COM lateral displacement during kicking moments existed across all groups. P demonstrated greater COP movements in forward, backward, left, and right directions. Long-term training in different skills affected mechanisms of body control during the kicking technique. K and D tended to prioritise maintaining vertical stability, upward power output, and efficient movements to ensure rapid, accurate striking while maintaining balance and stability, whereas P emphasised the horizontal posture, flexibility, expressive qualities, and artistry of their movements, which may be involving more body sway and adjustments during competitions.Conclusions: Athletes in different skill groups should develop personalised training plans tailored to their specific skill characteristics and competition demands. These plans aim to enhance the movement control abilities of athletes in various disciplines, ensuring they can deliver optimal performance during competitions.","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"52 1","pages":"2461132"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143494439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of biomarkers related to iron death in diabetic kidney disease based on machine learning algorithms.

IF 1.2 4区医学

Annals of Human Biology Pub Date : 2025-12-01 Epub Date: 2025-04-02 DOI: 10.1080/03014460.2025.2477248

Wen Xiong, Hongxia Liu, Bo Xiang, Guangyu Shang

{"title":"Identification of biomarkers related to iron death in diabetic kidney disease based on machine learning algorithms.","authors":"Wen Xiong, Hongxia Liu, Bo Xiang, Guangyu Shang","doi":"10.1080/03014460.2025.2477248","DOIUrl":"https://doi.org/10.1080/03014460.2025.2477248","url":null,"abstract":"Background: While ferroptosis has been recognised for its key role in tumour development, its involvement in DKD is not well understood. Identifying differentially expressed ferroptosis-related genes (DEIRGs) could help improve early diagnosis and treatment strategies for DKD.Aim: Diabetic kidney disease (DKD) is a complication of diabetes that can progress to end-stage renal disease. Early diagnosis and identification of biomarkers related to its pathogenesis are crucial. This study aims to investigate the role of ferroptosis, a type of programmed cell death, in DKD, which remains largely unexplored.Objective: The objective of this study was to screen for diagnosis-related DEIRGs (DDEIRGs) in DKD and construct a diagnostic model with high accuracy.Method: We intersected differentially expressed genes in the DKD dataset with ferroptosis-related genes to obtain DEIRGs. Gene importance was ranked using the random forest and Adaboost algorithms, and DDEIRGs were identified by intersecting results. A diagnostic model was constructed using logistic regression, and its accuracy was evaluated. Additionally, the immune landscape of DDEIRGs was analysed, and RT-qPCR was used to validate gene expression levels.Results: The diagnostic model constructed with logistic regression demonstrated high diagnostic accuracy for DKD. Immune landscape analysis of DDEIRGs provided further insights into their potential roles. RT-qPCR confirmed the differential expression of diagnosis-related genes.Conclusion: This study successfully identified diagnosis-related ferroptosis genes in DKD and constructed an accurate diagnostic model. These findings enhance our understanding of the role of ferroptosis in DKD and may contribute to the development of new diagnostic and therapeutic approaches.","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"52 1","pages":"2477248"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143765773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0