Burns最新文献

{"title":"Synergistic effects of amniotic membrane and human milk exosomes on burn wound healing","authors":"Ferda Işık ,&nbsp;Elif Tufan ,&nbsp;Güzin Göksun Sivas ,&nbsp;Esin Ak ,&nbsp;Aleyna Muhan ,&nbsp;Göksel Şener ,&nbsp;Tugba Tunali-Akbay","doi":"10.1016/j.burns.2025.107622","DOIUrl":"10.1016/j.burns.2025.107622","url":null,"abstract":"<div><h3>Background</h3><div>Thermal burns are one of the most common burns. Studies are ongoing to develop synthetic or biological wound dressings to ensure painless and scarless healing of burn wounds.</div></div><div><h3>Objectives</h3><div>This study aimed to combine the human amniotic membrane with breast milk-based exosomes and investigate their effects on burn wound healing.</div></div><div><h3>Methods</h3><div>24 Wistar Albino rats weighing 200–250 g and of both genders were used. Rats were divided into control, burn, burn+human amniotic membrane (hAM) and burn+hAM+Exosomes (hAM+Exo) groups. Burn injury was induced by exposing the back of rats to 90 °C water for 10 s. Rats were treated with hAM and hAM+ Exo for seven days after injury. At the end of the 7th day, the skin samples were taken and analyzed biochemically and histologically. TNF-<span><math><mi>α</mi></math></span>, IL-1<span><math><mi>β</mi></math></span>, type III collagen, malondialdehyde (MDA), glutathione (GSH), total protein, superoxide dismutase (SOD), and tissue factor (TF) activity were determined in skin samples.</div></div><div><h3>Results</h3><div>In the burn group, skin TNF- <span><math><mi>α</mi></math></span> levels increased, IL-1<span><math><mi>β</mi></math></span> and type III collagen levels decreased. Wound healing therapy reversed these results. In the hAM+Exo group, the TNF<em>-</em> <span><math><mi>α</mi></math></span> level was lower, and IL-1<span><math><mi>β</mi></math></span> and type III collagen levels were higher than in the hAM group. MDA and total protein levels increased, and GSH, tissue factor, and SOD activities decreased in the burn group. In hAM and hAM+Exo groups, MDA levels decreased, and GSH and SOD activity increased compared to the burn group. The GSH levels were significantly higher in the hAM+Exo group compared to the hAM group.</div></div><div><h3>Conclusion</h3><div>In conclusion, combining exosomes and amniotic membrane induced changes consistent with better wound healing than amniotic membrane alone.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107622"},"PeriodicalIF":3.2,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paediatric steam burns in New South Wales, Australia: A 14-year retrospective study","authors":"Rakib H. Sheikh ,&nbsp;Madeleine Jacques ,&nbsp;Laura Millhouse ,&nbsp;Andrew J.A. Holland ,&nbsp;Torey Lawrence","doi":"10.1016/j.burns.2025.107619","DOIUrl":"10.1016/j.burns.2025.107619","url":null,"abstract":"<div><h3>Background</h3><div>Burns from steam are often small but may cause significant harm. To further investigate this, a 14-year retrospective review was conducted of paediatric patients presenting for the treatment of a steam burn injury at The Children’s Hospital at Westmead (CHW), New South Wales (NSW), Australia between 2010 and 2024.</div></div><div><h3>Methods</h3><div>Data from the NSW Statewide Burns Injury Service and patient medical records were collected and analysed. This included information on patient demographics, burn injury, and treatment.</div></div><div><h3>Results</h3><div>A total of 159 patients were identified with steam burns. Steam burns were sustained from a variety of devices and appliances including steam vapourisers and other kitchen and household appliances. A significant increase (266 %) in steam burns was observed during 2022-4 over the previous years, with steam vapourisers accounting for 84 % of cases, coinciding with the peak of the COVID-19 outbreak in NSW. Males were more commonly affected (59.7 %), with hands being the most frequently burned area (78.6 %). Among the patients, 81.1 % were infants aged 0–1 year, 31 required grafting, and 20 developed hypertrophic scars requiring long-term care.</div></div><div><h3>Conclusion</h3><div>While most steam burns in children involved a small percentage of the total body surface area, they could still result in deep injuries with potential long-term functional impairment caused by the development of problematic scarring, particularly with burns affecting the hands. These findings highlight the need for increased awareness, prevention messaging, and promotion of prevention strategies to minimise harm and promote safer use of household appliances, particularly in homes with young children.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107619"},"PeriodicalIF":3.2,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bochum Burn Survival (BoBS) score - A novel machine learning-based burn survival prediction score developed with data from the German Burn Registry","authors":"Sonja Verena Schmidt ,&nbsp;Marius Drysch ,&nbsp;Felix Reinkemeier ,&nbsp;Flemming Puscz ,&nbsp;Jannik Hinzmann ,&nbsp;Marcus Lehnhardt ,&nbsp;German Burn Registry ,&nbsp;Christoph Wallner","doi":"10.1016/j.burns.2025.107614","DOIUrl":"10.1016/j.burns.2025.107614","url":null,"abstract":"<div><h3>Background</h3><div>Burn mortality prediction remains a critical aspect in burn medicine. Established scores, such as the ABSI or Baux score, experience continuous revision and improvement due to advances in critical care and surgical procedures. However, these scores often rely on predefined variables and limited statistical models. This study aimed to create a new prediction score that is based solely on machine learning techniques and to assess its performance against established traditional scoring systems.</div></div><div><h3>Methods</h3><div>Using different advanced machine learning methods, data from the German burn registry, encompassing over 10,000 cases, were analyzed regarding the most relevant factors concerning mortality and a new prediction score was created. A new prediction model was constructed, employing algorithms such as random forests and gradient boosting. Internal validation was conducted using cross-validation to ensure robustness and reproducibility.</div></div><div><h3>Results</h3><div>The Bochum Burn Survival (BoBS) score demonstrates strong predictive performance with an accuracy of 93.1 % and ROC AUC of 92.4 %, therefore surpassing traditional scores in predictive performance. Factors such as TBSA and age showed the strongest correlation with mortality, while comorbidities and treatment-specific variables contributed to model refinement. However, further adjustments and external validation beyond the German Burn Registry are crucial in the future.</div></div><div><h3>Discussion</h3><div>The BoBS score represents a paradigm shift in burn mortality prediction, leveraging the potential of machine learning to analyze complex, high-dimensional datasets. Compared to traditional models, the BoBS score offers improved accuracy while providing insights into underexplored variables that might impact patient outcomes. But challenges remain in integrating such models into clinical workflows and validating them across diverse populations.</div></div><div><h3>Conclusion</h3><div>This score represents a significant advancement in burn mortality prediction by providing an interpretable, machine learning-based scoring system developed using multicenter data from the German Burn Registry. Its application has the potential to enhance decision-making in burn care, marking a significant step forward in personalized medicine for critically injured burn patients.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107614"},"PeriodicalIF":3.2,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of paediatric burn patients and their caregivers on burn management at Ghana's premier burns centre: A qualitative study","authors":"Alberta Amissah Nyarko ,&nbsp;Natalie Benjamin-Damons ,&nbsp;Sonti Pilusa","doi":"10.1016/j.burns.2025.107620","DOIUrl":"10.1016/j.burns.2025.107620","url":null,"abstract":"<div><h3>Background</h3><div>Paediatric burn injuries have a significant impact on the lives of children and their families, requiring specialised care and management. Understanding the unique experiences of paediatric burn patients and their caregivers is crucial for improving burn management strategies and enhancing patient outcomes.</div></div><div><h3>Objectives</h3><div>This study explored the experiences of paediatric burn patients and their caregivers with regard to in -hospital management and post-hospitalization needs at Ghana’s premier burn centre.</div></div><div><h3>Methodology</h3><div>A qualitative study was conducted involving twelve paediatric burn patients aged 8–17 years (median age = 8.5 years; IQR = 7.0–10.0) and 12 caregivers (median age = 42.0 years; IQR = 34.3–46.5), all treated at a burns centre in Ghana from 2020 to the present. Semi-structured interview guides were used to gather data, and reflexive thematic analysis was employed to identify key themes.</div></div><div><h3>Results</h3><div>Four themes emerged from the data analysis: (1) causes and pathways of burns, (2) reflections on burns management, (3) outcome and post-hospitalisation needs, and (4) suggestions for improving burn care.</div></div><div><h3>Conclusion</h3><div>The findings highlight high satisfaction with burn management and healthcare professionals at Ghana’s premier burn centre. However, areas of improvement include procedural pain management, addressing persistent itchiness and scarring, and school integration of children post-hospitalisation. These results call for the development and implementation of standardized pain management protocols, targeted interventions for scar and itch relief, and structured psychosocial support for paediatric patients. Future research should also assess the effectiveness of these interventions.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107620"},"PeriodicalIF":3.2,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser micropatterned dermal templates support early rete ridge formation and basement membrane deposition when used with cultured epithelial autografts","authors":"Britani N. Blackstone ,&nbsp;Molly E. Baumann ,&nbsp;Summer C. Gallentine ,&nbsp;Dorothy M. Supp ,&nbsp;J. Kevin Bailey ,&nbsp;Heather M. Powell","doi":"10.1016/j.burns.2025.107613","DOIUrl":"10.1016/j.burns.2025.107613","url":null,"abstract":"<div><div>The success of cultured epithelial autografts (CEAs) in treating large surface area burns is limited by their fragility and poor adhesion to the wound bed. Rete ridges, interdigitations at the dermal-epidermal junction, are stem cell niches critical to dermal-epidermal adhesion and distribution of mechanical forces within the skin, but are slow to develop in CEA-treated burn wounds. A porcine burn-excise-autograft model was used to investigate the efficacy of an allogeneic dermal template (DT), seeded with fibroblasts and laser micropatterned to have dermal papillae-like topography, in improving outcomes with CEA. Autologous CEAs were applied to full-thickness wounds alone or with DTs that were flat (CEA+Flat) or micropatterned (CEA+Ridged). The use of a DT improved graft handleability and integration at the wound margins, and restored epidermal barrier function two weeks faster than CEAs alone. In CEA+Ridged grafts, increases in keratinocyte proliferation and basement membrane deposition were observed at 2 weeks post-grafting. Rete ridges were only present in CEA+Ridged grafts at week 2, and developed less frequently and shallower in CEA and CEA+Flat grafts over the course of the study. These results suggest that laser micropatterned DTs are suitable for co-transplantation with CEAs and can significantly improve graft adhesion and development.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107613"},"PeriodicalIF":3.2,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technological resources in the rehabilitation of adult burn patients: A scoping review","authors":"Inês Santos ,&nbsp;Marta Campos Ferreira ,&nbsp;Carla Silvia Fernandes","doi":"10.1016/j.burns.2025.107612","DOIUrl":"10.1016/j.burns.2025.107612","url":null,"abstract":"<div><h3>Introduction</h3><div>The importance of investigating innovative technologies to improve patient rehabilitation is fundamental in the current context of healthcare. This highlights the need to map the technological resources used in the rehabilitation of adult burn patients.</div></div><div><h3>Methods</h3><div>A scoping review was conducted according to the parameters set by the Joanna Briggs Institute (JBI) guidelines and structured using the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews). The scientific literature search covered various databases: Medline, CINAHL, SportDiscus, Psychology &amp; Behavioral Sciences Collection, Scopus, SciELO, and the Cochrane Library. The inclusion criteria considered studies related to the use of technological resources in the rehabilitation of burn patients. The research was conducted until November 2024.</div></div><div><h3>Results</h3><div>A total of 19 articles published between 2000 and 2024 were included. The technological resources analyzed included virtual reality (10 studies), exergames (6 studies), exoskeletons (4 studies), and augmented reality (1 study). These resources primarily aimed to promote motor functionality, increase muscle strength, and enhance joint range of motion.</div></div><div><h3>Conclusion</h3><div>The technologies applied to the rehabilitation of burn patients represent a promising advancement, with the potential to transform the paradigm of rehabilitation, making it more interactive. Future research should focus on a detailed analysis of the long-term benefits and on integrating these technologies into standard rehabilitation protocols.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107612"},"PeriodicalIF":3.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144606048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary exploration of efficacy assessment and optimal concentration of teprenone oral rehydration solution for the early management of post-burn shock","authors":"Xiang-yu Liu ,&nbsp;Yu-shou Wu ,&nbsp;Jia-ke Chai ,&nbsp;Xiao-wei Su ,&nbsp;Yi-rui Qu ,&nbsp;Fang-chao Hu ,&nbsp;Tian Liu ,&nbsp;Jin-guang Zheng ,&nbsp;Shao-fang Han ,&nbsp;Hui Zhou ,&nbsp;Yun-fei Chi","doi":"10.1016/j.burns.2025.107615","DOIUrl":"10.1016/j.burns.2025.107615","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate therapeutic efficacy of teprenone-enriched oral rehydration solution (TORS) relative to World Health Organization’s recommended Oral Rehydration Solution (WHO-ORS) and identify the optimal concentration of TORS for early burn shock intervention.</div></div><div><h3>Methods</h3><div>A total of 350 male Wistar rats (200–220 g) were randomly divided into seven groups (n = 50/group): Sham (no burn and no treatment) group, Burn (no treatment) group, WHO-ORS group, and four concentrations of TORS (TRS1–TRS4). All groups, except Sham group, were subjected to 50 % total body surface area (TBSA) third-degree scald burns. Resuscitation protocols commenced immediately post-burn and continued every 2 h for 8 h, delivering TORS at 2 mL/kg/%TBSA (modified Brooke formula). Survival rates were measured at 72 h post-burn. High-resolution laser Doppler was used for gastric blood flow measurement; gastrointestinal mucosal damage was assessed via optical and transmission electron microscopy; blood teprenone levels were determined using reverse-phase high-performance liquid chromatography. Lactate, hematocrit, hemoglobin, malondialdehyde, superoxide dismutase, and interleukin-33 levels were analyzed.</div></div><div><h3>Results</h3><div>TORS administration resulted in higher 72- h survival rates in both Burn and WHO-ORS controls (P &lt; 0.01 for TRS2 vs Burn), while exhibiting dose-dependent serum teprenone absorption. All TORS groups exhibited improved gastric blood flow, reduced gastric mucosal damage, and better performance in other measured parameters than the WHO-ORS group and Burn group. The TRS2 concentration was closest to the Sham group in most of the studied parameters.</div></div><div><h3>Conclusion</h3><div>The newly formulated TORS proved to be effectively emptied and absorbed by the gastrointestinal tract. This study establishes TORS as a viable oral resuscitation strategy, with TRS2 demonstrating optimal efficacy in improving tissue perfusion and survival outcomes over WHO-ORS, thereby offering a promising approach for early burn shock management. Further investigations are required to elucidate its underlying mechanisms.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107615"},"PeriodicalIF":3.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IBSP mediates fibroblast malignant behaviors in hypertrophic scars via interacting with SKP1","authors":"Ya Zhang ,&nbsp;Xiaojing Li ,&nbsp;Yunlin Ding ,&nbsp;Tingting Tao ,&nbsp;Teng Quan","doi":"10.1016/j.burns.2025.107617","DOIUrl":"10.1016/j.burns.2025.107617","url":null,"abstract":"<div><h3>Aims</h3><div>Hypertrophic scars (HS) are fibrotic skin conditions marked by abnormal myofibroblast proliferation and extracellular matrix accumulation. This study aimed to elucidate the functional effects and potential mechanisms of integrin-binding sialoprotein (IBSP) in hypertrophic scar fibroblasts.</div></div><div><h3>Materials and methods</h3><div>IBSP protein and wnt signaling pathway were screened by transcriptomics. To characterize the role of IBSP in hypertrophic scar fibroblasts, CCK8, transwell, and WB experiments were performed.</div></div><div><h3>Results</h3><div>IBSP protein and wnt signaling pathway were screened by transcriptomics. Since IBSP expression was elevated in proliferative scar fibroblasts, we performed IBSP protein knockdown, revealing a significant inhibition of proliferation, migration, and invasion. Western blotting experiments demonstrated that knockdown IBSP could inhibit wnt signaling pathway and collagen formation. Subsequent investigations indicated that IBSP knockdown reduced adenosine triphosphate (ATP) production and heightened reactive oxygen species (ROS) levels in hypertrophic scar fibroblasts. In order to investigate the potential mechanism of IBSP action, mass spectrometry analysis was performed. A combination of mass spectrometry, immunoprecipitation, and immunofluorescence verified that IBSP binds to SKP1. Notably, SKP1 knockdown markedly curtailed malignant behaviors in hypertrophic scar fibroblasts, including proliferation, migration, invasion, collagen synthesis, and ATP production. Moreover, SKP1 knockdown inhibited the wnt signaling pathway while inducing ROS production.</div></div><div><h3>Conclusion</h3><div>Collectively, our present study suggests that IBSP promotes the malignant process in hypertrophic scar fibroblasts.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107617"},"PeriodicalIF":3.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ChatGPT as a collaborative research assistant in the ICF linking process of the brief version of the Burn Specific Health Scale","authors":"Hatice Gül ,&nbsp;Murat Ali Çınar ,&nbsp;Kezban Bayramlar","doi":"10.1016/j.burns.2025.107609","DOIUrl":"10.1016/j.burns.2025.107609","url":null,"abstract":"<div><h3>Introduction</h3><div>Burn injuries profoundly affect multiple aspects of health-related quality of life (HRQoL). The Brief Version of the Burn Specific Health Scale (BSHS-B) is commonly used to assess HRQoL in burn survivors. Linking such tools to the International Classification of Functioning, Disability and Health (ICF) enhances data comparability and standardisation for patients with burn injuries. However, linking process is often complex and time-consuming. Large language models may support linking process and help streamline future linking studies in burn rehabilitation.</div></div><div><h3>Objectives</h3><div>This study evaluated the feasibility of using ChatGPT-4o as a collaborative assistant in the ICF linking process of BSHS-B items.</div></div><div><h3>Methods</h3><div>The study followed the refined ICF linking rules. In the first stage, two physiotherapists independently linked the contents of BSHS-B items to ICF categories. When the two linkers disagreed, a third assigned the item to a category. In the second stage, ChatGPT-4o guided by specialised prompting performed the same task according to linking rules. In the content analysis, Cohen’s Kappa coefficient was computed to evaluate the consistency between expert consensus and ChatGPT-4o-based linking. An agreement on item perspective analyses was also conducted. Frequencies of identified ICF categories across major domains were reported descriptively.</div></div><div><h3>Results</h3><div>The agreement between linkers on ICF category assignment was fair (κ = 0.41, p &lt; .001), while ChatGPT and expert consensus agreement was moderate (κ = 0.55, p &lt; .001). In the perspective analysis, agreement between experts was fair (κ = 0.21, p &lt; .01), whereas ChatGPT demonstrated almost perfect agreement with experts (κ = 0.86, p &lt; .001). A total of 25 ICF codes were identified, mainly in Activity Participation (52.11 %) and Body Functions (40.85 %).</div></div><div><h3>Conclusion</h3><div>ChatGPT demonstrated substantial potential in the ICF linking process as a supportive tool. While not replacing human expertise, ChatGPT may be able to reduce workload and facilitate ICF linking process.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107609"},"PeriodicalIF":3.2,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of hypopigmented scar with autologous skin cell suspension delivered through fractional ablative laser-assisted drug delivery does not lead to short-term re-pigmentation","authors":"Bonnie C. Carney ,&nbsp;Monica L. Collins ,&nbsp;Mary A. Oliver ,&nbsp;John W. Keyloun ,&nbsp;Lauren T. Moffatt ,&nbsp;Jeffrey W. Shupp ,&nbsp;Taryn E. Travis","doi":"10.1016/j.burns.2025.107603","DOIUrl":"10.1016/j.burns.2025.107603","url":null,"abstract":"<div><div>Post-burn hypertrophic scars often exhibit dyschromia, including hyper- and hypo-pigmentation. Inactivated melanocytes, typically residing in the epidermal basement membrane, pose a challenge for effective activation and repigmentation in scarred areas. This study explores an alternative approach: using laser-assisted drug delivery to transplant melanocyte-containing cell suspensions into hypopigmented scars. In a porcine model with induced scars, autologous skin cell suspensions (ASCS) were delivered via CO₂ fractional ablative laser-created channels. Longitudinal analysis using Image J revealed no increase in pigmented areas or discernible melanin levels by digital imaging or non-invasive probes at weeks 1 and 2. Histological examination further confirmed the absence of melanin in tissue biopsies, with a transient increase in epidermal thickness observed at Day 63. This approach did not achieve repigmentation of hypopigmented scars within the study's 2-week duration. Future investigations may refine this technique by modifying delivery protocols based on these findings.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107603"},"PeriodicalIF":3.2,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}