Behavioural Neurology最新文献_第9页

Communication, Feeding and Swallowing Disorders in Neurological Diseases 神经系统疾病中的沟通、进食和吞咽障碍

IF 2.8 4区医学

Behavioural Neurology Pub Date : 2022-04-21 DOI: 10.1155/2022/9851424

G. Nasios, L. Messinis, E. Dardiotis, J. Kassubek

引用次数: 0

Impact of the Aversive Effects of Drugs on Their Use and Abuse. 药物的厌恶效应对其使用和滥用的影响

IF 2.7 4区医学

Behavioural Neurology Pub Date : 2022-04-20 eCollection Date: 2022-01-01 DOI: 10.1155/2022/8634176

Anthony L Riley, Hayley N Manke, Shihui Huang

{"title":"Impact of the Aversive Effects of Drugs on Their Use and Abuse.","authors":"Anthony L Riley, Hayley N Manke, Shihui Huang","doi":"10.1155/2022/8634176","DOIUrl":"10.1155/2022/8634176","url":null,"abstract":"Drug use and abuse are complex issues in that the basis of each may involve different determinants and consequences, and the transition from one to the other may be equally multifaceted. A recent model of the addiction cycle (as proposed by Koob and his colleagues) illustrates how drug-taking patterns transition from impulsive (acute use) to compulsive (chronic use) as a function of various neuroadaptations leading to the downregulation of DA systems, upregulation of stress systems, and the dysregulation of the prefrontal/orbitofrontal cortex. Although the nature of reinforcement in the initiation and mediation of these effects may differ (positive vs. negative), the role of reinforcement in drug intake (acute and chronic) is well characterized. However, drugs of abuse have other stimulus properties that may be important in their use and abuse. One such property is their aversive effects that limit drug intake instead of initiating and maintaining it. Evidence of such effects comes from both clinical and preclinical populations. In support of this position, the present review describes the aversive effects of drugs (assessed primarily in conditioned taste aversion learning), the fact that they occur concurrently with reward as assessed in combined taste aversion/place preference designs, the role of aversive effects in drug-taking (in balance with their rewarding effects), the dissociation of these affective properties in that they can be affected in different ways by the same manipulations, and the impact of various parametric, experiential, and subject factors on the aversive effects of drugs and the consequent impact of these factors on their use and abuse potential.","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2022-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9045991/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48363378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitigated Oxidative Stress and Cognitive Impairments in Transient Global Ischemia using Niosomal Selegiline-NBP delivery 使用Niosomal Selegiline-NBP减轻短暂性全身缺血的氧化应激和认知障碍

IF 2.8 4区医学

Behavioural Neurology Pub Date : 2022-04-16 DOI: 10.1155/2022/4825472

Bahareh Jafari, Mahmoud Gharbavi, Yasamin Baghdadchi, H. Manjili, J. Mahmoudi, Iraj Jafari-Anarkoli, Shayan Amiri, M. Hosseini

{"title":"Mitigated Oxidative Stress and Cognitive Impairments in Transient Global Ischemia using Niosomal Selegiline-NBP delivery","authors":"Bahareh Jafari, Mahmoud Gharbavi, Yasamin Baghdadchi, H. Manjili, J. Mahmoudi, Iraj Jafari-Anarkoli, Shayan Amiri, M. Hosseini","doi":"10.1155/2022/4825472","DOIUrl":"https://doi.org/10.1155/2022/4825472","url":null,"abstract":"Stroke is the most common reason for adult disabilities and the second ground for death worldwide. Our previous study revealed that selegiline serves as an alternative candidate in transient hypoxia-ischemia. However, aggressive and restless behavior was observed in stroke-induced rats receiving 4 mg/kg selegiline. In comparison, 1 mg/kg selegiline could induce negligible therapeutic effects on mitochondrial dysfunction and histopathological changes. Therefore, we designed oral noisome-based selegiline attached to 4-(4-nitrobenzyl) pyridine to improve transient global ischemia by attenuating cognitive impairments, oxidative stress, and histopathological injury. The investigation was performed in transient hypoxia-ischemia-induced rats by oral administration of nanoformulation containing selegiline (0.25-1 mg/kg) for 4 weeks (3 times a week). Novel object recognition (NOR) was considered to evaluate their cognitive dysfunction. Oxidative stress parameters and brain histopathological assessments were determined following the scarification of rats. Outstandingly, our data demonstrated slower selegiline release from niosomes relative to free drug, which was also in a controlled manner. Our data confirmed significant improvement in cognitive behavior in the NOR test, an increase in glutathione level and total antioxidant power, a decline in MDA and protein carbonyl level, as well as a decreased number of dead cells in histopathological assessment after being exposed to (0.5-1 mg/kg) selegiline-NBP nanoformulation. These data manifested that the selegiline-NBP nanoformulation (0.5-1 mg/kg) could significantly reduce oxidative damage, cognitive dysfunction, and histopathological damage compared to transient hypoxia-ischemia rats, which is 20 times lower than the therapeutic dose in humans. Therefore, the proposed nanoformulation would be capable as an alternative candidate without side effects in stroke.","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2022-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45355442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Applications of Theranostics for Detecting and Targeting CNS Injuries and Diseases Theranotics在检测和靶向中枢神经系统损伤和疾病中的应用

IF 2.8 4区医学

Behavioural Neurology Pub Date : 2022-04-15 DOI: 10.1155/2022/9891859

Yu-Yo Sun, Horacio Soto, C. Kao, Cui Mei, Muh-Shi Lin

引用次数: 0

Multimodal Medical Image Fusion of Positron Emission Tomography and Magnetic Resonance Imaging Using Generative Adversarial Networks. 利用生成对抗性网络实现正电子发射断层扫描和磁共振成像的多模式医学图像融合

IF 2.8 4区医学

Behavioural Neurology Pub Date : 2022-04-14 eCollection Date: 2022-01-01 DOI: 10.1155/2022/6878783

R Nandhini Abirami, P M Durai Raj Vincent, Kathiravan Srinivasan, K Suresh Manic, Chuan-Yu Chang

{"title":"Multimodal Medical Image Fusion of Positron Emission Tomography and Magnetic Resonance Imaging Using Generative Adversarial Networks.","authors":"R Nandhini Abirami, P M Durai Raj Vincent, Kathiravan Srinivasan, K Suresh Manic, Chuan-Yu Chang","doi":"10.1155/2022/6878783","DOIUrl":"10.1155/2022/6878783","url":null,"abstract":"Multimodal medical image fusion is a current technique applied in the applications related to medical field to combine images from the same modality or different modalities to improve the visual content of the image to perform further operations like image segmentation. Biomedical research and medical image analysis highly demand medical image fusion to perform higher level of medical analysis. Multimodal medical fusion assists medical practitioners to visualize the internal organs and tissues. Multimodal medical fusion of brain image helps to medical practitioners to simultaneously visualize hard portion like skull and soft portion like tissue. Brain tumor segmentation can be accurately performed by utilizing the image obtained after multimodal medical image fusion. The area of the tumor can be accurately located with the information obtained from both Positron Emission Tomography and Magnetic Resonance Image in a single fused image. This approach increases the accuracy in diagnosing the tumor and reduces the time consumed in diagnosing and locating the tumor. The functional information of the brain is available in the Positron Emission Tomography while the anatomy of the brain tissue is available in the Magnetic Resonance Image. Thus, the spatial characteristics and functional information can be obtained from a single image using a robust multimodal medical image fusion model. The proposed approach uses a generative adversarial network to fuse Positron Emission Tomography and Magnetic Resonance Image into a single image. The results obtained from the proposed approach can be used for further medical analysis to locate the tumor and plan for further surgical procedures. The performance of the GAN based model is evaluated using two metrics, namely, structural similarity index and mutual information. The proposed approach achieved a structural similarity index of 0.8551 and a mutual information of 2.8059.","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2022-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9023223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47403993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Early Stroke Prediction Methods for Prevention of Strokes. 预防脑卒中的早期预测方法。

IF 2.8 4区医学

Behavioural Neurology Pub Date : 2022-04-11 eCollection Date: 2022-01-01 DOI: 10.1155/2022/7725597

Mandeep Kaur, Sachin R Sakhare, Kirti Wanjale, Farzana Akter

{"title":"Early Stroke Prediction Methods for Prevention of Strokes.","authors":"Mandeep Kaur, Sachin R Sakhare, Kirti Wanjale, Farzana Akter","doi":"10.1155/2022/7725597","DOIUrl":"10.1155/2022/7725597","url":null,"abstract":"The emergence of the latest technologies gives rise to the usage of noninvasive techniques for assisting health-care systems. Amongst the four major cardiovascular diseases, stroke is one of the most dangerous and life-threatening disease, but the life of a patient can be saved if the stroke is detected during early stage. The literature reveals that the patients always experience ministrokes which are also known as transient ischemic attacks (TIA) before experiencing the actual attack of the stroke. Most of the literature work is based on the MRI and CT scan images for classifying the cardiovascular diseases including a stroke which is an expensive approach for diagnosis of early strokes. In India where cases of strokes are rising, there is a need to explore noninvasive cheap methods for the diagnosis of early strokes. Hence, this problem has motivated us to conduct the study presented in this paper. A noninvasive approach for the early diagnosis of the strokes is proposed. The cascaded prediction algorithms are time-consuming in producing the results and cannot work on the raw data and without making use of the properties of EEG. Therefore, the objective of this paper is to devise mechanisms to forecast strokes on the basis of processed EEG data. This paper is proposing time series-based approaches such as LSTM, biLSTM, GRU, and FFNN that can handle time series-based predictions to make useful decisions. The experimental research outcome reveals that all the algorithms taken up for the research study perform well on the prediction problem of early stroke detection, but GRU performs the best with 95.6% accuracy, whereas biLSTM gives 91% accuracy and LSTM gives 87% accuracy and FFNN gives 83% accuracy. The experimental outcome is able to measure the brain waves to predict the signs of strokes. The findings can certainly assist the physicians to detect the stroke at early stages to save the lives of the patients.","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2022-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9017592/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"64786321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 51

Relationships between Personality Traits and Brain Gray Matter Are Different in Risky and Non-risky Drivers 风险和非风险司机的人格特征与脑灰质的关系不同

IF 2.8 4区医学

Behavioural Neurology Pub Date : 2022-04-05 DOI: 10.1155/2022/1775777

Laura Mas-Cuesta, S. Baltruschat, A. Cándido, A. Catena

{"title":"Relationships between Personality Traits and Brain Gray Matter Are Different in Risky and Non-risky Drivers","authors":"Laura Mas-Cuesta, S. Baltruschat, A. Cándido, A. Catena","doi":"10.1155/2022/1775777","DOIUrl":"https://doi.org/10.1155/2022/1775777","url":null,"abstract":"Personality traits such as impulsivity or sensitivity to rewards and punishments have been associated with risky driving behavior, but it is still unclear how brain anatomy is related to these traits as a function of risky driving. In the present study, we explore the neuroanatomical basis of risky driving behavior and how the level of risk-taking influences the relationship between the traits of impulsivity and sensitivity to rewards and punishments and brain gray matter volume. One hundred forty-four participants with different risk-taking tendencies assessed by real-life driving situations underwent MRI. Personality traits were assessed with self-report measures. We observed that the total gray matter volume varied as a function of risky driving tendencies, with higher risk individuals showing lower gray matter volumes. Similar results were found for volumes of brain areas involved in the reward and cognitive control networks, such as the frontotemporal, parietal, limbic, and cerebellar cortices. We have also shown that sensitivity to reward and punishment and impulsivity are differentially related to gray matter volumes as a function of risky driving tendencies. Highly risky individuals show lower absolute correlations with gray matter volumes than less risk-prone individuals. Taken together, our results show that risky drivers differ in the brain structure of the areas involved in reward processing, cognitive control, and behavioral modulation, which may lead to dysfunctional decision-making and riskier driving behavior.","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48888930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Classification of Myopathy and Amyotrophic Lateral Sclerosis Electromyograms Using Bat Algorithm and Deep Neural Networks. 基于Bat算法和深度神经网络的肌病和肌萎缩侧索硬化症肌电图分类

IF 2.8 4区医学

Behavioural Neurology Pub Date : 2022-04-04 eCollection Date: 2022-01-01 DOI: 10.1155/2022/3517872

A Bakiya, A Anitha, T Sridevi, K Kamalanand

{"title":"Classification of Myopathy and Amyotrophic Lateral Sclerosis Electromyograms Using Bat Algorithm and Deep Neural Networks.","authors":"A Bakiya, A Anitha, T Sridevi, K Kamalanand","doi":"10.1155/2022/3517872","DOIUrl":"10.1155/2022/3517872","url":null,"abstract":"Electromyograms (EMG) are a recorded galvanic action of nerves and muscles which assists in diagnosing the disorders associated with muscles and nerves. The efficient discrimination of abnormal EMG signals, myopathy and amyotrophic lateral sclerosis, engage crucial role in automatic diagnostic assistance tools, since EMG signals are nonstationary signals. Hence, for computer-aided identification of abnormalities, extraction of features, selection of superlative feature subset, and developing an efficient classifier are indispensable. Initially, time domain and Wigner-Ville transformed time-frequency features were extracted from abnormal EMG signals for experiments. The selection of substantial characteristics from time and time-frequency features was performed using bat algorithm. Extensively, deep neural network classifier is modelled for selected feature subset using bat algorithm from extracted time and time-frequency features. The performance of deep neural network exerting selected features from bat algorithm was compared with conventional artificial neural network. Results demonstrate that the deep neural network modelled with layers 2 and 3 (neurons = 2 and 4) using time domain features is efficient in classifying the abnormalities of EMG signals with an accuracy, sensitivity, and specificity of 100% and also exhibited finer performance. Correspondingly, the developed conventional single layer artificial neural network (neurons = 7) with time domain features has shown an accuracy of 83.3%, sensitivity of 100%, and specificity of 71.42%. The work materializes the significance of conventional and deep neural network using time and time-frequency features in diagnosing the abnormal signals exists in neuromuscular system using efficient classification.","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9001138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44022843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Clinical Factors Predicting Voluntary Driving Cessation among Patients with Parkinson's Disease 预测帕金森病患者自愿停车的临床因素

IF 2.8 4区医学

Behavioural Neurology Pub Date : 2022-03-20 DOI: 10.1155/2022/4047710

Hidetada Yamada, M. Nakamori, T. Nezu, Teppei Kotozaki, Juri Kitamura, T. Ohshita, Y. Sueda, H. Maruyama

{"title":"Clinical Factors Predicting Voluntary Driving Cessation among Patients with Parkinson's Disease","authors":"Hidetada Yamada, M. Nakamori, T. Nezu, Teppei Kotozaki, Juri Kitamura, T. Ohshita, Y. Sueda, H. Maruyama","doi":"10.1155/2022/4047710","DOIUrl":"https://doi.org/10.1155/2022/4047710","url":null,"abstract":"Factors that influence the decision of voluntary driving cessation in patients living with Parkinson's disease (PD) are still unclear. We aimed to reveal the factors affecting the decision of voluntary driving cessation in patients with PD. This hospital-based cross-sectional study recruited consecutive outpatients with PD. Data on sociodemographic and clinical characteristics and medication use were collected from the patients using semistructured interviews. Cognitive function was evaluated using the Japanese version of the Montreal Cognitive Assessment (MoCA-J). We excluded patients with dementia or motor impairment (Hoehn − Yahr stage > 3). We divided the patients into two groups, with and without voluntary driving cessation (D: driver; RD: retired driver), and conducted investigations using multivariate logistic regression analyses. Of the 40 patients, 8 (20.0%) voluntarily retired from driving. Patients who decided on driving cessation had a higher prevalence of freezing of gait (FOG) (D vs. RD, 25.0% vs. 87.5%; P = 0.001) and tended to have lower scores for attention in the MoCA-J (D vs. RD, 5.0 ± 1.2 vs. 4.1 ± 1.4; P = 0.086). Multivariable analysis showed that FOG was independently associated with driving cessation (odds ratio: 14.46, 95% confidence interval: 1.91–303.74). FOG was associated with voluntary driving cessation in patients with PD without dementia or severe motor impairment. Physicians should consider providing extensive social support to maintain patients' mobility and independence, especially if the patients have these clinical factors.","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2022-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46158286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Platelet P2Y12 Inhibitor in the Treatment and Prevention of Migraine: A Systematic Review and Meta-Analysis 血小板P2Y12抑制剂治疗和预防偏头痛的系统评价和荟萃分析

IF 2.8 4区医学

Behavioural Neurology Pub Date : 2022-03-20 DOI: 10.1155/2022/2118740

Fengzhi Wang, Yu Cao, Yanjie Liu, Zhanxiu Ren, Fuyong Li

{"title":"Platelet P2Y12 Inhibitor in the Treatment and Prevention of Migraine: A Systematic Review and Meta-Analysis","authors":"Fengzhi Wang, Yu Cao, Yanjie Liu, Zhanxiu Ren, Fuyong Li","doi":"10.1155/2022/2118740","DOIUrl":"https://doi.org/10.1155/2022/2118740","url":null,"abstract":"There have been speculation and research linking migraine with abnormalities of platelet aggregation and activation. The role of the P2Y12 platelet inhibitor in the treatment of migraine has not been established. We aim to evaluate the efficacy of the platelet P2Y12 inhibitor in the treatment of migraine and prevention of new-onset migraine headache (MHA) following transcatheter atrial septal defect closure (ASDC). We searched the PubMed, Web of Science, and Cochrane Library databases for relevant studies. The primary outcomes were the headache responder rate and the rate of new-onset migraine attacks following ASDC. Four studies for a total of 262 migraine patients with or without patent foramen ovale (PFO) and three studies involving 539 patients with antiplatelet treatment in the prevention of new-onset migraine following ASDC were included. The pooled responder rate of the P2Y12 inhibitor for migraine was 0.64 (95% CI: 0.43 to 0.81). For patients who underwent ASDC, the use of antiplatelet regimens including the P2Y12 inhibitor, compared with regimens excluding P2Y12 inhibitor, resulted in a lower rate of new-onset migraine (OR: 0.41, 95% CI: 0.22 to 0.77, P = 0.005). We concluded that the P2Y12 platelet inhibitor may have a primary prophylactic role in migraine patients with or without PFO and prevent new-onset MHA after ASDC. The responsiveness of the P2Y12 inhibitor could help select candidates who would benefit from PFO closure. It warrants further large-scale research to explore the role of the P2Y12 inhibitor, particularly in a proportion of migraine patients.","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2022-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42905074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5