Burns最新文献

{"title":"Letter to the Editor in response to “Does the dressing matter in pediatric partial-thickness burns?” Less is more: Rethinking dressing change frequency in pediatric burns through the lens of eco-design","authors":"Cyril Pernod, Erwan D’aranda, Anne-Claire Lukaszewicz, Jane Muret","doi":"10.1016/j.burns.2025.107664","DOIUrl":"10.1016/j.burns.2025.107664","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107664"},"PeriodicalIF":2.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Background pain, procedural pain and optimism are associated with pain post-discharge in burn survivors: A prospective cohort study","authors":"Chloe C. Balland ,&nbsp;Nancy E.E. Van Loey ,&nbsp;Helma W.C. Hofland ,&nbsp;Berno van Meijel ,&nbsp;Alette E.E. de Jong","doi":"10.1016/j.burns.2025.107669","DOIUrl":"10.1016/j.burns.2025.107669","url":null,"abstract":"<div><div>Pain following burn injuries can be severe and may persist after hospital discharge. The experience of pain is influenced by multiple biological and psychosocial factors. Post-discharge pain may be related to pain experienced during hospitalization as well as anxiety associated with these pain experiences. There are also protective factors; one notable example is optimism. However, the role of optimism in burn-related pain has not yet been investigated. This study aimed to describe the extent of pain measured over 14 consecutive days post-discharge and to examine its relationship with background pain, procedural pain, pain-related anxiety, and optimism. This multi-center longitudinal cohort study was conducted in five burns centres. The results showed that 50 % of the patients had a pain score ≥ 2 on a 0 – 10 scale after discharge, which on average decreased further over the next 14 days. However, a subgroup of patients maintained elevated pain levels. Patients with higher pain scores post-discharge were more likely to have experienced higher levels of background pain and procedural pain in-hospital and they scored lower on optimism. Pain-related anxiety did not independently contribute to pain post-discharge. The results indicate that patients with high pain scores during hospital admission may need specific attention regarding pain management when they leave the hospital. Furthermore, patients may benefit from optimism-inducing interventions in the hospital and thereafter.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107669"},"PeriodicalIF":2.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145049905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing burn mortality prediction: Reflections on the BoBS score and future directions for global application","authors":"Xiangqian Zhang,&nbsp;Nina Wang,&nbsp;Hanyang Su","doi":"10.1016/j.burns.2025.107662","DOIUrl":"10.1016/j.burns.2025.107662","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107662"},"PeriodicalIF":2.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plant-derived extracts in chronic wound management: Therapeutic promise and translational challenges","authors":"Weiping Cao ,&nbsp;Xia Ni ,&nbsp;Hui Sun,&nbsp;Mengtao Xing","doi":"10.1016/j.burns.2025.107665","DOIUrl":"10.1016/j.burns.2025.107665","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107665"},"PeriodicalIF":2.9,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ADSC-derived exosome-loaded in-situ photocrosslinkable GelMA hydrogels as a treatment strategy for wound healing","authors":"Jinli Zhang ,&nbsp;Changling Liu ,&nbsp;Xiaona Xie ,&nbsp;Yiping Hu ,&nbsp;Xiaojian Li ,&nbsp;Zhi Zhang","doi":"10.1016/j.burns.2025.107668","DOIUrl":"10.1016/j.burns.2025.107668","url":null,"abstract":"<div><h3>Background</h3><div>Adipose-derived mesenchymal stem cell exosomes (ADSC-Exos) show great promise in wound healing and cutaneous regeneration, but their therapeutic efficacy is limited by rapid systemic clearance, preventing sustained local action at the wound site. Gelatin methacryloyl (GelMA) is a photocrosslinking hydrogel with good biocompatibility and tunable mechanical properties. This study aimed to investigate the effects of GelMA hydrogels loaded with ADSC-Exos (GelMA/ADSC-Exos hydrogels) on the wound healing of full-thickness skin defects.</div></div><div><h3>Methods</h3><div>GelMA/ADSC-Exos hydrogels were prepared, and their physical and sustained-release properties were investigated. To assess the effect of GelMA/ADSC-Exos hydrogels on angiogenesis in vitro, the abilities of proliferation, migration, and tube formation of on human umbilical vein endothelial cells (HUVECs) cultured on GelMA/ADSC-Exos hydrogels were assayed. The effect of GelMA/ADSC-Exo hydrogels on wound healing was assessed using a mouse full-thickness excisional skin wound model. To elucidate the underlying mechanism, RNA sequencing was performed, and the effect of GelMA/ADSC-Exo hydrogels on the activity of macrophages was confirmed in vitro.</div></div><div><h3>Results</h3><div>The composite GelMA/ADSC-Exo hydrogels exhibited desirable mechanical and sustained release properties. They accelerated HUVEC proliferation, adhesion, and tube formation, as well as promoted wound healing in mice with full-thickness skin defects. Further studies showed that these hydrogels promoted macrophage M2 polarization and inhibited the activation of the TLR4/NF-κB pathway.</div></div><div><h3>Conclusions</h3><div>The GelMA/ADSC-Exo hydrogels could serve as a promising therapeutic strategy for wound healing.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107668"},"PeriodicalIF":2.9,"publicationDate":"2025-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145041838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A contractility-competent immortalized human sweat gland myoepithelial line with dual epithelial-mesenchymal characteristics","authors":"LiangLiang Liu ,&nbsp;TongHao Yao ,&nbsp;SiYuan Ren ,&nbsp;JingXin Liu ,&nbsp;Ning Li","doi":"10.1016/j.burns.2025.107659","DOIUrl":"10.1016/j.burns.2025.107659","url":null,"abstract":"<div><h3>Objective</h3><div>To isolate and culture primary human eccrine sweat gland myoepithelial cells (MECs) and establish novel immortalized myoepithelial cells (iMECs), thereby providing essential materials for sweat gland biology research.</div></div><div><h3>Methods</h3><div>Sweat gland secretory coils were microdissected from upper eyelid skin specimens obtained post-blepharoplasty. MECs were isolated through differential trypsinization combined with adhesion-based purification. Lentiviral vectors encoding SV40T were used to generate iMECs, with stable clones selected via Blasticidin resistance. Comprehensive characterization encompassed proliferation kinetics assessed through CCK-8 and EdU assays, immortalization validation via RT-PCR detection of SV40T expression, genetic authentication using Short tandem repeat (STR) profiling and karyotyping, phenotypic analysis through immunofluorescence staining for CK7, CK19, α-SMA, and Vimentin markers, and ultrastructural evaluation by transmission electron microscopy.</div></div><div><h3>Results</h3><div>Both MECs and iMECs exhibited a mesenchymal-like spindle morphology. iMECs demonstrated superior proliferative capacity, sustaining 50 passages with 2-fold higher EdU incorporation versus primary MECs (P &lt; 0.0001). Genetic authentication confirmed stable diploid karyotype (46, XX) and unique STR profile, excluding cross-contamination with existing cell lines. Phenotypic characterization revealed persistent co-expression of epithelial (CK7/CK19) and mesenchymal (α-SMA/Vimentin) markers in iMECs across passages, while maintaining negative expression for CEACAM5, CK14, CK17, and P63. Ultrastructural analysis validated the preservation of contractile myofilaments and intercellular junction complexes (desmosomes/zonula adherens) through transmission electron microscopy (TEM).</div></div><div><h3>Conclusion</h3><div>We demonstrate a reproducible methodology for isolating functionally competent MECs and establishing a phenotypically stable immortalized sweat gland myoepithelial line. The iMECs retain native biomarker profiles and ultrastructural features while overcoming primary cell senescence limitations, providing a transformative resource for glandular regeneration studies and sweat secretion pathophysiology modeling.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107659"},"PeriodicalIF":2.9,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bupivacaine hydrochloride-soaked dressings versus subcutaneous infiltration for postoperative analgesia in skin graft donor sites","authors":"Mohamed Sabry ,&nbsp;Mohab Abdelhalim Elsayed ,&nbsp;Shadwa Rabea Mohamed","doi":"10.1016/j.burns.2025.107658","DOIUrl":"10.1016/j.burns.2025.107658","url":null,"abstract":"<div><h3>Background</h3><div>Skin grafting is associated with postoperative pain. Bupivacaine hydrochloride, a local anesthetic, has been studied for its effectiveness in providing analgesia for donor sites following skin grafting. This study aimed to compare the efficacy of bupivacaine hydrochloride-soaked dressings with subcutaneous infiltration for managing postoperative donor site pain in patients undergoing skin grafting procedures.</div></div><div><h3>Patient and methods</h3><div>This randomized, controlled, double-blinded prospective study included 90 patients. The study participants were divided into three equal groups: Group A (bupivacaine-soaked dressing), Group B (subcutaneous infiltration), and Group C (control received conventional dressing without any adjuvants). Pain scores, ketorolac analgesia, and fentanyl requirements were recorded.</div></div><div><h3>Results</h3><div>Both Group A and Group B exhibited significantly lower postoperative pain scores compared to Group C (<em>p</em> &lt; 0.01). The time to first analgesic request was significantly prolonged in Groups A and B relative to Group C (<em>p</em> &lt; 0.0001). Furthermore, the frequency of analgesic use was markedly reduced: 80.0 % of patients in Group A and 66.7 % in Group B required ketorolac only 1–2 times, whereas 96.7 % of patients in Group C required it more than twice (<em>p</em> &lt; 0.0001). Fentanyl supplementation was rarely needed in Group A (0 %) and infrequent in Group B (6.7 %), compared to 46.7 % in Group C (<em>p</em> &lt; 0.0001).</div></div><div><h3>Conclusion</h3><div>The application of bupivacaine hydrochloride, whether administered via soaked dressings or local infiltration, demonstrates a significant postoperative analgesic effect. Applying bupivacaine-soaked dressing is recommended for ease of use and lack of requirement for specialized equipment or preparation.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107658"},"PeriodicalIF":2.9,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor regarding “Laser micropatterned dermal templates support early rete ridge formation and basement membrane deposition when used with cultured epithelial autografts”","authors":"Parth Aphale ,&nbsp;Himanshu Shekhar ,&nbsp;Shashank Dokania","doi":"10.1016/j.burns.2025.107656","DOIUrl":"10.1016/j.burns.2025.107656","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107656"},"PeriodicalIF":2.9,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144896649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating ΔpCO₂ into burn resuscitation strategies: Challenges and opportunities","authors":"Xiangqian Zhang,&nbsp;Hanyang Su","doi":"10.1016/j.burns.2025.107657","DOIUrl":"10.1016/j.burns.2025.107657","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107657"},"PeriodicalIF":2.9,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144866213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep disorder increases risk of psychiatric disorder in burn survivors","authors":"Jasmine Chaij ,&nbsp;George Golovko ,&nbsp;Juquan Song ,&nbsp;Steven E. Wolf ,&nbsp;Amina El Ayadi","doi":"10.1016/j.burns.2025.107654","DOIUrl":"10.1016/j.burns.2025.107654","url":null,"abstract":"<div><h3>Introduction</h3><div>Sleep plays a crucial role in the post-burn period, yet the relationship between sleep disturbances and psychological disorders following burn remains largely unexplored. We aimed to investigate this association and elucidate the role of sleep in the development of psychological disorders after burn injury.</div></div><div><h3>Methods</h3><div>Using the TriNetX database, a large, federated research network of de-identified patient data, we identified patients with burns and compared those who developed a first-time sleep disorder post-injury and those who did not. Cohorts were propensity-matched by age, gender, race, ethnicity, and total body surface area burned (TBSA). We evaluated new incidences of 26 psychological disorders, excluding patients with pre-existing mental disorders.</div></div><div><h3>Results</h3><div>9.54 % of patients developed a first-time sleep disorder post-burn injury, with this group being older (43.9 ± 21.3 vs 30.2 ± 22.3, p &lt; 0.001), predominately female (49.3 % vs. 45.4 %, p &lt; 0.001), and more likely to be White (65.4 % vs. 53.9 %, p &lt; 0.001). They exhibited a significantly increased risk of new psychological diagnoses such as eating disorders, 5.88 times higher, 95 % CI [4.85, 7.13] and obsessive-compulsive disorder, 3.77 times higher, 95 % CI [3.15, 4.52]. Anxiety-related disorders were also three times more likely in those with a new sleep disorder after burn (p &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>The emergence of new psychological diagnoses after burn is strongly associated with the onset of sleep disorders. These findings underscore the importance of closely monitoring sleep patterns in burn survivors, implementing environmental changes, and providing tailored treatment to optimize long-term outcomes.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 9","pages":"Article 107654"},"PeriodicalIF":2.9,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145049908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}