Burns最新文献

{"title":"Population pharmacokinetics and dosing optimisation of polymyxin B in patients with severe burns","authors":"Jun Yang ,&nbsp;Fang Liu ,&nbsp;Yunpei Zhao ,&nbsp;Mingjie Yu ,&nbsp;Yu Gan ,&nbsp;Ge Yang ,&nbsp;Lin Cheng ,&nbsp;Jing Cen ,&nbsp;Yongchuan Chen","doi":"10.1016/j.burns.2025.107696","DOIUrl":"10.1016/j.burns.2025.107696","url":null,"abstract":"<div><h3>Objective</h3><div>Data on polymyxin B (PMB) pharmacokinetics (PK) in patients with severe burns are scarce. We aimed to develop a population PK (PopPK) model for PMB in this population, identify factors influencing PK parameters, and optimise dosing regimens.</div></div><div><h3>Methods</h3><div>Plasma concentrations were measured using ultra-performance liquid chromatography–tandem mass spectrometry. PopPK modelling was performed with nonlinear mixed-effects modelling (NONMEM). Monte Carlo simulations were used to design PMB regimens targeting an optimal therapeutic window (AUC_ss, _24 h, 50–100 mg·h·L⁻¹) and a PK/pharmacodynamic threshold of AUC_ss, _24 h/MIC &gt; 50, with a ≥ 90 % probability of target attainment (PTA).</div></div><div><h3>Results</h3><div>A total of 118 PMB concentrations from 53 patients were analysed. A one-compartment model with first-order elimination was used to describe the data. Blood urea nitrogen (BUN) was a significant covariate, showing a negative correlation with clearance. Loading doses had a minimal effect on PTA or the proportion of patients achieving an AUC_ss, _24 h within the therapeutic window. At minimum inhibitory concentration (MIC) ≤ 0.5 mg·L⁻¹ , a 75 mg q12h regimen achieved &gt; 90 % PTA with low risk of supratherapeutic exposure (AUC_ss, _24 h &gt; 100 mg·h·L⁻¹). At MIC 1 mg·L⁻¹ , only the 100 mg q12h regimen in patients with moderate-to-high BUN achieved ≥ 90 % PTA.</div></div><div><h3>Conclusion</h3><div>Overall, this study provides PK insights into PMB dosing in patients with severe burns, supporting 75 mg q12h (for MIC ≤ 0.5 mg·L⁻¹) as an effective regimen. Regular BUN monitoring and therapeutic drug monitoring are recommended for personalised dosing.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107696"},"PeriodicalIF":2.9,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin tissue regeneration by Acanthus dioscoridis L. leaf extracts in vivo: Relevance to transforming growth factor β 1, antioxidants, and inflammatory factors","authors":"Khaled Abdul-Aziz Ahmed ,&nbsp;Khalid M. Alqaisi ,&nbsp;Noralhuda Ayad Ibrahim ,&nbsp;Ahmed A.J. Jabbar ,&nbsp;Hanan Ibrahim Althagbi ,&nbsp;Rawaz Rizgar Hassan ,&nbsp;Goran Noori Saleh ,&nbsp;Ahmed Hameed Al-Dabhawi ,&nbsp;Muneera S.M. Al-Saleem ,&nbsp;Fuad Othman Abdullah ,&nbsp;Jehan Y. Al-Humaidi ,&nbsp;Mohammed Muzibur Rahman","doi":"10.1016/j.burns.2025.107690","DOIUrl":"10.1016/j.burns.2025.107690","url":null,"abstract":"<div><div>Wound healing is an intricate process that requires special care and therapeutics to enhance skin regeneration. Considering natural products as a safer choice, the present investigation elucidated the phytochemical, acute toxicity, and wound-healing effects of <em>Acanthus dioscoridis</em> L. (LEAD) leaf extracts on excisional neck injury in rats. A uniform dorsal neck cut was formed in twenty-four albino rats, which were arbitrarily divided into 4 groups and treated daily (0.2 ml) with either normal saline (group A); intrasite gel (group B); LEAD 250 and 500 mg/kg of LEAD (groups C and E, respectively).</div><div>Phytochemical profiling of LEAD showed elevated total phenolic (111.4 and 105.4 mg/g GAE) and flavonoid (78.6 and 63.5 mg/g rutin) contents in ethyl acetate and methanolic extracts, respectively.</div><div>LEAD treatment did not cause toxic incidence in rats administered with up to 5 g/kg. The results of the wound trial unveiled increased therapeutic efficacy of LEAD, denoted by accelerated skin tissue regeneration and higher closure proportion compared to vehicle rats. Microscopical screening showed increased tissue hydroxyproline/collagen formation, fibroblast deposition, and reduced inflammatory cell infiltration.</div><div>Topical application of LEAD caused positive modulation of transforming growth factor β 1 (angiogenesis) in recovered skin, maintained skin homeostasis, and up-regulated tissue granulation/re-epithelialization. Moreover, LEAD treatment caused a significant down-regulation of ROS formation/oxidative stress in skin tissues (increased endogenous SOD, CAT), as well as lowered lipid peroxidation (MDA) generation. Serum inflammatory chemicals (TNF-α, IL-6, and IL-10) were significantly modulated following LEAD application. This study confirmed the wound healing potential of LEAD, which was mainly linked with its phenolics and flavonoids contents.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107690"},"PeriodicalIF":2.9,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative adjustable silicone nasal stents for nostril support","authors":"Chao Lian ,&nbsp;Zhan Su ,&nbsp;Xuelei Li,&nbsp;Xiaojun Liu,&nbsp;Xuanfen Zhang","doi":"10.1016/j.burns.2025.107694","DOIUrl":"10.1016/j.burns.2025.107694","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107694"},"PeriodicalIF":2.9,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BoBS beyond borders: Ensuring calibration and global utility in burn survival prediction","authors":"Cherdpong Cheonklang,&nbsp;Tirayut Veerasatian,&nbsp;Schawanya K. Rattanapitoon,&nbsp;Nathkapach K. Rattanapitoon","doi":"10.1016/j.burns.2025.107693","DOIUrl":"10.1016/j.burns.2025.107693","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107693"},"PeriodicalIF":2.9,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter regarding \"Postoperative acute kidney injury and risk factors for major adverse kidney events within 30 days of burn surgery\"","authors":"Maryam Yaseri,&nbsp;Seyedeh Sahereh Mortazavi Khatibani","doi":"10.1016/j.burns.2025.107681","DOIUrl":"10.1016/j.burns.2025.107681","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107681"},"PeriodicalIF":2.9,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter regarding \"From fun to frostbite: Cutaneous cold injuries linked to nitrous oxide, the experience of a tertiary burn centre in the UK\"","authors":"Bachir Meliani,&nbsp;Benjamin Tobalem,&nbsp;David Boccara,&nbsp;Lauren Ferrero,&nbsp;Marc Chaouat,&nbsp;Kevin Serror","doi":"10.1016/j.burns.2025.107689","DOIUrl":"10.1016/j.burns.2025.107689","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107689"},"PeriodicalIF":2.9,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Lower fluid resuscitation volumes in the first 24 h following a severe burn injury are independently associated with greater days alive and out of hospital: A retrospective cohort study\"","authors":"Song Zhou,&nbsp;Yunlai Zhao,&nbsp;Hongying Wang","doi":"10.1016/j.burns.2025.107679","DOIUrl":"10.1016/j.burns.2025.107679","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107679"},"PeriodicalIF":2.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145259918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of therapeutic storytelling on pain, fear, and anxiety levels in children undergoing burn dressing","authors":"Niran Çoban ,&nbsp;Sonay Göktaş ,&nbsp;Fatma Şahi̇n ,&nbsp;Selmin Köse","doi":"10.1016/j.burns.2025.107691","DOIUrl":"10.1016/j.burns.2025.107691","url":null,"abstract":"<div><h3>Aim</h3><div>This study aimed to assess the impact of therapeutic storytelling on pain, anxiety, fear, physiological parameters, and parental anxiety and satisfaction levels in children undergoing burn dressing procedures.</div></div><div><h3>Methods</h3><div>A randomized controlled trial was conducted between April 2023 and June 2024 with 60 pediatric patients and their parents in the burn unit of a hospital in Istanbul. Participants were randomized into two groups: the intervention group (n = 30), who listened to a digitized therapeutic story during burn dressing, and the control group (n = 30), who received standard care without additional intervention. Data were collected using the Descriptive Characteristics Form, Child Anxiety Meter-State, Child Fear Scale, Wong-Baker Pain Scale, Parental Satisfaction Scale, State-Trait Anxiety Scale, and a Physiological Parameters Form.</div></div><div><h3>Results</h3><div>The mean age of the children was 3.96 ± 0.99 years; 53.3 % were male, and 83.3 % lived in nuclear families. Children in the storytelling group experienced significantly lower pain, anxiety, and fear levels during and after the procedure compared to the control group (p &lt; 0.001). In the intervention group, anxiety levels progressively decreased from before to after dressing (p &lt; 0.001), while fear and anxiety in the control group increased during the procedure but decreased afterward. Significant differences were observed between the groups in pulse rate, systolic, and diastolic blood pressure across all dressing stages (p &lt; 0.001), whereas oxygen saturation levels showed no significant difference (p &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Listening to therapeutic stories in a digital format effectively reduced pain, anxiety, and fear during burn dressing in children, improved physiological parameters, and enhanced parental satisfaction. This is a simple, fast, and cost-effective art-based method that nurses can apply during burn dressing with minimal equipment and preparation.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107691"},"PeriodicalIF":2.9,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posttraumatic growth of Chinese burn patients: Prevalence, comparison, and predictors","authors":"SiNing Zhao ,&nbsp;Yongpei Yu ,&nbsp;Katherine P. Frey ,&nbsp;Stephen T. Wegener ,&nbsp;Renan C. Castillo","doi":"10.1016/j.burns.2025.107688","DOIUrl":"10.1016/j.burns.2025.107688","url":null,"abstract":"<div><h3>Objective</h3><div>The positive psychological transformation following burns, in contrast to the well-documented negative impacts, remains under-researched, particularly in lower-middle income countries (LMICs). Existing studies predominantly focus on high-income countries. This study examines the prevalence of posttraumatic growth (PTG) among Chinese adult burn patients, explores cross-cultural differences in PTG manifestation, and identifies predictors of PTG in this population.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional analysis of 132 adult patients recruited from two burn units in China. Assessments included the Posttraumatic Growth Inventory, Depression, Anxiety, and Stress Scales-21, Posttraumatic Stress Disorder Checklist, and the Multidimensional Scale of Perceived Social Support. Univariate and multivariate models were employed to evaluate potential influencing factors.</div></div><div><h3>Results</h3><div>The mean PTG score among the Chinese burn patients was 56.7 ± 25.0. Within this cohort, 46 % and 74 % of patients scored above the moderate level, depending on thresholds of 63 and 48, respectively. Model analysis identified significant positive associations between PTG and both increased social support and higher levels of depression. Additionally, time since injury and higher educational attainment were noteworthy predictors, with effects approaching statistical significance.</div></div><div><h3>Conclusion</h3><div>This study is the first to present data on both negative and positive psychological conditions among Chinese burn patients, revealing their interrelationship. The findings confirm the applicability of PTG models in LMICs and suggest cross-cultural differences in PTG compared to high-income nations. Increased social support and higher depression levels were significantly associated with PTG, while time since injury and educational attainment showed notable, albeit marginal, predictive value. These insights contribute to a valuable understanding of psychological growth pathways in LMICs.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107688"},"PeriodicalIF":2.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Renal function after severe burn trauma - Effects of reducing resuscitation fluid volume and changing fluid tonicity\"","authors":"Song Zhou,&nbsp;Yunlai Zhao,&nbsp;Guoying Wang","doi":"10.1016/j.burns.2025.107687","DOIUrl":"10.1016/j.burns.2025.107687","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107687"},"PeriodicalIF":2.9,"publicationDate":"2025-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}