Burns最新文献

{"title":"In vivo evaluation of bioactive glass-reinforced multifunctional composite hydrogel for thermal burn and chronic diabetic wound repair","authors":"Sarika Tomar ,&nbsp;Priyanka Surya ,&nbsp;Rakesh Pandey ,&nbsp;Soumyata Pathak ,&nbsp;Rashi Mathur ,&nbsp;Sweta Singh","doi":"10.1016/j.burns.2025.107618","DOIUrl":"10.1016/j.burns.2025.107618","url":null,"abstract":"<div><h3>Background</h3><div>Thermal burn injuries and chronic diabetic wounds pose a vast array of pathophysiological problems (low angiogenicity, persistent inflammation, bacterial infection, tissue necrosis) that contribute to delayed healing and poor regeneration as compared to normal wounds. Multifunctional hydrogels have recently gained immense popularity and become viable choices for chronic wound management because of their versatile functionality, like tunable properties, high biocompatibility, soft and moist microenvironment and mimicking natural tissue surrounding properties.</div></div><div><h3>Methods</h3><div>We first fabricated a multifunctional composite hydrogel (MCH) consisting of 5 % gelatin, 1 % chitosan, 100 ng/ml Cur-capped silver nanoparticles, and 1.5 % PDA-coated bioactive glass and evaluated its wound healing potential in burn and chronic diabetic wounds in BALB/c mice. The reduction in wound area was assessed at various time intervals. Also, structural changes and cellular responses were evaluated using H &amp; E staining and Masson Trichrome staining. The gene expression of <em>VEGFA, COL1A1, IL-6, IL-10,</em> and <em>TGF-β1</em> was evaluated using RT-PCR of tissue samples extracted from the healed area.</div></div><div><h3>Results</h3><div>The <em>in vivo</em> wound healing assessment in thermal burn wounds and diabetic wounds showed a significant reduction in wound area (up to 87 % and 80 % respectively) on day 14 in the wounds treated with MCH. These histological and molecular studies confirmed that the presence of bioactive glass in MCH aids in the polarization of macrophages from M1 to M2 phenotype, released Si ions induce blood vessel formation, and collagen deposition and the presence of Cur-AgNPs effectively reduces inflammation and induces collagen deposition in treated groups as compared to control groups.</div></div><div><h3>Conclusion</h3><div>The incorporation of PDA-coated BG endows the adhesivity and angiogenic and Cur-AgNPs provided antibacterial and anti-inflammatory/antioxidative propertied to hydrogel, to regulate the wound microenvironment at cellular and molecular levels render a vital paradigm to facilitate and accelerate the repair and regeneration of burn and chronic diabetic wounds.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107618"},"PeriodicalIF":2.9,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the utility of ΔpCO₂ and ScvO₂ in severe burns","authors":"Khadijeh Saravani,&nbsp;Seyed Mehdi Pourafzali,&nbsp;Ali Alimohammadi","doi":"10.1016/j.burns.2025.107666","DOIUrl":"10.1016/j.burns.2025.107666","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107666"},"PeriodicalIF":2.9,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor on \"Stress perception in burns patients: A cross-sectional study\" by ShuaiJie Guo, YuLin You, HuiYi Tan [Burns 51 (2025) 107528]","authors":"Zakiyeh Jafaryparvar","doi":"10.1016/j.burns.2025.107661","DOIUrl":"10.1016/j.burns.2025.107661","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107661"},"PeriodicalIF":2.9,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal links between programmed cell death and hypertrophic scars: Integrative analysis of multi-omics Mendelian randomization and preliminary experimental validation","authors":"Yushen Zhang,&nbsp;Chenyuyao Zhao,&nbsp;Ran Zhao","doi":"10.1016/j.burns.2025.107667","DOIUrl":"10.1016/j.burns.2025.107667","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to explore the causal relationship between programmed cell death (PCD) genes and the formation of hypertrophic scars (HS) using integrative multi-omics analysis (including DNA methylation, gene expression, and protein abundance) alongside preliminary experimental validation.</div></div><div><h3>Methods</h3><div>We leveraged publicly available databases (eQTL Gen, UKB-PPP, and FinnGen) to obtain quantitative trait loci (QTLs) data of DNA methylation, gene expression and protein abundance. We employed Mendelian randomization (MR) approaches to uncover causal relationships and validate robustness. The methods used included inverse variance weighted (IVW) analysis, false discovery rate (FDR), Cochran's Q test, I² statistic, MR-Egger regression, MR-PRESSO, leave-one-out method, co-localization analysis, and Steiger filtering test. Then, the multi-omic MR results were integrated and three tiers of genes were identified. Further, the tier 1 genes were chosen to perform drug prediction in DSigDB and molecular docking analyses with Autodock Vina. Lastly, the effects of the selected genes and drugs in HS were validated at both the tissue and cellular levels.</div></div><div><h3>Results</h3><div>Through integrating multi-omics data, we identified one tier 1 gene (GLB1), twelve tier 2 genes (including DAPK2, AP4E1, ARSA, CTSF, MSH6, NEDD4, PDK1, PELI3, RB1, UNC13D, CTSC, and GZMB), and two tier 3 genes (NOS3 and ITGA6), all of which show varying associations with HS. Particularly, the GLB1(cg05120113) was causal associated with HS risk in DNA methylation (OR=1.0972, 95 % CI: 1.0532–1.1430, FDR=0.0163), gene expression (OR=1.2923, 95 % CI: 1.1816–1.4135, FDR&lt;0.001) and protein abundance (OR=1.5430, 95 % CI: 1.3296–1.7905, FDR&lt;0.001). The candidate drugs for GLB1 included Fulvestrant (adjusted <em>P</em> = 0.046, Affinity=-8.8 kcal/mol) and Cyperquat (adjusted <em>P</em> = 0.036, Affinity=-6.2 kcal/mol). Further, the GLB1 expression and inhibitory effect of Fulvestrant were validated in HS tissues and HSFs. Additionally, significant changes in the mRNA and protein expression levels of fibrosis-related markers, including TGF-β1 and α-SMA, were observed in HSFs.</div></div><div><h3>Findings</h3><div>This study provides robust evidence for the causal involvement of PCD genes in HS formation and identified GLB1 along with 14 other potential genes. Fulvestrant demonstrated therapeutic potential for HS by modulating fibrosis-related pathways in fibroblasts.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107667"},"PeriodicalIF":2.9,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility, reliability, and clinical utility of skeletal muscle assessment with A-mode ultrasonography in hospitalized patients with burns","authors":"Frederiek G. Bosch ,&nbsp;Harriët Jager-Wittenaar ,&nbsp;Gretha C. Wesseling-Keuning ,&nbsp;Jakob Hiddingh ,&nbsp;Hans J. Eshuis ,&nbsp;Cees P. van der Schans ,&nbsp;Anuschka S. Niemeijer ,&nbsp;Marianne K. Nieuwenhuis","doi":"10.1016/j.burns.2025.107673","DOIUrl":"10.1016/j.burns.2025.107673","url":null,"abstract":"<div><h3>Objectives</h3><div>Amplitude-mode (A-mode) ultrasonography is a promising technique to monitor loss and recovery of skeletal muscle in patients with burns. However, its clinimetric properties are unknown. Therefore, we determined its feasibility, interrater, and intrarater reliability, and clinical utility.</div></div><div><h3>Methods</h3><div>Skeletal muscle thickness of upper arms and legs was assessed longitudinally in hospitalized adult patients with ≥ 5 % total body surface area (TBSA) burns, by pairs of two out of five raters. Feasibility was evaluated by % successful assessments, reliability by intra-class correlation coefficients (ICCs), and clinical utility by smallest detectable change (SDC).</div></div><div><h3>Results</h3><div>Thirty-four patients participated (77 % male; mean age 48 ± 17 y, median TBSA burned 12 % [IQR 7–19]). Images were acquired on 69 % of planned occasions, and 89 % of images could be analyzed. Overall interrater ICCs were ≥ 0.84 (for pairs: 0.63–0.99) and intrarater ICCs were ≥ 0.95 (for pairs: 0.45–0.99). The overall interrater SDC was ≤ 33 % of the measured mean (for pairs: 3–52 %), while intrarater SDC was ≤ 20 % (for pairs: 3–48 %). All five raters could measure legs with moderate to excellent reliability, whereas for arms some demonstrated poor reliability.</div></div><div><h3>Conclusion</h3><div>A-mode ultrasonography assessment of skeletal muscle in patients with burns is feasible. However, reliability and clinical utility are rater-dependent; therefore we recommend assessments by the same rater.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107673"},"PeriodicalIF":2.9,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An insight into the dynamic changes of myokines in burn patients undergoing physiotherapy","authors":"Maryamalsadat Sanjari,&nbsp;Fatemeh Davoodi Salestani,&nbsp;Amir Davoodi Salestani","doi":"10.1016/j.burns.2025.107660","DOIUrl":"10.1016/j.burns.2025.107660","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107660"},"PeriodicalIF":2.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144886952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of peripherally inserted central catheters and central venous catheters in burn patients: a retrospective cohort study","authors":"Jingyuan Lang,&nbsp;Yangping Wang,&nbsp;Qimeng Li,&nbsp;Zhiqiang Yuan,&nbsp;Gaoxing Luo,&nbsp;Haisheng Li","doi":"10.1016/j.burns.2025.107670","DOIUrl":"10.1016/j.burns.2025.107670","url":null,"abstract":"<div><h3>Background</h3><div>Central venous access devices, including peripherally inserted central catheters (PICCs) and central venous catheters (CVCs), are common treatment measures in burn patients. However, how to choose between PICCs and CVCs remains unclear. This study compared the clinical outcomes of CVCs and PICCs in burn patients.</div></div><div><h3>Methods</h3><div>This retrospective cohort study was performed in a major burn center in southwest China with 1500 burn patients admitted per year. All the burn patients receiving PICCs or CVCs were included. Catheter-related venous thrombosis (CRT), catheter-related infection (CRI), and infection profiles were analyzed.</div></div><div><h3>Results</h3><div>A total of 642 CVCs and 111 PICCs in 255 burn patients were included. The incidence of CRT in CVCs and PICCs were similar (CVCs: 4.7 % vs. PICCs: 5.4 %, p = 0.738). CVCs had higher incidence of catheter colonization (CVCs: 39.9 %, 42.4 per 1000 catheter-days vs. PICCs: 7.2 %, 2.86 per 1000 catheter-days, p &lt; 0.001) and of catheter-related blood stream infection (CRBSI) (CVCs: 14.5 %, 15.43 per 1000 catheter-days vs. PICCs: 0.9 %, 0.36 per 1000 catheter-days, p &lt; 0.001). Subgroup analyses stratified by total burn area, age, Baux score, pulmonary infection, shock, total parenteral nutrition, in-bed days, and operation times confirmed PICCs had similar CRT rate and lower CRI rate. CVCs were predominantly colonized by A. baumannii (32 %), P. aeruginosa (19.2 %) and S. aureus (18.3 %), and PICCs were mainly colonized by P. aeruginosa (40 %) and S. aureus (30 %). 77 % of colonizing bacteria of CVCs were multiple-drug resistant (MDR), and 80 % of colonizing bacteria of PICCs were MDR. There were no significant differences in CRIs among CVCs through femoral, internal jugular and subclavian veins. Internal jugular CVCs had significantly higher CRT rate than did femoral CVCs (10.0 % vs. 3.9 %, p = 0.021).</div></div><div><h3>Conclusion</h3><div>PICCs had a lower risk of catheter-related infection and a similar rate of catheter-related thrombosis than CVCs, particularly femoral CVCs. Multicenter randomized clinical trials are needed to validate these findings in the future.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107670"},"PeriodicalIF":2.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Public health risks of steam burns - Reflection on “Paediatric steam burns in New South Wales, Australia: A 14-year retrospective study”","authors":"Chongjia Luo","doi":"10.1016/j.burns.2025.107663","DOIUrl":"10.1016/j.burns.2025.107663","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107663"},"PeriodicalIF":2.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145048601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Control of invasive Pseudomonas burn wound infection with mafenide acetate electrospun wound dressing","authors":"Mia Mae Kiamco,&nbsp;Eliza A. Sebastian,&nbsp;S.L. Rajasekhar Karna,&nbsp;Andrea B. Fourcaudot,&nbsp;Ping Chen,&nbsp;David T. Silliman,&nbsp;Joseph R. Wolf,&nbsp;Johnathan J. Abercrombie,&nbsp;Kai P. Leung","doi":"10.1016/j.burns.2025.107674","DOIUrl":"10.1016/j.burns.2025.107674","url":null,"abstract":"<div><div>Invasive wound infections are a leading cause of mortality in burn patients. <em>Pseudomonas aeruginosa</em> is among the most prevalent organisms associated with invasive burn wound infections. It is most effectively prevented by Sulfamylon® cream. The active compound, mafenide acetate, enters the wound rapidly and achieves the local concentration of 2- to 5- fold above the minimal inhibitory concentration for <em>P. aeruginosa</em> at 1–2 hrs. However, within 8–10 hrs, the mafenide acetate concentration rapidly declines to subinhibitory concentrations, and the treatment needs to be reapplied. In this study, we described the development of an electrospun burn wound dressing that could sustain the treatment effect by continuously releasing mafenide acetate at therapeutic concentrations into burn wounds for ≥ 24 hrs. We demonstrated by scanning electron microscopy that the mafenide acetate electrospun wound dressing consisted of smooth and uniform fibers. The extent and rate of mafenide acetate release from the dressing were determined <em>in vitro</em> using drug release and skin permeation tests and <em>in vivo</em> using a rat burn model. Finally, the mafenide acetate electrospun wound dressing’s antimicrobial activity <em>in vitro</em> and its capability to control invasive <em>Pseudomonas</em> infection <em>in vivo</em> was determined using a modified AATCC 100 test and the modified Walker-Mason scalded rat burn model, respectively.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107674"},"PeriodicalIF":2.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145049906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baicalin promotes the survival of flaps by downregulating the JAK2-STAT3 signaling pathway","authors":"Jiapeng Deng,&nbsp;An Wang,&nbsp;Jialong Yang,&nbsp;Kaitao Wang,&nbsp;Dingsheng Lin","doi":"10.1016/j.burns.2025.107671","DOIUrl":"10.1016/j.burns.2025.107671","url":null,"abstract":"<div><h3>Background</h3><div>Skin flaps are commonly employed in wound reconstruction and plastic surgery, yet frequently develop distal necrosis post-transplantation. Baicalin, a principal bioactive compound derived from the traditional Chinese medicinal herb <em>Scutellaria baicalensis Georgi</em>, has not been systematically investigated for its potential to enhance flap viability.</div></div><div><h3>Materials and methods</h3><div>Firstly, this study used bioinformatics analysis to identify potential regulatory targets and signaling pathways involved in flap ischemia-reperfusion (I/R) injury. Secondly, a McFarlane random flap model (3 × 9 cm) was established on the back of rats to evaluate the effects of different doses of baicalin (60 mg/kg and 120 mg/kg, oral gavage) and JAK2-STAT3 inhibitor AG490 (1 mg/kg, intraperitoneal injection) on the random flap necrosis rate. Finally, on the 7th day after surgery, skin flap tissue was collected to evaluate the effects of baicalin on blood perfusion, neovascularization, histopathological changes, oxidative stress markers (SOD and MDA), JAK2-STAT3 signaling pathway, and apoptosis related protein (Bcl-2 and BAX) expression levels.</div></div><div><h3>Results</h3><div>Bioinformatics analysis shows that during the stages of tissue ischemia and reperfusion, signaling pathways such as VEGF, cytokines, JAK2-STAT3, and apoptosis play important regulatory roles. In the rat random flap model, research has found that baicalin reduces the rate of flap necrosis in a dose-dependent manner. The mechanism of action includes increasing blood flow perfusion and angiogenesis, reducing I/R injury, and inhibiting the inflammatory response by inhibiting the JAK2-STAT3 signaling pathway.</div></div><div><h3>Conclusions</h3><div>This study confirms that baicalin can promote the survival of random flaps and reveals the mechanism.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107671"},"PeriodicalIF":2.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145049909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}