Burns最新文献

{"title":"Does prolotherapy have an effect on the care of pressure injuries? A pilot study","authors":"Nermin Eroğlu ,&nbsp;Rukiye Kökkız ,&nbsp;Hatice Eda Eroğlu ,&nbsp;Hasan Koçoğlu","doi":"10.1016/j.burns.2024.107352","DOIUrl":"10.1016/j.burns.2024.107352","url":null,"abstract":"<div><h3>Background</h3><div>This study contributes to wound healing with prolotherapy in people with pressure injuries. The study was planned and conducted as a randomized controlled trial to determine the effect of prolotherapy on the care of pressure injuries.</div></div><div><h3>Methods</h3><div>The study was carried out with patients with pressure injuries in the intensive care unit of a city hospital between April and June 2023. A power analysis was performed, and the sample size was calculated as 20 patients, including 10 in the intervention and 10 in the control group. The patients in the experimental group were given wound care with gelofusine as prolotherapy in the morning and evening for three days, and the injury site was covered with a sterile sponge and fixation tape. The patients in the control group were treated with saline in the morning and evening for three days. In both groups, the wound width, depth, and length were measured and evaluated prior to each intervention for three days.</div></div><div><h3>Results</h3><div>In the study, a significant difference was found between the mean ages of the participants in the experimental and control groups (p &lt; 0.05). The decrease in width measurements in the experimental group was found to be statistically significant compared to the previous measurements, while the increase in width measurements in the control group was significant compared to the previous measurements (p &lt; 0.05). Depth measurements decreased statistically significantly in the experimental group, while they increased significantly in the control group compared to previous measurement values (p &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>In conclusion, it was determined that the administration of gelofusine for pressure injuries as prolotherapy in the experimental group may be more effective in wound healing than saline treatment applied in the control group. Further studies are warranted.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 2","pages":"Article 107352"},"PeriodicalIF":3.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medication management in burn patients: Key role of clinical pharmacists","authors":"Farzan Madadizadeh ,&nbsp;Golnaz Afzal","doi":"10.1016/j.burns.2024.107349","DOIUrl":"10.1016/j.burns.2024.107349","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 2","pages":"Article 107349"},"PeriodicalIF":3.2,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trichostatin A reverses rocuronium resistance in burn-injured rats","authors":"Xiao Zhao ,&nbsp;Huijuan Wang ,&nbsp;Dian Xu,&nbsp;Junzuo Fu,&nbsp;Hong Wang","doi":"10.1016/j.burns.2024.107351","DOIUrl":"10.1016/j.burns.2024.107351","url":null,"abstract":"<div><h3>Aims</h3><div>This study aimed to investigate whether the histone deacetylase HDAC4 inhibitor, trichostatin A (TSA), could reverse resistance to non-depolarizing muscle relaxants (NDMRs) caused by burn injuries.</div></div><div><h3>Materials and methods</h3><div>A rat burn injury model was established, in which TSA was administered to inhibit HDAC4 expression. The potency of rocuronium was assessed through tension tests, and the levels of HDAC4 and myogenin proteins were determined using Western blot. Additionally, siRNA was utilized to explore the effects of HDAC4 knockdown on rocuronium potency and protein expression.</div></div><div><h3>Results</h3><div>The burn injuries increased the IC₅₀ of rocuronium, which was reversed by TSA treatment. Furthermore, HDAC4 and myogenin protein expression levels were increased significantly in burned legs, a phenomenon that TSA effectively counteracted. HDAC4 knockdown decreased rocuronium IC₅₀ and lowered HDAC4 and myogenin protein expression in the subsequent burn injuries.</div></div><div><h3>Conclusion</h3><div>The HDAC4 inhibitor TSA has the ability to mitigate NDMR resistance in skeletal muscle via the HDAC4-myogenin pathway after burn injuries.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 2","pages":"Article 107351"},"PeriodicalIF":3.2,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel mouse model for studies of burn wound conversion using a top hat–shaped brass template","authors":"Norifumi Matsuda ,&nbsp;Chigusa Sato ,&nbsp;Kosuke Ishikawa ,&nbsp;Takahiro Miura ,&nbsp;Emi Funayama ,&nbsp;Yuhei Yamamoto ,&nbsp;Kanako Fuyama ,&nbsp;Shunsuke Ohnishi ,&nbsp;Taku Maeda","doi":"10.1016/j.burns.2024.107348","DOIUrl":"10.1016/j.burns.2024.107348","url":null,"abstract":"<div><h3>Introduction</h3><div>The pathophysiology of burn wound conversion is not fully understood. Animal models are needed to elucidate the underlying mechanisms and develop treatments. Here, we established a new reproducible mouse model that simulates this process, thereby facilitating studies of burn wound conversion.</div></div><div><h3>Materials and methods</h3><div>After anesthesia and depilation, 75 mice were randomly assigned to 5-, 15-, and 25-s contact groups, and a top hat–shaped brass template was heated in boiling water and applied to the lateral abdomen. The wound area was calculated from photographs and the percentage of the surviving area was determined. Histological samples were collected 1–96 h after injury.</div></div><div><h3>Results</h3><div>A 15-s contact time produced the desired 50 %–75 % interspace necrosis at 96 h after injury. The 5-s contact group had a mostly preserved interspace, while the 25-s contact group exhibited near-complete necrosis. Histologically, significant differences between the 5- and 15-s contact groups were seen in cutaneous appendage denaturation and panniculus carnosus denaturation early after injury.</div></div><div><h3>Conclusion</h3><div>Exposing mice to the heated template for 15 s provides a reproducible model for studying burn wound conversion mechanisms and treatments, facilitating further elucidation of burn pathophysiology and evaluation of therapies to prevent burn wound conversion.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 2","pages":"Article 107348"},"PeriodicalIF":3.2,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental experiences, coping and the impact of Family Burn Camp after paediatric burn injury: A qualitative study","authors":"Victoria Schei ,&nbsp;Anne Berit Guttormsen ,&nbsp;Lina S.T. Lernevall ,&nbsp;Stian Kreken Almeland ,&nbsp;Margrethe Aase Schaufel","doi":"10.1016/j.burns.2024.107344","DOIUrl":"10.1016/j.burns.2024.107344","url":null,"abstract":"<div><h3>Background</h3><div>Paediatric burn injuries constitute a transformative event for parents, shaping their lives in profound ways. This study explores parental experiences, coping mechanisms, and the impact of Family Burn Camp in the aftermath of paediatric burn injuries.</div></div><div><h3>Methods</h3><div>A qualitative study was conducted in 2019 comprising two focus group interviews with 15 parents at the Family Burn Camp in Stavern, Norway. Data was analysed using systematic text condensation.</div></div><div><h3>Results</h3><div>Four categories emerged outlining parental experiences and coping strategies: 1) From acute chaos to a scarred future; 2) The paradox of being a helper and being the one who needs help; 3) Being isolated as parents of burnt children and 4) Coping through dialogue, empowerment and Family Burn Camp. Balancing the role of caregiver while seeking support, parents often experienced emotional breakdown after completion of the child’s wound treatment, leading to loss of work function. Coping strategies emerged through fostering the child's self-esteem, with Family Burn Camp emerging as a beacon, deemed “<em>worth more than a thousand therapy sessions</em>”.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that increased psychological and economic support are needed during and after the child's physical recovery. Family Burn Camp is a crucial element in the rehabilitation process for the whole family.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 2","pages":"Article 107344"},"PeriodicalIF":3.2,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of an online self-management program for chronic burn pain: A randomized controlled trial of the Take Charge of Burn Pain program","authors":"Fenan S. Rassu ,&nbsp;Elena Staguhn ,&nbsp;Scott Ravyts ,&nbsp;Renan Castillo ,&nbsp;Shelley A. Wiechman ,&nbsp;Tricia Kirkhart ,&nbsp;Rachel V. Aaron ,&nbsp;Amy Acton ,&nbsp;Linda Ware ,&nbsp;Stephen M. Milner ,&nbsp;Leigh Ann Price ,&nbsp;James A. Fauerbach ,&nbsp;Jennifer A. Haythornthwaite ,&nbsp;Stephen T. Wegener","doi":"10.1016/j.burns.2024.107336","DOIUrl":"10.1016/j.burns.2024.107336","url":null,"abstract":"<div><div>This randomized controlled trial investigated the effectiveness of an online self-management program, \"Take Charge of Burn Pain (TCBP),\" for 96 individuals living with chronic burn pain. Participants were randomly assigned to either the 7-week TCBP program integrating cognitive-behavioral therapy techniques, pain education, and self-management strategies or an attention control group focused on general burn recovery information. Assessments conducted at baseline, post-treatment, and 2- and 5-month follow-ups included measures of pain severity, pain interference, pain self-efficacy, posttraumatic stress disorder symptoms, and depression. Compared to the control group, participants in the TCBP program demonstrated greater reductions in pain severity (mean difference: −1.24, 95 % CI: −1.93 to −0.55, p = 0.0007) and pain catastrophizing (mean difference: −5.41, 95 % CI: −10.33 to −0.49, p = 0.0318) post-treatment when adjusting for key variables. At the two-month follow-up, the TCBP group showed significant improvements in pain interference (P = 0.0123), self-efficacy (P = 0.0269), functional abilities (P = 0.0014), and social role participation (P = 0.0498) compared to the control group. Treatment effects were not sustained at 5-month follow-up. Participants in both groups reported high levels of satisfaction with the online intervention, with the majority finding the program helpful and easy to use, and being willing to recommend it to others with pain. Findings suggest preliminary support for short-term benefits of TCBP for managing certain facets of chronic burn pain. This underscores the need to refine digital approaches to maintain and promote long-term improvements. The potential of self-guided online psychological interventions to enhance pain coping strategies for burn survivors persists.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 2","pages":"Article 107336"},"PeriodicalIF":3.2,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142899915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors besides lamotrigine associated Stevens-Johnson Syndrome and toxic epidermal necrolysis","authors":"Kaveh Gharaei Nejad ,&nbsp;Reyhaneh Ghadarjani","doi":"10.1016/j.burns.2024.08.007","DOIUrl":"10.1016/j.burns.2024.08.007","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"50 9","pages":"Article 107241"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wounds within: The hidden scars of violent care","authors":"Xin Zhang,&nbsp;Xiu-Hang Zhang","doi":"10.1016/j.burns.2024.08.011","DOIUrl":"10.1016/j.burns.2024.08.011","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"50 9","pages":"Article 107245"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-risk burn patients might be hospitalized more during the COVID-19 period than pre-COVID period","authors":"Payman Salamati,&nbsp;Vafa Rahimi-Movaghar","doi":"10.1016/j.burns.2024.09.005","DOIUrl":"10.1016/j.burns.2024.09.005","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"50 9","pages":"Article 107266"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“To BAL or not to BAL, that is the question”: Variations in smoke inhalation injury guidelines from burn units and centres in England, Scotland and Wales","authors":"Ganesh Rajaratnam ,&nbsp;Alexander J. Baldwin","doi":"10.1016/j.burns.2024.09.012","DOIUrl":"10.1016/j.burns.2024.09.012","url":null,"abstract":"<div><h3>Aim</h3><div>To evaluate variations in diagnostic criteria and management recommendations for smoke inhalation injury (SII) amongst the burn networks of England, Scotland, and Wales.</div></div><div><h3>Methods</h3><div>A descriptive cross-sectional study examining SII guidelines provided by adult burn units and centres in England, Scotland and Wales.</div></div><div><h3>Results</h3><div>All 16 adult burn units and centres responded. Fourteen (87.5 %) had guidelines. Due to sharing of guidelines, ten unique guidelines were assessed. Diagnostic criteria showed variability with no universal criterion shared amongst guidelines. Bronchoscopy was recommended by 90 % of guidelines, but the timing varied. The use of bronchoscopic scoring systems was recommended by four guidelines. Bronchoalveolar lavage (BAL) was recommended by four, with considerable variation in frequency and choice of lavage fluid. All guidelines advised at least one nebulised agent: heparin (n = 8); N-acetyl cysteine (NAC) (n = 8); or salbutamol (n = 8). All guidelines included advice on carbon monoxide poisoning; however, carboxyhaemoglobin (COHb) cut-off levels for treatment varied (5 % [n-4], 10 % [n = 3], 15 % [n = 1]). All recommended high-flow oxygen. Seven (70 %) guidelines offered guidance on cyanide poisoning. Reduced/altered consciousness was the only consistent diagnostic criterion. Five (50 %) guidelines provided intubation guidance, emphasising the role of a ‘senior clinician’ as the intubator. Ventilatory guidance appeared in eight guidelines, focusing on lung protective ventilation (n = 8); oxygenation goals (n = 3); and permissive hypercapnia (n = 3). Within lung-protective ventilation, advice on tidal volume (6, or 6–8 ml/kg) and plateau pressures (&gt;30 cmH2O) were presented most commonly (n = 7).</div></div><div><h3>Conclusion</h3><div>This study has outlined the substantial variations in guidance for the management of SII. The results underscore the need for a national guideline outlining a standardised approach to the diagnosis and management of SII, within the limitations of the current evidence.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"50 9","pages":"Article 107273"},"PeriodicalIF":3.2,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}