Genetic polymorphism of 15 STR loci in agropastoral communities from central-northern Chile and relationships with other South American populations.

IF 1.2 4区医学 Q2 ANTHROPOLOGY

Annals of Human Biology Pub Date : 2025-12-01 Epub Date: 2025-04-29 DOI:10.1080/03014460.2025.2486156

Margarita Reyes-Madrid, Francisca Vásquez-Estay, Valentina Gutiérrez, Nicolás Montalva

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引用次数: 0

Abstract

Background: The agropastoral communities of Coquimbo, Chile, are characterised by their goat herding-based livelihoods, admixed ancestry, and transhumant mobility.

Aim: To explore the impact of these features on genetic diversity and interactions with neighbouring populations.

Subjects and methods: Genotypic polymorphisms of 15 STRs were analysed in 466 individuals from 15 communities. Forensic parameters were estimated. Genetic structure was assessed using R_ST, Nei's distances, MDS, dendrograms, and STRUCTURE, with 23 reference populations from Chile, South America and globally.

Results: A total of 158 alleles were observed, with frequencies ranging from 0.0011 to 0.5172. CSF1PO, D18S51, and Penta E showed deviation from Hardy-Weinberg equilibrium. The panel demonstrated high forensic performance (combined power of discrimination CPD > 0.999999999, combined power of exclusion CPE = 0.99999713817). No clear genetic structure was found within the Coquimbo communities. Regionally, Coquimbo clustered with northern Chile and north-west Argentina. Globally, it resembled other South American admixed populations, slightly differentiated from those from other regions.

Conclusions: The STRs analysed show high forensic potential, low genetic structure within the agropastoral communities, and important similarities with populations in northern Chile and north-west Argentina, supporting the relevance of trans-Andean mobility in shaping their genetic landscape.

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智利中北部农牧群落15个STR位点的遗传多态性及其与其他南美人群的关系

背景：智利科金博的农牧社区的特点是以放牧山羊为基础的生计、混合血统和迁移流动性。目的：探讨这些特征对遗传多样性和与邻近种群相互作用的影响。对象与方法：对来自15个社区的466例个体的15个str进行基因型多态性分析。估计了法医参数。采用RST、Nei’s距离、MDS、树突图和structure等方法对来自智利、南美和全球的23个参考种群进行遗传结构评估。结果：共检测到158个等位基因，频率范围为0.0011 ~ 0.5172。CSF1PO、D18S51和Penta E均偏离Hardy-Weinberg平衡。该面板具有较高的法医学性能（综合辨别能力CPD > 0.999999999，综合排除能力CPE = 0.99999713817）。在科金博部落中没有发现明确的遗传结构。在地区上，科金博与智利北部和阿根廷西北部聚集在一起。在全球范围内，它与其他南美混血儿相似，与其他地区的混血儿略有区别。结论：分析的STRs显示出很高的法医鉴定潜力，农牧群落内的遗传结构较低，与智利北部和阿根廷西北部的种群具有重要的相似性，支持跨安第斯山脉迁移与形成其遗传景观的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Human Biology 生物-公共卫生、环境卫生与职业卫生

CiteScore

3.40

自引率

5.90%

发文量

审稿时长

1 months

期刊介绍： Annals of Human Biology is an international, peer-reviewed journal published six times a year in electronic format. The journal reports investigations on the nature, development and causes of human variation, embracing the disciplines of human growth and development, human genetics, physical and biological anthropology, demography, environmental physiology, ecology, epidemiology and global health and ageing research.