{"title":"老年阿尔茨海默病患者胃饥饿素基因多态性、认知功能和日常生活活动的相关性","authors":"Wenguang Liu, Liyuan Wu, Jiaying Hu, Zhiyong Gao","doi":"10.1080/03014460.2025.2507048","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Single nucleotide polymorphisms (SNPs) of <i>ghrelin</i> gene are associated with cognitive function while ghrelin is associated with Alzheimer's disease (AD).</p><p><strong>Aim: </strong>To determine the relationship between <i>ghrelin</i> SNPs, cognitive function, and activities of daily living (ADLs) in elderly AD patients.</p><p><strong>Subjects and methods: </strong>This study included 100 elderly AD patients as the AD group, and 72 elderly healthy patients as the control group. Pearson's correlation analysis was performed.</p><p><strong>Results: </strong>The frequency of the A allele at rs55821288 was significantly higher in the AD group than the control group (<i>p</i> < 0.05). Similarly, the frequency of the AA genotype at rs55821288 was higher in the AD group than the control group (<i>p</i> < 0.05). The MMSE, QOL-AD, and ADLs scores were lower in the AD group than the control group (<i>p</i> < 0.05). Pearson's correlation analysis revealed that the A allele at rs55821288 was inversely correlated with the MMSE, QOL-AD, and ADLs scores (<i>p</i> < 0.05). The distribution of the AA genotype at the rs55821288 locus had a negative linear correlation with the MMSE, QOL-AD, and ADLs scores (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong><i>Ghrelin</i> allele A and genotype AA are closely associated with cognitive function and ADLs among elderly AD patients.</p>","PeriodicalId":50765,"journal":{"name":"Annals of Human Biology","volume":"52 1","pages":"2507048"},"PeriodicalIF":1.3000,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Correlations between <i>ghrelin</i> gene polymorphisms, cognitive function, and activities of daily living among elderly patients with Alzheimer's disease.\",\"authors\":\"Wenguang Liu, Liyuan Wu, Jiaying Hu, Zhiyong Gao\",\"doi\":\"10.1080/03014460.2025.2507048\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Single nucleotide polymorphisms (SNPs) of <i>ghrelin</i> gene are associated with cognitive function while ghrelin is associated with Alzheimer's disease (AD).</p><p><strong>Aim: </strong>To determine the relationship between <i>ghrelin</i> SNPs, cognitive function, and activities of daily living (ADLs) in elderly AD patients.</p><p><strong>Subjects and methods: </strong>This study included 100 elderly AD patients as the AD group, and 72 elderly healthy patients as the control group. Pearson's correlation analysis was performed.</p><p><strong>Results: </strong>The frequency of the A allele at rs55821288 was significantly higher in the AD group than the control group (<i>p</i> < 0.05). Similarly, the frequency of the AA genotype at rs55821288 was higher in the AD group than the control group (<i>p</i> < 0.05). The MMSE, QOL-AD, and ADLs scores were lower in the AD group than the control group (<i>p</i> < 0.05). Pearson's correlation analysis revealed that the A allele at rs55821288 was inversely correlated with the MMSE, QOL-AD, and ADLs scores (<i>p</i> < 0.05). The distribution of the AA genotype at the rs55821288 locus had a negative linear correlation with the MMSE, QOL-AD, and ADLs scores (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong><i>Ghrelin</i> allele A and genotype AA are closely associated with cognitive function and ADLs among elderly AD patients.</p>\",\"PeriodicalId\":50765,\"journal\":{\"name\":\"Annals of Human Biology\",\"volume\":\"52 1\",\"pages\":\"2507048\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Annals of Human Biology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/03014460.2025.2507048\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/4 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"ANTHROPOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Human Biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/03014460.2025.2507048","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/4 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"ANTHROPOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
背景：胃饥饿素基因的单核苷酸多态性（snp）与认知功能有关，而胃饥饿素与阿尔茨海默病（AD）有关。目的：探讨老年AD患者胃饥饿素snp与认知功能、日常生活活动（ADLs）之间的关系。对象与方法：本研究将100例老年AD患者作为AD组，72例老年健康患者作为对照组。进行Pearson相关分析。结果：AD组rs55821288位点A等位基因频率显著高于对照组（p p p p p p）结论：Ghrelin等位基因A和AA型与老年AD患者认知功能和adl密切相关。
Correlations between ghrelin gene polymorphisms, cognitive function, and activities of daily living among elderly patients with Alzheimer's disease.
Background: Single nucleotide polymorphisms (SNPs) of ghrelin gene are associated with cognitive function while ghrelin is associated with Alzheimer's disease (AD).
Aim: To determine the relationship between ghrelin SNPs, cognitive function, and activities of daily living (ADLs) in elderly AD patients.
Subjects and methods: This study included 100 elderly AD patients as the AD group, and 72 elderly healthy patients as the control group. Pearson's correlation analysis was performed.
Results: The frequency of the A allele at rs55821288 was significantly higher in the AD group than the control group (p < 0.05). Similarly, the frequency of the AA genotype at rs55821288 was higher in the AD group than the control group (p < 0.05). The MMSE, QOL-AD, and ADLs scores were lower in the AD group than the control group (p < 0.05). Pearson's correlation analysis revealed that the A allele at rs55821288 was inversely correlated with the MMSE, QOL-AD, and ADLs scores (p < 0.05). The distribution of the AA genotype at the rs55821288 locus had a negative linear correlation with the MMSE, QOL-AD, and ADLs scores (p < 0.05).
Conclusions: Ghrelin allele A and genotype AA are closely associated with cognitive function and ADLs among elderly AD patients.
期刊介绍：
Annals of Human Biology is an international, peer-reviewed journal published six times a year in electronic format. The journal reports investigations on the nature, development and causes of human variation, embracing the disciplines of human growth and development, human genetics, physical and biological anthropology, demography, environmental physiology, ecology, epidemiology and global health and ageing research.
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