音乐治疗对重症监护病房成人烧伤患者的背景疼痛、焦虑、抑郁、生命体征和药物使用的影响：一项随机对照试验

IF 2.9 3区医学 Q2 CRITICAL CARE MEDICINE

Burns Pub Date : 2025-06-26 DOI:10.1016/j.burns.2025.107587

Mark Ettenberger , Rafael Maya , Andrés Salgado-Vasco , Jose Gabriel Cordoba-Silva , Moshé Amarillo , William Betancourt-Zapata , Juliana Marín-Sánchez , Viviana Gómez-Ortega , Mario Valderrama

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引用次数: 0

摘要

烧伤患者在重症监护病房（ICU）经常经历疼痛和心理健康问题。本研究探讨现场音乐辅助放松（MAR）对ICU成人烧伤患者背景疼痛、心理健康、生命体征和药物管理的影响。这是一项随机对照试验，有两个平行组：标准治疗+ 在两周内进行最多6次MAR干预，与标准治疗单独进行对照。研究对象为82例ICU烧伤患者。主要结局是感觉到的背景疼痛。次要结局是焦虑和抑郁水平、生命体征和止痛药使用情况。此外，9例患者在MAR期间进行了脑电图、心电图和肌电图记录。结果表明，干预组在MAR第1和2期后的背景疼痛明显低于对照组，对报告严重疼痛的患者有很大的影响。时间对焦虑和抑郁都有显著影响，但这与治疗条件无关。在生命体征和止痛药使用方面没有发现差异。脑电生理信号分析显示，脑电图δ、θ、β、α频带发生显著变化，速度图低高频比显著降低，面肌电平均频率显著降低。结论音乐治疗可有效减轻住院早期的背景痛，特别是对重度疼痛患者。进一步的多中心研究需要更大的样本量来证实这些结果。试验注册：www.clinicaltrials.gov，标识符：NCT04571255。

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The effect of music therapy on background pain, anxiety, depression, vital signs, and medication usage in adult burn patients in the Intensive Care Unit: A randomized controlled trial

Introduction

Burn patients often experience pain and mental health difficulties in the Intensive Care Unit (ICU). This study investigated the effects of live Music-Assisted Relaxation (MAR) on background pain, mental health, vital signs, and medication administration in adult ICU burn patients.

Method

This was a randomized controlled trial with two parallel arms: standard care + up to six MAR interventions over two weeks, versus standard care alone. Participants were 82 adult ICU burn patients. Primary outcome was perceived background pain. Secondary outcomes were anxiety and depression levels, vital signs, and pain medication usage. Additionally, nine patients participated in electroencephalography, electrocardiography, and electromyography recordings during MAR.

Results

Results showed that background pain was significantly lower in the intervention group than in the control group after MAR sessions 1 and 2, with a large effect for patients reporting severe pain. Time had a significant effect on both anxiety and depression, but this was unrelated to the treatment condition. No differences were found for vital signs or pain medication administration. Analysis of electrophysiological signals during MAR revealed significant changes in delta, theta, beta, and alpha frequency bands during electroencephalography, a significant decrease of the low/high-frequency ratio of the tachogram, and significant decrease of mean frequency of facial electromyography.

Conclusions

The results suggest that music therapy might be effective in reducing background pain during the early stages of hospitalization and specifically for patients with severe pain. Further multicenter studies with a larger sample size are needed to confirm these results. Trial registration: www.clinicaltrials.gov, Identifier: NCT04571255.

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来源期刊

Burns 医学-皮肤病学

CiteScore

4.50

自引率

18.50%

发文量

304

审稿时长

72 days

期刊介绍： Burns aims to foster the exchange of information among all engaged in preventing and treating the effects of burns. The journal focuses on clinical, scientific and social aspects of these injuries and covers the prevention of the injury, the epidemiology of such injuries and all aspects of treatment including development of new techniques and technologies and verification of existing ones. Regular features include clinical and scientific papers, state of the art reviews and descriptions of burn-care in practice. Topics covered by Burns include: the effects of smoke on man and animals, their tissues and cells; the responses to and treatment of patients and animals with chemical injuries to the skin; the biological and clinical effects of cold injuries; surgical techniques which are, or may be relevant to the treatment of burned patients during the acute or reconstructive phase following injury; well controlled laboratory studies of the effectiveness of anti-microbial agents on infection and new materials on scarring and healing; inflammatory responses to injury, effectiveness of related agents and other compounds used to modify the physiological and cellular responses to the injury; experimental studies of burns and the outcome of burn wound healing; regenerative medicine concerning the skin.