Burns最新文献

{"title":"Endothelial dysfunction in areas of unburned skin in a burn injury model","authors":"Nithin Lankipalle ,&nbsp;Edward J. Kelly ,&nbsp;Bonnie C. Carney ,&nbsp;Eriks E. Ziedins ,&nbsp;Lauren T. Moffatt ,&nbsp;Jeffrey W. Shupp","doi":"10.1016/j.burns.2025.107624","DOIUrl":"10.1016/j.burns.2025.107624","url":null,"abstract":"<div><h3>Introduction</h3><div>Burn shock is mediated by a complex inflammatory response leading to endothelial cell dysfunction (EnD) and increased vascular permeability in large total body surface area (TBSA) injuries. Smaller TBSA burns do not induce systemic EnD. Previous studies in animal models have examined systemic markers of endothelial cell dysfunction following thermal injury and have aimed to characterize this dysfunction in various end organs. However, there is limited literature investigating EnD in the intact, unburned skin in burn patients. Intact skin with compromised microvasculature could lead to un-intended consequences during the process of achieving definitive wound closure. For this reason, we aimed to examine the presence of EnD in the unburned skin of burn injured animals.</div></div><div><h3>Methods</h3><div>Sprague-Dawley rats underwent thermal burn injury creation or sham procedures. Rats were subjected to 40 % TBSA scald burn, after which they were resuscitated with crystalloid (LR), LR+ early fresh frozen plasma (FFP), LR+late FFP, or LR+early albumin, and monitored for 24 h. At necropsy, Evans blue dye (EBD) was administered to assess vascular permeability and samples of healthy, unburned, intact skin were assessed using spectrophotometry. One-way ANOVA with multiple comparisons was used to compare groups. Intact skin was stained with antibodies to syndecan-1 (SDC-1), a component of the endothelial glycocalyx.</div></div><div><h3>Results</h3><div>EBD extraction was significantly higher in the intact skin of all 40 % TBSA injured animals (n = 17) vs. all control uninjured animals (n = 12) (p &lt; 0.05). The largest EBD extravasation was exhibited in animals that were resuscitated with LR alone. Compared to LR alone, early administration of FFP as an adjunct to LR significantly lowered the EBD levels (p &lt; 0.0001). Early administration of albumin did the same (p &lt; 0.05), but not to the same degree as the early FFP. Late administration of FFP at hour 8 did not ameliorate permeability (p &gt; 0.05). There was a significant increase in SDC-1 staining intensity in the burn LR+FFP groups compared to the burn LR group (p &lt; 0.05) indicating more intact and less shed SDC-1.</div></div><div><h3>Conclusions</h3><div>EnD is evident in the unburned skin of thermally injured rats based on a vascular permeability assay. Early administration of FFP led to amelioration of EnD in the unburned skin.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107624"},"PeriodicalIF":2.9,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic effects of amniotic membrane and human milk exosomes on burn wound healing","authors":"Ferda Işık ,&nbsp;Elif Tufan ,&nbsp;Güzin Göksun Sivas ,&nbsp;Esin Ak ,&nbsp;Aleyna Muhan ,&nbsp;Göksel Şener ,&nbsp;Tugba Tunali-Akbay","doi":"10.1016/j.burns.2025.107622","DOIUrl":"10.1016/j.burns.2025.107622","url":null,"abstract":"<div><h3>Background</h3><div>Thermal burns are one of the most common burns. Studies are ongoing to develop synthetic or biological wound dressings to ensure painless and scarless healing of burn wounds.</div></div><div><h3>Objectives</h3><div>This study aimed to combine the human amniotic membrane with breast milk-based exosomes and investigate their effects on burn wound healing.</div></div><div><h3>Methods</h3><div>24 Wistar Albino rats weighing 200–250 g and of both genders were used. Rats were divided into control, burn, burn+human amniotic membrane (hAM) and burn+hAM+Exosomes (hAM+Exo) groups. Burn injury was induced by exposing the back of rats to 90 °C water for 10 s. Rats were treated with hAM and hAM+ Exo for seven days after injury. At the end of the 7th day, the skin samples were taken and analyzed biochemically and histologically. TNF-<span><math><mi>α</mi></math></span>, IL-1<span><math><mi>β</mi></math></span>, type III collagen, malondialdehyde (MDA), glutathione (GSH), total protein, superoxide dismutase (SOD), and tissue factor (TF) activity were determined in skin samples.</div></div><div><h3>Results</h3><div>In the burn group, skin TNF- <span><math><mi>α</mi></math></span> levels increased, IL-1<span><math><mi>β</mi></math></span> and type III collagen levels decreased. Wound healing therapy reversed these results. In the hAM+Exo group, the TNF<em>-</em> <span><math><mi>α</mi></math></span> level was lower, and IL-1<span><math><mi>β</mi></math></span> and type III collagen levels were higher than in the hAM group. MDA and total protein levels increased, and GSH, tissue factor, and SOD activities decreased in the burn group. In hAM and hAM+Exo groups, MDA levels decreased, and GSH and SOD activity increased compared to the burn group. The GSH levels were significantly higher in the hAM+Exo group compared to the hAM group.</div></div><div><h3>Conclusion</h3><div>In conclusion, combining exosomes and amniotic membrane induced changes consistent with better wound healing than amniotic membrane alone.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107622"},"PeriodicalIF":3.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paediatric steam burns in New South Wales, Australia: A 14-year retrospective study","authors":"Rakib H. Sheikh ,&nbsp;Madeleine Jacques ,&nbsp;Laura Millhouse ,&nbsp;Andrew J.A. Holland ,&nbsp;Torey Lawrence","doi":"10.1016/j.burns.2025.107619","DOIUrl":"10.1016/j.burns.2025.107619","url":null,"abstract":"<div><h3>Background</h3><div>Burns from steam are often small but may cause significant harm. To further investigate this, a 14-year retrospective review was conducted of paediatric patients presenting for the treatment of a steam burn injury at The Children’s Hospital at Westmead (CHW), New South Wales (NSW), Australia between 2010 and 2024.</div></div><div><h3>Methods</h3><div>Data from the NSW Statewide Burns Injury Service and patient medical records were collected and analysed. This included information on patient demographics, burn injury, and treatment.</div></div><div><h3>Results</h3><div>A total of 159 patients were identified with steam burns. Steam burns were sustained from a variety of devices and appliances including steam vapourisers and other kitchen and household appliances. A significant increase (266 %) in steam burns was observed during 2022-4 over the previous years, with steam vapourisers accounting for 84 % of cases, coinciding with the peak of the COVID-19 outbreak in NSW. Males were more commonly affected (59.7 %), with hands being the most frequently burned area (78.6 %). Among the patients, 81.1 % were infants aged 0–1 year, 31 required grafting, and 20 developed hypertrophic scars requiring long-term care.</div></div><div><h3>Conclusion</h3><div>While most steam burns in children involved a small percentage of the total body surface area, they could still result in deep injuries with potential long-term functional impairment caused by the development of problematic scarring, particularly with burns affecting the hands. These findings highlight the need for increased awareness, prevention messaging, and promotion of prevention strategies to minimise harm and promote safer use of household appliances, particularly in homes with young children.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107619"},"PeriodicalIF":3.2,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bochum Burn Survival (BoBS) score - A novel machine learning-based burn survival prediction score developed with data from the German Burn Registry","authors":"Sonja Verena Schmidt ,&nbsp;Marius Drysch ,&nbsp;Felix Reinkemeier ,&nbsp;Flemming Puscz ,&nbsp;Jannik Hinzmann ,&nbsp;Marcus Lehnhardt ,&nbsp;German Burn Registry ,&nbsp;Christoph Wallner","doi":"10.1016/j.burns.2025.107614","DOIUrl":"10.1016/j.burns.2025.107614","url":null,"abstract":"<div><h3>Background</h3><div>Burn mortality prediction remains a critical aspect in burn medicine. Established scores, such as the ABSI or Baux score, experience continuous revision and improvement due to advances in critical care and surgical procedures. However, these scores often rely on predefined variables and limited statistical models. This study aimed to create a new prediction score that is based solely on machine learning techniques and to assess its performance against established traditional scoring systems.</div></div><div><h3>Methods</h3><div>Using different advanced machine learning methods, data from the German burn registry, encompassing over 10,000 cases, were analyzed regarding the most relevant factors concerning mortality and a new prediction score was created. A new prediction model was constructed, employing algorithms such as random forests and gradient boosting. Internal validation was conducted using cross-validation to ensure robustness and reproducibility.</div></div><div><h3>Results</h3><div>The Bochum Burn Survival (BoBS) score demonstrates strong predictive performance with an accuracy of 93.1 % and ROC AUC of 92.4 %, therefore surpassing traditional scores in predictive performance. Factors such as TBSA and age showed the strongest correlation with mortality, while comorbidities and treatment-specific variables contributed to model refinement. However, further adjustments and external validation beyond the German Burn Registry are crucial in the future.</div></div><div><h3>Discussion</h3><div>The BoBS score represents a paradigm shift in burn mortality prediction, leveraging the potential of machine learning to analyze complex, high-dimensional datasets. Compared to traditional models, the BoBS score offers improved accuracy while providing insights into underexplored variables that might impact patient outcomes. But challenges remain in integrating such models into clinical workflows and validating them across diverse populations.</div></div><div><h3>Conclusion</h3><div>This score represents a significant advancement in burn mortality prediction by providing an interpretable, machine learning-based scoring system developed using multicenter data from the German Burn Registry. Its application has the potential to enhance decision-making in burn care, marking a significant step forward in personalized medicine for critically injured burn patients.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107614"},"PeriodicalIF":3.2,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of decreasing acute burn re-epithelialisation time utilising Negative Pressure Wound Therapy on morbidity: A modelled, retrospective cohort study","authors":"Emma J. Lumsden ,&nbsp;Roy M. Kimble ,&nbsp;Robert S. Ware ,&nbsp;Bronwyn Griffin","doi":"10.1016/j.burns.2025.107621","DOIUrl":"10.1016/j.burns.2025.107621","url":null,"abstract":"<div><h3>Introduction</h3><div>Negative pressure wound therapy (NPWT) that is applied to an acute, paediatric burn at the initial debridement may decrease re-epithelialisation time by approximately 22 %. The clinical significance of this reduction is unknown. In addition, the implication of burn variables such as depth in conjunction with NPWT have not been considered. The aim of this study was to model the effect NPWT may have on burn morbidity by reducing re-epithelialisation time by 22 % when stratified by depth.</div></div><div><h3>Methods</h3><div>This modelled study used retrospective data from a single Australian quaternary paediatric burns unit. Data were from 2014 – 2016, the final period before NPWT was introduced into routine, acute burn care. Burn depths were defined as superficial partial thickness (SPT), deep dermal partial thickness (DPT), and full thickness (FT). The outcome was the effect reducing time to re-epithelialisation by 22 % had on therapeutic morbidity, stratified via depth.</div></div><div><h3>Results</h3><div>Overall, 803 participants were included. The odds ratio of being referred to scar clinic increased by 7.6 (95 % CI 4.4 – 13.1; p &lt; 0.001) for each incremental increase in burn depth. For DPT burns, the mean time to re-epithelialisation was 21.4 days (SE 0.7), and 134 (65.7 %) participants were referred to scar outpatient clinic. Modelled data demonstrated a 67.2 % (95 % CI 58.8 – 75.6) probability of scar outpatient clinic referral at day 21. When reducing re-epithelialisation time by 22 %, DPT burns re-epithelialised on day 16, which reduced the probability of scar outpatient clinic referral by 22.3 % (44.9 %, 95 % CI 35.6 – 54.3 %, p &lt; 0.001). Reducing time to re-epithelialisation by 22 % had minimal impact on SPT and FT burn morbidity.</div></div><div><h3>Conclusion</h3><div>The addition of NPWT as an acute, paediatric burn care adjunct is likely to have a clinically significant impact on DPT burn morbidity.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107621"},"PeriodicalIF":2.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of paediatric burn patients and their caregivers on burn management at Ghana's premier burns centre: A qualitative study","authors":"Alberta Amissah Nyarko ,&nbsp;Natalie Benjamin-Damons ,&nbsp;Sonti Pilusa","doi":"10.1016/j.burns.2025.107620","DOIUrl":"10.1016/j.burns.2025.107620","url":null,"abstract":"<div><h3>Background</h3><div>Paediatric burn injuries have a significant impact on the lives of children and their families, requiring specialised care and management. Understanding the unique experiences of paediatric burn patients and their caregivers is crucial for improving burn management strategies and enhancing patient outcomes.</div></div><div><h3>Objectives</h3><div>This study explored the experiences of paediatric burn patients and their caregivers with regard to in -hospital management and post-hospitalization needs at Ghana’s premier burn centre.</div></div><div><h3>Methodology</h3><div>A qualitative study was conducted involving twelve paediatric burn patients aged 8–17 years (median age = 8.5 years; IQR = 7.0–10.0) and 12 caregivers (median age = 42.0 years; IQR = 34.3–46.5), all treated at a burns centre in Ghana from 2020 to the present. Semi-structured interview guides were used to gather data, and reflexive thematic analysis was employed to identify key themes.</div></div><div><h3>Results</h3><div>Four themes emerged from the data analysis: (1) causes and pathways of burns, (2) reflections on burns management, (3) outcome and post-hospitalisation needs, and (4) suggestions for improving burn care.</div></div><div><h3>Conclusion</h3><div>The findings highlight high satisfaction with burn management and healthcare professionals at Ghana’s premier burn centre. However, areas of improvement include procedural pain management, addressing persistent itchiness and scarring, and school integration of children post-hospitalisation. These results call for the development and implementation of standardized pain management protocols, targeted interventions for scar and itch relief, and structured psychosocial support for paediatric patients. Future research should also assess the effectiveness of these interventions.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107620"},"PeriodicalIF":3.2,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser micropatterned dermal templates support early rete ridge formation and basement membrane deposition when used with cultured epithelial autografts","authors":"Britani N. Blackstone ,&nbsp;Molly E. Baumann ,&nbsp;Summer C. Gallentine ,&nbsp;Dorothy M. Supp ,&nbsp;J. Kevin Bailey ,&nbsp;Heather M. Powell","doi":"10.1016/j.burns.2025.107613","DOIUrl":"10.1016/j.burns.2025.107613","url":null,"abstract":"<div><div>The success of cultured epithelial autografts (CEAs) in treating large surface area burns is limited by their fragility and poor adhesion to the wound bed. Rete ridges, interdigitations at the dermal-epidermal junction, are stem cell niches critical to dermal-epidermal adhesion and distribution of mechanical forces within the skin, but are slow to develop in CEA-treated burn wounds. A porcine burn-excise-autograft model was used to investigate the efficacy of an allogeneic dermal template (DT), seeded with fibroblasts and laser micropatterned to have dermal papillae-like topography, in improving outcomes with CEA. Autologous CEAs were applied to full-thickness wounds alone or with DTs that were flat (CEA+Flat) or micropatterned (CEA+Ridged). The use of a DT improved graft handleability and integration at the wound margins, and restored epidermal barrier function two weeks faster than CEAs alone. In CEA+Ridged grafts, increases in keratinocyte proliferation and basement membrane deposition were observed at 2 weeks post-grafting. Rete ridges were only present in CEA+Ridged grafts at week 2, and developed less frequently and shallower in CEA and CEA+Flat grafts over the course of the study. These results suggest that laser micropatterned DTs are suitable for co-transplantation with CEAs and can significantly improve graft adhesion and development.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107613"},"PeriodicalIF":3.2,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technological resources in the rehabilitation of adult burn patients: A scoping review","authors":"Inês Santos ,&nbsp;Marta Campos Ferreira ,&nbsp;Carla Silvia Fernandes","doi":"10.1016/j.burns.2025.107612","DOIUrl":"10.1016/j.burns.2025.107612","url":null,"abstract":"<div><h3>Introduction</h3><div>The importance of investigating innovative technologies to improve patient rehabilitation is fundamental in the current context of healthcare. This highlights the need to map the technological resources used in the rehabilitation of adult burn patients.</div></div><div><h3>Methods</h3><div>A scoping review was conducted according to the parameters set by the Joanna Briggs Institute (JBI) guidelines and structured using the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews). The scientific literature search covered various databases: Medline, CINAHL, SportDiscus, Psychology &amp; Behavioral Sciences Collection, Scopus, SciELO, and the Cochrane Library. The inclusion criteria considered studies related to the use of technological resources in the rehabilitation of burn patients. The research was conducted until November 2024.</div></div><div><h3>Results</h3><div>A total of 19 articles published between 2000 and 2024 were included. The technological resources analyzed included virtual reality (10 studies), exergames (6 studies), exoskeletons (4 studies), and augmented reality (1 study). These resources primarily aimed to promote motor functionality, increase muscle strength, and enhance joint range of motion.</div></div><div><h3>Conclusion</h3><div>The technologies applied to the rehabilitation of burn patients represent a promising advancement, with the potential to transform the paradigm of rehabilitation, making it more interactive. Future research should focus on a detailed analysis of the long-term benefits and on integrating these technologies into standard rehabilitation protocols.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107612"},"PeriodicalIF":3.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel animal scar model after major burn with a high success rate of >70 % during an observation period of 300 days","authors":"Haoyu Gu ,&nbsp;Yingying Liu ,&nbsp;Lu Yang ,&nbsp;Zhenci Cui ,&nbsp;Wen Jiang ,&nbsp;Qiuyun Gu ,&nbsp;Tingting Shen ,&nbsp;Pengfei Luo ,&nbsp;Shichu Xiao ,&nbsp;Zhaofan Xia","doi":"10.1016/j.burns.2025.107616","DOIUrl":"10.1016/j.burns.2025.107616","url":null,"abstract":"<div><h3>Background</h3><div>Among all types of injuries, burns are one of the most prone to inducing scars. However, there is an absence of appropriate animal models for research. This study aimed to establish an easy and reliable animal model for major burn-induced scarring and evaluate its characteristics systematically.</div></div><div><h3>Methods</h3><div>Rats were subjected to deep second-degree burns covering approximately 30 % of the total body surface area (TBSA) using hot liquid (94℃-98℃). Wounds were meticulously dressed, and the dressing was changed every 1–3 days. Multivariate analysis was performed to explore the critical factors for modelling. Macroscopic features and their temporal evolution were observed from day 0 to day 300 after modelling. Skin ultrasound was used to assess physicochemical properties. Haematoxylin-eosin (HE) staining, Masson staining, and immunohistochemistry staining were performed to evaluate general histological characteristics and the dynamic distribution of specific cells. Western blotting and picrosirius red staining were performed to quantify the content and ratio of collagen Ⅰ and collagen Ⅲ.</div></div><div><h3>Results</h3><div>Scar formation around 40 days post-burn, higher rat weight, and wound dressing change frequency were associated with a high success rate of modelling. Macroscopically, scars exhibited distinctive pinkish pigmentation, increased firmness, absence of new hair growth, and long-term contraction. Ultrasound imaging and histopathological staining revealed an increase in the thickness of the epidermis and dermis. Compared with normal skin, diminished dermal density and water content, and elevated transepidermal water loss rate, haemoglobin content, and elastic retraction rate were revealed in scars. Microscopically, scars manifested marked thickening of the epidermis and dermis, diminished skin appendages, and abundant collagen fibre bundles. Activated fibroblasts and microvessels were significantly increased in scars compared with those in normal skin; moreover, collagen Ⅰ and collagen Ⅲ content and collagen Ⅰ to collagen Ⅲ ratio were increased.</div></div><div><h3>Conclusion</h3><div>The burn scar model in rats we constructed and continuously observed for 300 days replicates the intricate biological characteristics of scars post-burn, with simple and reliable methodology and a high success rate of more than 70 %.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107616"},"PeriodicalIF":2.9,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144780438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Comments and recommendations on the role of skin grafting in preventing infection in children with deep burns","authors":"Bo Wang ,&nbsp;Yu Huang,&nbsp;Xiaojun Chen","doi":"10.1016/j.burns.2025.107611","DOIUrl":"10.1016/j.burns.2025.107611","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107611"},"PeriodicalIF":2.9,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}