Burns最新文献

{"title":"A call for comprehensive protocols and strategies: Identifying pediatric non-accidental burns","authors":"Julia Bartkova, Aksharaa Gurubalasubramaniyan Iyer, Rei Ogawa","doi":"10.1016/j.burns.2025.107375","DOIUrl":"10.1016/j.burns.2025.107375","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 2","pages":"Article 107375"},"PeriodicalIF":3.2,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the skin microbiome with the biomechanical scar properties in patients with burns","authors":"Yeongyun Jung ,&nbsp;Cheolju Park ,&nbsp;Huseong Lee ,&nbsp;Jung Im Yun ,&nbsp;So Young Joo ,&nbsp;Cheong Hoon Seo ,&nbsp;Seung Tae Lee ,&nbsp;Minseok Kim ,&nbsp;Yoon Soo Cho","doi":"10.1016/j.burns.2025.107372","DOIUrl":"10.1016/j.burns.2025.107372","url":null,"abstract":"<div><h3>Background and objectives</h3><div>Skin microbiome dysbiosis can cause skin barrier dysfunction and stimulate scar property change. Skin barrier disruption post-burn injury leads to an imbalance in skin microbe diversity and distribution. We aimed to examine the changes in the skin microbiome of re-epithelialized burn scars.</div></div><div><h3>Material and methods</h3><div>Twenty three patients were enrolled between January 2020 and July 2022. Twenty-six (13 Scar 1, immediately after complete wound healing; and 13 Scar 2, 3 months after complete wound healing) of seventy-eight scar skin samples (39 Scar 1 and 39 scar 2) qualified for analysis. Microbial community analysis was performed. Biomechanical scar properties of each patient and their correlation with skin microbiome were investigated.</div></div><div><h3>Results</h3><div>The α-diversity of the scarred skin microbiome increased with time (Shannon’s index, <em>p</em> = 0.029; Simpson’s index, <em>p</em> = 0.009). The linear discriminant analysis effect size results showed that <em>Bacteroides</em> abundance decreased in scars after 3 months, whereas <em>Campylobacter</em> and <em>Cutibacterium</em> abundance increased. <em>Campylobacter</em> and <em>Cutibacterium</em> negatively and positively correlated with the final distensibility gross and biological elasticity, respectively. These results were consistent with the changes in the biomechanical properties of scars.</div></div><div><h3>Conclusion</h3><div>The scar skin microbial communities in patients with burns changed with biomechanical scar properties over time, and specific skin microorganisms correlated with biomechanical scar dynamics at the genus level.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 3","pages":"Article 107372"},"PeriodicalIF":3.2,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early coagulation changes as predictors of adverse outcomes in patients with severe burn and inhalation injuries","authors":"Shengyu Huang ,&nbsp;Dan Wang ,&nbsp;Qimin Ma ,&nbsp;Tuo Shen ,&nbsp;Dinghong Min ,&nbsp;Yusong Wang ,&nbsp;Xincheng Liao ,&nbsp;Rui Liu ,&nbsp;Haiming Xin ,&nbsp;Xiaoliang Li ,&nbsp;Zhaohong Chen ,&nbsp;Fei Chang ,&nbsp;Guanghua Guo ,&nbsp;Feng Zhu","doi":"10.1016/j.burns.2025.107373","DOIUrl":"10.1016/j.burns.2025.107373","url":null,"abstract":"<div><h3>Background</h3><div>Disorders of the coagulation pathway are triggered in patients with severe burn and inhalation injuries in the early stages. There are multiple early coagulation indices identified to correlate with adverse outcomes.</div></div><div><h3>Method</h3><div>A retrospective analysis of patients with severe burn and inhalation injuries from 12 centers in mainland China was performed to identify early changed coagulation indices with predictive value associated with four major 28-day adverse outcomes (death, anticoagulation, mechanical ventilation, continuous renal replacement therapy) by logistic regression. The optimal cut-off value was also determined by Youden's index.</div></div><div><h3>Results</h3><div>A total of 433 patients with severe burn and inhalation injuries were included in the study. Activated partial thromboplastin time (APTT) was found to be a risk factor for death, anticoagulation and continuous renal replacement therapy outcomes, while D-dimer was a risk factor for death and mechanical ventilation outcomes. Compared with previous definitions of coagulopathy, the occurrence of adverse outcomes was well predicted by both APTT and D-dimer. Patients were divided into high-risk and low-risk coagulopathy based on APTT and D-dimer cutoff values, with high-risk coagulopathy being an independent risk factor for death. Age, TBSA, lactate level, and pre-hospital infusion volume were identified as independent influencing factors on high-risk coagulopathy.</div></div><div><h3>Conclusion</h3><div>The coagulation indices APTT and D-dimer in the early post-hospitalization period have a good early warning effect in the severe burn and inhalation injuries population, by which early screening to identify high-risk coagulopathies can be performed and targeted interventions can be implemented.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 2","pages":"Article 107373"},"PeriodicalIF":3.2,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Documenting the human cost of incendiary weapons: Establishment of a global registry","authors":"Abbygale Willging,&nbsp;Bonnie Docherty,&nbsp;Ahmed Mokhallalati,&nbsp;Serhii Tertyshnyi,&nbsp;Zahed Katurji “Hamza Alkeab”,&nbsp;Karine Babayan,&nbsp;Sharon Chekijian,&nbsp;Aparna Cheran,&nbsp;Therese Prestsæter on behalf of Norwegian People’s Aid,&nbsp;Agneta Kallstrom,&nbsp;Barclay T. Stewart,&nbsp;Hannah Wild on behalf of the Explosive Weapons Trauma Care Collective","doi":"10.1016/j.burns.2024.107369","DOIUrl":"10.1016/j.burns.2024.107369","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 2","pages":"Article 107369"},"PeriodicalIF":3.2,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Building resilience: A promising approach to reduce anxiety in mothers and hospitalized children with burn injuries","authors":"Maryam Shaygan ,&nbsp;Zobeydeh Dehghan Manshadi ,&nbsp;Fahimeh Alsadat Hosseini ,&nbsp;Maryam Shaygan","doi":"10.1016/j.burns.2025.107374","DOIUrl":"10.1016/j.burns.2025.107374","url":null,"abstract":"<div><div>The psychological impact of pediatric burn injuries is profound, often resulting in elevated levels of anxiety for both children and their mothers. This quasi-experimental study was conducted to explore the effectiveness of a resilience training program aimed at reducing anxiety among mothers and their hospitalized children with burn injuries at a burn hospital in Shiraz, Iran. Fifty-six eligible mothers were initially selected through purposive sampling and assigned to either the experimental or control group in a 1:1 ratio through random assignment. The experimental group engaged in six sessions of the resilience training program. Anxiety levels were measured using the State Anxiety Inventory (SAI) and State Anxiety Inventory for Children (SAI-C) at multiple time points. Despite some dropouts, fifty mothers and their children were retained for analysis. The impact of the intervention on anxiety improvement was assessed using a Generalized Estimating Equation (GEE) model.. The results indicated that the resilience training program significantly reduced anxiety levels in both mothers and their children over time (p &lt; .001). This reduction in anxiety persisted for five days following the completion of six sessions for mothers and six days for children (p &lt; .05). Resilience training effectively addressed the psychological needs of mothers and their hospitalized children with burn injuries during the acute phase, significantly reducing anxiety levels and sustaining benefits for up to five days for mothers and six days for children post-intervention. While the impact of the training appeared to lessen over time, this underscores its importance in providing immediate support during a critical period. These findings suggest that resilience training is a valuable addition to clinical practice for the acute hospitalization phase, aimed at enhancing mental health and overall well-being in this vulnerable group.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 2","pages":"Article 107374"},"PeriodicalIF":3.2,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of tumescent anesthesia in managing pain for enzymatic debridement of burns. A case-control study","authors":"Giuseppe A.G. Lombardo ,&nbsp;Luciano Mangiameli ,&nbsp;Paolo Marchica ,&nbsp;Dario Melita ,&nbsp;Fortunata Caterina Alberti ,&nbsp;Isidoro Musmarra ,&nbsp;Francesco Ciancio ,&nbsp;Savino Borraccino ,&nbsp;Rosario Ranno","doi":"10.1016/j.burns.2024.107366","DOIUrl":"10.1016/j.burns.2024.107366","url":null,"abstract":"<div><h3>Introduction</h3><div>Burn injuries are a global health challenge, causing significant pain, tissue damage and complex wound management issues. Traditional treatments like surgical debridement, while effective, pose challenges such as blood loss, grafting requirements, and prolonged hospital stays. Enzymatic debridement, such as the Nexobrid procedure, effectively removes necrotic tissue but can be painful for patients. This study evaluates the efficacy of tumescent anesthesia with lidocaine (TLA) in managing pain during this procedure.</div></div><div><h3>Methods</h3><div>This retrospective case-control clinical study was conducted at Cannizzaro Hospital in Catania from January 2023 to January 2024. It included 23 patients aged ≥ 18 years with thermal burns on the trunk or multiple locations, who did not require mechanical ventilation due to other causes. The case group (TLA group) included 10 patients treated with tumescent anesthesia (TLA), while the control group (w/o TLA) included 13 patients managed with standard general/opioid methods. Pain was assessed using the Numeric Pain Scale (NPS) at multiple time points.</div></div><div><h3>Results</h3><div>Descriptive statistics were calculated for age, TBSA, and pain values measured with the NRS scale for each time interval. In the TLA group, the Friedman One-Way Repeated Measures ANOVA revealed a statistically significant reduction in perceived pain over time (p &lt; 0.001), which was not observed in the control group(p = 0.121). The Mann-Whitney U test indicated a statistically significant difference in pain between the two groups (p &lt; 0.05), with lower pain levels in the TLA group.</div></div><div><h3>Conclusion</h3><div>TLA effectively manages pain in burn patients undergoing enzymatic debridement.This approach improves patient outcomes and satisfaction by providing effective pain control, minimizing recovery time, and offering a viable alternative to traditional anesthesia methods. Further research with larger, multi-center studies is recommended to validate these findings and establish standardized protocols for TLA in burn care.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 2","pages":"Article 107366"},"PeriodicalIF":3.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142966732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of a randomized controlled trial of enteral vs intravenous resuscitation for adults with major burn injuries in Nepal","authors":"Raslina Shrestha ,&nbsp;Kajal Mehta ,&nbsp;Dinasha Dahanayake ,&nbsp;Manish Yadav ,&nbsp;Kiran Nakarmi ,&nbsp;Pariwesh Bista ,&nbsp;Shankar Rai ,&nbsp;Tam Pham ,&nbsp;Barclay T. Stewart","doi":"10.1016/j.burns.2024.107347","DOIUrl":"10.1016/j.burns.2024.107347","url":null,"abstract":"<div><h3>Introduction</h3><div>Enterally-based resuscitation (EResus) is safe, efficacious, and has operational advantages, particularly in low-resource settings. However, there is a lack of real-world effectiveness studies and evidence-based protocols, which hinders implementation. To address this gap, we conducted a feasibility study ahead of a randomized controlled trial (RCT) of enterally based versus usual resuscitation at a tertiary burn center in Nepal which had no prior clinical trial experience. We aimed to assess the feasibility of conducting collaborative and prospective clinical research in this setting, the acceptability of the intervention, and compliance with the resuscitation and study protocols.</div></div><div><h3>Methods</h3><div>We enrolled and randomized 30 participants. We collected quantitative and qualitative data from participants via resuscitation flowsheets (n = 30), along with in-depth interviews conducted before and after resuscitations with participants (n = 12) and providers (n = 45). Evidence of the capabilities to perform the trial as designed, the acceptability of the intervention, and compliance with the study and resuscitation protocols was identified and described through systematic evaluations of recruitment efficiency, protocol adherence, data collection accuracy, high patient consent rates, and detailed feedback collected through in-depth interviews with participants and providers.</div></div><div><h3>Results</h3><div>We demonstrated successful research collaboration through the maintenance of weekly study meetings, real-time WhatsApp communication, and funding that allowed for sustainable infrastructure development in Nepal. Screening of 562 burn patients resulted in 33 eligible participants, with a high acceptance rate, as 30 consented to enroll (91 % consent rate). The trial achieved high fidelity in resuscitation protocols, with 93 % adherence to the prescribed enteral resuscitation volumes. No participant dropped out during the study period, indicating strong retention and protocol adherence.</div></div><div><h3>Conclusion</h3><div>This study established the feasibility of performing a randomized trial in a low-resource context with no prior trial experience. Enterally-based resuscitation is an acceptable and favored intervention with a high rate of enrollment. Hospital staff were able to follow the study and resuscitation protocols with high fidelity, though some optimization was requested. With this evidence of feasibility, the trial will continue enrollment, and the future data may provide valuable insights for advancing burn resuscitation in low-resource settings.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 2","pages":"Article 107347"},"PeriodicalIF":3.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gliricidia sepium (Jacq.) Kunth. ex. Walp. leaves-derived biogenic nanohydrogel accelerates diabetic wound healing in rats over 21 days","authors":"Aya A. Wafaey ,&nbsp;Seham S. El-Hawary ,&nbsp;Mohamed A. El Raey ,&nbsp;Sahar S. Abdelrahman ,&nbsp;Alaa M. Ali ,&nbsp;A.S. Montaser ,&nbsp;Mohamed F. Abdelhameed ,&nbsp;Farid N. Kirollos","doi":"10.1016/j.burns.2024.107368","DOIUrl":"10.1016/j.burns.2024.107368","url":null,"abstract":"<div><div>This study focused on the potential of <em>Gliricidia sepium</em> (Jacq.) Kunth. ex. Walp. leaves zinc oxide nanoparticles hydrogel (GSL ZnONPs HG) for diabetic wound healing. The major components identified through HPLC analysis in <em>Gliricidia sepium</em> (Jacq.) Kunth. ex. Walp. leaves ethanolic extract (GSL) were apigenin-7<em>-O-</em>glucoside, kaempferol, and protocatechuic acid. These compounds exhibited anti-inflammatory properties. The hydrogel loaded with GSL ethanolic extract and <em>Gliricidia sepium</em> (Jacq.) Kunth. ex. Walp. leaves ethanolic extract zinc oxide nanoparticles (GSL ZnONPs) displayed controlled release and favorable swelling behavior. GSL ZnONPs HG enhanced tissue regeneration, reduced apoptosis, and modulated inflammation in diabetic wounds as demonstrated by wound morphology and closure measurements, as well as histopathological and immunohistochemical evaluations. It is important to highlight the dose-dependent behavior of GSL ZnONPs, demonstrating their effectiveness in promoting diabetic wound healing even at lower concentrations. This was supported by their response to various biomarkers through a significant reduction in vascular cell adhesion molecule-1 (VCAM-1) and advanced glycation end products levels (AGEs), and a notable increase in interleukin-10 (IL-10) and platelet-derived growth factor concentrations (PDGF). Collectively, the study highlights the potential of GSL ZnONPs HG as a promising approach to enhance diabetic wound healing.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 2","pages":"Article 107368"},"PeriodicalIF":3.2,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of operating theatre ambient temperature for major burn patients in a state-wide adult burns centre","authors":"Dangyi Peng ,&nbsp;Eldho Paul ,&nbsp;Sarah Lonie ,&nbsp;Samara Rosenblum ,&nbsp;Ruvina Perera ,&nbsp;G. Gleda Ang ,&nbsp;Heather Cleland ,&nbsp;Cheng Hean Lo","doi":"10.1016/j.burns.2024.107364","DOIUrl":"10.1016/j.burns.2024.107364","url":null,"abstract":"<div><h3>Introduction</h3><div>The aim of this study was to investigate the efficacy of limiting increases in theatre ambient temperature to 27°C to prevent intraoperative patient hypothermia. METHODS: This single-centre, comparative cohort clinical study investigated the management of theatre ambient temperatures involving patients with ≥ 20 % TBSA burn injuries at Victorian Adult Burns Service (Melbourne, Australia). Data from the intervention group (August 2021 - February 2023, theatre ambient temperature increase limited to 27°C) was compared with a historical cohort (August 2019 - August 2021). Patient hypothermia was defined as core temperature below 36°C. RESULTS: In total, 29 patients underwent 107 surgical procedures in the operating theatre. Patient hypothermia was recorded on 45 occasions (42.1 %) and of these, between 35.1 and 36.0°C on 28 occasions (62.2 %). There was no statistically significant difference in the incidence of hypothermia, hospital LOS, ICU LOS, total operations, or mortality between the study cohort and historical cohort. Patients who suffered hypothermia had lower BMI, lower preoperative temperature, and shorter ICU LOS<strong>.</strong> CONCLUSION: Increasing theatre ambient temperature to 27°C is adequate in most cases. A more nuanced approach with selective increase of theatre ambient temperature beyond 27°C, only where clinically indicated, is a refinement that will benefit both patients and staff.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 2","pages":"Article 107364"},"PeriodicalIF":3.2,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased prehospital mortality in patients with combined burns and trauma in Canada: Analysis of a provincial trauma registry database","authors":"James Nunn ,&nbsp;Jack Rasmussen ,&nbsp;Nelofar Kureshi ,&nbsp;Robert S. Green ,&nbsp;Mete Erdogan","doi":"10.1016/j.burns.2024.107363","DOIUrl":"10.1016/j.burns.2024.107363","url":null,"abstract":"<div><h3>Introduction</h3><div>The combination of burns and non-thermal trauma may have a synergistic effect on mortality. Our objective was to determine if burn patients with concomitant trauma are at increased risk of mortality in both the prehospital and in-hospital settings.</div></div><div><h3>Methods</h3><div>Data were collected from a population-based provincial trauma registry (2001–2019). Characteristics and outcomes of patients with trauma/burns were compared to isolated burn patients using t-tests, chi-square analysis and Fisher’s exact tests. Risk ratios (RRs) were calculated to evaluate the impact of concomitant trauma on mortality, stratified by % total body surface area (TBSA) and injury severity score (ISS). Firth's penalized maximum likelihood estimation (PMLE) approach was used to fit multivariable logistic regression models to the outcomes of prehospital mortality and in-hospital mortality.</div></div><div><h3>Results</h3><div>Of 436 burn patients, 29.8 % (130/436) had combined trauma/burns. Prehospital mortality in the trauma/burns group was 57.7 % (75/130) versus 43.1 % (132/306) in isolated burn patients. Prehospital mortality risk was highest in trauma/burn patients with % TBSA ≥ 70 (RR 3.87, 95 % CI 2.99–4.99) or ISS ≥ 25 (RR 2.49, 95 % CI 1.84–3.36). Concomitant trauma was associated with increased odds of prehospital mortality (OR 2.42, 95 % CI 1.27–4.69), but had no impact on in-hospital mortality.</div></div><div><h3>Conclusions</h3><div>Prehospital mortality was increased in patients with combined burns and trauma.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 2","pages":"Article 107363"},"PeriodicalIF":3.2,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}