Burns最新文献

{"title":"Preliminary exploration of efficacy assessment and optimal concentration of teprenone oral rehydration solution for the early management of post-burn shock","authors":"Xiang-yu Liu ,&nbsp;Yu-shou Wu ,&nbsp;Jia-ke Chai ,&nbsp;Xiao-wei Su ,&nbsp;Yi-rui Qu ,&nbsp;Fang-chao Hu ,&nbsp;Tian Liu ,&nbsp;Jin-guang Zheng ,&nbsp;Shao-fang Han ,&nbsp;Hui Zhou ,&nbsp;Yun-fei Chi","doi":"10.1016/j.burns.2025.107615","DOIUrl":"10.1016/j.burns.2025.107615","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate therapeutic efficacy of teprenone-enriched oral rehydration solution (TORS) relative to World Health Organization’s recommended Oral Rehydration Solution (WHO-ORS) and identify the optimal concentration of TORS for early burn shock intervention.</div></div><div><h3>Methods</h3><div>A total of 350 male Wistar rats (200–220 g) were randomly divided into seven groups (n = 50/group): Sham (no burn and no treatment) group, Burn (no treatment) group, WHO-ORS group, and four concentrations of TORS (TRS1–TRS4). All groups, except Sham group, were subjected to 50 % total body surface area (TBSA) third-degree scald burns. Resuscitation protocols commenced immediately post-burn and continued every 2 h for 8 h, delivering TORS at 2 mL/kg/%TBSA (modified Brooke formula). Survival rates were measured at 72 h post-burn. High-resolution laser Doppler was used for gastric blood flow measurement; gastrointestinal mucosal damage was assessed via optical and transmission electron microscopy; blood teprenone levels were determined using reverse-phase high-performance liquid chromatography. Lactate, hematocrit, hemoglobin, malondialdehyde, superoxide dismutase, and interleukin-33 levels were analyzed.</div></div><div><h3>Results</h3><div>TORS administration resulted in higher 72- h survival rates in both Burn and WHO-ORS controls (P &lt; 0.01 for TRS2 vs Burn), while exhibiting dose-dependent serum teprenone absorption. All TORS groups exhibited improved gastric blood flow, reduced gastric mucosal damage, and better performance in other measured parameters than the WHO-ORS group and Burn group. The TRS2 concentration was closest to the Sham group in most of the studied parameters.</div></div><div><h3>Conclusion</h3><div>The newly formulated TORS proved to be effectively emptied and absorbed by the gastrointestinal tract. This study establishes TORS as a viable oral resuscitation strategy, with TRS2 demonstrating optimal efficacy in improving tissue perfusion and survival outcomes over WHO-ORS, thereby offering a promising approach for early burn shock management. Further investigations are required to elucidate its underlying mechanisms.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107615"},"PeriodicalIF":3.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IBSP mediates fibroblast malignant behaviors in hypertrophic scars via interacting with SKP1","authors":"Ya Zhang ,&nbsp;Xiaojing Li ,&nbsp;Yunlin Ding ,&nbsp;Tingting Tao ,&nbsp;Teng Quan","doi":"10.1016/j.burns.2025.107617","DOIUrl":"10.1016/j.burns.2025.107617","url":null,"abstract":"<div><h3>Aims</h3><div>Hypertrophic scars (HS) are fibrotic skin conditions marked by abnormal myofibroblast proliferation and extracellular matrix accumulation. This study aimed to elucidate the functional effects and potential mechanisms of integrin-binding sialoprotein (IBSP) in hypertrophic scar fibroblasts.</div></div><div><h3>Materials and methods</h3><div>IBSP protein and wnt signaling pathway were screened by transcriptomics. To characterize the role of IBSP in hypertrophic scar fibroblasts, CCK8, transwell, and WB experiments were performed.</div></div><div><h3>Results</h3><div>IBSP protein and wnt signaling pathway were screened by transcriptomics. Since IBSP expression was elevated in proliferative scar fibroblasts, we performed IBSP protein knockdown, revealing a significant inhibition of proliferation, migration, and invasion. Western blotting experiments demonstrated that knockdown IBSP could inhibit wnt signaling pathway and collagen formation. Subsequent investigations indicated that IBSP knockdown reduced adenosine triphosphate (ATP) production and heightened reactive oxygen species (ROS) levels in hypertrophic scar fibroblasts. In order to investigate the potential mechanism of IBSP action, mass spectrometry analysis was performed. A combination of mass spectrometry, immunoprecipitation, and immunofluorescence verified that IBSP binds to SKP1. Notably, SKP1 knockdown markedly curtailed malignant behaviors in hypertrophic scar fibroblasts, including proliferation, migration, invasion, collagen synthesis, and ATP production. Moreover, SKP1 knockdown inhibited the wnt signaling pathway while inducing ROS production.</div></div><div><h3>Conclusion</h3><div>Collectively, our present study suggests that IBSP promotes the malignant process in hypertrophic scar fibroblasts.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107617"},"PeriodicalIF":3.2,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lower fluid resuscitation volumes in the first 24 hours following a severe burn injury are independently associated with greater days alive and out of hospital: A retrospective cohort study","authors":"Ben Gardiner ,&nbsp;Victoria Coles ,&nbsp;Elizabeth Vujcich ,&nbsp;Michael C. Reade ,&nbsp;Nermin Karamujic ,&nbsp;Elissa M. Milford","doi":"10.1016/j.burns.2025.107610","DOIUrl":"10.1016/j.burns.2025.107610","url":null,"abstract":"<div><h3>Background</h3><div>The optimal fluid resuscitation volume for severe burns is unknown. Clinical trials are challenged by the rarity of severe burns and the relatively low mortality rate resulting in the use of continuous surrogate outcomes to increase statistical power. Days alive and out of hospital (DAOH) at day 90 has been validated in the critically ill as a marker of long-term mortality and functional outcomes, although burns patients experience longer hospital admissions than the general critically ill population. We aimed to describe the association between fluid volume in the first 24 h post injury and DAOH at day 90 and day 180 (DAOH₉₀ and DAOH₁₈₀ respectively).</div></div><div><h3>Methods</h3><div>Retrospective cohort study of all 124 patients admitted with &gt; 20 % total body surface area (TBSA) burns to a major Australian burns referral centre ICU over a 5-year period.</div></div><div><h3>Results</h3><div>Median fluid volume in first 24 h was 4.8 (IQR 3.3–6.3) mL/kg/TBSA%. Using linear quantile regression modelling, after adjusting for age, TBSA%, injury severity, and inhalational injury, for every mL/kg/TBSA% increase in fluid in the first 24 h, there was a median decrease of 3.71 DAOH₉₀ (95 % CI 1.62–5.12, p = 0.002) and 4.41 DAOH₁₈₀ (95 % CI 2.21–7.22, p = 0.035). Restricted cubic spline modelling adjusted for the same covariates demonstrated a negative linear relationship between fluid volume in the first 24 h post injury and both DAOH₉₀ and DAOH₁₈₀ (p = 0.859 for DAOH₉₀ and p = 0.979 for DAOH₁₈₀).</div></div><div><h3>Conclusions</h3><div>Adjusting for known confounders, there was a negative linear relationship between fluid volumes in the first 24 h and DAOH₉₀ and DAOH₁₈₀. Either could be used as a continuous, patient-centred outcome for future clinical trials of severe burn resuscitation.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107610"},"PeriodicalIF":2.9,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144769245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ChatGPT as a collaborative research assistant in the ICF linking process of the brief version of the Burn Specific Health Scale","authors":"Hatice Gül ,&nbsp;Murat Ali Çınar ,&nbsp;Kezban Bayramlar","doi":"10.1016/j.burns.2025.107609","DOIUrl":"10.1016/j.burns.2025.107609","url":null,"abstract":"<div><h3>Introduction</h3><div>Burn injuries profoundly affect multiple aspects of health-related quality of life (HRQoL). The Brief Version of the Burn Specific Health Scale (BSHS-B) is commonly used to assess HRQoL in burn survivors. Linking such tools to the International Classification of Functioning, Disability and Health (ICF) enhances data comparability and standardisation for patients with burn injuries. However, linking process is often complex and time-consuming. Large language models may support linking process and help streamline future linking studies in burn rehabilitation.</div></div><div><h3>Objectives</h3><div>This study evaluated the feasibility of using ChatGPT-4o as a collaborative assistant in the ICF linking process of BSHS-B items.</div></div><div><h3>Methods</h3><div>The study followed the refined ICF linking rules. In the first stage, two physiotherapists independently linked the contents of BSHS-B items to ICF categories. When the two linkers disagreed, a third assigned the item to a category. In the second stage, ChatGPT-4o guided by specialised prompting performed the same task according to linking rules. In the content analysis, Cohen’s Kappa coefficient was computed to evaluate the consistency between expert consensus and ChatGPT-4o-based linking. An agreement on item perspective analyses was also conducted. Frequencies of identified ICF categories across major domains were reported descriptively.</div></div><div><h3>Results</h3><div>The agreement between linkers on ICF category assignment was fair (κ = 0.41, p &lt; .001), while ChatGPT and expert consensus agreement was moderate (κ = 0.55, p &lt; .001). In the perspective analysis, agreement between experts was fair (κ = 0.21, p &lt; .01), whereas ChatGPT demonstrated almost perfect agreement with experts (κ = 0.86, p &lt; .001). A total of 25 ICF codes were identified, mainly in Activity Participation (52.11 %) and Body Functions (40.85 %).</div></div><div><h3>Conclusion</h3><div>ChatGPT demonstrated substantial potential in the ICF linking process as a supportive tool. While not replacing human expertise, ChatGPT may be able to reduce workload and facilitate ICF linking process.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107609"},"PeriodicalIF":3.2,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of hypopigmented scar with autologous skin cell suspension delivered through fractional ablative laser-assisted drug delivery does not lead to short-term re-pigmentation","authors":"Bonnie C. Carney ,&nbsp;Monica L. Collins ,&nbsp;Mary A. Oliver ,&nbsp;John W. Keyloun ,&nbsp;Lauren T. Moffatt ,&nbsp;Jeffrey W. Shupp ,&nbsp;Taryn E. Travis","doi":"10.1016/j.burns.2025.107603","DOIUrl":"10.1016/j.burns.2025.107603","url":null,"abstract":"<div><div>Post-burn hypertrophic scars often exhibit dyschromia, including hyper- and hypo-pigmentation. Inactivated melanocytes, typically residing in the epidermal basement membrane, pose a challenge for effective activation and repigmentation in scarred areas. This study explores an alternative approach: using laser-assisted drug delivery to transplant melanocyte-containing cell suspensions into hypopigmented scars. In a porcine model with induced scars, autologous skin cell suspensions (ASCS) were delivered via CO₂ fractional ablative laser-created channels. Longitudinal analysis using Image J revealed no increase in pigmented areas or discernible melanin levels by digital imaging or non-invasive probes at weeks 1 and 2. Histological examination further confirmed the absence of melanin in tissue biopsies, with a transient increase in epidermal thickness observed at Day 63. This approach did not achieve repigmentation of hypopigmented scars within the study's 2-week duration. Future investigations may refine this technique by modifying delivery protocols based on these findings.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 8","pages":"Article 107603"},"PeriodicalIF":3.2,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144678371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of anterior segment optical coherence tomography angiography in predicting outcomes of acute ocular burns","authors":"Mahsan Samadi ,&nbsp;Hamidreza Ghanbari ,&nbsp;Hamed Ghasemi ,&nbsp;Ghazaleh Soltani ,&nbsp;Alireza Rezaei ,&nbsp;Zahra Montazeriani ,&nbsp;Mehrnaz Atighechian ,&nbsp;Ahmad Masoumi ,&nbsp;Mohammad Soleimani","doi":"10.1016/j.burns.2025.107604","DOIUrl":"10.1016/j.burns.2025.107604","url":null,"abstract":"<div><h3>Aim</h3><div>This study aims to investigate the role of anterior segment optical coherence tomography angiography (AS-OCTA) in determining the prognosis of ocular chemical injuries by correlating angiographic features with early complications and visual outcomes.</div></div><div><h3>Method</h3><div>Forty-six eyes of 36 patients with acute chemical injuries at Farabi Eye Hospital were studied prospectively. Participants received immediate medical care, followed by thorough ophthalmological examinations, including slit-lamp examination and AS-OCTA imaging. Angiographic parameters were analyzed for both superficial and deep layers of the ocular surface microcirculation in nasal and temporal quadrants.</div></div><div><h3>Results</h3><div>The study found that increases in deep and superficial vessel diameter indices (VDI) are associated with higher risk of corneal melting and keratitis, respectively, while a decrease in deep VDI is associated with a significantly higher risk of conjunctivalisation. Decreased superficial vessel length density (VLD) and limbal superficial vessel density (VD) are associated with higher risks of corneal opacification. Additionally, limbal ischemia was found to be significantly correlated with longer healing times.</div></div><div><h3>Conclusion</h3><div>AS-OCTA shows potential as a prognostic tool in ocular chemical injuries. Considering the early changes in angiographic parameters, we can predict specific post-chemical-burn complications.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107604"},"PeriodicalIF":3.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the scalpel: Unpacking grafting’s role in pediatric burn infection prevention","authors":"Yifan Wang ,&nbsp;Lianyi Bao","doi":"10.1016/j.burns.2025.107606","DOIUrl":"10.1016/j.burns.2025.107606","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107606"},"PeriodicalIF":3.2,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term sleep disturbance following burn injury: Insights from the Burn Model System","authors":"Anika Kim ,&nbsp;Paul Won ,&nbsp;Kara McMullen ,&nbsp;Barclay T. Stewart ,&nbsp;Jeffrey C. Schneider ,&nbsp;Collen M. Ryan ,&nbsp;Haig A. Yenikomshian","doi":"10.1016/j.burns.2025.107602","DOIUrl":"10.1016/j.burns.2025.107602","url":null,"abstract":"<div><h3>Objective</h3><div>To address the limited understanding of sleep disturbance (SD) among adult burn survivors by comprehensively examining its prevalence and related factors on a national scale using the Burn Model System (BMS) National Database.</div></div><div><h3>Summary background data</h3><div>SD is a common but underexplored sequela of burn injury, affecting burn survivors’ quality of life and functionality well beyond the initial injury. Existing data on SD and its co-morbidities in these patients are limited to select single-institution studies, lacking a comprehensive national perspective.</div></div><div><h3>Methods</h3><div>The BMS National Database was queried to identify burn patients responding to SD-related questions at 6 months, 12 months, 2 years, and 5 years post-injury. Descriptive statistics, subgroup analyses, and mixed-effects modeling were conducted to evaluate the prevalence, progression, and associated factors of SD at different time points.</div></div><div><h3>Results</h3><div>558 adult burn survivors met inclusion criteria. At 6 months post-injury, 34 % of participants reported SD, with 31 % still affected at 5 years. Demographic characteristics (age, gender, ethnicity) and clinical characteristics (body mass index (BMI), total body surface area burned (TBSA)) could not significantly predict the risk of SD. Mixed-effects modeling demonstrated a significant association between higher SD scores and increased depression and anxiety scores.</div></div><div><h3>Conclusions</h3><div>SD is a persistent condition among burn survivors, with prevalence continuing up to 5 years post-injury. Our study highlights the inability to predict SD based on demographic and clinical factors, underscoring the need for universal screening and interventions. In addition, the association between SD, depression, and anxiety calls for an integrated care approach that addresses both psychological and physical recovery in burn patients.</div></div>","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107602"},"PeriodicalIF":3.2,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144579885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “From fun to frostbite: Cutaneous cold injuries linked to nitrous oxide, the experience of a tertiary burn center in the UK””","authors":"Ming-yun Chi","doi":"10.1016/j.burns.2025.107605","DOIUrl":"10.1016/j.burns.2025.107605","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107605"},"PeriodicalIF":3.2,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An algorithm for the management of paediatric bicycle friction burns","authors":"Zak Vinnicombe,&nbsp;Marcus Dyer,&nbsp;Daniel Markeson","doi":"10.1016/j.burns.2025.107590","DOIUrl":"10.1016/j.burns.2025.107590","url":null,"abstract":"","PeriodicalId":50717,"journal":{"name":"Burns","volume":"51 7","pages":"Article 107590"},"PeriodicalIF":3.2,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144634366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}