Burns最新文献

{"title":"Corrigendum to “Nutraceutical Effects of Omega 9,6, and 3-Enriched Milk in Rats Submitted to Thermal Burning by Direct Conduct” [Burns 51(8) (2025) 107631]","authors":"Ana Paula Bomfim Soares Campelo , Erica Uchoa Holanda , Daniel Vieira Pinto , Flávia Almeida Santos , Reinaldo Barreto Oriá , Marcio Wilker Soares Campelo , Paulo Roberto Leitão de Vasconcelos","doi":"10.1016/j.burns.2025.107699","DOIUrl":"10.1016/j.burns.2025.107699","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107699"},"PeriodicalIF":2.9,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal effects of skin microbiota on hypertrophic scars via cytokines and immune phenotypes","authors":"Wei Shen , Hui Sun , Ying-Ming Ma , Yuan Wu, Hua-Jie Zhong, Xiao-Lei Xie","doi":"10.1016/j.burns.2025.107735","DOIUrl":"10.1016/j.burns.2025.107735","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107735"},"PeriodicalIF":2.9,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DermaBlade: A flexible scalpel for precise excision of burns","authors":"Dallan P. Dargan, Lawrence J. Gottlieb, Sebastian Q. Vrouwe","doi":"10.1016/j.burns.2025.107732","DOIUrl":"10.1016/j.burns.2025.107732","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107732"},"PeriodicalIF":2.9,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Post-transcriptional regulation of diabetic wound healing by junctional adhesion molecule A/miR-106b axis\"","authors":"Matin Mojaveri Samak","doi":"10.1016/j.burns.2025.107733","DOIUrl":"10.1016/j.burns.2025.107733","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107733"},"PeriodicalIF":2.9,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of negative pressure wound therapy on epidermal stem cells and keratinocyte growth factor in deep dermal burn injury: An experimental study","authors":"Muhammad Rosadi Seswandhana ,&nbsp;Hamim Majdy Awliya Humani ,&nbsp;Gita Christy Gabriela ,&nbsp;Ishandono Dachlan ,&nbsp;Estelita Liana ,&nbsp;Yohanes Widodo Wirohadidjojo ,&nbsp;Teguh Aryandono ,&nbsp;Budi Mulyono ,&nbsp;Irianiwati Widodo","doi":"10.1016/j.burns.2025.107719","DOIUrl":"10.1016/j.burns.2025.107719","url":null,"abstract":"<div><h3>Introduction</h3><div>Burns are the fourth most common accidental injury worldwide, predominantly occurring in developing countries. Wound healing in burns involves reduced cytokine secretion but increased chemokine and growth factor production compared to surgical wounds. Keratinocyte growth factor (KGF) regulates epidermal regeneration, an essential process in wound healing; while epidermal stem cells (ESCs) play a crucial role in wound closure and have potential for cell therapy. Negative pressure wound therapy (NPWT) promotes healing by improving blood flow, enhancing re-epithelialization, and reducing infection risk. This study investigates the effects of NaCl 0.9 %, intermittent and continuous NPWT, and silver sulfadiazine on ESC and KGF levels in deep dermal burns.</div></div><div><h3>Method</h3><div>Six male Yorkshire pigs received 20 deep dermal burns on the flank and dorsum, divided into four treatment groups: NaCl 0.9 %, continuous NPWT, intermittent NPWT, and silver sulfadiazine. Samples were collected on days 1, 3, 7, 14, and 21. ESCs were evaluated using CK19 immunohistochemistry as a marker. KGF levels were measured via ELISA. Data were analyzed with ANOVA, with significance set at <em>p</em> &lt; 0.05.</div></div><div><h3>Result</h3><div>Continuous NPWT showed the highest ESC counts at the wound edge on all observation days and at the wound center on days 3 and 21, though without statistical significance. KGF levels differed significantly among the groups on days 1, 3, and 7 (<em>p</em> &lt; 0.05), with the continuous NPWT group consistently showing the highest KGF levels. Statistical analysis revealed that treatment, observation day, and KGF levels significantly influenced ESC counts, accounting for 45 % of the variability (<em>p</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The continuous NPWT group demonstrated significantly elevated KGF levels on days 1, 3, and 7, which corresponded to a significant increase in ESC. Further research is warranted to confirm these findings.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107719"},"PeriodicalIF":2.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: “Comparison between multispectral imaging and laser Doppler imaging to predict burn wound requirements for surgery”","authors":"Poh Tan,&nbsp;Christopher J. Lewis","doi":"10.1016/j.burns.2025.107717","DOIUrl":"10.1016/j.burns.2025.107717","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107717"},"PeriodicalIF":2.9,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Return to work in adults after burn injury in Australia: Western Australian outcomes, 2006–2024","authors":"Inge Spronk ,&nbsp;Cameron Carling ,&nbsp;Daisy Ryan ,&nbsp;Fiona M. Wood ,&nbsp;Mark W. Fear ,&nbsp;Dale W. Edgar","doi":"10.1016/j.burns.2025.107710","DOIUrl":"10.1016/j.burns.2025.107710","url":null,"abstract":"<div><h3>Background</h3><div>After a burn, return to work (RTW) is a key goal to restore social integration and quality of life. Burn survivors face multidimensional obstacles as they attempt to RTW, including physical limitations, mental health impacts, and social stigma. This study aimed to investigate the RTW rate over time and identify patient-reported factors associated with no return to work within 12 months of a burn in an Australian context.</div></div><div><h3>Materials and methods</h3><div>This retrospective population registry study included all eligible adult burn patients injured between 2006 – 2024 in Western Australia (WA). Outcomes included: Sickness Impact Profile (SIP, work scale) and Burn-Specific Health Scale-Brief (BSHS-B, work domain). Data analyses involved mixed-effects adjusted regression models analyzing RTW rate, work impairment, and BSHS-B work domain over time.</div></div><div><h3>Results</h3><div>A sample of 953 patients (16.5 % of WA burn population) were included in the study cohort, with 84.6 % of these engaged prior to their injury in work outside managing their home. Most were male (70 %), with median age 36 years (IQR: 26.0–50.0) and 84 % had surgery. The median %TBSA was 2.4 % (IQR: 0.8–6.7 %), 15 % (n = 138) of the sample suffering major (≥10 %) burns. Work-related injury was reported by 22 %. Significant predictors of reduced RTW within one year, included contact burn (p = 0.021); electrical injury (p = 0.012); male sex (p = 0.045); multiple admissions (p = 0.003); prolonged wound healing (p &lt; 0.001); work-related injury (p = 0.008); and, more psychology sessions in the first month after burn (p &lt; 0.001). By 6 weeks post-burn, 38 % had RTW, increasing to 92 % of the sample by 12 months. The mean time to return was 40 days (SD 50 days). At one month, 79 % reported work impairment (SIP), declining to 61 % at 6 weeks and 50 % at 12 months. Receiving more occupational therapy 1–3 months post burn was associated with reduced reported work impairment (p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>While this study, which focussed on patient-reported outcome measures, confirmed that common, non-modifiable factors were barriers to return to work, timely multidisciplinary team input was shown to facilitate the high rate of return and early occupational therapy was associated with less reported work impairment, within one year after burn.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107710"},"PeriodicalIF":2.9,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerating burn wound healing using alginate/carboxymethyl cellulose nanogel containing Tussilago farfara and ZnO nanoparticle","authors":"Nariman Rezaei kolarijani ,&nbsp;Sepehr Zamani ,&nbsp;Maliheh Gharibshahian ,&nbsp;Niloofar Aldaghi ,&nbsp;Hossein Semyari ,&nbsp;Ahmad Vaez ,&nbsp;Majid Rahmati ,&nbsp;Sina Sohrabi ,&nbsp;Farhad Hedayat ,&nbsp;Anneh mohammad Gharravi ,&nbsp;Majid Salehi","doi":"10.1016/j.burns.2025.107700","DOIUrl":"10.1016/j.burns.2025.107700","url":null,"abstract":"<div><div>The use of hydrogel-based drug delivery systems can help achieve the functional integrity of the skin after injury. This study focuses on preparing alginate/carboxymethylcellulose/zinc oxide nanoparticles/<em>Tussilago farfara</em> hydrogel and evaluates its regenerative effects on burn wounds. Zinc oxide nanoparticles (ZnONPs) act as an antibacterial agent, while <em>Tussilago farfara</em> (<em>T. farfara</em>) facilitates the wound healing processes. Characteristics of hydrogel treatment groups, in vivo studies, and histopathological evaluation were assessed 14 days after treatment. The hydrogels were fully characterized and tested in vitro and in a rat model for biocompatibility and wound-healing efficacy. The results showed a porous structure, favorable swelling and degradation rates, optimal blood compatibility and blood clotting index, and blood absorption capacity. Biocompatibility was confirmed by MTT assay. <em>T. farfara</em>/ZnONPs-containing hydrogels showed antibacterial activity against <em>Staphylococcus aureus</em> and <em>Pseudomonas aeruginosa</em>. The histopathological results showed more complete re-epithelialization and tissue regeneration compared to the other investigated groups. The initial outcomes suggest that the alginate/carboxymethylcellulose/ZnO/<em>T. farfara</em> hydrogel could be a good way to treat burn wounds, but more research is needed to confirm this.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107700"},"PeriodicalIF":2.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of nature-based sounds on pain and anxiety during dressing changes in hospitalized burn patients: A randomized controlled clinical trial","authors":"Mohammadreza Zarei ,&nbsp;Mahdi Zarei ,&nbsp;Reza Biranvand ,&nbsp;Mahboubeh Rezaei ,&nbsp;Rezvan Ghafarzadegan","doi":"10.1016/j.burns.2025.107697","DOIUrl":"10.1016/j.burns.2025.107697","url":null,"abstract":"<div><h3>Background</h3><div>Burn injuries are associated with severe pain and anxiety, particularly during dressing changes. This study aimed to evaluate the effects of nature-based sounds (N-BSs) in alleviating pain intensity and anxiety levels in hospitalized burn patients.</div></div><div><h3>Methods</h3><div>This single-center, randomized controlled clinical trial enrolled 86 adult burn patients in Arak, Iran, between December 2023 and June 2024. Of these, 84 patients completed the study (2 withdrawals). Participants were randomly assigned to an experimental group (a 30-minute N-BS session during dressing changes) or a control group (regular dressing changes). Pain intensity (Visual Analog Scale [VAS]) and anxiety (State-Trait Anxiety Inventory [STAI-S]) were assessed before and after the intervention. Data were analyzed using Chi-square, t-tests, and paired t-tests (P &lt; 0.05).</div></div><div><h3>Results</h3><div>At baseline, there were no significant between-group differences in pain (P = 0.96; 95 % CI [−9.31, 0.98]) or anxiety (P = 0.63; 95 % CI [−4.96, 3.01]). Post-intervention, the N-BS group demonstrated a significant within-group reduction in pain (P &lt; 0.001; 95 % CI [0.57, 1.90]; effect size=0.58), whereas the control group did not (P = 0.12; 95 % CI [-0.12, 0.97]). However, between-group analysis showed no statistically significant difference in post-intervention pain (P = 0.06; 95 % CI [-0.61, 1.72]) or anxiety (P = 0.80; 95 % CI [-4.36, 3.36]). Analgesic consumption was also comparable between the two groups (P &gt; 0.49).</div></div><div><h3>Conclusion</h3><div>A single-session N-BS intervention may offer limited clinical benefits for pain and anxiety during dressing changes in burn patients. Future studies should investigate extended exposure durations, repeated sessions, and personalized stimuli to optimize the efficacy of N-BS in burn pain and anxiety management.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107697"},"PeriodicalIF":2.9,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights into hypoxia-induced impairment of autophagy in cardiomyocytes via the p38/MAPK/MAP4 pathway","authors":"Khadijeh Saravani,&nbsp;Seyed Mehdi Pourafzali,&nbsp;Batool Heydarisadegh,&nbsp;Ali Alimohammadi","doi":"10.1016/j.burns.2025.107695","DOIUrl":"10.1016/j.burns.2025.107695","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107695"},"PeriodicalIF":2.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}