Burns最新文献

{"title":"Can seeing the photos of patients' faces before burns affect nurses' quality of care?","authors":"Mohammad Ali Majdoddin, Masoud Yavari, Samad Karkhah, Mostafa Saeedinia","doi":"10.1016/j.burns.2025.107423","DOIUrl":"10.1016/j.burns.2025.107423","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107423"},"PeriodicalIF":3.2,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Open label randomized controlled trial of the efficacy and safety of NexoBrid compared to standard of care in children with burns","authors":"Yaron Shoham ,&nbsp;Lior Rosenberg ,&nbsp;RP Narayan ,&nbsp;Raphael Staubach ,&nbsp;Ruzsena Bene ,&nbsp;Mohan Kakola ,&nbsp;Stan J. Monstrey ,&nbsp;Yvonne Wilson ,&nbsp;Manoj Jha ,&nbsp;Giavonni M. Lewis ,&nbsp;Shawn Larson ,&nbsp;Adam J. Singer","doi":"10.1016/j.burns.2025.107417","DOIUrl":"10.1016/j.burns.2025.107417","url":null,"abstract":"<div><h3>Objectives</h3><div>This study evaluated the safety and efficacy of an enzymatic bromelain-based debridement (BBD) agent (NexoBrid®) in children with deep thermal burns.</div></div><div><h3>Methods</h3><div>We conducted a multicenter, open-label, parallel design, randomized controlled trial at 36 burn centers in Europe, US, Israel and India. Main eligibility criteria included children 0–18 years old, suffering from deep thermal burns covering 1–30 % of their total body surface area. Patients were randomized to either BBD or standard of care (SOC) eschar removal methods. Primary endpoints included time to complete eschar removal (superiority), percentage of wound area surgically excised (superiority) and blinded 12 months follow-up assessment of cosmesis and function using the Modified Vancouver Scar Scale (MVSS, non-inferiority).</div></div><div><h3>Results</h3><div>One hundred and forty-five children were enrolled between 2015 and 2020 (last patient completed 12-month follow-up on April 2021); 72 were randomized to BBD and 73 to SOC. All three primary endpoints of the study were met. The median time to complete eschar removal was significantly lower in the BBD arm (1 vs. 6 days, <em>P</em> &lt; 0.001). The mean [SD] percentage of wound area surgically excised was also significantly lower in the BBD arm (1.5 % [12.1 %] vs. 48.1 % [46.6 %], <em>P</em> &lt; 0.001). Mean [SD] 12-month MVSS scores were 3.8 [2.9] and 4.9 [3.3] in the BBD and SOC arms, respectively (non-inferiority demonstrated at P &lt; 0.001). The incidence of adverse events was similar between the groups, and there were no significant safety issues or deaths during the trial.</div></div><div><h3>Conclusions</h3><div>BBD was demonstrated to be safe and effective in children. Its use lead to a shorter time to complete eschar removal, a reduction in excisional surgery and non-inferior cosmesis and function results as compared to SOC eschar removal methods.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107417"},"PeriodicalIF":3.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification and validation of immune-related biomarkers and polarization types of macrophages in keloid based on bulk RNA-seq and single-cell RNA-seq analysis","authors":"Yuzhu Zhang ,&nbsp;Chenglong Fang ,&nbsp;Lizhong Zhang ,&nbsp;Fengyu Ma ,&nbsp;Meihong Sun ,&nbsp;Ning Zhang ,&nbsp;Nan Bai ,&nbsp;Jun Wu","doi":"10.1016/j.burns.2025.107413","DOIUrl":"10.1016/j.burns.2025.107413","url":null,"abstract":"<div><h3>Introduction</h3><div>Keloids are a common complication that occurs after injury. The pathogenesis of this disease remains unknown. Therefore, identifying immune-related biomarkers and macrophage polarization types in keloids can provide new insights into their treatment.</div></div><div><h3>Methods</h3><div>In this study, keloid-related bulk RNA-seq data (GSE83286, GSE212954, GSE92566, and GSE90051) were obtained from the Gene Expression Omnibus (GEO) database. The datasets GSE83286, GSE212964, and GSE92566 were combined to form a training set, while GSE90051 was utilized as an external validation set. Differentially expressed genes (DEGs) were detected by comparing keloid and normal samples within the training set. Differentially expressed immune-related genes (DIRGs) were then determined by intersecting the DEGs with immune-related genes (IRGs). Based on the protein-protein interaction (PPI) network, the top 40 DIRGs were selected for further analyses. Weighted Gene Co-expression Network Analysis (WGCNA), in conjunction with three machine learning techniques - least absolute shrinkage and selection operator (LASSO), support vector machine-recursive feature elimination (SVM-RFE), and random forest (RF) - employed to identify biomarkers. Subsequently, a nomogram model was constructed and validated. Single-cell RNA (scRNA) analysis was used to examine the expression of biomarkers at the cell-type level. Furthermore, since keloid is a chronic inflammatory disease and the abnormal polarization of macrophages is essential for the occurrence of this kind of disease, in this study we also endeavor to elucidate the state of macrophage polarization dysregulation within keloid, with the anticipation of generating novel concepts for the treatment of keloid. Finally, western blot (WB) and immunofluorescence (IF) analyses were carried out to confirm the expression levels of the biomarkers.</div></div><div><h3>Results</h3><div>A total of 740 DEGs were identified in the training set, comprising 331 up-regulated genes and 409 down-regulated genes. After intersecting with the IRGs, 73 DIRGs were obtained. Subsequently, the top 40 DIRGs were chosen for further analysis. Eventually, two biomarkers, namely BMP1 and IL1R1, were identified through WGCNA and the three machine learning methods. Their expression levels were then verified by single-cell analysis, WB, and IF analysis. Additionally, it was found that the number of M2 macrophages significantly increased, while the number of M1 macrophages decreased in keloids compared to normal samples.</div></div><div><h3>Conclusion</h3><div>BMP1 and IL1R1 might function as novel biomarkers and potential therapeutic targets for keloid treatment. Moreover, upregulating M1 macrophages and downregulating M2 macrophages could represent a promising approach for the treatment of keloids.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 3","pages":"Article 107413"},"PeriodicalIF":3.2,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143372480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of pre-existing cancer diagnoses on burn injury survival and morbidity","authors":"Phillip Keys ,&nbsp;Kassandra Corona ,&nbsp;Sheldon McCown ,&nbsp;Lyndon Huang ,&nbsp;Elvia Villarreal ,&nbsp;Jasmine Chaij ,&nbsp;Giovanna De La Tejera ,&nbsp;Douglas S. Tyler ,&nbsp;George Golovko ,&nbsp;Amina El Ayadi ,&nbsp;Juquan Song ,&nbsp;Steven E. Wolf","doi":"10.1016/j.burns.2025.107414","DOIUrl":"10.1016/j.burns.2025.107414","url":null,"abstract":"<div><h3>Objectives</h3><div>Severe burns place patients in a compromised state, especially those with pre-existing chronic diseases such as malignancy. Due to improvements in detection and treatment, cancer mortality has declined significantly, leaving a growing population of cancer survivors. Therefore, we wondered whether pre-existing cancer diagnoses influence patient outcomes following burn injury.</div></div><div><h3>Methods</h3><div>46,275 patients with a neoplasm diagnosis prior to experiencing a burn injury were identified using the TriNetX research network. Two control groups were organized: 1) cancer patients without burns and 2) burn patients with no history of cancer. The test group included patients with a pre-existing cancer diagnosis who received a subsequent burn injury. Outcomes included death, sepsis, nutritional deficiency, eating disorder, immunodeficiency, and depression. Odds ratios were calculated with 95 % confidence intervals.</div></div><div><h3>Results</h3><div>Of the nearly 10 million cancer patients, 0.45 % experienced a burn injury after diagnosis. Compared to propensity-matched burned patients without cancer, burned patients with a previous cancer diagnosis had increased odds of developing sepsis (2.013, 1.895–2.138), nutritional deficiency (1.874, 1.58–2.221), immunodeficiency (5.584, 4.85–7.06), eating disorder (2.384, 1.947–2.918), and depression (1.772, 1.695–1.853). The odds ratios of sepsis (1.718, 1.612–1.83), nutritional deficiency (1.963, 1.593–2.418), immunodeficiency (1.265, 1.098–1.459), eating disorder (2.569, 2.077–3.177), and depression (1.538, 1.468–1.611) were increased when compared to cancer patients without burn injury. Burned patients with a previous neoplasm of hematologic origin fared worse in the odds of developing the mentioned outcomes compared to those with solid neoplasms. Lastly, burned patients with any previous neoplasm who later received chemotherapy and/or radiation suffered worse outcomes than those who never received such treatment.</div></div><div><h3>Conclusion</h3><div>Patients who developed neoplasms before receiving a burn injury demonstrated considerable increases in odds of poor outcomes. Increased odds of developing poor outcomes were greater in those with hematologic neoplasms and those who received chemotherapy or radiation treatment.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 3","pages":"Article 107414"},"PeriodicalIF":3.2,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143377848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clinical study on the evaluation of rehabilitation outcomes in patients with deep hand burns using hand strength monitoring","authors":"Yaliga Ba ,&nbsp;Fang Li ,&nbsp;Yongfei Wu ,&nbsp;Te Ba ,&nbsp;Lingfeng Wang ,&nbsp;Shengjun Cao ,&nbsp;Quan Li","doi":"10.1016/j.burns.2025.107415","DOIUrl":"10.1016/j.burns.2025.107415","url":null,"abstract":"<div><h3>Background</h3><div>To provide reference for hand function assessment and treatment effectiveness by measuring changes in muscle strength before and after rehabilitation in patients with deep hand burns.</div></div><div><h3>Methods</h3><div>Clinical data from 112 patients with deep right hand burns treated at the Third Affiliated Hospital of Inner Mongolia Medical University were collected. Passive Functional Training: hand training was conducted using the continuous passive motion system, once daily for 40 minutes each session. The therapist performed resistance exercises, stretching training, and other motion therapies on the fingers. Specific pressure therapy was applied by the therapist based on the location and shape of the scars. Grip strength and finger to finger strength data of hand burn patients were measured before and after treatment on days 14, 21, 28, 35, 42, 60, 90, and 120 after wound healing. Scores from the Fugl-Meyer hand motor section, Michigan Hand Outcomes Questionnaire (MHQ), Vancouver Scar Scale (VSS), and Visual Analog Scale (VAS) for Pain were recorded before treatment. A two-way ANOVA was employed to evaluate the effects of time and group on rehabilitation outcomes. Pearson and Spearman correlation analysis were employed to explore correlations among variables.</div></div><div><h3>Results</h3><div>The two-way ANOVA analysis demonstrated significant effects of time, treatment, and their interaction (all <em>P</em> &lt; 0.001). Statistically significant differences in resultant force were observed between pre- and post-treatment at days 21, 28, 35, 42 and 60 ( all <em>P</em>＜0.001). The correlation coefficients between pre-treatment resultant force and Fugl-Meyer and MHQ scores were 0.848 and 0.852, respectively. The correlation coefficient between resultant force and grip strength was 0.899.</div></div><div><h3>Conclusions</h3><div>Measurement of hand muscle strength after wound healing could serve as a critical index for assessing hand function recovery status.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 4","pages":"Article 107415"},"PeriodicalIF":3.2,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143579214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"REsource Support To Optimize REcovery (RESTORE) scoping review: Evaluating aftercare resources for burn survivors","authors":"Mariana Velásquez-Cano ,&nbsp;Renee Noordzij ,&nbsp;Camille Carnevale ,&nbsp;Lauren J. Shepler ,&nbsp;Diana Tenney-Laperriere ,&nbsp;Lewis E. Kazis ,&nbsp;Colleen M. Ryan ,&nbsp;Mary D. Slavin ,&nbsp;Jeffrey C. Schneider","doi":"10.1016/j.burns.2024.107350","DOIUrl":"10.1016/j.burns.2024.107350","url":null,"abstract":"<div><h3>Background</h3><div>Burn survivors report limited resources as they transition to their communities after initial hospitalization. The aim of this project is to review literature that identifies resources provided to burn survivors and their supporters after discharge to their communities.</div></div><div><h3>Methods</h3><div>The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines were used to examine the following literature databases: PubMed, EMBASE, Web of Science, PsycInfo, and CINAHL. The World Health Organization (WHO) International Classification of Functioning, Disability and Health (ICF) Core Set for burn injury provided a framework to categorize resource content.</div></div><div><h3>Results</h3><div>Of the 637 articles screened, 27 met inclusion criteria. Data extraction identified resources categorized into the following ICF components: Body Functions, Activities and Participation, and Environmental Factors.</div></div><div><h3>Conclusion</h3><div>This review uses a conceptual framework to provide an overview of current published resources to support burn survivors following hospitalization. The identified resources addressed content such as health professionals, programs, psychological functioning after burn injury, scar management, and virtual resources. Based on the ICF framework, some gaps in resource content were noted such as pain, thermoregulation, interpersonal relationships, and self-care. Findings reveal relative strengths and gaps in resources, which can be used to better support burn survivors following hospitalization.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 1","pages":"Article 107350"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “Editorial board page” [Burns JBUR 50/8 (2024) Page i]","authors":"","doi":"10.1016/j.burns.2024.107338","DOIUrl":"10.1016/j.burns.2024.107338","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 1","pages":"Article 107338"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143183224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation into nurses’ emotion regulation while causing pain to adult patients during burns dressing changes: a qualitative study","authors":"Lucy Rudkin ,&nbsp;Lisa Williams ,&nbsp;Amanda C de C Williams","doi":"10.1016/j.burns.2024.107315","DOIUrl":"10.1016/j.burns.2024.107315","url":null,"abstract":"<div><h3>Background</h3><div>Burns can cause patients significant pain at the time of injury and during subsequent treatment. Other people’s pain often elicits empathic responses in observers. However, effective emotion regulation strategies are needed to manage personal distress, which may otherwise inhibit helping behaviour.</div></div><div><h3>Methods</h3><div>This study used an interpretative qualitative approach to conduct semi-structured interviews with burns nurses. Interviews explored emotion regulation strategies used by nurses whilst causing pain to adult patients during burns dressing changes. Transcripts were analysed using Braun and Clarke’s six stages of thematic analysis.</div></div><div><h3>Results</h3><div>Eight burns nurses participated in the interviews. Thematic analysis developed five themes: Emotions get in the way of being a good nurse; Pain’s an inevitable and justifiable part of treatment and healing; If I’m not made aware of the pain, maybe there is no pain; The pain’s due to other factors, not my actions; and Sometimes it’s too much.</div></div><div><h3>Conclusion</h3><div>Burns nurses’ attempts at regulating their emotions were influenced by their beliefs about what makes a ‘good’ nurse. Gross’s model of emotion regulation provides a useful framework for understanding these strategies, but further research is needed into the helpfulness thereof for nurses and patients.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 1","pages":"Article 107315"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142774566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nomogram based on burn characteristics and the National Early Warning Score to predict survival in severely burned patients","authors":"Ying Chen ,&nbsp;Yu Duan ,&nbsp;Qingshan Liu ,&nbsp;Yindi Li ,&nbsp;Mingyu Liu ,&nbsp;Hao Yan ,&nbsp;Yu Sun ,&nbsp;Bing Ma ,&nbsp;Guosheng Wu","doi":"10.1016/j.burns.2024.10.006","DOIUrl":"10.1016/j.burns.2024.10.006","url":null,"abstract":"<div><h3>Background</h3><div>Extensive burns are associated with a high mortality rate. Early prediction and action can reduce mortality. The National Early Warning Score (NEWS) is considered the best early warning score for predicting mortality. However, there has been no assessment conducted on the clinical prognostic significance of NEWS in individuals suffering from severe burns. The objective of this research was to establish a nomogram based on burn characteristics and the NEWS to predict survival in severely burned patients.</div></div><div><h3>Methods</h3><div>A retrospective analysis was performed on 335 patients diagnosed with extensive burns from 2005 to 2021 in the Department of Burn Surgery of Changhai Hospital, the First Affiliated Hospital of Naval Medical University. Univariate and multivariate analyses were used to determine independent prognostic factors. A nomogram was developed using these prognostic factors and its internal validity was assessed through bootstrap resampling.</div></div><div><h3>Results</h3><div>The results of multivariate analysis showed that the independent factors affecting the prognosis of severe burn patients were age, full-thickness burn, creatinine, inhalation tracheotomy, and the NEWS, all of which were identified to create the nomogram. The Akaike Information Criterion and Bayesian Information Criterion values of the nomogram demonstrated superior goodness-of-fit in predicting severe burns compared to NEWS, with lower scores (195.21 vs. 201.24; 221.91 vs. 224.12, respectively). The bootstrap-adjusted concordance index (C-index) of the nomogram yielded a higher value of 0.923(95 % CI 0.892–0.953), compared to NEWS which had a C-index of 0.699 (95 % CI 0.628–0.770). The calibration curves demonstrated excellent agreement between predicted probabilities and observed outcomes in the nomogram analysis. Furthermore, decision curve analysis indicated promising clinical utility for the proposed nomogram model. By applying an appropriate cutoff value derived from receiver operating characteristics curve analysis, it was observed that the high-risk group identified by the nomogram exhibited a significantly higher mortality rate than the low-risk group.</div></div><div><h3>Conclusion</h3><div>This study introduces an innovative nomogram that predicts the survival rate of individuals with severe burn injuries by combining clinical attributes and laboratory examinations, demonstrating superior efficacy compared to conventional NEWS systems.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 1","pages":"Article 107285"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142792713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The best stress ulcer prophylaxis in burn patients: The gap between research and practice","authors":"Farzan Madadizadeh ,&nbsp;Golnaz Afzal","doi":"10.1016/j.burns.2024.107341","DOIUrl":"10.1016/j.burns.2024.107341","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 1","pages":"Article 107341"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}