Burns最新文献

{"title":"The role of anterior segment optical coherence tomography angiography in predicting outcomes of acute ocular burns","authors":"Mahsan Samadi ,&nbsp;Hamidreza Ghanbari ,&nbsp;Hamed Ghasemi ,&nbsp;Ghazaleh Soltani ,&nbsp;Alireza Rezaei ,&nbsp;Zahra Montazeriani ,&nbsp;Mehrnaz Atighechian ,&nbsp;Ahmad Masoumi ,&nbsp;Mohammad Soleimani","doi":"10.1016/j.burns.2025.107604","DOIUrl":"10.1016/j.burns.2025.107604","url":null,"abstract":"<div><h3>Aim</h3><div>This study aims to investigate the role of anterior segment optical coherence tomography angiography (AS-OCTA) in determining the prognosis of ocular chemical injuries by correlating angiographic features with early complications and visual outcomes.</div></div><div><h3>Method</h3><div>Forty-six eyes of 36 patients with acute chemical injuries at Farabi Eye Hospital were studied prospectively. Participants received immediate medical care, followed by thorough ophthalmological examinations, including slit-lamp examination and AS-OCTA imaging. Angiographic parameters were analyzed for both superficial and deep layers of the ocular surface microcirculation in nasal and temporal quadrants.</div></div><div><h3>Results</h3><div>The study found that increases in deep and superficial vessel diameter indices (VDI) are associated with higher risk of corneal melting and keratitis, respectively, while a decrease in deep VDI is associated with a significantly higher risk of conjunctivalisation. Decreased superficial vessel length density (VLD) and limbal superficial vessel density (VD) are associated with higher risks of corneal opacification. Additionally, limbal ischemia was found to be significantly correlated with longer healing times.</div></div><div><h3>Conclusion</h3><div>AS-OCTA shows potential as a prognostic tool in ocular chemical injuries. Considering the early changes in angiographic parameters, we can predict specific post-chemical-burn complications.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107604"},"PeriodicalIF":3.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the scalpel: Unpacking grafting’s role in pediatric burn infection prevention","authors":"Yifan Wang ,&nbsp;Lianyi Bao","doi":"10.1016/j.burns.2025.107606","DOIUrl":"10.1016/j.burns.2025.107606","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107606"},"PeriodicalIF":3.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “From fun to frostbite: Cutaneous cold injuries linked to nitrous oxide, the experience of a tertiary burn center in the UK””","authors":"Ming-yun Chi","doi":"10.1016/j.burns.2025.107605","DOIUrl":"10.1016/j.burns.2025.107605","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107605"},"PeriodicalIF":3.2,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term sleep disturbance following burn injury: Insights from the Burn Model System","authors":"Anika Kim ,&nbsp;Paul Won ,&nbsp;Kara McMullen ,&nbsp;Barclay T. Stewart ,&nbsp;Jeffrey C. Schneider ,&nbsp;Collen M. Ryan ,&nbsp;Haig A. Yenikomshian","doi":"10.1016/j.burns.2025.107602","DOIUrl":"10.1016/j.burns.2025.107602","url":null,"abstract":"<div><h3>Objective</h3><div>To address the limited understanding of sleep disturbance (SD) among adult burn survivors by comprehensively examining its prevalence and related factors on a national scale using the Burn Model System (BMS) National Database.</div></div><div><h3>Summary background data</h3><div>SD is a common but underexplored sequela of burn injury, affecting burn survivors’ quality of life and functionality well beyond the initial injury. Existing data on SD and its co-morbidities in these patients are limited to select single-institution studies, lacking a comprehensive national perspective.</div></div><div><h3>Methods</h3><div>The BMS National Database was queried to identify burn patients responding to SD-related questions at 6 months, 12 months, 2 years, and 5 years post-injury. Descriptive statistics, subgroup analyses, and mixed-effects modeling were conducted to evaluate the prevalence, progression, and associated factors of SD at different time points.</div></div><div><h3>Results</h3><div>558 adult burn survivors met inclusion criteria. At 6 months post-injury, 34 % of participants reported SD, with 31 % still affected at 5 years. Demographic characteristics (age, gender, ethnicity) and clinical characteristics (body mass index (BMI), total body surface area burned (TBSA)) could not significantly predict the risk of SD. Mixed-effects modeling demonstrated a significant association between higher SD scores and increased depression and anxiety scores.</div></div><div><h3>Conclusions</h3><div>SD is a persistent condition among burn survivors, with prevalence continuing up to 5 years post-injury. Our study highlights the inability to predict SD based on demographic and clinical factors, underscoring the need for universal screening and interventions. In addition, the association between SD, depression, and anxiety calls for an integrated care approach that addresses both psychological and physical recovery in burn patients.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107602"},"PeriodicalIF":3.2,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144579885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An algorithm for the management of paediatric bicycle friction burns","authors":"Zak Vinnicombe,&nbsp;Marcus Dyer,&nbsp;Daniel Markeson","doi":"10.1016/j.burns.2025.107590","DOIUrl":"10.1016/j.burns.2025.107590","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107590"},"PeriodicalIF":3.2,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3D printed transparent face mask for burn scars management: French experience","authors":"Valerie Chauvineau,&nbsp;Valerie Joly,&nbsp;Emilie Hardy,&nbsp;Marie-Noelle Bartholomei","doi":"10.1016/j.burns.2025.107591","DOIUrl":"10.1016/j.burns.2025.107591","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107591"},"PeriodicalIF":3.2,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nucleotide-binding domain-like receptor protein 3 inflammasome contributes to vascular endothelial barrier dysfunction and shock after burn injury","authors":"Huilin Yu ,&nbsp;Fengjie Lyu ,&nbsp;Zhe Cheng ,&nbsp;Minghao Luo ,&nbsp;Bryan Richard Sasmita ,&nbsp;Yuan Lan ,&nbsp;Dingyi Lv","doi":"10.1016/j.burns.2025.107589","DOIUrl":"10.1016/j.burns.2025.107589","url":null,"abstract":"<div><h3>Objective</h3><div>Burn injury-induced systemic inflammation significantly contributes to vascular endothelial dysfunction and hypotension. This study aimed to investigate the role of the nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome in vascular endothelial barrier dysfunction following burn injury.</div></div><div><h3>Methods</h3><div>A 30 % total body surface area burn mouse model was established, and MCC950, a specific NLRP3 inhibitor, was administered (10 mg/kg) before and after burn injury. Serum collected from burned rats (burn serum, BS) at one day post-injury was applied to human acute mononuclear leukemia cells (THP-1) and human umbilical vein endothelial cells (HUVECs), with or without 10 μM MCC950<em>.</em> Blood pressure, 72-hour survival rates, serum levels of inflammatory cytokines (IL-1β and IL-18) and L-lactic acid (L-LA), and Evans blue staining of mesenteric arteries were measured. Protein expression of endothelial junction protein (VE-cadherin, ZO-1, occludin), MMP-9, NLRP3 inflammasome components (NLRP3, ASC, cleaved caspase-1), and pyroptosis executioner protein (N-terminal fragment of the gasdermin D protein, GSDMD-N) were examined both <em>in vivo</em> and <em>in vitro</em>. Cell viability and morphological changes of HUVECs, and inflammatory cytokines concentrations in THP-1 cell supernatants were also assessed.</div></div><div><h3>Results</h3><div>Burn injury significantly enhanced Evans blue extravasation in mesenteric arteries, and increased serum inflammatory cytokine and L-LA levels, accompanied by reduced blood pressure and decreased 72-hour survival rates <em>in vivo</em>. Burn injury or BS exposure led to decreased endothelial junction protein expression and increased expression of MMP-9, NLRP3 inflammasome components, and GSDMD-N both <em>in vivo</em> and <em>in vitro</em>. Furthermore, BS exposure resulted in reduced cell viability and evident pyroptotic morphology in HUVECs, along with elevated inflammatory cytokines in both the supernatants and lysates of THP-1 cells. Treatment with MCC950 effectively reversed all observed changes except for the protein expression of NLRP3 itself.</div></div><div><h3>Conclusion</h3><div>In burn injury, activation of the NLRP3 inflammasome is associated with enhanced inflammatory responses and endothelial cell pyroptosis, which may contribute to endothelial barrier dysfunction and the progression of shock.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107589"},"PeriodicalIF":3.2,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of music therapy on background pain, anxiety, depression, vital signs, and medication usage in adult burn patients in the Intensive Care Unit: A randomized controlled trial","authors":"Mark Ettenberger ,&nbsp;Rafael Maya ,&nbsp;Andrés Salgado-Vasco ,&nbsp;Jose Gabriel Cordoba-Silva ,&nbsp;Moshé Amarillo ,&nbsp;William Betancourt-Zapata ,&nbsp;Juliana Marín-Sánchez ,&nbsp;Viviana Gómez-Ortega ,&nbsp;Mario Valderrama","doi":"10.1016/j.burns.2025.107587","DOIUrl":"10.1016/j.burns.2025.107587","url":null,"abstract":"<div><h3>Introduction</h3><div>Burn patients often experience pain and mental health difficulties in the Intensive Care Unit (ICU). This study investigated the effects of live Music-Assisted Relaxation (MAR) on background pain, mental health, vital signs, and medication administration in adult ICU burn patients.</div></div><div><h3>Method</h3><div>This was a randomized controlled trial with two parallel arms: standard care + up to six MAR interventions over two weeks, versus standard care alone. Participants were 82 adult ICU burn patients. Primary outcome was perceived background pain. Secondary outcomes were anxiety and depression levels, vital signs, and pain medication usage. Additionally, nine patients participated in electroencephalography, electrocardiography, and electromyography recordings during MAR.</div></div><div><h3>Results</h3><div>Results showed that background pain was significantly lower in the intervention group than in the control group after MAR sessions 1 and 2, with a large effect for patients reporting severe pain. Time had a significant effect on both anxiety and depression, but this was unrelated to the treatment condition. No differences were found for vital signs or pain medication administration. Analysis of electrophysiological signals during MAR revealed significant changes in delta, theta, beta, and alpha frequency bands during electroencephalography, a significant decrease of the low/high-frequency ratio of the tachogram, and significant decrease of mean frequency of facial electromyography.</div></div><div><h3>Conclusions</h3><div>The results suggest that music therapy might be effective in reducing background pain during the early stages of hospitalization and specifically for patients with severe pain. Further multicenter studies with a larger sample size are needed to confirm these results. Trial registration: <span><span>www.clinicaltrials.gov</span><svg><path></path></svg></span>, Identifier: NCT04571255.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107587"},"PeriodicalIF":3.2,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of punch excision in the treatment of severe burn scars","authors":"Xin-Xin Chen,&nbsp;Zhe Yin,&nbsp;Duo Cai,&nbsp;Tai-yuan Ma,&nbsp;Xiu-Hang Zhang,&nbsp;Yu-Tang Li,&nbsp;Yi-Yi He,&nbsp;Qing-Hua Yu,&nbsp;Jia-Ao Yu","doi":"10.1016/j.burns.2025.107578","DOIUrl":"10.1016/j.burns.2025.107578","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aims to identify the therapeutic outcomes of punch excision in severe burn patients with extensive, excessive and long-lasting growth scars.</div></div><div><h3>Methods</h3><div>A retrospective comparative clinical observational study was conducted on patients with burn hypertrophic scars who were treated at the Department of Burn and Skin Wound Repair, First Hospital of Jilin University, between October 2022 and October 2024.</div></div><div><h3>Results</h3><div>A total of 49 patients with severe burn scars were included. Of these, 20 received combined treatment with ablative fractional carbon dioxide laser (AFCL) and punch excision (PE), while 29 were treated with AFCL alone. The AFCL+PE group showed faster and more significant improvements in scar height, pliability, and paresthesias. At 1 week post-treatment, the University of North Carolina 4P Scar Scale (UNC4P) pliability score decreased from 2.7 ± 0.5–2.2 ± 0.6, and the paresthesias score improved from 2.5 ± 0.7–1.9 ± 0.9. The Vancouver Scar Scale (VSS) pliability score dropped from 4.1 ± 0.8–3.4 ± 0.9, and the height score improved from 3.0 ± 0.0–2.1 ± 0.6. Significant improvements in scar sensation were noted, with the Semmes-Weinstein monofilament test decreasing from 32.9 ± 27.2 g pre-treatment to 15.0 ± 10.3 g at 1 week, further improving to 9.5 ± 7.7 g at 1 month and 8.4 ± 7.6 g at 3 months. All 20 patients tolerated the AFCL+PE treatment well, with no complications. The average healing time for PE was 11.7 ± 2.2 days. Postoperative adverse effects included pigmentation (n = 5), which appeared 7 days post-treatment, and mild itching (n = 1).</div></div><div><h3>Conclusion</h3><div>PE is a safe and effective method for scar management, with excellent suitability for hypertrophic burn scars. It can achieve significant rates of scar volume reduction, rapidly and extensively improve scar thickness, hardness, and scar sensation. As an emerging treatment, punch excision offers a distinct therapeutic mechanism and indications compared to existing methods. It holds the potential to become an integral part of current multi-modal scar management approaches. In the future, scar thickness and hardness may no longer be the primary concerns for patients with scars.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107578"},"PeriodicalIF":3.2,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does trauma center designation impact management, complications, and outcomes in burn patients? A National Trauma Data Bank analysis","authors":"Eloise W. Stanton ,&nbsp;Artur Manasyan ,&nbsp;Sean Donohue ,&nbsp;Justin Gillenwater ,&nbsp;Mathew Martin ,&nbsp;Kenji Inaba ,&nbsp;Haig A. Yenikomshian","doi":"10.1016/j.burns.2025.107588","DOIUrl":"10.1016/j.burns.2025.107588","url":null,"abstract":"<div><h3>Background</h3><div>Burn injuries, particularly those involving large total body surface area (TBSA), present significant challenges due to fluid shifts, increased metabolic demands, and heightened susceptibility to complications. Trauma center designation, ranging from Level 1 (highest acuity) to Level 3, reflects differences in resources, expertise, and care protocols, which may influence patient outcomes. This study evaluates the impact of trauma center designation on transfusion practices, complications, and mortality among burn patients.</div></div><div><h3>Methods</h3><div>The Trauma Quality Improvement Program (TQIP) database (2017–2022) was queried to identify burn patients by ICD-9/10 codes. Patients were categorized based on trauma center designation: Level 1 versus non-Level 1 (Levels 2 and 3). Outcomes analyzed included transfusion practices (e.g., packed red blood cells, plasma, platelets), inpatient complications, and mortality. Multivariable logistic regression was performed, adjusted for age, gender, %TBSA, inhalation injury, and Injury Severity Score (ISS). Subgroup analysis was performed for patients with burns &gt; 20 % TBSA.</div></div><div><h3>Results</h3><div>Among 72,474 burn patients, 47 % were treated at Level 1 centers. Patients at Level 1 centers presented with higher injury severity and had significantly higher rates of complications, including respiratory failure, sepsis, and surgical site infections. Despite the higher complication rates, Level 1 centers demonstrated significantly lower mortality compared to non-Level 1 centers (adjusted OR=0.46, 95 % CI 0.25–0.83, p = 0.011). Transfusion practices did not differ significantly between center levels after adjustment. In patients with burns &gt; 20 % TBSA, Level 1 centers maintained lower mortality rates (adjusted OR=0.83, 95 % CI 0.79–0.88, p &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>Trauma center designation is associated with significant differences in burn outcomes. Level 1 centers, despite managing more severe cases, demonstrate lower mortality, emphasizing the importance of specialized care for burn patients. Standardizing burn care protocols and optimizing transfer practices may further improve outcomes for this high-acuity population.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107588"},"PeriodicalIF":3.2,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144518764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}