Burns最新文献

{"title":"Ferroptosis and necroptosis may be involved in the formation and progression of hydrofluoric acid burn wounds: Results from an RNA-Seq analysis","authors":"Fuying Li ,&nbsp;Jianda Zhou ,&nbsp;Ke Shi ,&nbsp;Quanyong He ,&nbsp;Wuliang Diao ,&nbsp;Hao Peng ,&nbsp;Geao Liang ,&nbsp;Chi Zhong ,&nbsp;Wengjuan Li ,&nbsp;Dan Xu","doi":"10.1016/j.burns.2025.107513","DOIUrl":"10.1016/j.burns.2025.107513","url":null,"abstract":"<div><h3>Background</h3><div>Hydrofluoric acid (HF) burns have potentially serious consequences. The molecular mechanism of wound development is still unclear. This study aims to preliminarily explore the programmed cell death mode that may be involved in hydrofluoric acid burns by using transcriptome sequencing technology and to provide a theoretical basis for a new treatment approach for hydrofluoric acid burns.</div></div><div><h3>Methods</h3><div>The rat model of hydrofluoric acid burn skin was constructed, and the differentially expressed genes after HF burn were screened by transcriptome sequencing technology. HE staining, TUNEL staining, immunohistochemistry, biochemical detection, and qRT-PCR were used to preliminarily verify the mode of cell death involved in hydrofluoric acid burn wounds.</div></div><div><h3>Results</h3><div>The sequencing results suggest that the differential genes after HF burn were enriched in ferroptosis, apoptosis, and necroptosis pathways in cell growth and death aspects. HE staining confirmed HF burn wounds were progressively aggravated. The positive cells of TUNEL staining in the wound gradually increased. Compared with the normal group, the content of MDA in serum and skin tissue increased and the content of GSH decreased at 4, 8, 12, 24, and 48 hours after HF burn (P &lt; 0.05). The level of serum Fe^2 + in the HF burn group was higher than that in the normal group at 4 h, 8 h, and 12 h postburn (P &lt; 0.05). The level of serum Fe²⁺ at 24 h and 48 h postburn was higher than that of the normal group, but the difference was not statistically significant. The content of Fe²⁺ in skin tissue increased and reached its peak at 12 h (P &lt; 0.05). The serum calcium level decreased to its lowest level at 24 hours postburn (P &lt; 0.05). Immunohistochemistry showed that the expressions of GPX4, FTH1, and Bcl-2 proteins in hydrofluoric acid burn wounds were down-regulated, while the expression of HO-1, Bax, RIPK1, and MLKL was increased (P &lt; 0.05). RIPK3 expression was not significantly different. qRT-PCR showed that the expression of HO-1, FTH1, SLC39A14, SLC39A8, CYBB, ACSL4, Bax, RIPK1, MLKL, IL-1β, and IL-6 increased, while the expression of ACSL1, ACSL6, GPX4, and Bcl-2 decreased after hydrofluoric acid burn compared with the normal group (P &lt; 0.05). The RIPK3 gene expression did not change significantly.</div></div><div><h3>Conclusions</h3><div>Ferroptosis and necroptosis are involved in the formation and progression of HF burn wounds. Early blocking of ferroptosis may be a potential therapeutic for blocking the progress of hydrofluoric acid burn wounds. Necroptosis involvment in the occurrence and development of hydrofluoric acid burn wounds may be a non-classical pathway.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107513"},"PeriodicalIF":3.2,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geospatial analysis of community-level social and environmental barriers for adult burn injury survivors in North Texas","authors":"Pyung Kim ,&nbsp;Dohyeong Kim ,&nbsp;Richard Scotch ,&nbsp;Dohyo Jeong ,&nbsp;Karen Kowalske","doi":"10.1016/j.burns.2025.107512","DOIUrl":"10.1016/j.burns.2025.107512","url":null,"abstract":"<div><h3>Purpose</h3><div>This study investigates geographic variations in community integration among burn injury survivors in North Texas and identifies community-level social and environmental factors that influence their post-injury community reintegration.</div></div><div><h3>Methods</h3><div>We utilized data from the Burn Model System (BMS) National Database, focusing on 153 adult burn injury survivors in North Texas who sustained injuries between 2015 and 2022. We conducted county-level mapping to visualize temporal changes in Community Integration Questionnaire (CIQ) scores by comparing pre-injury scores to post-injury scores at 6 and 12 months. Next, we categorized counties into two groups: (1) counties with consistent declines in CIQ scores over the 12-month post-injury period, and (2) all other counties with burn injury survivors. We then compared county-level community characteristics between these two groups, focusing on four factors: socioeconomic conditions, access to healthcare, public safety, and the built environment.</div></div><div><h3>Results</h3><div>There were geographic disparities in CIQ score changes among counties after burn injury. Counties with consistent decreases in CIQ scores had significantly higher levels of poverty, higher unemployment rates, increased crime rates, and lower access to healthy food options compared to other counties.</div></div><div><h3>Conclusions</h3><div>The findings suggest that rural counties may lack a supportive environment for burn injury survivors, highlighting the need for targeted interventions to promote community integration. Implementing strategies to reduce socioeconomic disparities, enhance public safety, and improve access to nutritious food could help facilitate better community reintegration outcomes for burn injury survivors. Furthermore, clinicians can leverage these insights by offering patient-level supports—such as localized telehealth services, peer support group referrals at discharge, and guidance on local resources—to help individuals navigate environmental barriers and maintain community engagement after returning home.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107512"},"PeriodicalIF":3.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The significance of completing burn excision within one week after injury","authors":"Yasuhiko Kaita,&nbsp;Takeaki Matsuda,&nbsp;Yoshihiro Yamaguchi","doi":"10.1016/j.burns.2025.107506","DOIUrl":"10.1016/j.burns.2025.107506","url":null,"abstract":"<div><h3>Background</h3><div>Burn wound excision is crucial for infection control in burn patients. Based on previous studies, the Japanese Society of Burn Injuries recommended that the surgical debridement be completed within one week after injury for patients with a burned area of 30 % or more. However, there have been no reports examining the significance of completing resection of the burn wound within one week. This study was aimed to clarify the importance of completing burn excision within one week after injury for 30 % or more in flame burn patients.</div></div><div><h3>Methods</h3><div>Data from 66 flame burn patients who underwent surgical excision from January 2005 to December 2024 were analyzed retrospectively.</div></div><div><h3>Results</h3><div>There were no significant differences between the completed and uncompleted groups in terms of age, sex, severity of burn, the presence of inhalation injury, the use of cadaver skin, and the ICU length of stay. The presence of bacteremia within two weeks after injury was significantly lower in the completed group compared to the uncompleted group, and the mortality rate in the completed group was lower than that of the uncompleted group. In the logistic regression analysis, the completion of burn excision within one week was independently associated with the incidence of bacteremia but not mortality.</div></div><div><h3>Conclusions</h3><div>Completing burn excision within one week is important for infection control in flame burn patients with the total burn surface area of 30 % or more.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107506"},"PeriodicalIF":3.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Component analysis of polyherbal repair recipe and its pharmacological mechanisms in burn wound healing","authors":"Xiangwei Qu ,&nbsp;Shanqin You ,&nbsp;Zhaoxiang Zeng ,&nbsp;Xueyuan Zhao ,&nbsp;Lijun Zhang ,&nbsp;Wan Li ,&nbsp;Rongzeng Huang ,&nbsp;Chengwu Song ,&nbsp;Jiangcheng He ,&nbsp;Xugui Li ,&nbsp;Xingliang Xiang ,&nbsp;Shuna Jin","doi":"10.1016/j.burns.2025.107514","DOIUrl":"10.1016/j.burns.2025.107514","url":null,"abstract":"<div><h3>Background</h3><div>The Jiusheng Wound Repair Recipe (JSWR), a folk prescription of traditional Chinese medicine, has been used clinically for treating burns and scalds with notable efficacy. However, its chemical components and pharmacological mechanisms remain unclear.</div></div><div><h3>Methods</h3><div>Ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) was utilized to analyze JSWR's chemical composition. A wound healing model in Kunming mice assessed the effects of JSWR on healing rates, collagen synthesis, angiogenesis, and inflammation through histological and immunohistochemical techniques. Potential pharmacological mechanisms were explored by metabolomic analysis.</div></div><div><h3>Results</h3><div>All 530 components were identified or characterized in JSWR. It significantly accelerated wound healing and reduced TNF-α and IL-6 levels. The expression of CD31 and collagen I and III were enhanced, while COX-2 expression was reduced. 19 critical metabolites and key metabolic pathways were explored by metabolomics.</div></div><div><h3>Conclusions</h3><div>JSWR effectively promoted wound healing through enhancing collagen deposition and angiogenesis, and by inhibiting inflammation. Further exploration of mechanisms would be valuable to the application and development of JSWR.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107514"},"PeriodicalIF":3.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143854647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Laser for Burn Scars (ELABS) - Randomised controlled trial of pulsed dye laser treatment and standard care versus standard care alone for the treatment of hypertrophic burn scars","authors":"Mark P. Brewin ,&nbsp;Sharon Docherty ,&nbsp;Vanessa Heaslip ,&nbsp;Shelley Rhodes ,&nbsp;Obioha C. Ukoumunne ,&nbsp;Naomi C. Burnett-Fry ,&nbsp;Katie Breheny ,&nbsp;Jonathon M. Pleat ,&nbsp;Kate M. Attrill ,&nbsp;Kayvan Shokrollahi ,&nbsp;Quentin Frew ,&nbsp;Christopher J. Lewis","doi":"10.1016/j.burns.2025.107500","DOIUrl":"10.1016/j.burns.2025.107500","url":null,"abstract":"<div><h3>Background</h3><div>Hypertrophic burn scarring (HBS) is described as “the greatest unmet challenge after burn injury”. This ELABS trial hypothesised that early pulsed dye laser (PDL) treatment of HBS improves both scar quality and quality of life (QoL).</div></div><div><h3>Methods</h3><div>A parallel arm randomised controlled trial to assess the effectiveness and cost-effectiveness of PDL was undertaken at seven centres in the UK. Patients were eligible if their burn injury was within three months of wound healing, and ineligible either with history of keloid scarring or aged &lt; 16 years. A total of 153 (77 male, 76 female) participants were recruited between Nov 17, 2021, and Jun 30, 2023, and were randomised using software in a 1:1 ratio stratified by study centre; 138 (69 each arm) were included in the final complete-case analysis. Both study arms received standard care, and the intervention arm received three PDL treatments. The primary outcome was patient-rated scar quality (POSAS) at six months. The trial was registered with International Standard Randomised Controlled Trial Number registry (ISRCTN14392301).</div></div><div><h3>Findings</h3><div>Early PDL showed a statistically significant improvement in patient-rated scar quality (p = 0·041) and the secondary outcome, participant’s perception of change in scar quality (p = 0·01), at six months. There were no statistically significant differences for Quality-of-Life, observer-rated POSAS scar quality, or colour measurement. Early PDL was not cost-effective at 6 months follow-up for the willingness-to-pay threshold of £20,000 per Quality-Adjusted-Life-Year (QALY). There were no unexpected adverse events related to the intervention.</div></div><div><h3>Interpretation</h3><div>Early PDL treatment of HBS is safe and shows improvement for patient-rated scar quality but not QoL at six months. As scar maturation is prolonged and dynamic, longer-term follow-up of upwards of two years is required both to understand the eventual clinical effect on scar outcome and to make any definitive conclusion concerning cost-effectiveness.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107500"},"PeriodicalIF":3.2,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implementation of a multimodal pain protocol in adult burn patients","authors":"Alyssa Garelli ,&nbsp;Allison N. Boyd ,&nbsp;Michelle Brown ,&nbsp;Taylor Rhew ,&nbsp;Molly Tieman ,&nbsp;Brett C. Hartman ,&nbsp;Todd A. Walroth","doi":"10.1016/j.burns.2025.107515","DOIUrl":"10.1016/j.burns.2025.107515","url":null,"abstract":"<div><div>The 2020 American Burn Association guidelines recommend a multimodal approach to pain management comprised of both opioids and non-opioids. The purpose of this study was to compare outcomes before and after implementation of a multimodal pain order set in the burn admission order set within the electronic medical record. This single center, retrospective, cohort study was conducted at an American Burn Association-verified burn center. The pre-group (n = 64) and post-group (n = 63) were well-matched with respect to all baseline demographics, such as total body surface area, length of stay, mechanical ventilation, and number of procedures. The primary outcome was daily morphine milligram equivalents received cumulatively through admission day seven. There was a significant reduction in cumulative median morphine milligram equivalents received in the post-group compared to the pre-group (172 versus 97, p = 0.042) without worsening evidence of pain. Doses of scheduled acetaminophen (62.5 % versus 95.2 %, p &lt; 0.001), ibuprofen (31.3 % versus 42.9 %, p = 0.017), and ketamine (14.1 % versus 28.6 %, p = 0.043) were significantly increased in the post-group. Multimodal order set integration significantly improved guideline recommended multimodal analgesic use and is one effective method to increase non-opioid analgesic use for acute pain following a burn injury.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107515"},"PeriodicalIF":3.2,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143874470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and feasibility of electrospinning technology for pediatric burns: Insights from a retrospective cohort study","authors":"Or Givol ,&nbsp;Michelle Cleary ,&nbsp;Rachel Kornhaber ,&nbsp;Erik Biros ,&nbsp;Josef Haik ,&nbsp;Adi Klein","doi":"10.1016/j.burns.2025.107509","DOIUrl":"10.1016/j.burns.2025.107509","url":null,"abstract":"<div><h3>Introduction</h3><div>Burns are a common injury in children, and they are treated with various pain management strategies and procedural sedation during dressing changes and debridement. Electrospinning dressing technology is a promising approach for advanced wound care, potentially improving healing outcomes and reducing complications. This retrospective study assessed the safety and feasibility of using electrospinning technology in pediatric burn patients.</div></div><div><h3>Materials and methods</h3><div>This retrospective cohort study included pediatric patients with partial-thickness burns treated between July 2022 and September 2023. Eighteen patients with burns were dressed using electrospinning technology, compared to 38 receiving standard care. The study also compared the number of procedural sedations, doses of opiates, and duration of non-opiate analgesic treatments, as well as the incidence of burn site deepening and burn site infections.</div></div><div><h3>Results</h3><div>The electrospinning dressing yielded patient outcomes comparable to standard care regarding sedation treatments, analgesics, and burn site infections. Additionally, the electrospinning dressing and standard care were similar in cases that required transfer to a specialised burn center or parents refusing treatment.</div></div><div><h3>Conclusion</h3><div>Electrospinning dressing technology showed non-inferiority to standard care in this small cohort of pediatric burns. Larger, prospective, randomized controlled trials are needed to confirm these findings and assess their long-term benefits and cost-effectiveness.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 6","pages":"Article 107509"},"PeriodicalIF":3.2,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Violent burns are associated with poorer life satisfaction and unemployment after injury","authors":"Artur Manasyan ,&nbsp;Kara A. McMullen ,&nbsp;Kimberly Roaten ,&nbsp;Jacob A. Bentley ,&nbsp;Sunia Choudhury ,&nbsp;Sarah A. Stoycos ,&nbsp;Haig A. Yenikomshian ,&nbsp;Maxwell B. Johnson","doi":"10.1016/j.burns.2025.107504","DOIUrl":"10.1016/j.burns.2025.107504","url":null,"abstract":"<div><h3>Background</h3><div>Assaults can result in violent burn injuries, leading to a profound impact on survivors. These burns can cause physical pain, psychological trauma, and challenges in employment. In this study, we aim to explore socioeconomic demographics and longitudinal psychosocial outcomes associated with violent burns.</div></div><div><h3>Methods</h3><div>Adult participants admitted for acute burn injury between 1993 and 2023 within the Burn Model System (BMS) database were included in the study. Patients with self-inflicted burn injuries were excluded. Participant demographics were summarized using descriptive statistics and compared between the intentional and unintentional burn cohorts with Wilcoxon-Mann-Whitney and Chi-square tests. A logistic regression model was constructed to investigate longitudinal occurrences of anxiety, depression, and posttraumatic stress symptoms, posttraumatic growth, employment status, and satisfaction with life.</div></div><div><h3>Results</h3><div>A total of 4668 patients were included in the study, of whom 147 (3.15 %) sustained violent burns. The intentional burn cohort was more likely to be Black (<em>p</em> &lt; 0.001), unemployed (<em>p</em> &lt; 0.001), have lower income (<em>p</em> = 0.001), and less likely to have completed graduate education (<em>p</em> &lt; 0.001) than the unintentional burn cohort. Participants with intentional burn injuries had larger burns (24.0 vs. 16.6 % total body surface area, <em>p</em> &lt; 0.001). Post-burn anxiety, depression, post-traumatic growth, and post-traumatic stress were not significantly associated with burn intentionality. After controlling for burn total body surface area, patients with violent burns were more likely to experience unemployment (<em>p</em> &lt; 0.001) and poorer satisfaction with life (<em>p</em> &lt; 0.001) after injury.</div></div><div><h3>Conclusions</h3><div>Violent, intentional burn injuries disproportionately impact historically marginalized and socioeconomically disadvantaged individuals. These injuries lead to poorer quality of life without an equivalent impact on psychological health across groups. Future research should focus on exploring dissatisfaction with life, barriers to employment, and the role of vocational counseling in addressing these challenges within this patient population.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107504"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective decontamination of the digestive tract in burn patients: A systematic review with meta-analysis","authors":"Emma Atsuko Tsuchiya ,&nbsp;Jacob Jensen-Abbew ,&nbsp;Mette Krag ,&nbsp;Morten Hylander Møller ,&nbsp;Martin Risom Vestergaard ,&nbsp;Nicolai Haase ,&nbsp;Marie Helleberg ,&nbsp;Rikke Holmgaard ,&nbsp;Johan Heiberg","doi":"10.1016/j.burns.2025.107501","DOIUrl":"10.1016/j.burns.2025.107501","url":null,"abstract":"<div><h3>Background</h3><div>In mechanically ventilated adult patients in the intensive care unit (ICU), selective decontamination of the digestive tract (SDD) has been shown to reduce the risk of infections and improve survival. While the benefits of SDD have been documented in this population, it remains unclear whether burn patients, who are at increased risk of infection and have distinct clinical characteristics, may experience similar benefits. In this systematic review we aimed to assess the desirable and undesirable patient-important effects of administering SDD to burn patients.</div></div><div><h3>Methods/design</h3><div>We conducted a systematic review with meta-analysis of randomized clinical trials (RCTs) assessing the effects of SDD versus placebo or no SDD in burn patients. The primary outcome was 30-day mortality. Secondary outcomes included serious adverse events, antimicrobial resistance, pneumonia, blood stream infections, ICU- and hospital-free days, and 90-day mortality. We searched all major databases and followed the recommendations provided by the Cochrane Collaboration and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The certainty of evidence was assessed according to the Grading of Recommendations Assessment, Development, and Evaluation approach.</div></div><div><h3>Results</h3><div>We identified four RCTs with a total of 457 burn patients. All trials were assessed as having either ‘some concerns’ or ‘high risk’ of bias. The evidence was found to be very uncertain across all outcomes assessed. For mortality, the relative risk (RR) was 0.62 (95 % confidence interval (CI) 0.22–1.78, I² = 75 %, random-effects model (REM), very low certainty evidence). For pneumonia, the RR was 0.75 (95 % CI 0.48–1.19, I² = 0 %, fixed-effect model, very low certainty evidence). For bloodstream infections, the RR was 1.10 (95 % CI 0.71–1.69, I² = 0 %, REM, very low certainty evidence). For hospital length of stay, the mean difference was −2.03 days (95 % CI −9.64–5.59, I² = 51 %, REM, very low certainty evidence). We did not perform meta-analyses for the remaining secondary outcomes due to limited or no data. Trial sequential analysis could not be performed due to insufficient number of total participants and events in the included trials.</div></div><div><h3>Conclusion</h3><div>We found that the certainty of evidence is very low about the effects of SDD on patient-important outcomes in burn patients. Extrapolating from the evidence on mechanically ventilated adult ICU patients may be reasonable until more data from RCTs in burn patients emerge.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107501"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143839552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do burn injury prevention interventions change what people know and how people think? A systematic review investigating the impact on psychological constructs","authors":"Cara Salt ,&nbsp;Laura Shepherd ,&nbsp;Richard Cooke ,&nbsp;Gemma Hurst","doi":"10.1016/j.burns.2025.107499","DOIUrl":"10.1016/j.burns.2025.107499","url":null,"abstract":"<div><h3>Introduction</h3><div>Burns can result in life-long physical and psychological difficulties. Interventions aimed at preventing burns are therefore important. Behaviour change theories propose that psychological variables (e.g., knowledge, attitudes, beliefs, self-efficacy) are associated with injury prevention behaviour. However, whether or not burn prevention interventions impact psychological variables is uncertain. This systematic review aimed to address this gap in the literature.</div></div><div><h3>Methods</h3><div>A systematic review was conducted according to PRISMA guidelines. Electronic databases (CINAHL, MEDLINE, PubMed and Scopus) were searched for randomized control trials (RCTs) of burn prevention interventions which measured at least one psychological construct. Studies were quality assessed using the Effective Public Health Practice Project (EPHPP) quality assessment tool.</div></div><div><h3>Results</h3><div>Eight studies met inclusion criteria. A narrative synthesis was conducted. Seven RCTs detailed interventions aimed at reducing paediatric burns (five delivered to parents/caregivers and two delivered to children). One RCT was aimed at adults. All RCTs measured burns knowledge, but findings were mixed about whether knowledge changed following interventions. Four RCTs measured self-efficacy, with all finding an increased perceived ability to engage in burn prevention behaviour following interventions. Risk perceptions (e.g., around the perceived severity and susceptibility of burns) were rarely measured.</div></div><div><h3>Conclusion</h3><div>To date, burn prevention RCTs have mainly focused on paediatric burns and most often measured knowledge change. However, the impact of interventions on knowledge is variable. Future burn prevention interventions should measure a range of psychological constructs, as these are likely to be important in burn prevention behaviour.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 5","pages":"Article 107499"},"PeriodicalIF":3.2,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}