Burns最新文献

{"title":"Factors affecting skin keratinocyte and fibroblast extraction yields for the production of living skin substitutes to treat severely burned patients","authors":"Ludivine Dubourget ,&nbsp;Danielle Larouche ,&nbsp;Sergio Cortez Ghio ,&nbsp;Véronique J. Moulin ,&nbsp;Chanel Beaudoin-Cloutier ,&nbsp;Lucie Germain","doi":"10.1016/j.burns.2025.107805","DOIUrl":"10.1016/j.burns.2025.107805","url":null,"abstract":"<div><h3>Backgrounds</h3><div>As autografting is limited for severely burned patients due to a lack of healthy donor sites, tissue-engineered autologous skin substitutes have emerged as a promising alternative. Yet, challenges persist, particularly regarding production time. Since cell culture is influenced by multiple factors, identifying these factors is crucial for improving culture yields. This retrospective study aimed to identify factors affecting skin cell extraction yields.</div></div><div><h3>Methods</h3><div>Culture data (method used, etc.) and clinical data (medical history, etc.) from all available patient records over a 35-year-period were collected. 18 variables were assessed using XGBoost as a variable selection tool, before fitting mixed-effects multivariate linear modeling.</div></div><div><h3>Results</h3><div>As expected, age inversely correlated with keratinocyte and fibroblast extraction yields, decreasing by 0.048 × 10⁶ cells/cm² per year (CI_95 % = [-0.065;-0.031]) and 0.035 × 10⁶ cells/cm² per year (CI_95 % = [-0.050;-0.019]), respectively. Keratinocyte yield also rose by 0.936 × 10⁶ cells/cm² (CI_95 % = [0.175;1.697]) when hairs could be grasped during the epidermis-dermis separation. Conversely, fibroblast yield increased by 0.042 × 10⁶ cells/cm² per day post-burn (CI_95 % = [0.007;0.076]) and by 0.019 × 10⁶ cells/cm² per percentage of TBSA burned (CI_95 % = [0.002;0.036]).</div></div><div><h3>Conclusions</h3><div>This findings provide valuable insights into factors influencing skin cell extraction yields, which may help optimize skin biopsy parameters, ultimately improving production efficiency.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107805"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145842455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fire safety measures in commercial complex residents: Application of protection motivation theory","authors":"Mohammadreza Shokouhi ,&nbsp;Fahimeh Ramezani ,&nbsp;Ali Fardi ,&nbsp;Maryam Afshari ,&nbsp;Salman Khazaei ,&nbsp;Forouzan Rezapur-Shahkolai","doi":"10.1016/j.burns.2025.107830","DOIUrl":"10.1016/j.burns.2025.107830","url":null,"abstract":"<div><h3>Background</h3><div>Fires in commercial buildings are of particular concern given their essential role in economic and social development. While fire safety research has often emphasized structural aspects of buildings, comparatively less attention has been paid to residents’ behavioral responses during fire incidents. Moreover, a considerable portion of the existing literature on fire safety lacks a robust theoretical foundation. To address this gap, the present study applies the Protection Motivation Theory (PMT) to examine factors influencing fire prevention behaviors among residents of commercial complexes.</div></div><div><h3>Materials and methods</h3><div>This cross-sectional study was conducted between September and December 2024 among 910 residents of commercial complexes in Hamadan. Participants were selected using a stratified sampling method based on complex size, followed by simple random sampling for individual inclusion. Data were collected through structured interviews with a questionnaire consisting of two sections: demographic and background information, and constructs derived from the PMT.</div></div><div><h3>Results</h3><div>The mean age of participants was 41.6 years, with an average of 7.6 working hours per day. Most participants were male (81.2 %) and had a middle school level of education (52.2 %). Nearly 12.2 % reported previous experience with a fire incident. In addition, higher scores of perceived susceptibility, perceived severity, fear, self-efficacy, response efficacy, perceived rewards, and protection motivation were associated with increased engagement in preventive measures. Daily working hours were also found to have a statistically significant correlation with the adoption of protective behaviors against fire in commercial buildings.</div></div><div><h3>Conclusion</h3><div>The findings of this study highlight the critical importance of fire prevention among individuals working in commercial complexes, given their unique occupational conditions. To ensure effective planning and implementation of preventive and intervention programs, it is essential to comprehensively identify the determinants of protective behaviors.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107830"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: The rise of the robot authors","authors":"Leopoldo C. Cancio","doi":"10.1016/j.burns.2026.107862","DOIUrl":"10.1016/j.burns.2026.107862","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107862"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glucagon-like peptide-1 receptor agonists after recent burn injury are associated with lower rates of infection, mortality, and opioid prescriptions","authors":"Matthew Q. Dao ,&nbsp;Anika Y. Kim ,&nbsp;Sarah Wang ,&nbsp;Paul Won ,&nbsp;Matteo Laspro ,&nbsp;T. Justin Gillenwater ,&nbsp;Haig A. Yenikomshian ,&nbsp;Maxwell B. Johnson","doi":"10.1016/j.burns.2025.107848","DOIUrl":"10.1016/j.burns.2025.107848","url":null,"abstract":"<div><h3>Introduction</h3><div>Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are widely prescribed for glycemic control and weight loss. In addition, these medications have been associated with anti-inflammatory activity, modulation of wound healing, and reduction of substance use disorders. Therefore, GLP-1 RAs may have therapeutic benefits in burn care. This study investigates whether early administration of GLP-1 RAs after burn injury is associated with clinical outcomes.</div></div><div><h3>Methods</h3><div>The Global Collaborative Network was queried in TriNetX, a database of electronic health records. The treatment group included burn patients who received GLP-1 RAs within 30 days of injury. This group was propensity matched with patients who did not receive GLP-1 RAs. Patients were matched by demographics, comorbidities, and burn characteristics. Outcomes at 90 days and 1 year following burn injury were compared, with statistical significance defined as p &lt; 0.05.</div></div><div><h3>Results</h3><div>Following matching, each group was composed of 3231 patients. At 90 days post-burn, the GLP-1 RA group had significantly lower rates of soft tissue infection, opioid prescriptions, readmission, and mortality (all p &lt; 0.05). At 1 year post-burn, lower rates of opioid prescriptions, readmission, and mortality persisted (all p &lt; 0.05), while soft tissue infection rates remained numerically lower but did not reach statistical significance. No significant differences were observed for wound disruption, hypertrophic scar formation, or contracture formation at either time point.</div></div><div><h3>Conclusions</h3><div>GLP-1 RAs after recent burn injury were associated with lower risk of infection, opioid prescriptions, readmission, and mortality. Their utility in burn care is promising, and additional research is needed.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107848"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Galangin enhances skin flap survival by inhibiting ferroptosis via SIRT1-mediated FOXO1 deacetylation","authors":"Jialong Yang ,&nbsp;An Wang ,&nbsp;Zhengyang Qi ,&nbsp;Panshen Xu ,&nbsp;Hebin Pan ,&nbsp;Weilong Song ,&nbsp;Kaitao Wang ,&nbsp;Dingsheng Lin","doi":"10.1016/j.burns.2026.107872","DOIUrl":"10.1016/j.burns.2026.107872","url":null,"abstract":"<div><h3>Background</h3><div>Skin flap necrosis due to ischemia-reperfusion (I/R) injury remains a major obstacle in plastic and reconstructive surgery. Galangin (Gal) is a natural flavonoid with potent antioxidant and anti-inflammatory properties; its effect on ischemic flap necrosis remains unclear.</div></div><div><h3>Methods</h3><div>Network pharmacology and molecular docking were used to predict the interaction between Gal and SIRT1. In vitro, human umbilical vein endothelial cells were subjected to oxygen-glucose deprivation/reperfusion to simulate I/R injury, and subsequent assessments of cell viability and ferroptosis were performed. The SIRT1 inhibitor EX527 and the ferroptosis inhibitor Ferrostatin-1 were used to verify the ferroptosis-related mechanisms. In vivo, a modified McFarlane skin flap model was created in rats. Gal-treated groups were compared to a control group to evaluate flap survival, blood perfusion, histological changes, and the expression of key proteins in the SIRT1/FOXO1 pathway.</div></div><div><h3>Results</h3><div>In vitro, Gal protected HUVECs by suppressing ferroptosis. Mechanistically, Gal upregulated SIRT1, promoted FOXO1 deacetylation, increased expression of downstream proteins and inhibited lipid peroxidation. These protective effects were diminished by SIRT1 inhibition. In vivo, Gal treatment significantly increased flap survival area and blood perfusion in a dose-dependent manner. It also suppressed neutrophil infiltration, reduced MDA levels, increased SOD activity, and inhibited pro-inflammatory cytokines and activate anti-ferroptosis proteins.</div></div><div><h3>Conclusions</h3><div>Gal enhances skin flap survival by suppressing ferroptosis, oxidative stress, and inflammation via activation of the SIRT1/FOXO1 pathway.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107872"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the patient: A dyadic intervention paradigm for improved post-burn recovery outcomes","authors":"Jonathan Bayuo","doi":"10.1016/j.burns.2026.107868","DOIUrl":"10.1016/j.burns.2026.107868","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107868"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Characterization and analysis of the skin mycobiome in keloid: A case-control study","authors":"Yan-Yan Chen ,&nbsp;Yi-Fei Yang ,&nbsp;Yu-Yun Xiong,&nbsp;Hui Sun ,&nbsp;Yu-Mei Li","doi":"10.1016/j.burns.2026.107866","DOIUrl":"10.1016/j.burns.2026.107866","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107866"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Impact of hospital procedure volume on inpatient outcomes of burns covering 20–50 % of the total body surface receiving skin allograft: An analysis of the US Nationwide Inpatient Sample 2005–2020” [Burns 51(8) (2025) 107647]","authors":"Chao-Ming Wu","doi":"10.1016/j.burns.2025.107831","DOIUrl":"10.1016/j.burns.2025.107831","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107831"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146023640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burned for the likes: A comparative study of train surfing injuries, high-voltage trauma, and social media perspectives","authors":"Luzie Hofmann ,&nbsp;Aijia Cai ,&nbsp;Tabea Breckwoldt,&nbsp;Gregory Reid,&nbsp;Lukas Naef,&nbsp;Mauro Vasella,&nbsp;Jennifer A. Watson,&nbsp;Bong-Sung Kim","doi":"10.1016/j.burns.2025.107833","DOIUrl":"10.1016/j.burns.2025.107833","url":null,"abstract":"<div><h3>Background</h3><div>This study presents the clinical course of train surfing (TS) high-voltage (HV) injuries versus other HV burn victims (non-TS, NT) in Switzerland and explores the potential role of social media in promoting this risky behavior.</div></div><div><h3>Methods</h3><div>HV accidents involving unauthorized individuals on railroad tracks from 2016 to 2023 were retrospectively collected from the Federal Office of Transport (FOT) and the Swiss Transportation Safety Investigation Board (STSB). Additionally, clinical data of TS and NT patients treated at the University Hospital Zurich (USZ) Burn Center during 2016–2024 were retrospectively analyzed to compare injury severity, clinical course, and healthcare costs. An exploratory social media content analysis was also conducted to assess the potential influence of TS trends on TikTok and Instagram on the behavior’s popularity and perception.</div></div><div><h3>Results</h3><div>The FOT and STSB recorded 29 train-related HV accidents. 41 HV patients were treated at USZ, including 12 TS patients. TS were younger (43.6 vs. 20.3 years) and suffered more severe injuries (18.5 % vs. 44.3 % burned total body surface area, TBSA), higher rates secondary injuries (100 % vs. 31 %), longer ICU stays (48.5 vs. 13.2 days), and more complications (100 % vs. 58.6 %) than NT patients. As a result, rehabilitation time and hospitalization costs increased for TS (109 vs. 73 days and CHF 503 152 vs. CHF 174 307). Social media analysis revealed that TS-related content was popular and often glamorized the activity, with safety warnings frequently bypassed, potentially contributing to increased engagement in this risky behavior.</div></div><div><h3>Conclusion</h3><div>TS causes worse outcomes and higher medical costs compared to NT. Review of social media posts suggested that TS-related content achieved high visibility (measured by views, likes, and shares) and was often portrayed in an appealing or thrill-seeking manner, hence ‘glamorized’ the activity. This underscores the urgent need for targeted prevention and awareness efforts to reduce these avoidable injuries.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107833"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“A window of looking at the good, bad, and the stress:” A mixed-methods art therapy study with hospitalized adult burn patients","authors":"Bani Malhotra ,&nbsp;Linwood R. Haith Jr. ,&nbsp;Patricia A. Shewokis ,&nbsp;Johanna Czamanski-Cohen ,&nbsp;Minjung Shim ,&nbsp;Megan Stair-Buchmann ,&nbsp;Girija Kaimal","doi":"10.1016/j.burns.2025.107821","DOIUrl":"10.1016/j.burns.2025.107821","url":null,"abstract":"<div><h3>Background</h3><div>Improving psychosocial functioning in hospitalized burn survivors involves minimizing distress and pain and fostering emotion regulation. Art therapy could uniquely address the non-verbal aspects of distressing experiences, facilitating healthy emotional expression.</div></div><div><h3>Method</h3><div>This small N mixed-methods study examined the effect of 4-session art therapy intervention among 12 adult hospitalized burn patients on psychosocial outcomes of distress (Distress thermometer), affect (Positive and Negative Affect Schedule), change-perception (Patient Global Impression of Change), pain (Graphic Numeric Rating Scale), and self-expression and regulation (Self-Expression and Emotion Regulation in Art Therapy Scale, SERATS).</div></div><div><h3>Results</h3><div>Quantitative results using repeated ANOVA showed significant improvements in distress (F[1,9]=6.84, p = .028), positive affect (F[1,8]=5.5, p = 0.047), negative affect (F[1,8]=8.12, p = .022), and pain (F[1,9]=13.22, p = .005) across the four sessions. The global percentage change indicated positive trends in the outcomes. Changes did not reach statistical significance within-sessions. One-sample t-test showed a significant improvement in patients’ impression of change (t[10]=−4.183, two-sided p = .002) with mean responses approaching ‘much improved.’ Patients perceived art therapy as fostering emotional expression and regulation ‘often’ indicated by mean response scores approaching “4” for each item on SERATS. Thematic analysis elaborated on symptom management, expanded expression and perspective with art serving as tangible reminders, and creative engagement across sessions and with varied art media. Mixed-methods integration demonstrated congruent findings across art therapy sessions.</div></div><div><h3>Conclusion</h3><div>Art therapy can be a viable intervention to boost psychosocial health in hospitalized burn patients.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"52 2","pages":"Article 107821"},"PeriodicalIF":2.9,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145842457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}