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Violent burns are associated with poorer life satisfaction and unemployment after injury 暴力烧伤与较低的生活满意度和受伤后失业有关
IF 3.2 3区 医学
Burns Pub Date : 2025-04-14 DOI: 10.1016/j.burns.2025.107504
Artur Manasyan , Kara A. McMullen , Kimberly Roaten , Jacob A. Bentley , Sunia Choudhury , Sarah A. Stoycos , Haig A. Yenikomshian , Maxwell B. Johnson
{"title":"Violent burns are associated with poorer life satisfaction and unemployment after injury","authors":"Artur Manasyan ,&nbsp;Kara A. McMullen ,&nbsp;Kimberly Roaten ,&nbsp;Jacob A. Bentley ,&nbsp;Sunia Choudhury ,&nbsp;Sarah A. Stoycos ,&nbsp;Haig A. Yenikomshian ,&nbsp;Maxwell B. Johnson","doi":"10.1016/j.burns.2025.107504","DOIUrl":"10.1016/j.burns.2025.107504","url":null,"abstract":"<div><h3>Background</h3><div>Assaults can result in violent burn injuries, leading to a profound impact on survivors. These burns can cause physical pain, psychological trauma, and challenges in employment. In this study, we aim to explore socioeconomic demographics and longitudinal psychosocial outcomes associated with violent burns.</div></div><div><h3>Methods</h3><div>Adult participants admitted for acute burn injury between 1993 and 2023 within the Burn Model System (BMS) database were included in the study. Patients with self-inflicted burn injuries were excluded. Participant demographics were summarized using descriptive statistics and compared between the intentional and unintentional burn cohorts with Wilcoxon-Mann-Whitney and Chi-square tests. A logistic regression model was constructed to investigate longitudinal occurrences of anxiety, depression, and posttraumatic stress symptoms, posttraumatic growth, employment status, and satisfaction with life.</div></div><div><h3>Results</h3><div>A total of 4668 patients were included in the study, of whom 147 (3.15 %) sustained violent burns. The intentional burn cohort was more likely to be Black (<em>p</em> &lt; 0.001), unemployed (<em>p</em> &lt; 0.001), have lower income (<em>p</em> = 0.001), and less likely to have completed graduate education (<em>p</em> &lt; 0.001) than the unintentional burn cohort. Participants with intentional burn injuries had larger burns (24.0 vs. 16.6 % total body surface area, <em>p</em> &lt; 0.001). Post-burn anxiety, depression, post-traumatic growth, and post-traumatic stress were not significantly associated with burn intentionality. After controlling for burn total body surface area, patients with violent burns were more likely to experience unemployment (<em>p</em> &lt; 0.001) and poorer satisfaction with life (<em>p</em> &lt; 0.001) after injury.</div></div><div><h3>Conclusions</h3><div>Violent, intentional burn injuries disproportionately impact historically marginalized and socioeconomically disadvantaged individuals. These injuries lead to poorer quality of life without an equivalent impact on psychological health across groups. Future research should focus on exploring dissatisfaction with life, barriers to employment, and the role of vocational counseling in addressing these challenges within this patient population.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107504"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Selective decontamination of the digestive tract in burn patients: A systematic review with meta-analysis 选择性去污在烧伤患者的消化道:系统回顾与荟萃分析
IF 3.2 3区 医学
Burns Pub Date : 2025-04-14 DOI: 10.1016/j.burns.2025.107501
Emma Atsuko Tsuchiya , Jacob Jensen-Abbew , Mette Krag , Morten Hylander Møller , Martin Risom Vestergaard , Nicolai Haase , Marie Helleberg , Rikke Holmgaard , Johan Heiberg
{"title":"Selective decontamination of the digestive tract in burn patients: A systematic review with meta-analysis","authors":"Emma Atsuko Tsuchiya ,&nbsp;Jacob Jensen-Abbew ,&nbsp;Mette Krag ,&nbsp;Morten Hylander Møller ,&nbsp;Martin Risom Vestergaard ,&nbsp;Nicolai Haase ,&nbsp;Marie Helleberg ,&nbsp;Rikke Holmgaard ,&nbsp;Johan Heiberg","doi":"10.1016/j.burns.2025.107501","DOIUrl":"10.1016/j.burns.2025.107501","url":null,"abstract":"<div><h3>Background</h3><div>In mechanically ventilated adult patients in the intensive care unit (ICU), selective decontamination of the digestive tract (SDD) has been shown to reduce the risk of infections and improve survival. While the benefits of SDD have been documented in this population, it remains unclear whether burn patients, who are at increased risk of infection and have distinct clinical characteristics, may experience similar benefits. In this systematic review we aimed to assess the desirable and undesirable patient-important effects of administering SDD to burn patients.</div></div><div><h3>Methods/design</h3><div>We conducted a systematic review with meta-analysis of randomized clinical trials (RCTs) assessing the effects of SDD versus placebo or no SDD in burn patients. The primary outcome was 30-day mortality. Secondary outcomes included serious adverse events, antimicrobial resistance, pneumonia, blood stream infections, ICU- and hospital-free days, and 90-day mortality. We searched all major databases and followed the recommendations provided by the Cochrane Collaboration and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The certainty of evidence was assessed according to the Grading of Recommendations Assessment, Development, and Evaluation approach.</div></div><div><h3>Results</h3><div>We identified four RCTs with a total of 457 burn patients. All trials were assessed as having either ‘some concerns’ or ‘high risk’ of bias. The evidence was found to be very uncertain across all outcomes assessed. For mortality, the relative risk (RR) was 0.62 (95 % confidence interval (CI) 0.22–1.78, I<sup>2</sup> = 75 %, random-effects model (REM), very low certainty evidence). For pneumonia, the RR was 0.75 (95 % CI 0.48–1.19, I<sup>2</sup> = 0 %, fixed-effect model, very low certainty evidence). For bloodstream infections, the RR was 1.10 (95 % CI 0.71–1.69, I<sup>2</sup> = 0 %, REM, very low certainty evidence). For hospital length of stay, the mean difference was −2.03 days (95 % CI −9.64–5.59, I<sup>2</sup> = 51 %, REM, very low certainty evidence). We did not perform meta-analyses for the remaining secondary outcomes due to limited or no data. Trial sequential analysis could not be performed due to insufficient number of total participants and events in the included trials.</div></div><div><h3>Conclusion</h3><div>We found that the certainty of evidence is very low about the effects of SDD on patient-important outcomes in burn patients. Extrapolating from the evidence on mechanically ventilated adult ICU patients may be reasonable until more data from RCTs in burn patients emerge.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107501"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do burn injury prevention interventions change what people know and how people think? A systematic review investigating the impact on psychological constructs 烧伤预防干预会改变人们的认知和思维吗?研究对心理构念影响的系统综述
IF 3.2 3区 医学
Burns Pub Date : 2025-04-14 DOI: 10.1016/j.burns.2025.107499
Cara Salt , Laura Shepherd , Richard Cooke , Gemma Hurst
{"title":"Do burn injury prevention interventions change what people know and how people think? A systematic review investigating the impact on psychological constructs","authors":"Cara Salt ,&nbsp;Laura Shepherd ,&nbsp;Richard Cooke ,&nbsp;Gemma Hurst","doi":"10.1016/j.burns.2025.107499","DOIUrl":"10.1016/j.burns.2025.107499","url":null,"abstract":"<div><h3>Introduction</h3><div>Burns can result in life-long physical and psychological difficulties. Interventions aimed at preventing burns are therefore important. Behaviour change theories propose that psychological variables (e.g., knowledge, attitudes, beliefs, self-efficacy) are associated with injury prevention behaviour. However, whether or not burn prevention interventions impact psychological variables is uncertain. This systematic review aimed to address this gap in the literature.</div></div><div><h3>Methods</h3><div>A systematic review was conducted according to PRISMA guidelines. Electronic databases (CINAHL, MEDLINE, PubMed and Scopus) were searched for randomized control trials (RCTs) of burn prevention interventions which measured at least one psychological construct. Studies were quality assessed using the Effective Public Health Practice Project (EPHPP) quality assessment tool.</div></div><div><h3>Results</h3><div>Eight studies met inclusion criteria. A narrative synthesis was conducted. Seven RCTs detailed interventions aimed at reducing paediatric burns (five delivered to parents/caregivers and two delivered to children). One RCT was aimed at adults. All RCTs measured burns knowledge, but findings were mixed about whether knowledge changed following interventions. Four RCTs measured self-efficacy, with all finding an increased perceived ability to engage in burn prevention behaviour following interventions. Risk perceptions (e.g., around the perceived severity and susceptibility of burns) were rarely measured.</div></div><div><h3>Conclusion</h3><div>To date, burn prevention RCTs have mainly focused on paediatric burns and most often measured knowledge change. However, the impact of interventions on knowledge is variable. Future burn prevention interventions should measure a range of psychological constructs, as these are likely to be important in burn prevention behaviour.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107499"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A call for comprehensive protocols and strategies: Identifying pediatric non-accidental burns. 呼吁制定全面的方案和策略:确定儿童非意外烧伤。
IF 3.2 3区 医学
Burns Pub Date : 2025-04-14 DOI: 10.1016/j.burns.2025.107419
Julia Bartkova, Aksharaa Gurubalasubramaniyan Iyer, Rei Ogawa
{"title":"A call for comprehensive protocols and strategies: Identifying pediatric non-accidental burns.","authors":"Julia Bartkova, Aksharaa Gurubalasubramaniyan Iyer, Rei Ogawa","doi":"10.1016/j.burns.2025.107419","DOIUrl":"https://doi.org/10.1016/j.burns.2025.107419","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":" ","pages":"107419"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innovative use of nasal stents to prevent adhesive nasal deformities following facial burns 创新使用鼻支架,防止面部烧伤后的粘连性鼻畸形
IF 3.2 3区 医学
Burns Pub Date : 2025-04-14 DOI: 10.1016/j.burns.2025.107505
Chao Lian, Xue-Lei Li, Xiao-Jun Liu, Xuan-Fen Zhang
{"title":"Innovative use of nasal stents to prevent adhesive nasal deformities following facial burns","authors":"Chao Lian,&nbsp;Xue-Lei Li,&nbsp;Xiao-Jun Liu,&nbsp;Xuan-Fen Zhang","doi":"10.1016/j.burns.2025.107505","DOIUrl":"10.1016/j.burns.2025.107505","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107505"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nile tilapia skin in burn wound healing: A scoping review 尼罗罗非鱼皮在烧伤创面愈合中的应用综述
IF 3.2 3区 医学
Burns Pub Date : 2025-04-14 DOI: 10.1016/j.burns.2025.107503
Andrew Laurie Bustaman , Peter Nugraha Soekmadji , Ardo Sanjaya
{"title":"Nile tilapia skin in burn wound healing: A scoping review","authors":"Andrew Laurie Bustaman ,&nbsp;Peter Nugraha Soekmadji ,&nbsp;Ardo Sanjaya","doi":"10.1016/j.burns.2025.107503","DOIUrl":"10.1016/j.burns.2025.107503","url":null,"abstract":"<div><div>Burn wound management involves complex phases, with wound closure crucial for reducing mortality risk and achieving functional recovery. Though effective, traditional methods like skin grafting face limitations in extensive burns. Nile tilapia skin (NTS) has emerged as a promising alternative due to its high collagen content, biocompatibility, and moisture retention properties. A scoping review was conducted using EMBASE, Medline, and Cochrane Library databases. Inclusion criteria targeted studies using NTS in burn wound management across human and animal models. Outcomes analyzed included healing time, protein or gene expression changes, and cell proliferation. Articles were systematically screened and narratively synthesized. Of the 1035 articles retrieved, 13 met the inclusion criteria. Small-scale studies demonstrated that NTS accelerates wound healing, enhances re-epithelialization, and reduces pain compared to conventional treatments. Clinical trials highlighted faster recovery, decreased analgesic use, and fewer dressing changes in NTS-treated burns. However, these trials have marked limitations due to small study sample sizes, variability in application methods, and limited long-term outcome data. Mechanistically, NTS promotes cell migration, modulates inflammatory responses, and enhances angiogenesis. Its biocompatibility and antimicrobial properties further support its use. NTS represents a cost-effective, accessible alternative for burn wound management. However, standardizing protocols and conducting larger trials are essential for broader adoption. Addressing current treatment gaps can improve outcomes, particularly in low-resource environments. Further research is needed to standardize its use and optimize its therapeutic impact.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107503"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating inter-and intra-rater reliability in the bronchoscopic grading of burn inhalation injury: The iBRONCH-BII study 评估支气管镜下烧伤吸入性损伤分级的内部和内部可靠性:iBRONCH-BII研究
IF 3.2 3区 医学
Burns Pub Date : 2025-04-13 DOI: 10.1016/j.burns.2025.107502
Eleana T. Kumana , Walton N. Charles , Helena Milton-Jones , Kaladerhan Agbontaen , Sabri Soussi , Ken Dunn , Roger Davies , Joanne Atkins , Ceri Beynon , Emmanuel Charbonney , Dashiell Gantner , Julian Giles , Isabel Jones , Niall Martin , Oliver Pantet , Odhran Shelley , Alice Sisson , Jagdish Sokhi , Barclay T. Stewart , Timothy Vorster , Suveer Singh
{"title":"Evaluating inter-and intra-rater reliability in the bronchoscopic grading of burn inhalation injury: The iBRONCH-BII study","authors":"Eleana T. Kumana ,&nbsp;Walton N. Charles ,&nbsp;Helena Milton-Jones ,&nbsp;Kaladerhan Agbontaen ,&nbsp;Sabri Soussi ,&nbsp;Ken Dunn ,&nbsp;Roger Davies ,&nbsp;Joanne Atkins ,&nbsp;Ceri Beynon ,&nbsp;Emmanuel Charbonney ,&nbsp;Dashiell Gantner ,&nbsp;Julian Giles ,&nbsp;Isabel Jones ,&nbsp;Niall Martin ,&nbsp;Oliver Pantet ,&nbsp;Odhran Shelley ,&nbsp;Alice Sisson ,&nbsp;Jagdish Sokhi ,&nbsp;Barclay T. Stewart ,&nbsp;Timothy Vorster ,&nbsp;Suveer Singh","doi":"10.1016/j.burns.2025.107502","DOIUrl":"10.1016/j.burns.2025.107502","url":null,"abstract":"<div><h3>Background</h3><div>The evidence that the severity of burn inhalation injury (BII) impacts clinical outcomes is inconsistent. This may be due to misclassification arising from the subjectivity in bronchoscopically grading BII using systems such as the Abbreviated Injury Score (AIS). This study aimed to evaluate inter- and intra-rater reliability in the grading of BII using the AIS.</div></div><div><h3>Methodology</h3><div>In a cohort study, specialist burns clinicians (n = 17) and novices (n = 10) graded sixteen BII bronchoscopic images using the AIS during an online meeting. Inter-rater reliability was evaluated using the Kappa statistic (k), with values &lt; 0.60 considered clinically inadequate. The grade rating process was repeated after seven days to evaluate intra-rater reliability. Evaluation of reliability in the grading of BII bronchoscopy reports was conducted as a sensitivity analysis.</div></div><div><h3>Results</h3><div>Amongst all raters, inter-rater reliability was low for grading images (k = 0.30, 95 % confidence interval (CI): 0.29–0.31). Intra-rater reliability was higher than inter-rater reliability, but was still low, with median image grade rate k = 0.45 (interquartile range [IQR]:0.24–0.53). Intensivists demonstrated the highest rater reliability.</div></div><div><h3>Conclusion</h3><div>Reliability in rating the grade of BII by bronchoscopic images was clinically inadequate. Strategies to improve the reliability of reporting the grade of BII are required.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107502"},"PeriodicalIF":3.2,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Grading criteria on radionecrosis of skin (GCRNS) in adult patients: Insights from Delphi study and validation process. 成人患者放射性皮肤坏死(GCRNS)的分级标准:来自德尔菲研究和验证过程的见解。
IF 3.2 3区 医学
Burns Pub Date : 2025-04-07 DOI: 10.1016/j.burns.2025.107473
Meng-Yue Zhu, Fei Yang, Wei-Guo Xie, Mao-Mao Xi, Shu-Hua Liu, Wei Zhang, De-Yun Wang, Wei-Dong Zhang, Gang Yu, Nan-Hong Jiang
{"title":"Grading criteria on radionecrosis of skin (GCRNS) in adult patients: Insights from Delphi study and validation process.","authors":"Meng-Yue Zhu, Fei Yang, Wei-Guo Xie, Mao-Mao Xi, Shu-Hua Liu, Wei Zhang, De-Yun Wang, Wei-Dong Zhang, Gang Yu, Nan-Hong Jiang","doi":"10.1016/j.burns.2025.107473","DOIUrl":"https://doi.org/10.1016/j.burns.2025.107473","url":null,"abstract":"<p><strong>Background: </strong>Radionecrosis of skin (RNS) is the severe consequence of radiodermatitis (RD), which is a common complication experienced in up to 95 % of cancer patients after radiation therapy (RT). Recent publications revealed an absence of grading criteria for RNS and only crude forms for RD. However, treatments for RNS of different severity vary widely in terms of treatment difficulty and prognosis. This Delphi study aims to provide wound repair surgeons and oncologists a comprehensive guide for accurate RNS diagnosis, facilitating more effective surgical or operative interventions.</p><p><strong>Methods: </strong>A three-round Delphi method was conducted between May and September 2022, involving 24 experts who specialize in the care or research of RNS. The process identified and weighted primary and secondary items to create a scale that reflects the severity of RNS. A receiver operating characteristic (ROC) curve was generated using the expert's ratings (n = 15) as the benchmark to establish the grading criteria on RNS (GCRNS) with patient data (n = 64). To assess test-retest reliability, 32 physicians re-evaluate 64 patients' files 2 weeks after their initial evaluation. The correlation between expert ratings and physician's re-evaluated grading was calculated to confirm concurrent validity.</p><p><strong>Results: </strong>The final GCRNS consisted of 18 secondary items categorized under 6 primary items, including ulcer duration, peripheral skin, ulcer area, underlying disease, ulcer depth, and severe complications. Severity classification thresholds were proposed by ROC curve, defining severity levels as mild, moderate, and severe. Six primary items were positively correlated the severity of RNS with affirming its concurrent validity (r = 0.751, p < 0.001). Good internal consistency (α=0.831) and test-retest reliability (r = 0.969, p < 0.001) were demonstrated.</p><p><strong>Conclusions: </strong>GCRNS is an expert-driven and comprehensive approach to RNS assessment for further wound repair. By improving diagnostic accuracy, particularly among junior surgeons, GCRNS with strong concurrent validity and reliability, enhances clinical decision-making and supports more effective treatment planning.</p>","PeriodicalId":50717,"journal":{"name":"Burns","volume":" ","pages":"107473"},"PeriodicalIF":3.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Naringenin loaded nanomicelles effect on second-degree burn in Balb/c mice: A promising formulation for wound healing 纳米柚皮苷对 Balb/c 小鼠二度烧伤的影响:有望促进伤口愈合的配方
IF 3.2 3区 医学
Burns Pub Date : 2025-04-07 DOI: 10.1016/j.burns.2025.107494
Fatemeh Monzavipourbana , Mahmoud Reza Jaafari , Shima Afrasiabi , Partow Mirzaee Saffari , Javad Zarqi , Gholamreza Hassanzadeh , Seyyedeh Elaheh Mousavi , Seyed Mahdi Rezayat , Alireza Partoazar
{"title":"Naringenin loaded nanomicelles effect on second-degree burn in Balb/c mice: A promising formulation for wound healing","authors":"Fatemeh Monzavipourbana ,&nbsp;Mahmoud Reza Jaafari ,&nbsp;Shima Afrasiabi ,&nbsp;Partow Mirzaee Saffari ,&nbsp;Javad Zarqi ,&nbsp;Gholamreza Hassanzadeh ,&nbsp;Seyyedeh Elaheh Mousavi ,&nbsp;Seyed Mahdi Rezayat ,&nbsp;Alireza Partoazar","doi":"10.1016/j.burns.2025.107494","DOIUrl":"10.1016/j.burns.2025.107494","url":null,"abstract":"<div><div>Burns can cause long-term complications and require immediate and effective treatment in patients. The therapeutic potential of naringenin (NG) is hampered by its hydrophobic nature. To improve the bioavailability and efficacy of NG in experimental burn wounds in mice, NG-loaded nanomicelles (NGMs) were prepared using the thin-film hydration method. The characterization of the formulation in different concentrations (0.3 %, 0.6 %, and 1.25 %) was carried out using HPLC, DLS, and TEM techniques. A second-degree burn was inflicted on the back of the mice for evaluation of NGM efficacy. The NGM formulation was evaluated topically on the treated mice for wound recovery, improvement of histological and immunohistochemical parameters, and <em>in vitro</em> antibacterial activity. The effect of NGMs on wound healing was evaluated by hematoxylin and eosin (H&amp;E) and Masson’s trichrome staining (MT), and expression of transforming growth factor-β (TGF-β) and nuclear factor-κB (NFκ-B) using immunohistochemistry (IHC). The characterization tests revealed nanosized micelles with dimensions around 7 nm and a high entrapment efficiency percentage of NG which had sustained release behavior. Wound healing was significantly faster in mice treated with NGMs (0.3 %) compared to other concentrations, silver sulfadiazine (SSD), and an untreated group. IHC analysis of mice receiving NGMs (0.3 %) showed a significant reduction in NFκ-B, while TGF-β1 was increased. In addition, NGMs exhibited significant bactericidal activity against <em>Staphylococcus aureus</em> and <em>Pseudomonas aeruginosa in vitro</em>. These findings show that NGMs accelerate the wound-healing process and lead to regeneration of the epidermis without the need for additional medication.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107494"},"PeriodicalIF":3.2,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143829047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Understanding drivers of fire risk with people experiencing homelessness 了解无家可归者火灾风险的驱动因素
IF 3.2 3区 医学
Burns Pub Date : 2025-04-05 DOI: 10.1016/j.burns.2025.107482
Caitlin M. Orton , Mark Gannon , Aldina Mešić , Mona Chambers , Leslie Enzian , Tam N. Pham , Barclay T. Stewart
{"title":"Understanding drivers of fire risk with people experiencing homelessness","authors":"Caitlin M. Orton ,&nbsp;Mark Gannon ,&nbsp;Aldina Mešić ,&nbsp;Mona Chambers ,&nbsp;Leslie Enzian ,&nbsp;Tam N. Pham ,&nbsp;Barclay T. Stewart","doi":"10.1016/j.burns.2025.107482","DOIUrl":"10.1016/j.burns.2025.107482","url":null,"abstract":"<div><div>Fire hazards affecting people who are unhoused span natural and built environments, social circumstances, and human behavior. Identifying key drivers of fire risk and burn injury can inform injury prevention and control initiatives. We conducted 12 key informant interviews with burn patients who were unhoused. Deductive and inductive strategies were used to code transcripts. Corcoran’s conceptual model of fire risk was applied in order to group factors into environmental, social, and behavioral categories. The most frequently used fire sources were propane, hand sanitizer, and other alcohol-based liquids. Unsafely contained open flames and improper propane tank storage were frequently identified hazards. Participants described the interplay of environmental, social, and behavioral factors that need to be accounted for when addressing fire hazards. For example, the use of propane heaters inside tents is common because it is effective in warming living spaces and limits the risk of having equipment stolen. This project identified specific environmental risks, socioeconomic risks, and their interplay with identified fire hazards as foundational to injury control for people experiencing homelessness. Injury prevention strategies need to be evaluated within the complex environments of homelessness (e.g., exposure to severe weather, unsafe and potentially violent living conditions, substance use, social marginalization, and limited access to injury prevention media).</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107482"},"PeriodicalIF":3.2,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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