Burns最新文献

{"title":"A novel mouse model for studies of burn wound conversion using a top hat–shaped brass template","authors":"Norifumi Matsuda ,&nbsp;Chigusa Sato ,&nbsp;Kosuke Ishikawa ,&nbsp;Takahiro Miura ,&nbsp;Emi Funayama ,&nbsp;Yuhei Yamamoto ,&nbsp;Kanako Fuyama ,&nbsp;Shunsuke Ohnishi ,&nbsp;Taku Maeda","doi":"10.1016/j.burns.2024.107348","DOIUrl":"10.1016/j.burns.2024.107348","url":null,"abstract":"<div><h3>Introduction</h3><div>The pathophysiology of burn wound conversion is not fully understood. Animal models are needed to elucidate the underlying mechanisms and develop treatments. Here, we established a new reproducible mouse model that simulates this process, thereby facilitating studies of burn wound conversion.</div></div><div><h3>Materials and methods</h3><div>After anesthesia and depilation, 75 mice were randomly assigned to 5-, 15-, and 25-s contact groups, and a top hat–shaped brass template was heated in boiling water and applied to the lateral abdomen. The wound area was calculated from photographs and the percentage of the surviving area was determined. Histological samples were collected 1–96 h after injury.</div></div><div><h3>Results</h3><div>A 15-s contact time produced the desired 50 %–75 % interspace necrosis at 96 h after injury. The 5-s contact group had a mostly preserved interspace, while the 25-s contact group exhibited near-complete necrosis. Histologically, significant differences between the 5- and 15-s contact groups were seen in cutaneous appendage denaturation and panniculus carnosus denaturation early after injury.</div></div><div><h3>Conclusion</h3><div>Exposing mice to the heated template for 15 s provides a reproducible model for studying burn wound conversion mechanisms and treatments, facilitating further elucidation of burn pathophysiology and evaluation of therapies to prevent burn wound conversion.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 2","pages":"Article 107348"},"PeriodicalIF":3.2,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental experiences, coping and the impact of Family Burn Camp after paediatric burn injury: A qualitative study","authors":"Victoria Schei ,&nbsp;Anne Berit Guttormsen ,&nbsp;Lina S.T. Lernevall ,&nbsp;Stian Kreken Almeland ,&nbsp;Margrethe Aase Schaufel","doi":"10.1016/j.burns.2024.107344","DOIUrl":"10.1016/j.burns.2024.107344","url":null,"abstract":"<div><h3>Background</h3><div>Paediatric burn injuries constitute a transformative event for parents, shaping their lives in profound ways. This study explores parental experiences, coping mechanisms, and the impact of Family Burn Camp in the aftermath of paediatric burn injuries.</div></div><div><h3>Methods</h3><div>A qualitative study was conducted in 2019 comprising two focus group interviews with 15 parents at the Family Burn Camp in Stavern, Norway. Data was analysed using systematic text condensation.</div></div><div><h3>Results</h3><div>Four categories emerged outlining parental experiences and coping strategies: 1) From acute chaos to a scarred future; 2) The paradox of being a helper and being the one who needs help; 3) Being isolated as parents of burnt children and 4) Coping through dialogue, empowerment and Family Burn Camp. Balancing the role of caregiver while seeking support, parents often experienced emotional breakdown after completion of the child’s wound treatment, leading to loss of work function. Coping strategies emerged through fostering the child's self-esteem, with Family Burn Camp emerging as a beacon, deemed “<em>worth more than a thousand therapy sessions</em>”.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that increased psychological and economic support are needed during and after the child's physical recovery. Family Burn Camp is a crucial element in the rehabilitation process for the whole family.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 2","pages":"Article 107344"},"PeriodicalIF":3.2,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of an online self-management program for chronic burn pain: A randomized controlled trial of the Take Charge of Burn Pain program","authors":"Fenan S. Rassu ,&nbsp;Elena Staguhn ,&nbsp;Scott Ravyts ,&nbsp;Renan Castillo ,&nbsp;Shelley A. Wiechman ,&nbsp;Tricia Kirkhart ,&nbsp;Rachel V. Aaron ,&nbsp;Amy Acton ,&nbsp;Linda Ware ,&nbsp;Stephen M. Milner ,&nbsp;Leigh Ann Price ,&nbsp;James A. Fauerbach ,&nbsp;Jennifer A. Haythornthwaite ,&nbsp;Stephen T. Wegener","doi":"10.1016/j.burns.2024.107336","DOIUrl":"10.1016/j.burns.2024.107336","url":null,"abstract":"<div><div>This randomized controlled trial investigated the effectiveness of an online self-management program, \"Take Charge of Burn Pain (TCBP),\" for 96 individuals living with chronic burn pain. Participants were randomly assigned to either the 7-week TCBP program integrating cognitive-behavioral therapy techniques, pain education, and self-management strategies or an attention control group focused on general burn recovery information. Assessments conducted at baseline, post-treatment, and 2- and 5-month follow-ups included measures of pain severity, pain interference, pain self-efficacy, posttraumatic stress disorder symptoms, and depression. Compared to the control group, participants in the TCBP program demonstrated greater reductions in pain severity (mean difference: −1.24, 95 % CI: −1.93 to −0.55, p = 0.0007) and pain catastrophizing (mean difference: −5.41, 95 % CI: −10.33 to −0.49, p = 0.0318) post-treatment when adjusting for key variables. At the two-month follow-up, the TCBP group showed significant improvements in pain interference (P = 0.0123), self-efficacy (P = 0.0269), functional abilities (P = 0.0014), and social role participation (P = 0.0498) compared to the control group. Treatment effects were not sustained at 5-month follow-up. Participants in both groups reported high levels of satisfaction with the online intervention, with the majority finding the program helpful and easy to use, and being willing to recommend it to others with pain. Findings suggest preliminary support for short-term benefits of TCBP for managing certain facets of chronic burn pain. This underscores the need to refine digital approaches to maintain and promote long-term improvements. The potential of self-guided online psychological interventions to enhance pain coping strategies for burn survivors persists.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 2","pages":"Article 107336"},"PeriodicalIF":3.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors besides lamotrigine associated Stevens-Johnson Syndrome and toxic epidermal necrolysis","authors":"Kaveh Gharaei Nejad ,&nbsp;Reyhaneh Ghadarjani","doi":"10.1016/j.burns.2024.08.007","DOIUrl":"10.1016/j.burns.2024.08.007","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"50 9","pages":"Article 107241"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wounds within: The hidden scars of violent care","authors":"Xin Zhang,&nbsp;Xiu-Hang Zhang","doi":"10.1016/j.burns.2024.08.011","DOIUrl":"10.1016/j.burns.2024.08.011","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"50 9","pages":"Article 107245"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-risk burn patients might be hospitalized more during the COVID-19 period than pre-COVID period","authors":"Payman Salamati,&nbsp;Vafa Rahimi-Movaghar","doi":"10.1016/j.burns.2024.09.005","DOIUrl":"10.1016/j.burns.2024.09.005","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"50 9","pages":"Article 107266"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“To BAL or not to BAL, that is the question”: Variations in smoke inhalation injury guidelines from burn units and centres in England, Scotland and Wales","authors":"Ganesh Rajaratnam ,&nbsp;Alexander J. Baldwin","doi":"10.1016/j.burns.2024.09.012","DOIUrl":"10.1016/j.burns.2024.09.012","url":null,"abstract":"<div><h3>Aim</h3><div>To evaluate variations in diagnostic criteria and management recommendations for smoke inhalation injury (SII) amongst the burn networks of England, Scotland, and Wales.</div></div><div><h3>Methods</h3><div>A descriptive cross-sectional study examining SII guidelines provided by adult burn units and centres in England, Scotland and Wales.</div></div><div><h3>Results</h3><div>All 16 adult burn units and centres responded. Fourteen (87.5 %) had guidelines. Due to sharing of guidelines, ten unique guidelines were assessed. Diagnostic criteria showed variability with no universal criterion shared amongst guidelines. Bronchoscopy was recommended by 90 % of guidelines, but the timing varied. The use of bronchoscopic scoring systems was recommended by four guidelines. Bronchoalveolar lavage (BAL) was recommended by four, with considerable variation in frequency and choice of lavage fluid. All guidelines advised at least one nebulised agent: heparin (n = 8); N-acetyl cysteine (NAC) (n = 8); or salbutamol (n = 8). All guidelines included advice on carbon monoxide poisoning; however, carboxyhaemoglobin (COHb) cut-off levels for treatment varied (5 % [n-4], 10 % [n = 3], 15 % [n = 1]). All recommended high-flow oxygen. Seven (70 %) guidelines offered guidance on cyanide poisoning. Reduced/altered consciousness was the only consistent diagnostic criterion. Five (50 %) guidelines provided intubation guidance, emphasising the role of a ‘senior clinician’ as the intubator. Ventilatory guidance appeared in eight guidelines, focusing on lung protective ventilation (n = 8); oxygenation goals (n = 3); and permissive hypercapnia (n = 3). Within lung-protective ventilation, advice on tidal volume (6, or 6–8 ml/kg) and plateau pressures (&gt;30 cmH2O) were presented most commonly (n = 7).</div></div><div><h3>Conclusion</h3><div>This study has outlined the substantial variations in guidance for the management of SII. The results underscore the need for a national guideline outlining a standardised approach to the diagnosis and management of SII, within the limitations of the current evidence.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"50 9","pages":"Article 107273"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tourniquet burns: Best practices for alcohol skin preparation","authors":"John Warner-Levy ,&nbsp;James D. Bedford,&nbsp;Karl Walsh","doi":"10.1016/j.burns.2024.09.013","DOIUrl":"10.1016/j.burns.2024.09.013","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"50 9","pages":"Article 107274"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing wound treatment with superoxide dismutase-loaded solid lipid nanoparticles","authors":"Hui Sun ,&nbsp;Wei Shen ,&nbsp;Hui-Qiong Nie ,&nbsp;Yi Yao ,&nbsp;Ying-Ming Ma ,&nbsp;Zhi-Hong Ma ,&nbsp;Hua-Jie Zhong","doi":"10.1016/j.burns.2024.06.012","DOIUrl":"10.1016/j.burns.2024.06.012","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"50 9","pages":"Article 107195"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141577605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between neighborhood disadvantage and patient-reported outcomes in burn survivors","authors":"Arushi Biswas ,&nbsp;Zachary H. Zamore ,&nbsp;Zohra Aslami ,&nbsp;Rafael Felix P. Tiongco ,&nbsp;Ayman Ali ,&nbsp;Carisa M. Cooney ,&nbsp;Mark D. Fisher ,&nbsp;Julie A. Caffrey ,&nbsp;Sheera F. Lerman","doi":"10.1016/j.burns.2024.06.013","DOIUrl":"10.1016/j.burns.2024.06.013","url":null,"abstract":"<div><h3>Background</h3><div>Burns can cause long-term complications including pain and poor physical function. While neighborhood disadvantage is associated with burn severity, its effect on long-term complications has not been investigated. We hypothesized that patients from areas of higher area of deprivation index (ADI) will report poorer long-term outcomes.</div></div><div><h3>Methods</h3><div>We linked patient data from the Burn Model System with ADI state decile (1 = least, 10 = most disadvantaged) using year and residence at time of injury. We performed bivariate analyses to identify associations between ADI and patient and burn characteristics and multivariate regressions to determine whether ADI was associated with PROMIS-29 pain and physical function 6- and 24-months post-burn.</div></div><div><h3>Results</h3><div>We included 780 patients; 69 % male, median age = 46 years, median ADI = 6, and median TBSA = 8 %. Multivariate regressions adjusting for TBSA, race, age, sex, anxiety, depression, and pain interference demonstrated that higher ADI was a significant predictor of higher pain intensity 6- (p = 0.001) and 24-months (p = 0.037) post-burn but not worse physical function 24-months post-burn (p = 0.089).</div></div><div><h3>Conclusions</h3><div>Higher neighborhood disadvantage was associated with higher long-term pain intensity post-burn. This study highlights the importance of socioeconomic factors that may impact long-term outcomes and the use of aggregate markers to identify patients at risk for worse outcomes.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"50 9","pages":"Article 107196"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141577607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}