{"title":"Forensic parameters and population analysis of 21 autosomal STR loci in the Wuhu Han population from Anhui Province, East China.","authors":"Yanyan Yang, Qianqian Li, Xinrui Yang, Ziwei Zhang, Yongliang Hu, Yue Zhang, Fang He","doi":"10.1080/03014460.2023.2298470","DOIUrl":"10.1080/03014460.2023.2298470","url":null,"abstract":"<p><strong>Background: </strong>At present, there are no available genetic data on the AGCU EX22 Kit from the Wuhu Han population.</p><p><strong>Aim: </strong>This study investigates the applicability of the AGCU EX22 kit, designed for the Chinese population for forensic analysis and population genetics of the Wuhu Han population.</p><p><strong>Subjects and methods: </strong>Bloodstains from 1565 unrelated healthy individuals in Wuhu city, Anhui Province, were collected for analysis. The AGCU EX22 kit was used for amplification, and capillary electrophoresis was used to separate the amplification products. Allele frequencies and forensic parameters were determined. The Wuhu Han population was compared to 10 reference populations through genetic distance, a phylogenetic neighbor-joining tree and principal component analysis.</p><p><strong>Results: </strong>In total, 281 alleles and 1187 genotypes were observed. No significant deviations from Hardy-Weinberg equilibrium at any locus were found after Bonferroni's correction. The 21 autosomal short tandem repeat (STR) genetic markers exhibited high informativeness and polymorphism. The cumulative power of discrimination and power of exclusion were 0.999999999999999999999999913380 and 0.999999996752339, respectively. Population comparisons revealed a genetic affinity between Wuhu Han and southern Han populations, except for the Guangdong Han population, which aligned with the traditional geographical division in China.</p><p><strong>Conclusion: </strong>The AGCU EX22 Kit, containing 21 STR loci, is suitable for forensic application and population genetics studies in the Wuhu Han population.</p>","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139514157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annals of Human BiologyPub Date : 2024-02-01Epub Date: 2024-01-22DOI: 10.1080/03014460.2023.2294743
Kuo Zeng, Dong Zhao
{"title":"Genetic polymorphism analysis and forensic application evaluation of 57 insertion/deletion polymorphisms from Yi ethnic group in Yunnan.","authors":"Kuo Zeng, Dong Zhao","doi":"10.1080/03014460.2023.2294743","DOIUrl":"10.1080/03014460.2023.2294743","url":null,"abstract":"<p><strong>Background: </strong>As a new kind of diallelic genetic marker, insertion/deletion (InDel) polymorphisms have recently been used in forensic science. However, there are relatively few studies on the forensic evaluation of InDel genetic polymorphisms from different populations.</p><p><strong>Aim: </strong>The aim of the present work is to assess the genetic polymorphism and forensic applicability of 57 InDels from the Yi ethnic group and explore the genetic background of this group.</p><p><strong>Subjects and methods: </strong>A total sample of 122 unrelated individuals of Yi group from the Yunnan province were genotyped by the AGCU indel 60 Kit. Multiplex population genetic analyses on the same 57 InDels were carried out among the Yunnan Yi group and 29 reference populations.</p><p><strong>Results: </strong>The average allele frequency of these loci in the Yi ethnic group was 0.485. Heterozygosity, polymorphism information content, and the power of discrimination were 0.477, 0.362, and 0.612, respectively. The combined power of discrimination and the combined power of exclusion reached to 0.99999999999999999669 and 0.999962965, respectively. The results showed that 57 InDels polymorphisms have high genetic polymorphisms in the Yi ethnic group.</p><p><strong>Conclusions: </strong>The 57 InDels could be used for forensic individual identification, paternity testing, and intercontinental population discrimination, with the potential for use in biogeographic ancestry inference.</p>","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139514158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Genetic variants in <i>BDNF</i> (<i>rs6265</i> and <i>rs11030119</i>) and stroke susceptibility: a case-control analysis in South India.","authors":"Anushree Muraleedharan Nair, Chandrasudan Ramamoorthi, Madhushri Arumugam Senthilkumar, Remasri Kanniyapillai, Praveen Kumar Chandra Sekar, Akram Husain Rehman Syed Rasheed, Subramaniyan Kannaian, Ramakrishnan Veerabathiran","doi":"10.1080/03014460.2024.2415984","DOIUrl":"https://doi.org/10.1080/03014460.2024.2415984","url":null,"abstract":"<p><strong>Background: </strong>Stroke occurs when the blood supply to part of the cerebral cortex is blocked, depriving it of oxygen and glucose, leading to cell death. It is a multifactorial disorder influenced by genetic, vascular, and environmental factors.</p><p><strong>Aim: </strong>This study investigated the association between two polymorphisms of the <i>brain-derived neurotrophic factor</i> (BDNF) gene, <i>rs6265</i> and <i>rs11030119</i>, and stroke risk in a South Indian population.</p><p><strong>Subjects and methods: </strong>The study included 163 stroke cases and 160 healthy controls. Genomic DNA was extracted, and genotyping of <i>rs6265</i> and <i>rs11030119</i> polymorphisms was done using ARMS-PCR. Allelic and genotype frequencies were calculated, and odds ratios (OR) with 95% confidence intervals (CI) were determined using SPSS version 21.0.</p><p><strong>Results: </strong>The <i>rs6265</i> polymorphism was significantly associated with stroke risk, with the GG genotype more frequent in controls (OR 1.79, 95% CI 1.05-1.76, <i>p</i> = 0.01). The <i>rs11030119</i> polymorphism showed a positive association, with the AA genotype more prevalent in cases (OR 2.70, 95% CI 1.34-5.44, <i>p</i> = 0.003).</p><p><strong>Conclusion: </strong>This study suggests an association between <i>BDNF</i> polymorphisms (<i>rs6265</i>, <i>rs1103011</i>9) and stroke risk in a South Indian population. Further research in larger populations is necessary to confirm these findings and explore the mechanisms involved.</p>","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142570354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annals of Human BiologyPub Date : 2024-02-01Epub Date: 2024-03-13DOI: 10.1080/03014460.2024.2323037
Julio Lara-Riegos, Hugo Azcorra, Juan Carlos Salazar-Rendón, Víctor Arana-Argáez, María Teresa Castillo-Burguete, Nina Mendez-Dominguez
{"title":"Birthweight and its association with cardiometabolic risk parameters in rural Maya children from Yucatan, Mexico.","authors":"Julio Lara-Riegos, Hugo Azcorra, Juan Carlos Salazar-Rendón, Víctor Arana-Argáez, María Teresa Castillo-Burguete, Nina Mendez-Dominguez","doi":"10.1080/03014460.2024.2323037","DOIUrl":"10.1080/03014460.2024.2323037","url":null,"abstract":"<p><strong>Background: </strong>Knowledge about the influence of early developmental factors on cardiometabolic health in the Maya is limited.</p><p><strong>Aim: </strong>To analyse the relationship between birthweight (BW) and cardiometabolic parameters in a sample of rural Maya children from Yucatan, Mexico.</p><p><strong>Subjects and methods: </strong>We took anthropometric measurements and obtained data on BW and fasting blood samples in a sample of 75 children aged 5-14 years. Dependent variables were: fat mass index (FMI), body mass index (BMI), glucose (G), triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL), LDL/HDL and TC/HDL ratios and metabolic index (TGxG/HDL<sup>2</sup>). Outcomes were transformed to <i>y</i> = 100 log(e)x and the resulting estimates are interpreted as symmetrical percentage differences. The main independent variable was BW z-score. Multiple linear regression analyses were used to assess the relationship between BW and outcomes.</p><p><strong>Results: </strong>An increase of one standard deviation in BW predicted 6.6% (95% CI [-11.6, -1.6]) decrease in HDL and 11% (95% CI [3.7, 18.4]), 7.8% (95% CI [2.3, 13.2]) and 19.6% (95% CI [3.1, 36]) increases in LDL/HDL, TC/HDL and metabolic index, respectively.</p><p><strong>Conclusion: </strong>Higher birthweights were associated with adverse levels of biochemical parameters in this sample of rural Maya children.</p>","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140121262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annals of Human BiologyPub Date : 2024-02-01Epub Date: 2024-06-27DOI: 10.1080/03014460.2024.2368851
Theresa E Gildner, Samuel S Urlacher, Katherine L Nemeth, Jade A Beauregard, Marcela Pfaff Nash, Angela Zhang, Sophie Waimon, Tara J Cepon-Robins
{"title":"Dual burden of infectious and chronic disease in low-resource U.S. communities: examining relationships between infection, adiposity, and inflammation.","authors":"Theresa E Gildner, Samuel S Urlacher, Katherine L Nemeth, Jade A Beauregard, Marcela Pfaff Nash, Angela Zhang, Sophie Waimon, Tara J Cepon-Robins","doi":"10.1080/03014460.2024.2368851","DOIUrl":"https://doi.org/10.1080/03014460.2024.2368851","url":null,"abstract":"<p><strong>Background: </strong>Rising global obesity rates are linked with inflammation and associated morbidities. These negative outcomes are generally more common in low-resource communities within high-income countries; however, it is unclear how frequent infectious disease exposures in these settings may influence the relationship between adiposity and inflammation.</p><p><strong>Aim: </strong>We test associations between adiposity measures and distinct forms of inflammation among adults (<i>n</i> = 80) living in low-resource U.S. communities experiencing high levels of obesity and pathogen exposure.</p><p><strong>Subjects and methods: </strong>Adiposity measures included BMI and percent body fat. Inflammation measures included systemic inflammation (C-reactive protein [CRP]) and localised intestinal inflammation (faecal calprotectin [FC]). The relationship between a condition characterised by elevated inflammation (<i>Helicobacter pylori</i> infection) and adiposity was also considered.</p><p><strong>Results: </strong>Adiposity was not significantly related to FC concentration. However, both adiposity measures were positively related with odds of CRP elevation and <i>H. pylori</i> infection was associated with significantly lower adiposity measures (all <i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>For this disadvantaged U.S. sample, the association between adiposity and inflammation varies by the systemic/localised nature of inflammation and the likely underlying cause of inflammation. Defining these associations will improve understanding of how rising obesity rates shape long-term health inequities, with implications for more effective intervention design.</p>","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141460553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annals of Human BiologyPub Date : 2024-02-01Epub Date: 2024-01-24DOI: 10.1080/03014460.2023.2297733
Duarte Freitas, António Antunes, Martine Thomis, Ricardo Silva, Gonçalo Marques, Alípio Silva, Rui Nunes, Marcelo Delgado, Paulo Jardim, Rubina Xíxaro, Joana Silva, Francisco Fernandes, Robert M Malina
{"title":"Interrelationships among skeletal age, growth status and motor performances in female athletes 10-15 years.","authors":"Duarte Freitas, António Antunes, Martine Thomis, Ricardo Silva, Gonçalo Marques, Alípio Silva, Rui Nunes, Marcelo Delgado, Paulo Jardim, Rubina Xíxaro, Joana Silva, Francisco Fernandes, Robert M Malina","doi":"10.1080/03014460.2023.2297733","DOIUrl":"10.1080/03014460.2023.2297733","url":null,"abstract":"<p><strong>Background: </strong>Motor performances of youth are related to growth and maturity status, among other factors.</p><p><strong>Aim: </strong>To estimate the contribution of skeletal maturity status <i>per se</i> to the motor performances of female athletes aged 10-15 years and the mediation effects of growth status on the relationships.</p><p><strong>Subjects and methods: </strong>Skeletal age (TW3 RUS SA), body size, proportions, estimated fat-free mass (FFM), motor performances, training history and participation motivation were assessed in 80 non-skeletally mature female participants in several sports. Hierarchical and regression-based statistical mediation analyses were used.</p><p><strong>Results: </strong>SA <i>per se</i> explained a maximum of 1.8% and 5.8% of the variance in motor performances of athletes aged 10-12 and 13-15 years, respectively, over and above that explained by covariates. Body size, proportions, and hours per week of training and participation motivation explained, respectively, a maximum of 40.7%, 18.8%, and 22.6% of the variance in performances. Mediation analysis indicated specific indirect effects of SA through stature and body mass, alone or in conjunction with FFM on performances.</p><p><strong>Conclusion: </strong>SA <i>per se</i> accounted for small and non-significant amounts of variance in several motor performances of female youth athletes; rather, SA influenced performances indirectly through effects on stature, body mass and estimated FFM.</p>","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139547581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annals of Human BiologyPub Date : 2024-02-01Epub Date: 2024-05-03DOI: 10.1080/03014460.2024.2342529
Paula van Dommelen, Cécile Schat-Savy, Arjan Huizing, Symone Detmar, Leonhard A Bakker, Paul H Verkerk
{"title":"Health status and public health needs in a Togolese child health care centre modelled after the Dutch system.","authors":"Paula van Dommelen, Cécile Schat-Savy, Arjan Huizing, Symone Detmar, Leonhard A Bakker, Paul H Verkerk","doi":"10.1080/03014460.2024.2342529","DOIUrl":"https://doi.org/10.1080/03014460.2024.2342529","url":null,"abstract":"<p><strong>Background: </strong>The charity foundation Association Soutien Enfants Togo started a child health care (CHC) centre in Togo that was modelled after the Dutch high-quality CHC system to improve child health.</p><p><strong>Aim: </strong>To describe health care data of children who visited the centre.</p><p><strong>Subjects and methods: </strong>Data were routinely collected between October 2010-July 2017. Outcomes were completed vaccinations, growth, development, lifestyle, physical examination, and laboratory testing results.</p><p><strong>Results: </strong>In total, 8,809 children aged 0-24 years were available. Half (47.5%) of children aged 0-4 years did not receive all eligible free vaccinations from the government. The proportions of stunted children (all) or with a developmental delay (0-4 years) were 10.1% and 9.5%, respectively. In total, 40-50% of all children did not wash their hands with soap after toilet or before eating, or did not use clean drinking water. Furthermore, 5.1-6.6% had insufficient vision, high eye pressure or hearing loss. Sickle cell disease was detected in 5.3%.</p><p><strong>Conclusion: </strong>A large group of children in need of prevention and early treatment were detected, informed and treated by the centre. Further research is needed to confirm if this strategy can improve children's health in Sub-Saharan Africa. Our data are available for further research.</p>","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140873195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annals of Human BiologyPub Date : 2024-02-01Epub Date: 2024-10-14DOI: 10.1080/03014460.2024.2407111
Marie-Françoise Rolland-Cachera
{"title":"Child BMI trajectories: the history of a concept over the last four decades.","authors":"Marie-Françoise Rolland-Cachera","doi":"10.1080/03014460.2024.2407111","DOIUrl":"https://doi.org/10.1080/03014460.2024.2407111","url":null,"abstract":"","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142479907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annals of Human BiologyPub Date : 2024-02-01Epub Date: 2024-03-20DOI: 10.1080/03014460.2024.2321128
Juliet K Brophy, Debra R Bolter, Marina Elliott, John Hawks, Lee R Berger
{"title":"An examination of <i>Homo naledi</i> early juveniles recovered from the Rising Star cave system, South Africa.","authors":"Juliet K Brophy, Debra R Bolter, Marina Elliott, John Hawks, Lee R Berger","doi":"10.1080/03014460.2024.2321128","DOIUrl":"10.1080/03014460.2024.2321128","url":null,"abstract":"<p><strong>Background: </strong>Six <i>Homo naledi</i> early juveniles were recovered from U.W. 101 (Dinaledi Chamber), U.W. 102 (Lesedi Chamber), and U.W. 110 in the Rising Star cave system.</p><p><strong>Aim: </strong>This paper develops the information for the <i>H. naledi</i> early juvenile life stage, as defined by a combination of deciduous and permanent dentition, and the eruption of the first permanent molar.</p><p><strong>Subjects and methods: </strong>The growing number of young individuals recovered from the Rising Star cave system allows us to gain a better understanding of their variation, or lack thereof, and provides a basis to estimate broad ranges for age at death of the individuals. The individuals are identified and described through craniodental remains and spatial associations.</p><p><strong>Results and conclusion: </strong>Our results show that the teeth are remarkably consistent across the localities in their metric and non-metric traits, and our analyses refine previous estimations on dental eruptions with the first permanent molar erupting first in the sequence among permanent teeth.</p>","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140177517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Annals of Human BiologyPub Date : 2024-02-01Epub Date: 2024-09-20DOI: 10.1080/03014460.2024.2390834
Stephanie M Koning, Jacob Aronoff, Shanting Chen, Taylor Hargrove, Jessica Polos, Thomas W McDade
{"title":"Violence victimisation and young adult cardiometabolic health: the role of timing and social identity.","authors":"Stephanie M Koning, Jacob Aronoff, Shanting Chen, Taylor Hargrove, Jessica Polos, Thomas W McDade","doi":"10.1080/03014460.2024.2390834","DOIUrl":"10.1080/03014460.2024.2390834","url":null,"abstract":"<p><strong>Background: </strong>Adolescent violence victimisation is associated with a spectrum of adult social and behavioural health outcomes, including adverse mental health symptoms. However, underlying social stress mechanisms linking adolescent victimisation to adult cardiometabolic health remains poorly understood.</p><p><strong>Aim: </strong>The current study aims to reveal how adolescent and adult interpersonal violence exposures each get \"under the skin\" to affect adult metabolic syndrome, including direct victimisation and, additionally, witnessing violence.</p><p><strong>Subjects and methods: </strong>We use a nationally representative longitudinal cohort, the National Longitudinal Study of Adolescent to Adult Health, and leverage a quasi-experimental approach, propensity score matching regression analysis (<i>n</i> = 14,267).</p><p><strong>Results: </strong>We find that adolescent violence exposure carries an enduring effect on young adult metabolic syndrome risk factor incidence and high-risk status, which is independent of young adult violence. Violence effects do not vary by sex or racial identity.</p><p><strong>Conclusion: </strong>In sum, adolescent exposure to direct interpersonal violence significantly affects young adult cardiometabolic health in ways suggesting adolescence is a sensitive period for the onset of harmful cardiometabolic effects in early adulthood. Findings warrant future study of underlying pathways and how these effects shape social inequities in cardiometabolic health among U.S. adults broadly.</p>","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11463841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142300085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}