Annals of Thoracic Medicine最新文献

{"title":"The impact of radiometabolic features on the stage and survival in small cell lung cancer.","authors":"Coskun Dogan, Sedanur Coskun Tok, Sibel Karakaya, Elif Torun Parmaksiz, Ferhan Karatas, Aysenur Toksöz Yildirim, Serkan Güngör, Onur İncealtın, Sacit İçten","doi":"10.4103/atm.atm_87_25","DOIUrl":"10.4103/atm.atm_87_25","url":null,"abstract":"<p><strong>Background: </strong>Small-cell lung cancer (SCLC) is a highly aggressive malignancy with a poor prognosis. 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) plays a critical role in staging, as elevated FDG uptake is associated with tumor aggressiveness and metabolic activity. Although radiometabolic parameters such as maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) have been proposed as prognostic markers, existing data remain inconsistent. This study aimed to investigate the association between these parameters and disease stage and overall survival (OS) in SCLC patients.</p><p><strong>Methods: </strong>Patients diagnosed with lung cancer between May 2022 and June 2023 were retrospectively reviewed and divided into two groups: those with SCLC (Group 1) and those with non-SCLC (Group 2). Demographic, clinical, radiological (thoracic CT), and radiometabolic (PET/CT) features, treatment history, staging, and mortality data (based on the national death registry) were collected.</p><p><strong>Results: </strong>A total of 111 patients (mean age: 65.2 years) were included, of whom 65 (58.6%) had SCLC. In the SCLC group, 55 (85.9%) had extensive-stage disease and 9 (14.1%) had limited-stage disease. Mean SUVmax, MTV, and TLG values were significantly higher in extensive-stage disease (12.5, 87.2, and 624.2, respectively) than in limited-stage disease (7.1, 7.0, and 37.0) (<i>P</i> < 0.05). Median OS was 12.5 months. Cutoff values for poor prognosis were identified as SUVmax ≥10, MTV ≥40, and TLG ≥170, with significantly shorter OS observed above these thresholds (<i>P</i> < 0.05). While SUVmax alone was not an independent predictor of survival (<i>P</i> > 0.05), MTV and TLG were identified as significant prognostic indicators in multivariate analysis (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>In SCLC, higher SUVmax values are associated with advanced disease stage. However, MTV and TLG may serve as more reliable independent prognostic biomarkers for survival.</p>","PeriodicalId":50760,"journal":{"name":"Annals of Thoracic Medicine","volume":"21 3","pages":"140-146"},"PeriodicalIF":2.3,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13395222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148580857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of β-agonists in prevention and treatment of acute lung injury: A meta-analysis of randomized controlled trials.","authors":"Yuxiang Liu, Peng Ding, Qian Yang, Penghui Zhou, Weiyi Liu, Peiyang Gao","doi":"10.4103/atm.atm_212_25","DOIUrl":"10.4103/atm.atm_212_25","url":null,"abstract":"<p><p>Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) carry high mortality with limited drug therapies. β-agonists are potential candidates due to bronchodilatory and anti-inflammatory effects. This meta-analysis evaluated their efficacy and safety in ALI/ARDS. Randomized controlled trials (RCTs) of β-agonists in ALI/ARDS were identified through PubMed, Cochrane Library, Embase, Web of Science, and Scopus. Relative risks were used for dichotomous outcomes and mean differences for continuous outcomes. The Cochrane tool was used to evaluate bias, and Cochran's Q and the I2 statistics were used to evaluate heterogeneity. Six RCTs involving 1213 participants met the inclusion criteria. Beta-agonists significantly reduced ventilator-free days (mean difference - 1.98, 95% confidence interval [CI]: -3.21 to - 0.75, P = 0.002, I2 = 68%) and intensive care unit (ICU)-free days (-6.57, P = 0.001). They were associated with nonsignificant trend toward higher 28-day mortality (risk ratio: 1.23, P = 0.10) and a significant increase in 90-day mortality (risk ratio: 1.39, 95% CI: 1.03-1.89, P = 0.03). Sensitivity analysis confirmed robust results, showing increased risk of cardiac arrhythmias (risk ratio: 1.89, P = 0.0008) but no significant effect on organ failure-free days (-0.99, P = 0.31). In ARDS/ALI, β-agonists reduce ventilator-and ICU-free days but increase 90-day mortality and arrhythmia risk, with no impact on organ failure-free days. β-agonists are linked to long-term risks, such as increased mortality and arrhythmias, but they provide little clinical benefit in terms of reducing ventilator or intensive care unit time. They have no effect on the incidence of ARDS/ALI or outcomes of organ failure.</p>","PeriodicalId":50760,"journal":{"name":"Annals of Thoracic Medicine","volume":"21 2","pages":"57-66"},"PeriodicalIF":2.3,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of intensive care unit versus general ward monitoring on length of stay in chronic obstructive pulmonary disease patients after bronchoscopic lung volume reduction.","authors":"Andrew M Rabah, Jeffrey H Jennings, Medha R Cherabuddi, Rebecca A Priebe, Joseph F Hanania, Avi Cohen","doi":"10.4103/atm.atm_56_25","DOIUrl":"10.4103/atm.atm_56_25","url":null,"abstract":"<p><strong>Background: </strong>Bronchoscopic lung volume reduction (BLVR) offers several advantages over lung volume reduction surgery, such as faster recovery, fewer complications, and reduced infection risk; however, it also carries a risk of pneumothorax (PTX). This risk has led to the routine practice of admitting patients for observation to the intensive care unit (ICU) across various hospitals. However, the impact of care level, whether in the ICU or general ward, on length of stay (LOS) and postprocedural complications in BLVR patients remains unknown. This study aims to determine whether acuity of care affects LOS and postprocedural complication rates in patients who underwent BLVR.</p><p><strong>Methods: </strong>We retrospectively reviewed 240 patients' electronic medical records, calculated median LOS, and compared factors that influence LOS in patients admitted to the pulmonary ward (PW) and the ICU.</p><p><strong>Results: </strong>Our data revealed no statistically significant difference between the median LOS between patients who were admitted to the PW (median 3 days, 95% confidence interval [CI]: 3-5) versus the ICU (median 3 days, 95% CI: 3-5). Postprocedural complications, including PTX, respiratory failure, arrhythmias requiring intervention, rates of valve removal during admission, and time from identification of PTX to chest tube placement, were similar between PW and ICU.</p><p><strong>Conclusions: </strong>With structured nursing education, monitoring post-BLVR patients in a nonhigh-acuity setting appears to be a safe alternative to ICU admission in facilities that perform BLVR.</p>","PeriodicalId":50760,"journal":{"name":"Annals of Thoracic Medicine","volume":"21 2","pages":"76-81"},"PeriodicalIF":2.3,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135309/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between the severity of asthma and computed tomography-based large airway structural changes among children under 3 years of age.","authors":"Xin Hou, Nan Li, Jing Yu, Yuewen Hao, Chaozong Ma, Jianli Pan, Jixin Liu, Peng Zhang","doi":"10.4103/atm.atm_207_24","DOIUrl":"10.4103/atm.atm_207_24","url":null,"abstract":"<p><strong>Background: </strong>The absence of objective and quantitative criteria of pediatric asthma is a persistent barrier in the early diagnosis and assessment of severity. Alterations in major airway structures in individuals with asthma may indicate the severity of the disease. This study was conducted to determine the correlation between the morphologic characteristics of the respiratory tract with the degrees of the severity of asthma among the children under 3 years old.</p><p><strong>Methods: </strong>A retrospective analysis of low-dose computed tomography (CT) data was performed to determine the potential predictive value of morphologic characteristics of big airways in determining the response to pharmacologic treatment in children with asthma <3 years of age. The analysis was performed using a machine learning approach.</p><p><strong>Results: </strong>Two hundred and forty-four children with asthma were diagnosed with moderate (<i>n</i> = 164) and severe (<i>n</i> = 80) asthma by observing the drug treatment responses. When comparing across groups, patients with severe asthma displayed a greater degree of uneven wall thickness and ellipticity in the airways. This finding indicates that there are subtle alterations in the morphologic structure of big airways in children with severe asthma. In addition, the airway morphologic data were utilized to accurately classify moderate and severe cases, achieving an area under the receiver operating characteristic curve of 0.83 and an accuracy of 0.79.</p><p><strong>Conclusion: </strong>The morphologic characteristics of the respiratory tract are closely related to the degrees of the severity of asthma among the children under 3 years old.</p>","PeriodicalId":50760,"journal":{"name":"Annals of Thoracic Medicine","volume":"21 2","pages":"95-102"},"PeriodicalIF":2.3,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Staged and repeat endobronchial valve treatment for a right middle lobe giant bulla and left lower lobe emphysema in a patient with severe COPD.","authors":"Eung Gu Lee, Chin Kook Rhee","doi":"10.4103/atm.atm_222_24","DOIUrl":"10.4103/atm.atm_222_24","url":null,"abstract":"<p><p>With increasing evidence of meaningful clinical benefit in patients with advanced emphysema, bronchoscopic lung volume reduction (BLVR) using endobronchial valves (EBVs) was included in the Global Initiative for Chronic Obstructive Lung Disease report, as well as US Food and Drug Administration approval. However, bilateral BLVR using an EBV has been rarely reported. We report a case of successful and safe bilateral BLVR with staged EBV insertion. A 65-year-old male was diagnosed with chronic obstructive pulmonary disease 5 years prior and has severe heterogeneous emphysema mainly situated in the right upper lobe and left lower lobe (LLL) with giant bullae in the right middle lobe. First, we successfully inserted an EBV into the right middle bronchus, and the bullae decreased dramatically in size. After 6 months of initial valve implantation, we inserted five additional valves into the left lower bronchi of the patient. About 3 years after the secondary EBV insertion, this patient experienced hemoptysis and aggravation of dyspnea. In bronchoscopy, EBV inserted into LB6 was displaced with the formation of granulation tissue, so the EBV was removed. Later, LB6 was fully obstructed by granulation tissue. Then, we inserted an additional EBV into the LLL basal segmental bronchus, and complete atelectasis of the LLL occurred. The patient's pulmonary function, symptoms, and quality of life were further improved. BLVR can serve as a good alternative treatment for appropriately selected patients, and the procedure can be repeated on the contralateral side of the lung. It is important to recognize granulation tissue formation and deal with them appropriately.</p>","PeriodicalId":50760,"journal":{"name":"Annals of Thoracic Medicine","volume":"21 1","pages":"53-56"},"PeriodicalIF":2.3,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12904501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous renal replacement therapy combined with ulinastatin in acute respiratory distress syndrome: A systematic review and meta-analysis.","authors":"Siyao Zeng, Zhipeng Yao, Yue Li, Junbo Zheng, Hongliang Wang","doi":"10.4103/atm.atm_32_25","DOIUrl":"10.4103/atm.atm_32_25","url":null,"abstract":"<p><p>Acute respiratory distress syndrome (ARDS) is a severe clinical condition with high mortality, and effective adjunctive therapies remain limited. In recent years, continuous renal replacement therapy (CRRT) and ulinastatin have both been applied in ARDS management, but the clinical value of their combined use is still unclear. Therefore, we conducted a systematic review and meta-analysis to evaluate the efficacy of CRRT combined with ulinastatin compared with CRRT alone in patients with ARDS. A comprehensive search of 11 English and Chinese databases was performed from inception to August 29, 2025. Randomized controlled trials enrolling adult patients with ARDS and comparing CRRT plus ulinastatin versus CRRT alone were included. Mortality was the primary outcome, and secondary outcomes included intensive care unit (ICU) length of stay, mechanical ventilation time (MVT), Acute Physiology and Chronic Health Evaluation II (APACHE II) score at 7 days, oxygenation index (OI) at 7 days, and partial pressure of oxygen (PaO₂) at 7 days. Five studies involving 384 patients met the inclusion criteria. Pooled analysis showed that combination therapy significantly reduced mortality (risk ratio [RR] = 0.37, 95% confidence interval [CI] 0.23-0.60), ICU length of stay, MVT, and APACHE II scores at 7 days, and significantly improved OI and PaO₂ at 7 days compared with CRRT alone. Overall, current evidence of limited quality suggests that CRRT combined with ulinastatin may improve short-term clinical outcomes in patients with ARDS. Future rigorous, large-scale, multicenter randomized controlled trials are essential to verify these findings.</p>","PeriodicalId":50760,"journal":{"name":"Annals of Thoracic Medicine","volume":"21 1","pages":"4-11"},"PeriodicalIF":2.3,"publicationDate":"2026-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12904523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Saudi Thoracic Society guidelines for community acquired pneumonia: A model for translating evidence into national practice.","authors":"Marcos I Restrepo","doi":"10.4103/atm.atm_348_25","DOIUrl":"10.4103/atm.atm_348_25","url":null,"abstract":"","PeriodicalId":50760,"journal":{"name":"Annals of Thoracic Medicine","volume":"21 1","pages":"1-3"},"PeriodicalIF":2.3,"publicationDate":"2025-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12904512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing polysomnography auto scoring with the standard of care in sleep medicine.","authors":"Faris Alhejaili","doi":"10.4103/atm.atm_283_24","DOIUrl":"10.4103/atm.atm_283_24","url":null,"abstract":"<p><strong>Background: </strong>Manual polysomnography is considered as the gold-standard for diagnosis of sleep disorders. However, it is a labor intensive and time-consuming task and is being replaced by automated sleep scoring systems.</p><p><strong>Methods: </strong>This cross-sectional study was conducted at Sleep Medicine and Research Center, King Abdulaziz University Hospital, Jeddah, Saudi Arabia, between January 2022 and July 2024, the correlation and agreement between various parameters recorded through automated and manual sleep scoring.</p><p><strong>Results: </strong>Of a total of 442 participants, 234 (53.4%) were male and 206 (46.6%) were female. The mean age of participants was 48 ± 18.5 years. A moderate degree of agreement was found between apnea-hypopnea index (AHI) (κ = 0.510) and respiratory disturbance index supine (κ = 0.474) recorded through automated and manual scoring (<i>P</i> < 0.001). A fair degree of agreement (κ = 0.308) was recorded for AHI-rapid eye movement (<i>P</i> < 0.001) (<i>P</i> < 0.001). Intra-class correlation showed a good agreement between total sleep time (TST) recorded through both systems (ICC = 0.727, <i>P</i> < 0.001). AHI events recorded through both systems showed good agreement (ICC = 0.753, <i>P</i> < 0.001), whereas an excellent agreement was observed for TST supine (ICC = 0.902, <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>There appears to be a marked variation in the accuracy of various sleep parameters by automated sleep recording. Further studies that utilize advance machine learning algorithms can help better understanding of the role of automated sleep scoring in screening and diagnosis of sleep disorders.</p>","PeriodicalId":50760,"journal":{"name":"Annals of Thoracic Medicine","volume":"21 1","pages":"21-28"},"PeriodicalIF":2.3,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12904513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large cell neuroendocrine carcinoma of unknown primary presenting with pleural fluid: A diagnostic pitfall with lymphoma-like features.","authors":"Md Ali Osama, Rachana Meena, Saumyaranjan Mallick, Akash Kumar, Sanjay Kumar Meena, Ashish Wadekar, Deepali Jain","doi":"10.4103/atm.atm_174_25","DOIUrl":"10.4103/atm.atm_174_25","url":null,"abstract":"<p><p>Large-cell neuroendocrine carcinoma (LCNEC), a rare and aggressive malignancy, most commonly arising in the lungs but infrequently presenting at unusual locations or with atypical features. Diagnosing LCNEC can be particularly challenging when the primary site is unknown and when clinical and radiologic findings mimic other malignancies. Here, we describe a case involving an elderly male who presented only with generalized lymphadenopathy and pleural effusion, initially raising suspicion for a hematologic neoplasm. Detailed cytological and immunocytochemical evaluation of pleural fluid played a pivotal role in reaching the final diagnosis. This case underscores the diagnostic complexity of LCNEC with unknown primary and highlights the importance of cytological analysis in cases where conventional diagnostic approaches are limited.</p>","PeriodicalId":50760,"journal":{"name":"Annals of Thoracic Medicine","volume":"21 3","pages":"172-176"},"PeriodicalIF":2.3,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13395208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148580941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A tool for recognizing asthma nonadherence during disease management: A prospective cohort study.","authors":"Qiao Zhang, Yi Lan, Qinqin Wang, Lingjun Liu, Hong Li, Shuo Wang, Xuxu Gou, Xiuqing Liao, Qianli Ma","doi":"10.4103/atm.atm_256_24","DOIUrl":"10.4103/atm.atm_256_24","url":null,"abstract":"<p><strong>Background: </strong>The adherence of asthma patients remains an urgent issue that needs to be addressed, and there is still a lack of tools for the rapid identification of nonadherence.</p><p><strong>Methods: </strong>A number of factors associated with increased risk of nonadherence were compared with adherence assessed using the Medication Adherence Report Scale for Asthma (MARS-A). Among them was the tool for recognizing asthma nonadherence (TRAN), which is the ratio between the patient's perceived overall health measured using a 0-100 visual analog scale and their asthma control test score. The development set used data from a multicenter, prospective cohort study in asthma. The TRAN was then validated in a further test set of asthma patients.</p><p><strong>Results: </strong>Data from 518 participants who completed 3-month follow-up formed the development set. TRAN was the best predictor of nonadherence as defined by MARS-A (odds ratio = 9.14; 95% confidence interval [CI]: 4.16, 20.10; <i>P</i> < 0.01) in univariate logistic regression analysis. Its area under the curve (AUC) for identifying nonadherent patients was 0.810 (95% CI: 0.753, 0.866), at a cutoff score of 1.08, its sensitivity was 82.0%, specificity was 84.4%, positive predictive value (PPV) was 55.8%, and negative predictive value (NPV) was 95.1%. In the validation group (<i>n</i> = 175), the AUC was 0.75 with PPV and NPV at 56.4% and 90.8%, respectively.</p><p><strong>Conclusion: </strong>The TRAN is a simple method for the initial screening of asthma patients for potential nonadherence.</p>","PeriodicalId":50760,"journal":{"name":"Annals of Thoracic Medicine","volume":"21 1","pages":"46-52"},"PeriodicalIF":2.3,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12904507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}