Behavioural Neurology最新文献_第7页

Prophylactic Zinc Administration Combined with Swimming Exercise Prevents Cognitive-Emotional Disturbances and Tissue Injury following a Transient Hypoxic-Ischemic Insult in the Rat 锌的预防性给药与游泳运动相结合预防大鼠短暂性缺氧缺血性损伤后的认知情绪障碍和组织损伤

IF 2.8 4区医学

Behavioural Neurology Pub Date : 2022-05-20 DOI: 10.1155/2022/5388944

A. Aguilar-Peralta, Alejandro González-Vázquez, Constantino Tomás-Sanchez, Victor M Blanco-Alvarez, D. Martínez-Fong, J. González-Barrios, I. D. Limón, Lourdes Millán-Pérez Peña, G. Flores, Guadalupe Soto-Rodriguez, E. Brambila, J. Cebada, Viridiana Vargas-Castro, B. A. Leon-Chavez

{"title":"Prophylactic Zinc Administration Combined with Swimming Exercise Prevents Cognitive-Emotional Disturbances and Tissue Injury following a Transient Hypoxic-Ischemic Insult in the Rat","authors":"A. Aguilar-Peralta, Alejandro González-Vázquez, Constantino Tomás-Sanchez, Victor M Blanco-Alvarez, D. Martínez-Fong, J. González-Barrios, I. D. Limón, Lourdes Millán-Pérez Peña, G. Flores, Guadalupe Soto-Rodriguez, E. Brambila, J. Cebada, Viridiana Vargas-Castro, B. A. Leon-Chavez","doi":"10.1155/2022/5388944","DOIUrl":"https://doi.org/10.1155/2022/5388944","url":null,"abstract":"Exercise performance and zinc administration individually yield a protective effect on various neurodegenerative models, including ischemic brain injury. Therefore, this work was aimed at evaluating the combined effect of subacute prophylactic zinc administration and swimming exercise in a transient cerebral ischemia model. The prophylactic zinc administration (2.5 mg/kg of body weight) was provided every 24 h for four days before a 30 min common carotid artery occlusion (CCAO), and 24 h after reperfusion, the rats were subjected to swimming exercise in the Morris Water Maze (MWM). Learning was evaluated daily for five days, and memory on day 12 postreperfusion; anxiety or depression-like behavior was measured by the elevated plus maze and the motor activity by open-field test. Nitrites, lipid peroxidation, and the activity of superoxide dismutase (SOD) and catalase (CAT) were assessed in the temporoparietal cortex and hippocampus. The three nitric oxide (NO) synthase isoforms, chemokines, and their receptor levels were measured by ELISA. Nissl staining evaluated hippocampus cytoarchitecture and Iba-1 immunohistochemistry activated the microglia. Swimming exercise alone could not prevent ischemic damage but, combined with prophylactic zinc administration, reversed the cognitive deficit, decreased NOS and chemokine levels, prevented tissue damage, and increased Iba-1 (+) cell number. These results suggest that the subacute prophylactic zinc administration combined with swimming exercise, but not the individual treatment, prevents the ischemic damage on day 12 postreperfusion in the transient ischemia model.","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46280662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of the NMDA Receptor in the Anticonvulsant Effect of Ellagic Acid in Pentylenetetrazole-Induced Seizures in Male Mice NMDA受体在Ellagic酸对戊四唑诱导的雄性小鼠癫痫发作的抗惊厥作用中的作用

IF 2.8 4区医学

Behavioural Neurology Pub Date : 2022-05-11 DOI: 10.1155/2022/9015842

Mohammad Rahimi-Madiseh, Z. Lorigooini, Shakiba Nasiri Boroujeni, Marziyeh Taji, H. Amini-khoei

引用次数: 2

Neuropsychiatric Symptoms in Clinically Defined Parkinson's Disease: An Updated Review of Literature 临床定义帕金森病的神经精神症状:最新文献综述

IF 2.8 4区医学

Behavioural Neurology Pub Date : 2022-05-09 DOI: 10.1155/2022/1213393

Paloma Macías-García, Raúl Rashid-López, Á. J. Cruz-Gómez, Elena Lozano-Soto, Florencia Sanmartino, R. Espinosa-Rosso, J. González-Rosa

{"title":"Neuropsychiatric Symptoms in Clinically Defined Parkinson's Disease: An Updated Review of Literature","authors":"Paloma Macías-García, Raúl Rashid-López, Á. J. Cruz-Gómez, Elena Lozano-Soto, Florencia Sanmartino, R. Espinosa-Rosso, J. González-Rosa","doi":"10.1155/2022/1213393","DOIUrl":"https://doi.org/10.1155/2022/1213393","url":null,"abstract":"Background Neuropsychiatric symptoms (NPS) are a common and potentially serious manifestation of Parkinson's disease (PD) but are frequently overlooked in favor of a focus on motor symptomatology. Here, we conducted a literature review of the prevalence and type of NPS experienced by PD patients with a clinically defined course of their illness. Methods We identified reports of NPS in patients with PD and mean disease duration over 3 years. Three databases—PubMed, Scopus, and Dialnet—were searched for relevant literature published between 2010 and 2020. Predefined exclusion criteria were applied prior to a descriptive analysis of the literature base. Results In all, 87 unique reports were identified and 30 met inclusion and exclusion criteria. These included 7142 patients with PD (male: 67.3%; mean age: 66.2 years; mean disease duration: 6.7 years). The most frequent NPS were mood disorders (apathy, depression, and anxiety), psychosis, and impulse control disorders (ICD). Treatment with dopamine agonists was identified as an important risk factor for ICD. Co-occurrence of NPS and cognitive dysfunction was also evidenced in a number of studies. Patients with more significant cognitive deficits and higher levels of NPS appeared to be of older age with a longer disease duration and to have more severe motor symptoms. Conclusions NPS, most commonly mood disorders (apathy, depression, and anxiety), psychosis, and ICDs are frequent manifestations of PD. The results of this review reflect the need to develop unified validated assessment protocols for NPS in PD, as well as to improve their management in clinical practice.","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45302098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Shared Etiology in Autism Spectrum Disorder and Epilepsy with Functional Disability 自闭症谱系障碍和癫痫伴功能障碍的共同病因

IF 2.8 4区医学

Behavioural Neurology Pub Date : 2022-04-27 DOI: 10.1155/2022/5893519

Aqeela Zahra, YunFu Wang, Qun Wang, Jianping Wu

引用次数: 6

The Mental Status Examination Handbook. 精神状态检查手册。

IF 2.8 4区医学

Behavioural Neurology Pub Date : 2022-04-27 DOI: 10.1097/WNN.0000000000000306

H. Kirshner

引用次数: 3

Protective Effect of Melatonin on Nonylphenol-Induced Reproductive and Behavioral Disorders in First-Generation Adult Male Rats 褪黑素对壬基酚诱导的第一代成年雄性大鼠生殖和行为障碍的保护作用

IF 2.8 4区医学

Behavioural Neurology Pub Date : 2022-04-26 DOI: 10.1155/2022/1877761

Mahsa Tavakoli, A. Moghadamnia, F. Pourabdolhossein, M. Asghari, S. Kazemi

{"title":"Protective Effect of Melatonin on Nonylphenol-Induced Reproductive and Behavioral Disorders in First-Generation Adult Male Rats","authors":"Mahsa Tavakoli, A. Moghadamnia, F. Pourabdolhossein, M. Asghari, S. Kazemi","doi":"10.1155/2022/1877761","DOIUrl":"https://doi.org/10.1155/2022/1877761","url":null,"abstract":"Methods Pregnant Wistar rats were randomly assigned into five groups: control, NP (25 mg/kg), NP (25 mg/kg)+MLT (10 mg/kg), NP (25 mg/kg)+MLT (20 mg/kg), and MLT (20 mg/kg). The duration of treatment was 21 days from gestation time. Morris water maze was used to assess learning and memory. NP concentrations of serum and testicular tissue were measured by HPLC. Histological analysis of testicular tissues was done by H&E staining. Results Behavioral study showed that NP does not impair learning and memory in first-generation rats. Histomorphometric results showed that NP can significantly reduce the cross-sectional area of the seminiferous tubules and the epithelium, the diameter and number of seminiferous tubules, the thickness of the epithelium, and the number of spermatocytes and spermatogonia compared to other groups. MLT reversed the NP-induced histomorphometric. Also, it changes and increased the activity of superoxide dismutase (SOD), total antioxidant capacity (TAC), and catalase (CAT). The level of malondialdehyde (MDA) significantly decreased in MLT-treated groups compared with the NP group. Conclusion Our finding showed that MLT enhanced the learning process and reduced NP-induced testicular tissue damage through its antioxidants and cytoprotective effects.","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42951634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Graph Theoretical Analysis of Semantic Fluency in Patients with Parkinson's Disease 帕金森病患者语义流畅性的图论分析

IF 2.8 4区医学

Behavioural Neurology Pub Date : 2022-04-23 DOI: 10.1155/2022/6935263

Guanyu Zhang, Jinghong Ma, P. Chan, Zheng Ye

{"title":"Graph Theoretical Analysis of Semantic Fluency in Patients with Parkinson's Disease","authors":"Guanyu Zhang, Jinghong Ma, P. Chan, Zheng Ye","doi":"10.1155/2022/6935263","DOIUrl":"https://doi.org/10.1155/2022/6935263","url":null,"abstract":"Semantic fluency is the ability to name items from a given category within a limited time, which relies on semantic memory, working memory, and executive function. Semantic disfluency is a common problem in Parkinson's disease (PD) and Alzheimer's disease (AD). We demonstrated a graph theoretical analysis of semantic fluency in patients with PD (N = 86), patients with AD (N = 40), and healthy controls (HC, N = 88). All participants completed a standard animal fluency test. Their verbal responses were recorded, transcripted, and transformed into directed speech graphs. Patients with PD generated fewer correct words than HC and more correct words than patients with AD. Patients with PD showed higher density, shorter diameter, and shorter average shortest path length than HC, but lower density, longer diameter, and longer average shortest path length than patients with AD. It suggests that patients with PD produced relatively smaller and denser speech graphs. Moreover, in PD, the densities of speech graphs correlated with the severity of non-motor symptoms, but not the severity of motor symptoms. The graph theoretical analysis revealed new features of semantic disfluency in patients with PD.","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45011986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Communication, Feeding and Swallowing Disorders in Neurological Diseases 神经系统疾病中的沟通、进食和吞咽障碍

IF 2.8 4区医学

Behavioural Neurology Pub Date : 2022-04-21 DOI: 10.1155/2022/9851424

G. Nasios, L. Messinis, E. Dardiotis, J. Kassubek

引用次数: 0

Mitigated Oxidative Stress and Cognitive Impairments in Transient Global Ischemia using Niosomal Selegiline-NBP delivery 使用Niosomal Selegiline-NBP减轻短暂性全身缺血的氧化应激和认知障碍

IF 2.8 4区医学

Behavioural Neurology Pub Date : 2022-04-16 DOI: 10.1155/2022/4825472

Bahareh Jafari, Mahmoud Gharbavi, Yasamin Baghdadchi, H. Manjili, J. Mahmoudi, Iraj Jafari-Anarkoli, Shayan Amiri, M. Hosseini

{"title":"Mitigated Oxidative Stress and Cognitive Impairments in Transient Global Ischemia using Niosomal Selegiline-NBP delivery","authors":"Bahareh Jafari, Mahmoud Gharbavi, Yasamin Baghdadchi, H. Manjili, J. Mahmoudi, Iraj Jafari-Anarkoli, Shayan Amiri, M. Hosseini","doi":"10.1155/2022/4825472","DOIUrl":"https://doi.org/10.1155/2022/4825472","url":null,"abstract":"Stroke is the most common reason for adult disabilities and the second ground for death worldwide. Our previous study revealed that selegiline serves as an alternative candidate in transient hypoxia-ischemia. However, aggressive and restless behavior was observed in stroke-induced rats receiving 4 mg/kg selegiline. In comparison, 1 mg/kg selegiline could induce negligible therapeutic effects on mitochondrial dysfunction and histopathological changes. Therefore, we designed oral noisome-based selegiline attached to 4-(4-nitrobenzyl) pyridine to improve transient global ischemia by attenuating cognitive impairments, oxidative stress, and histopathological injury. The investigation was performed in transient hypoxia-ischemia-induced rats by oral administration of nanoformulation containing selegiline (0.25-1 mg/kg) for 4 weeks (3 times a week). Novel object recognition (NOR) was considered to evaluate their cognitive dysfunction. Oxidative stress parameters and brain histopathological assessments were determined following the scarification of rats. Outstandingly, our data demonstrated slower selegiline release from niosomes relative to free drug, which was also in a controlled manner. Our data confirmed significant improvement in cognitive behavior in the NOR test, an increase in glutathione level and total antioxidant power, a decline in MDA and protein carbonyl level, as well as a decreased number of dead cells in histopathological assessment after being exposed to (0.5-1 mg/kg) selegiline-NBP nanoformulation. These data manifested that the selegiline-NBP nanoformulation (0.5-1 mg/kg) could significantly reduce oxidative damage, cognitive dysfunction, and histopathological damage compared to transient hypoxia-ischemia rats, which is 20 times lower than the therapeutic dose in humans. Therefore, the proposed nanoformulation would be capable as an alternative candidate without side effects in stroke.","PeriodicalId":50733,"journal":{"name":"Behavioural Neurology","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2022-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45355442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Applications of Theranostics for Detecting and Targeting CNS Injuries and Diseases Theranotics在检测和靶向中枢神经系统损伤和疾病中的应用

IF 2.8 4区医学

Behavioural Neurology Pub Date : 2022-04-15 DOI: 10.1155/2022/9891859

Yu-Yo Sun, Horacio Soto, C. Kao, Cui Mei, Muh-Shi Lin

引用次数: 0