Burns最新文献

{"title":"Naringenin loaded nanomicelles effect on second-degree burn in Balb/c mice: A promising formulation for wound healing","authors":"Fatemeh Monzavipourbana ,&nbsp;Mahmoud Reza Jaafari ,&nbsp;Shima Afrasiabi ,&nbsp;Partow Mirzaee Saffari ,&nbsp;Javad Zarqi ,&nbsp;Gholamreza Hassanzadeh ,&nbsp;Seyyedeh Elaheh Mousavi ,&nbsp;Seyed Mahdi Rezayat ,&nbsp;Alireza Partoazar","doi":"10.1016/j.burns.2025.107494","DOIUrl":"10.1016/j.burns.2025.107494","url":null,"abstract":"<div><div>Burns can cause long-term complications and require immediate and effective treatment in patients. The therapeutic potential of naringenin (NG) is hampered by its hydrophobic nature. To improve the bioavailability and efficacy of NG in experimental burn wounds in mice, NG-loaded nanomicelles (NGMs) were prepared using the thin-film hydration method. The characterization of the formulation in different concentrations (0.3 %, 0.6 %, and 1.25 %) was carried out using HPLC, DLS, and TEM techniques. A second-degree burn was inflicted on the back of the mice for evaluation of NGM efficacy. The NGM formulation was evaluated topically on the treated mice for wound recovery, improvement of histological and immunohistochemical parameters, and <em>in vitro</em> antibacterial activity. The effect of NGMs on wound healing was evaluated by hematoxylin and eosin (H&amp;E) and Masson’s trichrome staining (MT), and expression of transforming growth factor-β (TGF-β) and nuclear factor-κB (NFκ-B) using immunohistochemistry (IHC). The characterization tests revealed nanosized micelles with dimensions around 7 nm and a high entrapment efficiency percentage of NG which had sustained release behavior. Wound healing was significantly faster in mice treated with NGMs (0.3 %) compared to other concentrations, silver sulfadiazine (SSD), and an untreated group. IHC analysis of mice receiving NGMs (0.3 %) showed a significant reduction in NFκ-B, while TGF-β1 was increased. In addition, NGMs exhibited significant bactericidal activity against <em>Staphylococcus aureus</em> and <em>Pseudomonas aeruginosa in vitro</em>. These findings show that NGMs accelerate the wound-healing process and lead to regeneration of the epidermis without the need for additional medication.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107494"},"PeriodicalIF":3.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishing new education standards in burns – A scoping review","authors":"Agnieszka Surowiecka ,&nbsp;Zofia Górecka ,&nbsp;Magdalena Kozicka ,&nbsp;Magdalena Staśkiewicz ,&nbsp;Sylwia Panek ,&nbsp;Marek Majewski ,&nbsp;Grzegorz Wilhelm ,&nbsp;Marcelina Podleśna ,&nbsp;Jerzy Strużyna ,&nbsp;Kamil Torres","doi":"10.1016/j.burns.2025.107493","DOIUrl":"10.1016/j.burns.2025.107493","url":null,"abstract":"<div><h3>Introduction</h3><div>This scoping review aimed to provide an overview of prospective new burn education requirements.</div></div><div><h3>Data source</h3><div>Three independent researchers (AS, ZG, MK) screened the articles in medical databases (PubMed, Scopus, Google Scholar).</div></div><div><h3>Study inclusion and exclusion criteria</h3><div>The inclusion filters were “education + burn” or “simulation + burns” and “Entrustable Professional Activity + burns”. Titles, abstracts and full texts in English were filtered to choose original articles and reviews describing novel methods in education in burns.</div></div><div><h3>Results</h3><div>The search strategy identified 2214 records. 24 studies were enrolled into the study.</div></div><div><h3>Conclusions</h3><div>Medical simulation in burns and Entrustable Professional Activities are promising tools in burn education. Skill-specific unified Entrustable Professional Activities should be established to improve burn team performance.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107493"},"PeriodicalIF":3.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enablers and barriers to participation in physical activity programs while hospitalized after burn injury: The patient perspective","authors":"Anita Plaza ,&nbsp;Brooke Mulliss ,&nbsp;Julie Adsett ,&nbsp;Andrea McKittrick ,&nbsp;Allison Hill ,&nbsp;Prue McRae ,&nbsp;Alison Mudge","doi":"10.1016/j.burns.2025.107479","DOIUrl":"10.1016/j.burns.2025.107479","url":null,"abstract":"<div><h3>Background</h3><div>Physical activity is an essential component of burn rehabilitation; however, the patient experience of factors that contribute to physical activity participation while hospitalized after burn injury has not yet been described. This study aimed to identify enablers and barriers to participation in physical activity while hospitalized after burn injury from the patient perspective.</div></div><div><h3>Methods</h3><div>A qualitative descriptive study design was undertaken. Purposive sampling was used to recruit adults with burn injuries admitted to the burn center between February and July 2022. Semi-structured interviews were conducted by a research assistant not involved in clinical care, audio-recorded and transcribed verbatim. All de-identified transcripts were analyzed using an inductive thematic approach and organized into major themes.</div></div><div><h3>Results</h3><div>Twenty participants (18 males) with average age of 47 years and mean burn size of 13.8 % total body surface area were included. Factors which influenced patients’ ability to participate in physical activity were summarized into six major themes: 1) Burn injury factors; 2) Patient factors; 3) Staff support; 4) Family support; 5) Peer support; 6) Environmental factors. Pain, fear of causing further pain or harm and beliefs regarding the need for rest to achieve wound healing were identified as major barriers to physical activity performance. Family support and supportive care from staff were highly valued enablers.</div></div><div><h3>Conclusion</h3><div>This is the first study to describe the patient experience of physical activity participation while hospitalized after a burn injury. Understanding the patient perspective is integral to developing appropriate multi-component interventions to promote increased physical activity early after burn injury.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107479"},"PeriodicalIF":3.2,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early ambulation following lower limb burn and surgery is associated with improved long-term functional outcome and reduced hospital length of stay: A longitudinal cohort study","authors":"Claudia J. Tatlow ,&nbsp;Dana A. Hince ,&nbsp;Chelsea K. Evans ,&nbsp;Piers Truter ,&nbsp;Pip C. Pienaar ,&nbsp;Fiona M. Wood ,&nbsp;Max Bulsara ,&nbsp;Aaron Berghuber ,&nbsp;Paul M. Gittings ,&nbsp;Dale W. Edgar","doi":"10.1016/j.burns.2025.107474","DOIUrl":"10.1016/j.burns.2025.107474","url":null,"abstract":"<div><h3>Introduction</h3><div>Ambulating early after lower limb burn surgery has been associated with a multitude of in-hospital and short-term benefits. However, long-term functional recovery following lower limb burns is poorly understood, especially if grafting surgery is required.</div></div><div><h3>Objectives</h3><div>This study aimed to explore the association between early ambulation following lower limb burn injury and surgery, long-term lower limb functional recovery and secondly, hospital length of stay (LOS).</div></div><div><h3>Methods</h3><div>This retrospective longitudinal cohort study reported data from 1718 adult patients treated by a tertiary hospital burn center in Western Australia between February 2011 and December 2019 following a lower limb burn injury.</div></div><div><h3>Results</h3><div>Comparable lower limb function outcomes were found at six weeks after injury regardless of burn severity or timing of ambulation. Early ambulation pathways were associated with the likelihood of achieving a better long-term functional recovery over the first year after burn. A positive association was also confirmed between early ambulation and hospital LOS. After adjustment, patients who ambulated early after burn and surgery had a LOS of 1.76 days less than patients who ambulated early after burn but late after surgery (IRR 1.22, 95 % CI:1.13–1.3, p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Early ambulation before the third day after lower limb burn injury and surgery was associated with improved long-term functional outcome trajectory to one year and reduced hospital LOS by of 1.76 days when patients ambulated early after surgery. Future investigations with larger, targeted samples of complex patients are warranted to explore the influence of early ambulation on the outcomes of multi-morbidity subgroups.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107474"},"PeriodicalIF":3.2,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxic shock syndrome (TSS) and burns: A structured triage pathway","authors":"Kin Seng Tong,&nbsp;Clare Thomas,&nbsp;Barbara Minto,&nbsp;Lisa Hyde,&nbsp;Yvonne Wilson,&nbsp;Federica D’Asta","doi":"10.1016/j.burns.2025.107480","DOIUrl":"10.1016/j.burns.2025.107480","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107480"},"PeriodicalIF":3.2,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the potential role of PANoptosis-related genes in burns via bioinformatic analyses and experimental validation","authors":"Jiacong Chen ,&nbsp;Qin Zhou ,&nbsp;Yang Cao ,&nbsp;Xuexian Tang ,&nbsp;Yan Zhang ,&nbsp;Lin Wang ,&nbsp;Junxi Li ,&nbsp;Bing Liang","doi":"10.1016/j.burns.2025.107477","DOIUrl":"10.1016/j.burns.2025.107477","url":null,"abstract":"<div><h3>Background</h3><div>The treatment of burns is highly challenging due to their complex pathophysiological mechanisms. PANoptosis, as an important form of cell death, is suggested to play a crucial role in the inflammatory response and tissue damage following burns. However, the role of PANoptosis-related biomarkers in the pathophysiological processes of burns remains unclear. In this study, we aim to identify PANoptosis-related signature genes and validate them as biomarkers in burns</div></div><div><h3>Methods</h3><div>Burn-related datasets were obtained from the Gene Expression Omnibus（GEO） database. GSE37069 was used for bioinformatic analysis and machine learning, while GSE19743 was used specifically for external validation. A set of PANoptosis-associated genes was obtained from the GeneCards database. Three machine learning models (LASSO, RF, and SVM-RFE) and WGCNA were utilized to screen for signature genes. The diagnostic efficacy of the identified genes was assessed through receiver operating characteristic (ROC) curves. Gene Set Enrichment Analysis (GSEA) was performed to identify pathways associated with the signature genes, while single-sample gene set enrichment analysis (ssGSEA) was employed to investigate the immune landscape. Finally, Western blotting and RT-qPCR were employed to validate the signature genes.</div></div><div><h3>Results</h3><div>BCL-2, CCAR1, CERK, TRIAP1, S100A8, and SNHG1 were identified as signature genes. The biological processes involving these genes mainly include endocytosis, apoptosis, and ECM receptor interaction. Immune infiltration analysis revealed that neutrophils, eosinophils, M0 macrophages, and monocytes are significantly elevated in burn samples. Additionally, these signature genes showed significant correlations with multiple immune cell types. Finally, Western blotting and RT-qPCR analysis revealed that the expression levels of BCL2, CCAR1, CERK, and TRIAP1 were significantly down-regulated in the burn groups compared to the normal groups, with the exception of S100A8.</div></div><div><h3>Conclusion</h3><div>Our study has identified BCL-2, CCAR1, CERK, and TRIAP1 as reliable potential biomarkers for burn injuries. These genes play crucial roles in immune response, wound healing, and anti-apoptotic mechanisms, which are key pathological processes involved in the progression of burn injuries. Specifically, BCL-2, CCAR1, CERK, and TRIAP1 have been shown to significantly impact the regulation of inflammation, the efficiency of wound repair, and the prevention of cell apoptosis during burn injury.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107477"},"PeriodicalIF":3.2,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burns list of reviewers, 2024","authors":"","doi":"10.1016/j.burns.2025.107465","DOIUrl":"10.1016/j.burns.2025.107465","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107465"},"PeriodicalIF":3.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143808124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: New directions for Burns in 2025","authors":"Leopoldo C. Cancio","doi":"10.1016/j.burns.2025.107464","DOIUrl":"10.1016/j.burns.2025.107464","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107464"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Film fixation for facial burns: Sandwich technique and 3D silicone facemask","authors":"Chao Lian,&nbsp;Xue-Lei Li,&nbsp;Xiao-Jun Liu,&nbsp;Xuan-Fen Zhang","doi":"10.1016/j.burns.2025.107459","DOIUrl":"10.1016/j.burns.2025.107459","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107459"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genital burn injuries: Insights from 10 years of consumer product-related incidents","authors":"Iryna Dovirak ,&nbsp;Eylon J. Arbel ,&nbsp;Alyssa D. Reese ,&nbsp;Aidan W. O’Shea ,&nbsp;Peter C. Evancho ,&nbsp;Mark S. Burke ,&nbsp;John Rutkowski","doi":"10.1016/j.burns.2025.107457","DOIUrl":"10.1016/j.burns.2025.107457","url":null,"abstract":"<div><div>Genital burns are a rare but debilitating source of injury to patients’ physical and psychological well-being. Earlier studies have found that genital burns disproportionately affect the pediatric male population. Our study aim is to provide an updated epidemiological overview of genital burn injuries and discuss steps to mitigate genital complications. In the ten-year period between 2013 and 2022, there was an incidence of 13,667 genital burns, most of which occurred in the home and involved water. Additionally, the number of transfers necessary for genital burns, almost a fifth of patients (17.9 %) in the present study, is markedly higher than the three percent transfer rate for all burns noted in the literature. These findings underscore the importance of developing more robust public health initiatives to prevent genital burns in the pediatric population. To reduce patient transfers for genital burns and delays in care, further research must be done to create equitable access to verified burn centers.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107457"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}