Burns最新文献

{"title":"Dermatological diseases in conflict areas: A neglected crisis","authors":"Suela Këlliçi, Entela Puca, Monika Fida, Edmond Puca, Najada Çomo","doi":"10.1016/j.burns.2025.107447","DOIUrl":"10.1016/j.burns.2025.107447","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107447"},"PeriodicalIF":3.2,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coagulation abnormalities in major burn patients: Insights and future considerations","authors":"Amirhosein Kamrava , Shahab Aali","doi":"10.1016/j.burns.2025.107445","DOIUrl":"10.1016/j.burns.2025.107445","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107445"},"PeriodicalIF":3.2,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143642455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation and assessment of polylactic acid-curcumin nanofibrous wound dressing containing silver nanoparticles for burn wound treatment","authors":"Mehri Moayedi ,&nbsp;Tahmineh Ahmadi ,&nbsp;Vahid Nekouie ,&nbsp;Majid Taghian Dehaghani ,&nbsp;Shahrokh Shojaei ,&nbsp;Soheila Zamalui Benisi ,&nbsp;Hamid Reza Bakhsheshi-Rad","doi":"10.1016/j.burns.2025.107442","DOIUrl":"10.1016/j.burns.2025.107442","url":null,"abstract":"<div><div>This study aims to produce and evaluate nanofibrous wound dressings through the electrospinning method, utilizing polylactic acid (PLA), curcumin (Cur), and silver nanoparticles (AgNPs). For this purpose, five types of wound dressings with PLA, PLA+Cur, PLA+Cur+ 1 %AgNPs, PLA+Cur+ 2 %AgNPs and PLA+Cur+ 3 %AgNPs were produced using the electrospinning method. Analysis of the Fourier transform infrared spectroscopy and scanning electron microscopic observations indicated successful fabrication, with nanometer diameters achieved in all electrospun samples. Examination of water absorption of wound dressings revealed that over 40 h the electrospun samples had variable water absorption between 0 % and 0.25 %. The results of the curcumin release test over one week showed that the nanofibers with PLA+Cur+ 2 %AgNPs exhibited the lowest release rate, while those with PLA+Cur+ 3 %AgNPs showed the highest release. Assessment of mechanical properties revealed that the tensile strength of the nanofibers increased by adding curcumin to polylactic acid, while the addition of a high content of AgNPs led to a decrease in tensile strength. Also, the PLA+Cur dressing demonstrated 84.06 % and the PLA+Cur+ 3 %AgNPs dressing exhibited 99.12 % antibacterial properties. The cell culture test demonstrated that the incorporation of curcumin and AgNPs increasedboth the growth and proliferation, as well as the adhesion on the nanofibrous wound dressing. Thus, the PLA+Cur+ 1 %AgNPs nanofibrous scaffold, as a multipurpose dressing, presented considerable promise for wound healing and burn treatment.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107442"},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between platelet-to-lymphocyte ratio at admission and short-term mortality in severe burn patients: a meta-analysis","authors":"Zhuo Wang ,&nbsp;Zhengjun Cui ,&nbsp;Peisheng Wang","doi":"10.1016/j.burns.2025.107444","DOIUrl":"10.1016/j.burns.2025.107444","url":null,"abstract":"<div><h3>Background</h3><div>The platelet-to-lymphocyte ratio (PLR) reflects a pro-inflammatory state, which has been related to the severity and poor prognosis in severe burn patients. However, the results of the previous studies were not consistent. This meta-analysis aims to evaluate the relationship between PLR at admission and short-term mortality in severe burn injuries.</div></div><div><h3>Methods</h3><div>A comprehensive search was conducted in PubMed, Embase, Web of Science, Wanfang, and CNKI for studies published until September 9, 2024. Cohort studies assessing PLR and short-term mortality in severe burn patients were included. Mean difference (MD) for PLR between survivors and nonsurvivors of severe burn, and odds ratios (OR) for short-term mortality (during hospitalization or within 90 days) comparing between patients with a high versus a low PLR at admission were summarized.</div></div><div><h3>Results</h3><div>Eleven cohort studies with 4,515 patients were included. The analysis revealed that PLR at admission was significantly lower in survivors compared to nonsurvivors (MD: -14.17; 95% confidence interval [CI]: -28.01 to -0.34; p = 0.04). Subgroup analyses showed consistent findings across various demographics, including age, sex, total body surface area affected by burn, proportion of patients with inhalation injury, follow-up duration, and different study quality scores (p for subgroup difference all &gt; 0.05). Furthermore, a high PLR at admission was associated with an increased risk of short-term mortality (OR: 1.37; 95% CI: 1.16 to 1.63; p &lt; 0.001).</div></div><div><h3>Conclusions and recommendations</h3><div>A high PLR at admission is associated with an increased risk of short-term mortality in severe burn patients.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107444"},"PeriodicalIF":3.2,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143826103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: Burn rotations in general surgery residency","authors":"Barret J. Halgas,&nbsp;Jonathan B. Lundy,&nbsp;Leopoldo C. Cancio","doi":"10.1016/j.burns.2025.107430","DOIUrl":"10.1016/j.burns.2025.107430","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107430"},"PeriodicalIF":3.2,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of an electrospun bioveil is safe and does not decrease skin graft take on burn wounds: A randomised, controlled clinical trial","authors":"María Dolores Pérez-Del-Caz ,&nbsp;Nieves Vanaclocha ,&nbsp;Pilar Sepúlveda Sanchis ,&nbsp;María Blanes ,&nbsp;Bruno Marco ,&nbsp;Rafael Botella Estrada ,&nbsp;Eduardo García-Granero Ximénez ,&nbsp;Luís Sabater Ortí ,&nbsp;Aranzazu Pérez-Plaza","doi":"10.1016/j.burns.2025.107427","DOIUrl":"10.1016/j.burns.2025.107427","url":null,"abstract":"<div><h3>Introduction</h3><div>Split-thickness skin autografts are the gold standard for surgical treatment of burns. In preclinical studies, the use of SKINHEALTEX PLGA, an electrospun poly(lactic-co-glycolide) acid (PLGA) bioveil, placed between autografts and their bed has shown potential to stimulate dermal regeneration, increase graft take and improve scar quality. These properties have not yet been evaluated in human clinical trials.</div></div><div><h3>Objective</h3><div>The primary goal of this study was to evaluate tolerability and safety of SKINHEALTEX PLGA on human tissues, specifically, split-thickness skin autografts and wound beds of debrided burns.</div></div><div><h3>Materials and methods</h3><div>A double-blind randomised controlled clinical trial was conducted with adult patients with deep burns requiring surgical treatment, for 4 years (November 2018 to September 2022). Each patient acted as their own control, and they were followed for 12 months. In the control area a skin autograft was applied, while in the treatment area SKINHEALTEX PLGA was interposed between the autograft and the bed. The outcome variables were incidence of adverse events, the percentage of graft take (evaluated clinically), and Vancouver Scar Scale and Patient and Observer Scar Assesment Scale scores.</div></div><div><h3>Results</h3><div>The bioveil was well tolerated in the 26 patients that were recruited. No adverse events related to SKINHEALTEX PLGA were observed. No statistically significant differences were observed in split-thickness skin autograft take and subsequent scar quality between the control group (split-thickness skin autografts alone) and the autograft and SKINHEALTEX PLGA group.</div></div><div><h3>Conclusion</h3><div>This is the first clinical trial investigating the application of an electrospun biomaterial in the treatment of burns using skin autografts. SKINHEALTEX PLGA is a biocompatible and safe product that can be applied as an interface between autografts and the debrided bed of a burn without reducing graft take. Further research is needed to assess the value of SKINHEALTEX PLGA for burn wounds and its potential as an administration route of molecules than enhance dermal regeneration in burn patients.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107427"},"PeriodicalIF":3.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143508089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to: Cement burns among manual labourers in the UK: An urgent call for improved safety measures and education","authors":"Kevin Serror ,&nbsp;Alexandre Saiporn ,&nbsp;Lauren Ferrero ,&nbsp;Pr David Boccara ,&nbsp;Pr Marc Chaouat","doi":"10.1016/j.burns.2025.107429","DOIUrl":"10.1016/j.burns.2025.107429","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107429"},"PeriodicalIF":3.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143471232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the dressing matter in pediatric partial-thickness burns: a systematic review and meta-analysis","authors":"Milly S van de Warenburg ,&nbsp;Bente Teeuwen ,&nbsp;Stefan Hummelink ,&nbsp;Dietmar JO Ulrich ,&nbsp;Mariëlle LAW Vehmeijer-Heeman","doi":"10.1016/j.burns.2025.107428","DOIUrl":"10.1016/j.burns.2025.107428","url":null,"abstract":"<div><div>Superficial partial thickness burns typically receive nonoperative treatment, whereas deep partial thickness burns, which are prone to hypertrophic scarring, are usually managed through debridement followed by autologous split-thickness skin grafting. Various therapies have been developed to prevent wound infection and to enhance wound healing in pediatric partial-thickness burns. However, the choice of dressing by the surgeon can be influenced by various factors. It is worth noting that there is no standardized approach across all burn centers, leading to variations in care practices. To optimize pediatric patient care, a systematic review was conducted following PRISMA guidelines to review existing treatment options for partial thickness burns in children. Outcomes of interest were wound healing time, dressing changes, length of hospital stay, wound infections, need for grafting despite treatment, and hypertrophic scarring. A total of 68 studies with 8199 patients were included. The mean age of the included patients was 3.1 years, and the mean total body surface area of the burns was 15.6 %. Treatment groups included topical agents, bandages, skin analogues, or unclassified. Considering all treatment outcomes evaluated in this systematic review of the literature, non-silver dressings and skin analogues may have some benefit over topical agents in terms of wound healing time, length of hospital stay, hypertrophic scarring, pain management, and cost saving. Dressing changes, wound infections, and need for grafting did not significantly change between various treatments.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107428"},"PeriodicalIF":3.2,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of silk dressings in the treatment of skin injuries: A systematic review","authors":"Leen Vermoesen ,&nbsp;Ignace De Decker ,&nbsp;Jozef Verbelen ,&nbsp;Henk Hoeksema ,&nbsp;Kimberly De Mey ,&nbsp;Petra De Coninck ,&nbsp;Julie van Durme ,&nbsp;Nathalie Roche ,&nbsp;Stan Monstrey ,&nbsp;Karel E.Y. Claes","doi":"10.1016/j.burns.2025.107426","DOIUrl":"10.1016/j.burns.2025.107426","url":null,"abstract":"<div><h3>Background</h3><div>Skin injuries like superficial burns and skin graft donor sites are currently managed using various dressings. Frequent challenges include discomfort and trauma during dressing changes, suboptimal healing and significant scarring. Silk dressings show promise by reducing the need for frequent changes, allowing wound evaluation due to its transparency, exerting antibacterial properties, and minimizing scarring. However, silk is not yet widely adopted in clinical settings.</div></div><div><h3>Methods</h3><div>A systematic review was conducted. A search through 3 databases (PubMed, Embase, Cochrane Library) according to the PRISMA guidelines was performed. Only RCTs, cohort studies, case-control studies and case series were included. Appropriate quality tests were performed.</div></div><div><h3>Results</h3><div>1373 search results were identified. After deduplication, 979 were screened by title and abstract, of which 20 full-text articles remained and ultimately, 9 articles were included. Parameters examined were: healing duration, pain, subjective and objective skin measurements, adverse events, infection rates, transparency and price.</div></div><div><h3>Conclusion</h3><div>Silk dressings demonstrate comparable efficacy to existing dressings concerning transparency, healing time, pain, erythema, pigmentation, water loss normalization, firmness, visco-elasticity recovery, microcirculation, adverse events and infection rates. They are an economically interesting alternative for managing superficial partial-thickness skin burns and skin graft donor sites. Nonetheless, larger high-quality studies are needed to confirm these findings.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107426"},"PeriodicalIF":3.2,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do allografts present a risk to burn patients? Allografts and HLA-sensitization","authors":"Joshua Tsai ,&nbsp;Luka Kim ,&nbsp;Isabel Jones ,&nbsp;Samuel Culbert ,&nbsp;Tuna Ozyurekoglu","doi":"10.1016/j.burns.2025.107424","DOIUrl":"10.1016/j.burns.2025.107424","url":null,"abstract":"<div><h3>Objective</h3><div>This meta-analysis aimed to quantify sensitization rates following allograft usage and determine whether allografts have an increased risk of long-term sensitization compared to alternative therapies in burn patients.</div></div><div><h3>Methods</h3><div>Systematic review, meta-analysis and meta-regression of post-operative sensitization in burn patients were performed following Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidance (Prospero registration: CRD42024497137). Database searches were conducted on MEDLINE, Embase, CENTRAL using ProQuest Dialog.</div><div>We included all studies reporting post-operative sensitization in burn patients that were not case series or singular case reports. Meta-analysis was used to compare the risk of sensitization for allograft versus alternative therapies.</div></div><div><h3>Results</h3><div>Six studies (Allograft Patients: 71; Non-Allograft Patients: 95) were included (n = 166). Overall, 73 % (CI: 39 %-92 %) of burn patients were sensitized following allograft. Patients receiving allograft were at a significantly increased risk of sensitization (OR 13.14 [95 % CI: 1.32–131.00]). However, on sub-group analysis, when directly comparing patients who received allograft and transfusion versus those who received transfusion alone, there was not a significantly increased risk of sensitization (OR 7.68 [95 % CI:.61–95.86]).</div></div><div><h3>Conclusion</h3><div>Allograft is associated with a significantly increased risk of sensitization in burn patients. However, it is not clear whether burn patients already receiving transfusion will have an increased risk of sensitization from adding allograft. Further studies are required to demonstrate the multifactorial causes of sensitization within the burned population to explain the significance of the contribution from allograft and/or transfusion reported within the literature. Clinicians must carefully weigh the immediate benefits of allografts against the potential long-term challenges of sensitization, especially where alternative wound therapies are possible.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107424"},"PeriodicalIF":3.2,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}