Burns最新文献

{"title":"Corrigendum to “Th1/Th2 cytokine levels: A potential diagnostic tool for patients with necrotizing fasciitis” [Burns 49 (2023) 200–208]","authors":"Xiang-Wei Ling , Ting-Ting Zhang , Meng-Meng Ling , Wei-Hao Chen , Chun-Hui Huang , Guo-Liang Shen","doi":"10.1016/j.burns.2024.107371","DOIUrl":"10.1016/j.burns.2024.107371","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 3","pages":"Article 107371"},"PeriodicalIF":3.2,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143350212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and validation of immune-related biomarkers and polarization types of macrophages in keloid based on bulk RNA-seq and single-cell RNA-seq analysis","authors":"Yuzhu Zhang ,&nbsp;Chenglong Fang ,&nbsp;Lizhong Zhang ,&nbsp;Fengyu Ma ,&nbsp;Meihong Sun ,&nbsp;Ning Zhang ,&nbsp;Nan Bai ,&nbsp;Jun Wu","doi":"10.1016/j.burns.2025.107413","DOIUrl":"10.1016/j.burns.2025.107413","url":null,"abstract":"<div><h3>Introduction</h3><div>Keloids are a common complication that occurs after injury. The pathogenesis of this disease remains unknown. Therefore, identifying immune-related biomarkers and macrophage polarization types in keloids can provide new insights into their treatment.</div></div><div><h3>Methods</h3><div>In this study, keloid-related bulk RNA-seq data (GSE83286, GSE212954, GSE92566, and GSE90051) were obtained from the Gene Expression Omnibus (GEO) database. The datasets GSE83286, GSE212964, and GSE92566 were combined to form a training set, while GSE90051 was utilized as an external validation set. Differentially expressed genes (DEGs) were detected by comparing keloid and normal samples within the training set. Differentially expressed immune-related genes (DIRGs) were then determined by intersecting the DEGs with immune-related genes (IRGs). Based on the protein-protein interaction (PPI) network, the top 40 DIRGs were selected for further analyses. Weighted Gene Co-expression Network Analysis (WGCNA), in conjunction with three machine learning techniques - least absolute shrinkage and selection operator (LASSO), support vector machine-recursive feature elimination (SVM-RFE), and random forest (RF) - employed to identify biomarkers. Subsequently, a nomogram model was constructed and validated. Single-cell RNA (scRNA) analysis was used to examine the expression of biomarkers at the cell-type level. Furthermore, since keloid is a chronic inflammatory disease and the abnormal polarization of macrophages is essential for the occurrence of this kind of disease, in this study we also endeavor to elucidate the state of macrophage polarization dysregulation within keloid, with the anticipation of generating novel concepts for the treatment of keloid. Finally, western blot (WB) and immunofluorescence (IF) analyses were carried out to confirm the expression levels of the biomarkers.</div></div><div><h3>Results</h3><div>A total of 740 DEGs were identified in the training set, comprising 331 up-regulated genes and 409 down-regulated genes. After intersecting with the IRGs, 73 DIRGs were obtained. Subsequently, the top 40 DIRGs were chosen for further analysis. Eventually, two biomarkers, namely BMP1 and IL1R1, were identified through WGCNA and the three machine learning methods. Their expression levels were then verified by single-cell analysis, WB, and IF analysis. Additionally, it was found that the number of M2 macrophages significantly increased, while the number of M1 macrophages decreased in keloids compared to normal samples.</div></div><div><h3>Conclusion</h3><div>BMP1 and IL1R1 might function as novel biomarkers and potential therapeutic targets for keloid treatment. Moreover, upregulating M1 macrophages and downregulating M2 macrophages could represent a promising approach for the treatment of keloids.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 3","pages":"Article 107413"},"PeriodicalIF":3.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of pre-existing cancer diagnoses on burn injury survival and morbidity","authors":"Phillip Keys ,&nbsp;Kassandra Corona ,&nbsp;Sheldon McCown ,&nbsp;Lyndon Huang ,&nbsp;Elvia Villarreal ,&nbsp;Jasmine Chaij ,&nbsp;Giovanna De La Tejera ,&nbsp;Douglas S. Tyler ,&nbsp;George Golovko ,&nbsp;Amina El Ayadi ,&nbsp;Juquan Song ,&nbsp;Steven E. Wolf","doi":"10.1016/j.burns.2025.107414","DOIUrl":"10.1016/j.burns.2025.107414","url":null,"abstract":"<div><h3>Objectives</h3><div>Severe burns place patients in a compromised state, especially those with pre-existing chronic diseases such as malignancy. Due to improvements in detection and treatment, cancer mortality has declined significantly, leaving a growing population of cancer survivors. Therefore, we wondered whether pre-existing cancer diagnoses influence patient outcomes following burn injury.</div></div><div><h3>Methods</h3><div>46,275 patients with a neoplasm diagnosis prior to experiencing a burn injury were identified using the TriNetX research network. Two control groups were organized: 1) cancer patients without burns and 2) burn patients with no history of cancer. The test group included patients with a pre-existing cancer diagnosis who received a subsequent burn injury. Outcomes included death, sepsis, nutritional deficiency, eating disorder, immunodeficiency, and depression. Odds ratios were calculated with 95 % confidence intervals.</div></div><div><h3>Results</h3><div>Of the nearly 10 million cancer patients, 0.45 % experienced a burn injury after diagnosis. Compared to propensity-matched burned patients without cancer, burned patients with a previous cancer diagnosis had increased odds of developing sepsis (2.013, 1.895–2.138), nutritional deficiency (1.874, 1.58–2.221), immunodeficiency (5.584, 4.85–7.06), eating disorder (2.384, 1.947–2.918), and depression (1.772, 1.695–1.853). The odds ratios of sepsis (1.718, 1.612–1.83), nutritional deficiency (1.963, 1.593–2.418), immunodeficiency (1.265, 1.098–1.459), eating disorder (2.569, 2.077–3.177), and depression (1.538, 1.468–1.611) were increased when compared to cancer patients without burn injury. Burned patients with a previous neoplasm of hematologic origin fared worse in the odds of developing the mentioned outcomes compared to those with solid neoplasms. Lastly, burned patients with any previous neoplasm who later received chemotherapy and/or radiation suffered worse outcomes than those who never received such treatment.</div></div><div><h3>Conclusion</h3><div>Patients who developed neoplasms before receiving a burn injury demonstrated considerable increases in odds of poor outcomes. Increased odds of developing poor outcomes were greater in those with hematologic neoplasms and those who received chemotherapy or radiation treatment.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 3","pages":"Article 107414"},"PeriodicalIF":3.2,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REsource Support To Optimize REcovery (RESTORE) scoping review: Evaluating aftercare resources for burn survivors","authors":"Mariana Velásquez-Cano ,&nbsp;Renee Noordzij ,&nbsp;Camille Carnevale ,&nbsp;Lauren J. Shepler ,&nbsp;Diana Tenney-Laperriere ,&nbsp;Lewis E. Kazis ,&nbsp;Colleen M. Ryan ,&nbsp;Mary D. Slavin ,&nbsp;Jeffrey C. Schneider","doi":"10.1016/j.burns.2024.107350","DOIUrl":"10.1016/j.burns.2024.107350","url":null,"abstract":"<div><h3>Background</h3><div>Burn survivors report limited resources as they transition to their communities after initial hospitalization. The aim of this project is to review literature that identifies resources provided to burn survivors and their supporters after discharge to their communities.</div></div><div><h3>Methods</h3><div>The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines were used to examine the following literature databases: PubMed, EMBASE, Web of Science, PsycInfo, and CINAHL. The World Health Organization (WHO) International Classification of Functioning, Disability and Health (ICF) Core Set for burn injury provided a framework to categorize resource content.</div></div><div><h3>Results</h3><div>Of the 637 articles screened, 27 met inclusion criteria. Data extraction identified resources categorized into the following ICF components: Body Functions, Activities and Participation, and Environmental Factors.</div></div><div><h3>Conclusion</h3><div>This review uses a conceptual framework to provide an overview of current published resources to support burn survivors following hospitalization. The identified resources addressed content such as health professionals, programs, psychological functioning after burn injury, scar management, and virtual resources. Based on the ICF framework, some gaps in resource content were noted such as pain, thermoregulation, interpersonal relationships, and self-care. Findings reveal relative strengths and gaps in resources, which can be used to better support burn survivors following hospitalization.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 1","pages":"Article 107350"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Editorial board page” [Burns JBUR 50/8 (2024) Page i]","authors":"","doi":"10.1016/j.burns.2024.107338","DOIUrl":"10.1016/j.burns.2024.107338","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 1","pages":"Article 107338"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143183224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation into nurses’ emotion regulation while causing pain to adult patients during burns dressing changes: a qualitative study","authors":"Lucy Rudkin ,&nbsp;Lisa Williams ,&nbsp;Amanda C de C Williams","doi":"10.1016/j.burns.2024.107315","DOIUrl":"10.1016/j.burns.2024.107315","url":null,"abstract":"<div><h3>Background</h3><div>Burns can cause patients significant pain at the time of injury and during subsequent treatment. Other people’s pain often elicits empathic responses in observers. However, effective emotion regulation strategies are needed to manage personal distress, which may otherwise inhibit helping behaviour.</div></div><div><h3>Methods</h3><div>This study used an interpretative qualitative approach to conduct semi-structured interviews with burns nurses. Interviews explored emotion regulation strategies used by nurses whilst causing pain to adult patients during burns dressing changes. Transcripts were analysed using Braun and Clarke’s six stages of thematic analysis.</div></div><div><h3>Results</h3><div>Eight burns nurses participated in the interviews. Thematic analysis developed five themes: Emotions get in the way of being a good nurse; Pain’s an inevitable and justifiable part of treatment and healing; If I’m not made aware of the pain, maybe there is no pain; The pain’s due to other factors, not my actions; and Sometimes it’s too much.</div></div><div><h3>Conclusion</h3><div>Burns nurses’ attempts at regulating their emotions were influenced by their beliefs about what makes a ‘good’ nurse. Gross’s model of emotion regulation provides a useful framework for understanding these strategies, but further research is needed into the helpfulness thereof for nurses and patients.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 1","pages":"Article 107315"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomogram based on burn characteristics and the National Early Warning Score to predict survival in severely burned patients","authors":"Ying Chen ,&nbsp;Yu Duan ,&nbsp;Qingshan Liu ,&nbsp;Yindi Li ,&nbsp;Mingyu Liu ,&nbsp;Hao Yan ,&nbsp;Yu Sun ,&nbsp;Bing Ma ,&nbsp;Guosheng Wu","doi":"10.1016/j.burns.2024.10.006","DOIUrl":"10.1016/j.burns.2024.10.006","url":null,"abstract":"<div><h3>Background</h3><div>Extensive burns are associated with a high mortality rate. Early prediction and action can reduce mortality. The National Early Warning Score (NEWS) is considered the best early warning score for predicting mortality. However, there has been no assessment conducted on the clinical prognostic significance of NEWS in individuals suffering from severe burns. The objective of this research was to establish a nomogram based on burn characteristics and the NEWS to predict survival in severely burned patients.</div></div><div><h3>Methods</h3><div>A retrospective analysis was performed on 335 patients diagnosed with extensive burns from 2005 to 2021 in the Department of Burn Surgery of Changhai Hospital, the First Affiliated Hospital of Naval Medical University. Univariate and multivariate analyses were used to determine independent prognostic factors. A nomogram was developed using these prognostic factors and its internal validity was assessed through bootstrap resampling.</div></div><div><h3>Results</h3><div>The results of multivariate analysis showed that the independent factors affecting the prognosis of severe burn patients were age, full-thickness burn, creatinine, inhalation tracheotomy, and the NEWS, all of which were identified to create the nomogram. The Akaike Information Criterion and Bayesian Information Criterion values of the nomogram demonstrated superior goodness-of-fit in predicting severe burns compared to NEWS, with lower scores (195.21 vs. 201.24; 221.91 vs. 224.12, respectively). The bootstrap-adjusted concordance index (C-index) of the nomogram yielded a higher value of 0.923(95 % CI 0.892–0.953), compared to NEWS which had a C-index of 0.699 (95 % CI 0.628–0.770). The calibration curves demonstrated excellent agreement between predicted probabilities and observed outcomes in the nomogram analysis. Furthermore, decision curve analysis indicated promising clinical utility for the proposed nomogram model. By applying an appropriate cutoff value derived from receiver operating characteristics curve analysis, it was observed that the high-risk group identified by the nomogram exhibited a significantly higher mortality rate than the low-risk group.</div></div><div><h3>Conclusion</h3><div>This study introduces an innovative nomogram that predicts the survival rate of individuals with severe burn injuries by combining clinical attributes and laboratory examinations, demonstrating superior efficacy compared to conventional NEWS systems.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 1","pages":"Article 107285"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The best stress ulcer prophylaxis in burn patients: The gap between research and practice","authors":"Farzan Madadizadeh ,&nbsp;Golnaz Afzal","doi":"10.1016/j.burns.2024.107341","DOIUrl":"10.1016/j.burns.2024.107341","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 1","pages":"Article 107341"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of cellulose dressings in burn wound management: a systematic review and meta-analysis","authors":"Tristan Hill ,&nbsp;Abdal Qadir Zafar ,&nbsp;Tal D. Ellenbogen ,&nbsp;Neil C. Mathias ,&nbsp;Neil D. Muscat ,&nbsp;Dimitrios Papakonstantinou ,&nbsp;Rokhan Yousaf Zai ,&nbsp;Asad Maqbool ,&nbsp;Shafiq Rahman","doi":"10.1016/j.burns.2024.107318","DOIUrl":"10.1016/j.burns.2024.107318","url":null,"abstract":"<div><h3>Introduction</h3><div>Burn wound management is challenging, especially in paediatric patients when optimising outcomes. Superficial burns are generally managed conservatively with dressings; however, frequent dressing changes can be a source of pain and discomfort. Cellulose dressings mitigate these problems, and current reports in the literature have demonstrated positive outcomes when compared against routine dressing types. The authors aim to report a systematic review and meta-analysis on the use of cellulose-based dressings in burn wound management.</div></div><div><h3>Methods</h3><div>This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement standards. The primary outcome measures were epithelialisation rate, duration of hospital stay, and the number of dressing changes. The electronic databases of MEDLINE, EMBASE, CINAHL, Google Scholar, PubMed and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched. OpenMeta [analyst] software was used for data synthesis.</div></div><div><h3>Results</h3><div>Eleven studies were included in the qualitative synthesis with eight articles meeting the inclusion criteria for quantitative analysis, with cellulose-based dressings showing a significantly increased rate of healing on mean difference analysis: 1.350 (0.007, 2.694), standard error; 0.685, p = 0.049. A shorter duration of hospital stay was also observed in the cellulose cohort: 6.583 (5.739, 7.428), standard error 0.431, p &lt; 0.001. Likewise the frequency of dressing changes was lower: odds ratio 0.125 (0.015, 1.062), p &lt; 0.001. There was no difference in the infection rate compared to standard dressings.</div></div><div><h3>Conclusion</h3><div>Cellulose dressings can expedite wound healing whilst reducing the duration of hospitalisation and frequency of dressing changes compared to standard dressings in burn wound management. The authors however recommend further high quality trials to enhance the current evidence base.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 1","pages":"Article 107318"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and quantification of physical activity in critically ill burn patients: A feasibility study","authors":"Y. Dikkema ,&nbsp;L.J. Mouton ,&nbsp;K.W. Gerrits ,&nbsp;M. van der Steen-Dieperink ,&nbsp;J. Eshuis ,&nbsp;C.P. van der Schans ,&nbsp;S.M.H.J. Scholten-Jaegers ,&nbsp;A.S. Niemeijer ,&nbsp;M.K. Nieuwenhuis","doi":"10.1016/j.burns.2024.107312","DOIUrl":"10.1016/j.burns.2024.107312","url":null,"abstract":"<div><h3>Background</h3><div>Physical activity is essential in burn care to counteract the effects of severe burns and inactivity during hospitalization. However, detailed knowledge of performed physical activities is lacking. This study evaluated the feasibility of a dual accelerometer-based method to assess type, frequency, and duration of physical activity in critically ill burn patients during hospitalization.</div></div><div><h3>Methods</h3><div>A prospective observational study was conducted at the burn center of the Martini Hospital, Groningen, The Netherlands. Eligible were patients with a total body surface area (TBSA) burned of ≥ 15 % or an indication for intensive care. Patients wore two accelerometers, one on the chest and one on the diagonally opposite thigh. An algorithm converted accelerometer data into type, frequency, and duration of activities common for intensive care patients. An activity diary was used to assess non-wear time and its content, e.g., surgery.</div></div><div><h3>Results</h3><div>Five patients (20–60 years, 13–31 % TBSA burned, LOS 30–65 days) were included. Per patient, 14–49 days (17,380–61,796 min) could be analyzed of which 7–14 % was non-wear time. During wear time, 86–95 % of activities could be identified and quantified. However, processing the data was labor-intensive.</div></div><div><h3>Conclusion</h3><div>The dual accelerometer-based method proved feasible for research purposes. For clinical application, further refinement of data processing is required.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 1","pages":"Article 107312"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}