Burns最新文献

{"title":"Impact of dysglycemia during the ebb and flow phases of critically ill burn patients: An observational study","authors":"Nico Haehn ,&nbsp;Marius Huehn ,&nbsp;Magdalena Ralser ,&nbsp;Dmitrij Ziles ,&nbsp;Gernot Marx ,&nbsp;Jana Christina Mossanen ,&nbsp;Benedikt Schaefer ,&nbsp;Justus Patrick Beier ,&nbsp;Thomas Breuer ,&nbsp;Matthias Manfred Deininger","doi":"10.1016/j.burns.2025.107454","DOIUrl":"10.1016/j.burns.2025.107454","url":null,"abstract":"<div><h3>Background</h3><div>Critically ill burn patients face severe metabolic stress, divided into early ebb and late flow phases, causing dysglycemia. While detrimental effects of hyper- and hypoglycemia in burn patients have been reported over the entire stay, its impact during the ebb and flow phases remains unexplored. This study is the first to investigate phase-separated dysglycemia for outcome prediction.</div></div><div><h3>Methods</h3><div>This retrospective, single-center observational study examined burn ICU patients between 2009 and 2022. Non-severe (ABSI&lt;7) and severe (ABSI≥7) burn patients were investigated separately. Furthermore, the effect of low (&lt;50 %) versus high (≥50 %) dysglycemic rates (&lt;70 or &gt;140 mg/dL) was evaluated within the ebb and flow phases. Dysglycemia was calculated using the time-unified rate, an innovative method representing blood glucose over time. The primary outcome of this study was mortality.</div></div><div><h3>Results</h3><div>This study included 67 non-severe and 101 severe burn patients. During the flow compared to the ebb phase, non-severe burn patients showed increased hyperglycemic rates (&gt;140 mg/dL, p = 0.027) and mean blood glucose levels (p = 0.003), while severe burn patients showed increased glycemic variability (p &lt; 0.001) and hypoglycemic rates (&lt;70 mg/dL, p = 0.003). Non-severe burn patients with high dysglycemic rates showed increased length of ICU stay (ebb: p = 0.029, flow: p = 0.040) and pneumonia incidence (ebb: p = 0.005, flow: p = 0.002) compared to patients with low dysglycemic rates. High dysglycemic rate was associated with higher mortality in severe burn patients (ebb: p = 0.027, flow: p = 0.008). Multivariate logistic regression revealed that hyper- (OR: 1.034, 95 %-CI: [1.001–1.068], p = 0.045) and hypoglycemic rates (OR: 1.744, 95 %-CI: [1.180–2.577], p = 0.005) during the flow, but not the ebb phase, predicted mortality in severe burn patients.</div></div><div><h3>Conclusions</h3><div>This study suggests that increased dysglycemic rate plays a relevant role in both non-severe and severe burn patients, with a varying impact. Over time, the flow phase was characterized by higher glycemic variability as well as hyper- and hypoglycemic rates, with the latter two predicting mortality in severe burn patients. While larger cohorts are needed to confirm these findings, the data indicate that reducing the dysglycemic rate, particularly during the flow phase, could improve outcomes in critically ill burn patients.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107454"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonfatal hospital-treated pediatric and adolescent burn cases in the United States: A 2019–2022 National Electronic Injury Surveillance System analysis","authors":"Rebecca K. Hoffman ,&nbsp;Bruce A. Lawrence ,&nbsp;Bina Ali ,&nbsp;Jennifer Leonardo ,&nbsp;Ted R. Miller","doi":"10.1016/j.burns.2025.107455","DOIUrl":"10.1016/j.burns.2025.107455","url":null,"abstract":"<div><div>Burn injuries experienced by infants, children, and adolescents are prevalent and costly—psychologically, physically, and economically. Previous studies have acknowledged the dangers of pediatric burns; however, the literature was missing a thorough portrayal of the contemporary pediatric and adolescent burns landscape in the United States. The current study used 2019–2022 National Electronic Injury Surveillance System (NEISS) data to describe nonfatal pediatric and adolescent burn cases, including prevalence, burn type, body parts affected, product involvement, and differences by age and sex. We identified 300,541 burn survivors among children 0–19 in the 2019–2022 NEISS data. Burn injuries were most experienced by children under 5, especially among 1- and 2-year-olds. More boys than girls were burn victims, with the sex difference most noticeable among the youngest and oldest age groups. Over 94 % of pediatric and adolescent burn cases were categorized as thermal, scald, or chemical. Scald burns were the only type that affected a higher percentage of girls than boys. Hot water was the item most often involved in pediatric and adolescent burn cases, and the hand was the body part most often affected. These findings both corroborate and extend the pediatric burns literature. Identifying the most frequent burn profiles by age, sex, type, body parts affected, and product involved among children and adolescents 0–19 in the United States enabled us to pinpoint risk factors and offer guidance on prevention.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107455"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Worldwide recommendations for enzymatic debridement with bromelain-based agent (Nexobrid®) in burn care: A call for French health authorities to reconsider their position","authors":"Kevin Serror,&nbsp;David Boccara,&nbsp;Lauren Ferrero,&nbsp;Benjamin Tobalem,&nbsp;Olivier Mathieu,&nbsp;Marc Chaouat","doi":"10.1016/j.burns.2025.107452","DOIUrl":"10.1016/j.burns.2025.107452","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107452"},"PeriodicalIF":3.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"World burn care and the multidisciplinary team","authors":"Yangmyung Ma,&nbsp;Gemma Stewart,&nbsp;Elizabeth Chipp,&nbsp;Sarah Bache","doi":"10.1016/j.burns.2025.107453","DOIUrl":"10.1016/j.burns.2025.107453","url":null,"abstract":"<div><div>Burn care is a multifaceted, multiparametric and multimodal process that requires a multidisciplinary team to improve patient outcomes and skills of health professionals through standardisation, regardless of the environment. This work proposes a framework of personal quality improvement that aims to provide a basis for an effective multidisciplinary team that can deliver harmonisation of clinical practice based on practice guidelines and minimise the micro and macro barriers adding to the global burden of burn care. The key focus of the framework is on the effort to closely engage and merge with the larger systems of healthcare as well as with colleagues and the public to create a ‘wider multidisciplinary team’. This would help broaden the scope of influence and impact of any changes made to burn care. In this way, communication, coordination and shared decision-making between various professionals are fundamental principles of achieving excellent quality of care.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107453"},"PeriodicalIF":3.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suprathel’s usability and effectiveness for the treatment of paediatric partial thickness burns: a 10-year retrospective cohort study","authors":"Milly S van de Warenburg ,&nbsp;Selafa El Yadari ,&nbsp;Stefan Hummelink ,&nbsp;Dietmar JO Ulrich ,&nbsp;MLAW Vehmeijer-Heeman","doi":"10.1016/j.burns.2025.107451","DOIUrl":"10.1016/j.burns.2025.107451","url":null,"abstract":"<div><div>Suprathel has been introduced in our centre since 2014 for superficial to deep partial thickness burns. To evaluate healing outcomes and usability of Suprathel in our paediatric population, we conducted a retrospective cohort study, including all paediatric patients treated with Suprathel for burn wounds since its introduction. The studied population consisted of 92 patients, with a mean age of 4 years [3 months −17 years]. The median wound healing time for the entire cohort was 12.5 days, with no significant differences between the age groups. If wounds were found to be colonized during treatment, the majority of pathogens were Staphylococcus aureus (55.8 %). Seven percent of the patients required a split-thickness skin graft after approximately ten days. The use of Suprathel as epidermal dressing for treatment of partial thickness burns in the paediatric population demonstrates favourable adherence to the wound bed, and reduces the need for frequent dressing changes; the lack of increased wound infections underscore its benefits in paediatric burn care. Our findings suggest no significant differences in outcomes based on the timing of application, wound location, or wound bed preparation, and confirms its efficacy in mobile areas such as the hands.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107451"},"PeriodicalIF":3.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Confounders of the skin microbiome and wound healing in burn patients","authors":"Alireza Pourali,&nbsp;Shahab Aali,&nbsp;Amirhosein Kamrava","doi":"10.1016/j.burns.2025.107450","DOIUrl":"10.1016/j.burns.2025.107450","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107450"},"PeriodicalIF":3.2,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143768344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Have the recent advancements in wound repair and scar management technology improved the quality of life in burn patients?","authors":"Bishara Atiyeh,&nbsp;Tarek F. El Hachem,&nbsp;Rawad Chalhoub,&nbsp;Saif E. Emsieh","doi":"10.1016/j.burns.2025.107443","DOIUrl":"10.1016/j.burns.2025.107443","url":null,"abstract":"<div><h3>Background</h3><div>The negative physical and psychosocial impact of scars, in particular burn scars, has been well documented. Altered personal appearance together with impaired function related to pain, heat intolerance, and contracture formation may last a lifetime and eventually can lead to low self-esteem and poor social and psychological adjustments. Though most patients recover within the first years and many report generally good life satisfaction and moderate quality of life (QoL), some severely burned patients continue to report impaired QoL almost 10 years after injury. It is repeatedly mentioned in the literature that patients’ QoL and health-related quality of life (HRQoL) can be improved by improving wound healing and burn scar quality. Determining whether advances in burn wound healing and scar management modalities are positively impacting the lives of surviving patients is the aim of this review.</div></div><div><h3>Methods</h3><div>A systematic literature review was used to identify studies measuring QoL of patients surviving severe burn injuries following various interventions to improve burn wound healing and scar quality.</div></div><div><h3>Results</h3><div>A limited number of studies was identified. Given the limited available data, a narrative review approach including qualitative studies and reviews in addition to identifying common themes, trends, and gaps in the existing literature was deemed more appropriate for a comprehensive analysis.</div></div><div><h3>Conclusion</h3><div>The assumption that progress made in recent decades to improve burn wound healing and scar quality would improve QoL remains largely hypothetical. Except for functional release of burn scar contractures, improved scar aesthetic quality does not necessarily translate into improved QoL of surviving patients. Well-designed comparative studies are largely lacking.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107443"},"PeriodicalIF":3.2,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of lncRNA biomarkers for keloid diagnosis and functional characterization of CPEB2-AS1","authors":"Shengjing Xu ,&nbsp;Yali Jiang ,&nbsp;Xianggong Zhu ,&nbsp;Yanting Rao ,&nbsp;Min Zhang ,&nbsp;Yan Lu","doi":"10.1016/j.burns.2025.107448","DOIUrl":"10.1016/j.burns.2025.107448","url":null,"abstract":"<div><h3>Background</h3><div>Keloids are pathological scars marked by excessive tissue growth, and their diagnosis currently depends on clinical observation, lacking objective biomarkers. Although the regulatory role of long non-coding RNAs (lncRNAs) in various diseases has drawn attention, their function in keloids remains unclear.</div></div><div><h3>Methods</h3><div>This study employed high-throughput sequencing, bioinformatics analysis and machine learning algorithms to identify differentially expressed lncRNAs in keloid tissues and to construct a diagnostic model. The relationship between these lncRNAs and immune responses, as well as gene expression regulation, was explored through immune signature analysis and co-expression networks. The role of CPEB2-AS1 in keloids was investigated through expression validation, pan-cancer analysis and functional experiments.</div></div><div><h3>Results</h3><div>Four key differentially expressed lncRNAs were identified, enabling the development of an effective diagnostic model that distinguishes keloid tissues from healthy controls. Immune signature analysis revealed a positive correlation between CPEB2-AS1 and immune cell activity. Co-expression networks and functional enrichment analysis suggested that these lncRNAs may regulate RNA processing and nucleic acid binding. Expression validation and pan-cancer analysis confirmed their abnormal expression in keloids. Functional experiments demonstrated that CPEB2-AS1 significantly influences cell proliferation, migration, invasion and apoptosis.</div></div><div><h3>Conclusion</h3><div>This study identifies new molecular markers for the early diagnosis of keloids and highlights the potential role of CPEB2-AS1 in keloid progression, offering insights for future therapeutic strategies.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107448"},"PeriodicalIF":3.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Shah Suit – A bespoke dressing for paediatric patients with non-burn skin loss","authors":"Katherine Radcliffe,&nbsp;Adrian Karangura,&nbsp;Clare Rivers,&nbsp;Mamta Shah","doi":"10.1016/j.burns.2025.107441","DOIUrl":"10.1016/j.burns.2025.107441","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107441"},"PeriodicalIF":3.2,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143636789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lateral thinking: different perspectives on burn care","authors":"Muhammad Adil Abbas Khan,&nbsp;Yangmyung Ma","doi":"10.1016/j.burns.2025.107446","DOIUrl":"10.1016/j.burns.2025.107446","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107446"},"PeriodicalIF":3.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143643668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}