Behavioural Neurology最新文献

{"title":"An Updated Overview of the Magnetic Resonance Imaging of Brain Iron in Movement Disorders","authors":"N. Tambasco, P. Nigro, A. Chiappiniello, F. Paolini Paoletti, Sara Scialpi, S. Simoni, P. Chiarini, L. Parnetti","doi":"10.1155/2022/3972173","DOIUrl":"https://doi.org/10.1155/2022/3972173","url":null,"abstract":"Brain iron load is one of the most important neuropathological hallmarks in movement disorders. Specifically, the iron provides most of the paramagnetic metal signals in the brain and its accumulation seems to play a key role, although not completely explained, in the degeneration of the basal ganglia, as well as other brain structures. Moreover, iron distribution patterns have been implicated in depicting different movement disorders. This work reviewed current literature on Magnetic Resonance Imaging for Brain Iron Detection and Quantification (MRI-BIDQ) in neurodegenerative processes underlying movement disorders.","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44602433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurobehavioral Differences of Valproate and Risperidone on MK-801 Inducing Acute Hyperlocomotion in Mice","authors":"Po-An Chen, Hui-Yi Wang, C. Sun, Mao-Liang Chen, Yi-Chyan Chen","doi":"10.1155/2022/1048463","DOIUrl":"https://doi.org/10.1155/2022/1048463","url":null,"abstract":"Objective\u0000The glutamate system plays a major role in the development of neuropsychiatric disorders such as addiction, epilepsy, dementia, and psychosis. MK-801 (dizocilpine), an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, could increase locomotor activity and stereotyped neurobehaviors mimicking schizophrenic-like features in the mouse model. The study would explore the neuropharmacological differences of risperidone and valproic acid on the MK-801-induced neurobehavioral changes.\u0000\u0000\u0000Methods\u0000The subjects were male C57BL/6J mice obtained from the National Laboratory Animal Center. Drug effects were assessed using the open field with a video-tracking system and gaiting tests. After habitation, risperidone (0, 0.1 mg/kg) or valproic acid (0, 200 mg/kg) was injected and ran locomotion for 30 mins. Sequentially, mice were followed by intraperitoneal injection (i.p.) with MK-801 (0, 0.2 mg/kg) and ran locomotion for 60 mins. Gaiting behaviors such as step angles, stride lengths, and stance widths were measured following the study drugs.\u0000\u0000\u0000Results\u0000The results showed that risperidone and valproic acid alone could not alter the locomotor activities. Following the MK-801 injection, the travelled distance and speed in the entire open field dramatically increased. The dose 0.1 mg/kg of risperidone could totally inhibit the MK-801-induced hyperlocomotion compared with that of the saline-injected group (p < 0.001). The valproic acid (200 mg/kg) partially suppressed the hyperlocomotion which is induced by MK801.\u0000\u0000\u0000Conclusion\u0000The more dominant effect of risperidone to rescue MK-801 induced hyperlocomotion compared with that of valproic acid. The partial suppression of valproic acid may imply the psychopharmacological evidence as adjuvant effect to treat psychotic patients through tuning glutamatergic neurotransmission.","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47232300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retracted: Propofol Causes Consciousness Loss by Affecting GABA-A Receptor in the Nucleus Basalis of Rats","authors":"Behavioural Neurology","doi":"10.1155/2022/9840256","DOIUrl":"https://doi.org/10.1155/2022/9840256","url":null,"abstract":"[This retracts the article DOI: 10.1155/2020/9370891.].","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46443976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metformin Alleviates Autistic-Like Behaviors Elicited by High-Fat Diet Consumption and Modulates the Crosstalk Between Serotonin and Gut Microbiota in Mice","authors":"Wenlin Deng, Haoran Ke, Siqi Wang, Zitong Li, Si-tao Li, Pinjing Lv, Fang Li, Ye Chen","doi":"10.1155/2022/6711160","DOIUrl":"https://doi.org/10.1155/2022/6711160","url":null,"abstract":"The biological mechanisms linking diet-related obesity and autistic behaviors remain unclear. Metformin has proven to be beneficial in the treatment of many syndromes, including autism spectrum disorder. Therefore, the aim of this study was to assess whether metformin treatment could ameliorate metabolic and behavioral alterations in C57BL/6 mice kept on a high-fat diet (HFD), and whether these changes were related to modifications in the gut microbiota and 5-HT levels. As expected, ten weeks of HFD ingestion increased body weight, adiposity, and glucose levels. HFD-fed mice showed a marked aggravation of repetitive behaviors (marble burying and self-grooming), and this was prevented by metformin administration. In addition, HFD-fed mice increased the total distance travelled in the open field test. This hyperactivity was counteracted by metformin cotreatment. In the elevated plus maze test, HFD-fed mice showed a reduced number of entries into the open arms. Interestingly, both HFD and metformin cotreatment increased social interactions in the three-chamber test. HFD increased the levels of intestinal tryptophan and 5-hydroxyindoleacetic acid. Metformin stimulated gut tryptophan and promoted the synthesis of 5-HT in the HFD group. Lactococcus, Trichococcus, Romboutsia, and Faecalibaculum were enriched in HFD-fed mice, whereas the HFD group cotreated with metformin was enriched in Intestinimonas and L. reuteri. Faecalibacterium was positively correlated with sociability and 5-HT pathway components in mice that received metformin. In summary, HFD consumption elicited a complex phenotype comprising higher levels of anxiety-like and repetitive behaviors but also increased sociability. Metformin could potentially improve HFD-induced disorders in the autistic spectrum through a mechanism involving positive modulation of 5-HT levels in the gut and its microbiota composition.","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43625434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RDW-to-ALB Ratio Is an Independent Predictor for 30-Day All-Cause Mortality in Patients with Acute Ischemic Stroke: A Retrospective Analysis from the MIMIC-IV Database.","authors":"Ping Liu,&nbsp;Su Luo,&nbsp;Xiang-Jie Duan,&nbsp;Xiang Chen,&nbsp;Quan Zhou,&nbsp;Yan Jiang,&nbsp;Xia Liu","doi":"10.1155/2022/3979213","DOIUrl":"https://doi.org/10.1155/2022/3979213","url":null,"abstract":"<p><strong>Purpose: </strong>Previous studies have shown that the peripheral red blood cell distribution width (RDW) and human serum albumin (ALB) were both predictors of the risk and mortality of cerebrovascular diseases, and the ratio of RDW to ALB (RAR) was a combined new index that can predict the prognosis of the cardiovascular and respiration systemic diseases, but its role in cerebrovascular diseases had not been effectively evaluated. This study is aimed at exploring whether RAR can effectively predict the 30-day all-cause mortality of acute ischemic stroke (AIS) patients.</p><p><strong>Methods: </strong>This retrospective cohort study was conducted on AIS patients (age > 18 years) in the intensive care database MIMIC-IV. The RAR was measured based on the red blood cell distribution width and albumin. The main result was 30-day all-cause mortality, and the secondary results were ICU mortality and hospital mortality. Obtain the odds ratio (OR) estimate from the logistic regression model of log-transformed RAR values and mortality. We had used another database for external validation.</p><p><strong>Results: </strong>A total of 1412 patients were enrolled, with an average age of 68.8 ± 15.9, including 708 (50.1%) males. When log-transformed RAR values were used as a continuous variable, as the values increases, the risk of death increases (30-day all-cause mortality OR = 4.02 (2.21, 7.32) <i>P</i> < 0.0001, ICU mortality OR = 3.81 (1.92, 7.54) <i>P</i> = 0.0001, and hospital mortality OR = 3.31 (1.83, 6.00) <i>P</i> < 0.0001), when the values were used as three-category variables and as a trend variable was also positively correlated with each mortality rate. Especially as the categorical variables, a dose-response relationship was clearly observed, that was, as the category of RAR increased (Q1 to Q3), the HR value of the risk of death gradually steadily increased. Such a relationship can also be observed in the external validation database. In the subgroup analysis, we observed an increased risk of death in the patient with hyperlipidemia and low HAS-BLED scores; however, no significant interaction was found in other subgroup analyses (including the diagnostic sequence of AIS).</p><p><strong>Conclusion: </strong>RAR was a predictor of mortality in AIS patients. However, more in-depth research is needed to further analyze and confirm the role of RAR in AIS patients.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2022 ","pages":"3979213"},"PeriodicalIF":2.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9780005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10802831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor Resonance Flexibility to Emotion-Enriched Context in Parkinson's Disease Patients.","authors":"Giovanna Lagravinese,&nbsp;Ambra Bisio,&nbsp;Marco Bove,&nbsp;Alessandro Botta,&nbsp;Gaia Bonassi,&nbsp;Roberta Marchese,&nbsp;Piero Ruggeri,&nbsp;Elisa Pelosin,&nbsp;Laura Avanzino","doi":"10.1155/2022/6487419","DOIUrl":"https://doi.org/10.1155/2022/6487419","url":null,"abstract":"<p><p>In healthy people, motor resonance mechanisms are flexible to negative emotional contextual clues with greater motor resonance during the observation of a reach to grasp movement performed in an environment eliciting disgust. The link between emotion and motor control has become an interesting topic in Parkinson's disease (PD). Here, we aimed to study the response of the mirror neuron system, specifically motor resonance, to an emotion-enriched context in people with PD. Corticospinal excitability was recorded in a total of 44 participants, divided into two groups (23 PD patients and 21 healthy subjects). We recorded motor-evoked potentials from a muscle involved in the grasping movement while participants were watching the same reach-to-grasp movement embedded in surrounds with negative emotional valence, but different levels of arousal: sadness (low arousal) and disgust (high arousal). Basic motor resonance mechanisms were less efficient in PD than controls. Responsiveness to emotional contextual clues eliciting sadness was similar between PD and controls, whereas responsiveness to emotional contextual clues eliciting disgust was impaired in PD patients. Our findings show reduced motor resonance flexibility to the disgusting context, supporting the hypothesis that PD patients may have a deficit in \"translating\" an aversive motivational state into a physiologic response. The amygdala, which is implicated in the appraisal of fearful stimuli and response to threatening situations, might be implicated in this process.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2022 ","pages":"6487419"},"PeriodicalIF":2.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9900249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10681621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Online Learning System on Students Affected with Stroke Disease.","authors":"Sobia Wassan,&nbsp;Chen Xi,&nbsp;Tian Shen,&nbsp;Kamal Gulati,&nbsp;Kinza Ibraheem,&nbsp;Rana M Amir Latif Rajpoot","doi":"10.1155/2022/4847066","DOIUrl":"https://doi.org/10.1155/2022/4847066","url":null,"abstract":"<p><p>Stroke, also known as a cerebrovascular accident, is a medical emergency that causes temporary or permanent behavioral dysfunction in people. Sleep deprivation affects our brains in a variety of ways. The advantages of sleep much justify the risks of not having enough sleep. Sleep deprivation (SD) includes a variety of factors, including prolonged awake. Neuroimaging investigates SD's impact on attention, working memory, mood, and hippocampal learning. We analyzed how this data enriches our mechanistic understanding of these alterations and the clinical illnesses linked with sleep disruption. We have used Cronbach's alpha to test the reliability of a scale, so we then have 19 individual attributes responding to 174 participants via survey. The evaluated result shows the reliability statistics; the value for Cronbach's alpha is .962, which is very excellent as it reaches 1. So, there is very strong reliability. If the value falls under .6, we look back to the mean and standard deviation table and remove the attribute with low values for mean or standard deviation and try the remaining attributes. Cronbach's alpha tells us which attribute or item to delete to increase the reliability, and we also have analyzed the correlation among the class students while watching the same video lecture. We have collected data for at least ten students watching the same video using a webcam. Once the data is collected, we then have applied some correlation techniques to determine the class students' behavior towards the same video lecture. This way, we can see the overall behavior of the class upon a specific video lecture. The study further reveals that subjective happiness is influenced by its efficiency, entertainment value, and effectiveness. Does the research offer an original emphasis on analyzing how does lack of sleep affect our brains? Sleep loss frameworks are minimal compared to the benefits of sleep.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2022 ","pages":"4847066"},"PeriodicalIF":2.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8843983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10072017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Customer Experience towards the Product during a Coronavirus Outbreak.","authors":"Sobia Wassan,&nbsp;Tian Shen,&nbsp;Chen Xi,&nbsp;Kamal Gulati,&nbsp;Danish Vasan,&nbsp;Beenish Suhail","doi":"10.1155/2022/4279346","DOIUrl":"https://doi.org/10.1155/2022/4279346","url":null,"abstract":"Nowadays, sentimental analysis of consumers' review is becoming much crucial in the marketing world. It is not just giving ideas to the firms that how consumers like their product or service, but it would also help them make their service better. In this article, the statistical method identifies the relationship of many factors in consumer feedback. It introduces a deep-based learning method called DSC (deep sentiment classifier) to determine whether or not to recommend the reviewed product thoroughly. Our suggested method also investigates the effect sizes of the feedback, such as positives, negatives, and neutrals. We used the women's clothing review dataset containing 22,642 records after preprocessing of the results. Experimental studies show that the recommendations are an excellent positive sentiment indicator. In comparison, ratings become fuzzy performance metrics in product reviews. The 10-fold cross-validation analysis shows that the recommended form has the top F1 score (93.56%) in the sentimental classification on average and the recommended classification (88.32%) on average. A comparative description of other classifiers focused on machine learning, for example, KNN, random forest, logistic regression, decision tree, support vector machine multilayer perceptron, and naïve Bayes, also demonstrates that DSC gives the best possible result. We have tested DSC on the dataset IMDB (Internet Video Database), which includes the sentiment of the 50,000 movie reviews (25000 for training and 25000 for testing). In comparison to other baseline methods, DSC obtained an excellent classification score for this experiment.","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2022 ","pages":"4279346"},"PeriodicalIF":2.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8917442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10072027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Acupuncture and Rehabilitation Training on Limb Movement and Living Ability of Patients with Hemiplegia after Stroke.","authors":"Juhua Zhang,&nbsp;Yingmei Mu,&nbsp;Yunxia Zhang","doi":"10.1155/2022/2032093","DOIUrl":"https://doi.org/10.1155/2022/2032093","url":null,"abstract":"<p><p>Stroke is a disease with a high disability rate, having a serious impact on that patient's working and daily survival quality and bringing economic burden to the family and society. Patients with stroke hemiplegia are mostly tetraplegic and have difficulty regulating their balance, and their long-term symmetry has been destroyed. The application in the rehabilitation process of acupuncture in patients with hemorrhagic stroke may produce unexpected effects. It is very effective to study the effect of acupuncture combined with rehabilitation training on limb movement and patient survival. It is very helpful in improving normal motor function and normal life, increasing joint mobility and muscle strength, and reducing muscle tension. In this paper, it is found that the observational group has a complication rate of 2.13%, in contrast to 17.02% as in the group of control, and the pin-prick combined with a rehabilitative training makes a significant improvement to the patients. This study provides suggestions for the study to investigate acupuncture combined with recovery exercise on limb movement and living capacities of people with stroke paraparesis.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2022 ","pages":"2032093"},"PeriodicalIF":2.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9072040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10370343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Verbal Reasoning Impairment in Parkinson's Disease.","authors":"Antonina Luca,&nbsp;Giulia Donzuso,&nbsp;Concetta D'Agate,&nbsp;Claudio Terravecchia,&nbsp;Calogero Cicero Edoardo,&nbsp;Giovanni Mostile,&nbsp;Giorgia Sciacca,&nbsp;Alessandra Nicoletti,&nbsp;Mario Zappia","doi":"10.1155/2022/3422578","DOIUrl":"https://doi.org/10.1155/2022/3422578","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study was to assess verbal reasoning (VR) functioning in patients with Parkinson's disease (PD) and healthy controls (HCs).</p><p><strong>Methods: </strong>The non-demented PD patients and HCs matched by age and global cognition were enrolled in this study. VR was assessed with the verbal reasoning test (VRT), total score, and subsets.</p><p><strong>Results: </strong>Eighty-seven PD patients (51 men; mean age 63.8 ± 7.9 years) and 87 HCs (46 men; mean age 63.7 ± 8.0 years) were enrolled. At univariate analysis, PD patients presented a significantly lower score in the VRT subset classification (12.3 ± 2.1) than HCs (12.9 ± 1.7) with an odds ratio (OR) of 0.8 (95% confidence interval [CI] 0.70-0.98; <i>p</i> = 0.003). The strength of association was also confirmed at multivariate analysis (OR = 0.8, 95% CI 0.70-0.98; <i>p</i> = 0.003). Moreover, in PD patients, a statistically significant positive correlation was found between VRT-classification and MoCA scores (<i>r</i> = 0.330; <i>p</i> = 0.002).</p><p><strong>Conclusions: </strong>PD patients presented lower VR performance than HCs.</p>","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":"2022 ","pages":"3422578"},"PeriodicalIF":2.8,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9759383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10461861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}