Characterizing Cerebral Imaging and Electroclinical Features of Five Pseudohypoparathyroidism Cases Presenting with Epileptic Seizures.

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

Behavioural Neurology Pub Date : 2022-08-12 eCollection Date: 2022-01-01 DOI:10.1155/2022/8710989

Zijuan Qi, Zhensheng Li, Quwen Gao, Li Dong, Jian Lin, Kairun Peng, Wei Xiang, Bingmei Deng

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引用次数: 1

Abstract

Objective: To characterize the cerebral imaging and electroclinical features and investigate their etiological contributions to seizures in pseudoparathyroidism (PHP).

Methods: The clinical symptoms, biochemical imaging by magnetic resonance imaging (MRI) and computed tomography (CT) tests, and electroencephalogram (EEG) manifestations of five PHP patients with seizures were retrospectively collected and analyzed.

Results: Physical examination showed an average stature in cases 2~4 and short stature in cases 1 and 5. X-ray tests suggested ectopic calcification in four patients. The seizures in four cases were effectively controlled with antiseizure medicines (ASMs). Cerebral CT scans showed extensive brain calcifications in the bilateral basal ganglia (all five cases), cerebellum (cases 1, 3, and 5), thalamus (case 4), and cerebral cortex. Cerebral MRI showed short T1 signals mainly in the basal ganglia. EEG records revealed focal EEG abnormalities, including abnormal slow waves and epileptiform discharges, mainly over the temporal and frontal lobes. The brain areas with focal EEG abnormalities and calcification did not always coincide.

Conclusion: The seizures in PHP can be focal to bilateral tonic-clonic. ASMs are effective in epilepsy combined with PHP. Intracranial calcification is not a reliable etiological cause of epilepsy in PHP patients.

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5例假性甲状旁腺功能低下伴癫痫发作的脑影像学和脑电临床特征分析。

目的:探讨假性甲状旁腺功能亢进(PHP)癫痫发作的脑显像和脑电临床特征及其病因。方法:回顾性分析5例PHP癫痫发作患者的临床症状、磁共振(MRI)、CT (CT)生化检查及脑电图(EEG)表现。结果:体格检查2~4例为中等身材，1、5例为矮小身材。x线检查提示4例患者异位钙化。抗癫痫药物有效控制了4例癫痫发作。脑部CT扫描显示双侧基底节区(所有5例)、小脑(病例1、3和5)、丘脑(病例4)和大脑皮层广泛的脑钙化。脑MRI显示短T1信号主要在基底节区。脑电图记录显示局灶性脑电图异常，包括异常慢波和癫痫样放电，主要在颞叶和额叶。局灶性脑电图异常和钙化的脑区并不总是重合的。结论:PHP患者的癫痫发作可以双侧强直-阵挛为主。asm对癫痫合并PHP有效。颅内钙化不是PHP患者癫痫的可靠病因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Behavioural Neurology 医学-临床神经学

CiteScore

5.40

自引率

3.60%

发文量

审稿时长

>12 weeks

期刊介绍： Behavioural Neurology is a peer-reviewed, Open Access journal which publishes original research articles, review articles and clinical studies based on various diseases and syndromes in behavioural neurology. The aim of the journal is to provide a platform for researchers and clinicians working in various fields of neurology including cognitive neuroscience, neuropsychology and neuropsychiatry. Topics of interest include: ADHD Aphasia Autism Alzheimer’s Disease Behavioural Disorders Dementia Epilepsy Multiple Sclerosis Parkinson’s Disease Psychosis Stroke Traumatic brain injury.