Burns最新文献

{"title":"CD147 inhibition reduced fibronectin expression in TGF-β1-induced keloid fibroblasts by targeting Smad2 signaling pathway","authors":"Jian-Sheng Diao ,&nbsp;Hui-Cong Du ,&nbsp;Juan Wu ,&nbsp;Xin-Nan Han ,&nbsp;Meng-Lu Wu ,&nbsp;Rong-Guang Lai ,&nbsp;Md Atiqur Rahman ,&nbsp;Mao-Guo Shu","doi":"10.1016/j.burns.2025.107472","DOIUrl":"10.1016/j.burns.2025.107472","url":null,"abstract":"<div><h3>Background</h3><div>CD147 is closely involved in the progression of fibrosis and tumor formation in various tissues, however, its role in keloid formation remains unknown. In this study, we investigate the expression of CD147 in keloids and explore its functional roles.</div></div><div><h3>Methods</h3><div>CD147 expression in human keloid tissues was assessed using immunohistopathology and western blot analysis. Human keloid fibroblasts (KFs) were cultured and treated with TGF-β1 alone or in combination with the CD147 inhibitor AC-73. Western blot and immunofluorescence were employed to examine CD147 and fibronectin expression levels in KFs post-treatment. Additionally, the effect of CD147 inhibitor on Smad2 phosphorylation and fibronectin protein levels in TGF-β1-induced KFs was evaluated by western blot. Finally, a keloid-bearing nude mouse model was established to investigate the therapeutic effect of AC-73 in vivo.</div></div><div><h3>Results</h3><div>CD147 expression was significantly higher in keloid tissues compared to normal skin. TGF-β1 treatment upregulated CD147 and fibronectin expressions in cultured KFs. Inhibition of CD147 with AC-73 reduced the expression levels of both CD147 and fibronectin in KFs. Additionally, AC-73 markedly attenuated TGF-β1-induced fibronectin expression and suppressed Smad2 phosphorylation. In the nude mouse model, AC-73 significantly reduced the gross weight of xenotransplanted keloid tissues.</div></div><div><h3>Conclusion</h3><div>These findings suggest that CD147 is closely involved in keloid progression. Inhibition of CD147 downregulates TGF-β1-induced fibronectin expression in KFs by targeting Smad2 signaling pathway. Thus, CD147 may serve as a promising therapeutic target for keloid treatment.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107472"},"PeriodicalIF":3.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Redefining the concept of the elderly burn patient: Analysis of a multicentre international dataset","authors":"Nina C. Dempsey ,&nbsp;Kayvan Shokrollahi ,&nbsp;Laura Cappuyns ,&nbsp;Ascanio Tridente ,&nbsp;Daren K. Heyland","doi":"10.1016/j.burns.2025.107468","DOIUrl":"10.1016/j.burns.2025.107468","url":null,"abstract":"<div><h3>Background</h3><div>The elderly are highly vulnerable to major burn injuries. Typically, ‘elderly’ is accepted as ≥ 65 years of age. This cut-off is arbitrary, lacks a robust evidence base and is potentially damaging from a clinical-decision-making perspective. The study objective was to utilise a large international dataset of major burns to stratify mortality risk by age and objectively define ‘elderly’ patients with significantly higher risk of poor outcome.</div></div><div><h3>Methods</h3><div>We performed a sub-analysis of the RE-ENERGIZE clinical trial dataset. RE-ENERGIZE included 1200 patients admitted to 54 burn centres worldwide with 2nd and/or 3rd degree burns, who were expected to require skin grafting. In a first-of-its-kind age stratification study, we stratified major burns patients by five-year age intervals. Logistic regression and Cox proportional hazards analyses were performed with three-month mortality and time-to-discharge-alive (TTDA) as the primary and secondary outcomes.</div></div><div><h3>Results</h3><div>Three-month mortality was 15.41 %. Age was associated with three-month mortality upon multivariable logistic regression analysis (p = 0.000, OR=1.06, CI=1.05–1.08), independently of total burn surface area burned (TBSA%), Acute Physiology and Chronic Health Evaluation II (APACHE II) and Charlson Comorbidity Index (CCI). Age 80 + was independently associated with increased mortality and TTDA, when compared to all referent 5-year age groups (<em>p</em> ≤ 0.000–0.043). The Lethal Dose 50 (LD50) for the 80 + group was 20.5 %.</div></div><div><h3>Conclusions</h3><div>We present a new threshold of risk stratification in patients with major burns; Patients ≥ 80 years have a significantly poorer outcome, irrespective of injury severity, resultant critical illness severity, and variables including comorbidities, which has implications for prognostication and management decisions.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107468"},"PeriodicalIF":3.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143877090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accelerated wound healing of enzymatically debrided deep dermal burn wounds after the use of fish skin (Kerecis Omega3 Wound®) in comparison to Suprathel®","authors":"Wolfram Heitzmann,&nbsp;Julia Enzmann,&nbsp;Maria von Kohout,&nbsp;Maximilian Maria Mattern,&nbsp;Jan Akkan,&nbsp;Paul Christian Fuchs,&nbsp;Jennifer Lynn Schiefer","doi":"10.1016/j.burns.2025.107471","DOIUrl":"10.1016/j.burns.2025.107471","url":null,"abstract":"&lt;div&gt;&lt;div&gt;Recent studies have shown that long-term scarring from burns is significantly reduced through the use of enzymatic debridement. Following enzymatic debridement of deep dermal burns, numerous wound dressings are available that provide an adequate wound environment and ideal conditions for rapid wound healing. In German burn centres, Suprathel® has mostly been used for this purpose. Since 2019, the alternative Kerecis Omega3 Wound®, which is derived from fish skin, has been used as an alternative in burn medicine. Therefore, we conducted a single-centre prospective, open, comparative, and intra-individual clinical study to gain initial experience in the use of Kerecis Omega3 Wound®, establish a treatment algorithm and compare Suprathel® and Kerecis Omega3 Wound® in the treatment of deep dermal burns after enzymatic debridement with respect to wound healing, exudation and pain. After enzymatic debridement of deep dermal burns of the hand and foot, wounds were divided into two areas: one was treated with Suprathel® and the other with Kerecis Omega3 Wound®. Dressing changes and wound checks were carried out on days 2, 4, 8, 12, 16, 24, and 48, after application. With this, initial experience concerning the handling of Kerecis Omega3 Wound® was gained and wound healing, infection, exudation, and pain were documented. In the period from January 1, 2022, to October 1, 2023, 22 patients between the ages of 18 and 83 years with deep dermal burns were treated. Satisfactory results were obtained in all cases; no patients had to undergo a second debridement followed by skin grafting. Mean healing time after the use of Kerecis Omega3 Wound was 17 days (min 8 days, max 25 days) whereas it was 23 days (min 12 days, max 42 days) in the Suprathel-Areas. No infections were observed in both groups. Exudation throughout the wound healing process was significantly higher in the Kerecis Omega3 Wound group than in the Suprathel group, whereas no significant differences in pain levels were documented. The management of dressing changes, the assessment of the progress of wound healing and adjusting the level of moisture in the dressings were obstacles, which could only be overcome by appropriate experience of the burn surgeon. In particular, adjusting the degree of moisture had a major influence on the progress of wound healing. Depending on these parameters, very different healing processes of the fish skin, from early dissolution into the so-called “active slough”, to the drying out of the wound dressing to form a crust and remaining there for several weeks. In all 22 patients, however, the treatment led to spontaneous wound healing and satisfactory results without the need of skin grafting or other surgical procedures. Kerecis Omega3 Wound® is safe to use and suitable for the treatment of deep dermal burn wounds following enzymatic debridement. Its application leads to accelerated wound healing compared to the use of Suprathel®, however, owing to the differen","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107471"},"PeriodicalIF":3.2,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of perceived fatigue in burn survivors: A systematic review of cross-sectional and longitudinal studies","authors":"J.M. Prent ,&nbsp;M. Wildekamp ,&nbsp;S. Scholten-Jaegers ,&nbsp;H. Houdijk ,&nbsp;M.K. Nieuwenhuis ,&nbsp;L.J. Mouton","doi":"10.1016/j.burns.2025.107469","DOIUrl":"10.1016/j.burns.2025.107469","url":null,"abstract":"<div><h3>Objective</h3><div>Perceived fatigue significantly impacts quality of life after burns, yet how often it occurs is unknown. Therefor this study assessed the prevalence of perceived fatigue of burn survivors.</div></div><div><h3>Methods</h3><div>In February 2023, a systematic literature search was performed in CINAHL, Embase, PsycInfo, PubMed and Web of Science. Studies reporting the prevalence of post-burn perceived fatigue were included.</div></div><div><h3>Results</h3><div>In ten cross-sectional studies of moderate-high quality with measurements between 5.3 days and 42 years post burn, the prevalence of perceived fatigue varied between 5 % and 78 % with no apparent time trends. Broad study populations hindered explaining this varying prevalence by age or %TBSA. In four high-quality longitudinal studies with 3–5 measurements between 1 and 24 months post burn, the prevalence decreased over time, dropping from approximately 70 to 50 % in adults and 65 to 28 % in children. Studies used various measurement instruments and cut-off points for operationalizing perceived fatigue, severely limiting the interpretation and comparison of prevalence rates across studies.</div></div><div><h3>Conclusions</h3><div>The high prevalence and persistent nature of perceived fatigue among burn survivors emphasize its crucial role in burn rehabilitation. Future studies should prioritize identifying individuals with adverse trajectories of perceived fatigue and unravelling underlying mechanisms to develop effective treatments for reducing post-burn perceived fatigue.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107469"},"PeriodicalIF":3.2,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do paediatric patients with suspected non-accidental burn injuries have worse clinical outcomes? A 5-year retrospective review from a UK burns centre","authors":"Daniel Dolan ,&nbsp;Nikolaos Arkoulis ,&nbsp;Alison C. Gray ,&nbsp;David McGill ,&nbsp;CJ Tollan ,&nbsp;Thomas Reekie ,&nbsp;Sharon Ramsay ,&nbsp;Joanna Tannock","doi":"10.1016/j.burns.2025.107467","DOIUrl":"10.1016/j.burns.2025.107467","url":null,"abstract":"<div><h3>Background</h3><div>Burns are a very common reason for attendance and admission of children to hospital. Non-accidental injury (NAI) and child protection concerns (CP) are crucially important in paediatric burns presentations – prevalence in the UK is reported between 5 % and 14 %. This range reflects challenges in identifying suspicious injuries, as well as the underlying geographic and socioeconomic variations in practice.</div></div><div><h3>Aims</h3><div>This study examines the demographics, management, and outcomes of paediatric burns admissions with NAI or CP concerns in a UK burns centre.</div></div><div><h3>Methods</h3><div>Retrospective analysis of all acute paediatric burns and thermal injury patients admitted at the Royal Hospital for Children, Glasgow 2018–2022 inclusive.</div></div><div><h3>Results</h3><div>594 eligible patients were identified, with a mean age of 4.67 years, a mean % total body surface area burn (%TBSA) of 3.65 % and scald burns being the most common mechanism (59.3 %). The majority of patients (84.2 %) were managed conservatively.</div><div>94 (15.8 %) patients had concerns relating to CP issues or potential NAI during their admission. These patients were more likely to have larger %TBSA injuries (P &lt; 0.001), to have a longer duration of admission (P &lt; 0.001) and to be from a more socioeconomically disadvantaged background (P = 0.007). There was no statistically significant difference in mean age, need for surgery, positive microbiology, antibiotic use and duration of follow up.</div></div><div><h3>Discussion</h3><div>The prevalence of NAI/CP concerns in our series was higher than the UK mean, possibly reflecting socioeconomic disparities. Suspected NAI cases were not associated with worse clinical outcomes.</div><div>We recommend that individual burn services examine their own patient cohorts to determine NAI prevalence and interpret these findings in the context of their geography and socioeconomic composition. A primary focus of teams treating paediatric burn patients should be on prompt recognition of suspicious injuries, escalation through local safeguarding channels, and influencing public health prevention policies, where applicable.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107467"},"PeriodicalIF":3.2,"publicationDate":"2025-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor regarding “The use of smartphone thermography to evaluate wound healing in second-degree burns”","authors":"Juan Zhang,&nbsp;Hai fen Li,&nbsp;Qing Shi","doi":"10.1016/j.burns.2025.107466","DOIUrl":"10.1016/j.burns.2025.107466","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107466"},"PeriodicalIF":3.2,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burns list of reviewers, 2024","authors":"","doi":"10.1016/j.burns.2025.107465","DOIUrl":"10.1016/j.burns.2025.107465","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107465"},"PeriodicalIF":3.2,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143808124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: New directions for Burns in 2025","authors":"Leopoldo C. Cancio","doi":"10.1016/j.burns.2025.107464","DOIUrl":"10.1016/j.burns.2025.107464","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107464"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143693983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Film fixation for facial burns: Sandwich technique and 3D silicone facemask","authors":"Chao Lian,&nbsp;Xue-Lei Li,&nbsp;Xiao-Jun Liu,&nbsp;Xuan-Fen Zhang","doi":"10.1016/j.burns.2025.107459","DOIUrl":"10.1016/j.burns.2025.107459","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107459"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143685657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genital burn injuries: Insights from 10 years of consumer product-related incidents","authors":"Iryna Dovirak ,&nbsp;Eylon J. Arbel ,&nbsp;Alyssa D. Reese ,&nbsp;Aidan W. O’Shea ,&nbsp;Peter C. Evancho ,&nbsp;Mark S. Burke ,&nbsp;John Rutkowski","doi":"10.1016/j.burns.2025.107457","DOIUrl":"10.1016/j.burns.2025.107457","url":null,"abstract":"<div><div>Genital burns are a rare but debilitating source of injury to patients’ physical and psychological well-being. Earlier studies have found that genital burns disproportionately affect the pediatric male population. Our study aim is to provide an updated epidemiological overview of genital burn injuries and discuss steps to mitigate genital complications. In the ten-year period between 2013 and 2022, there was an incidence of 13,667 genital burns, most of which occurred in the home and involved water. Additionally, the number of transfers necessary for genital burns, almost a fifth of patients (17.9 %) in the present study, is markedly higher than the three percent transfer rate for all burns noted in the literature. These findings underscore the importance of developing more robust public health initiatives to prevent genital burns in the pediatric population. To reduce patient transfers for genital burns and delays in care, further research must be done to create equitable access to verified burn centers.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107457"},"PeriodicalIF":3.2,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143834130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}