Clinical and Investigative Medicine最新文献_第6页

A Discussion With Dr. Philippe Campeau, Medical Geneticist and Clinician-Scientist. 与医学遗传学家、临床科学家Philippe Campeau博士的讨论。

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2022-03-23 DOI: 10.25011/cim.v45i1.38228

Danny Jomaa, Philippe M. Campeau

引用次数: 0

Spring 2022: Clinician Investigator Trainee Association Of Canada (CITAC). 2022年春季:加拿大临床研究员培训协会(CITAC)。

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2022-03-23 DOI: 10.25011/cim.v45i1.38101

Melissa Phuong, Valera Castanov, C. Turco, Robert X. Lao, Wenxuan Wang, Amelia T Yuan, Heather T Whittaker

引用次数: 0

Long Term Prognostic Value Of SYNTAX Score II Among Stemi Patients-A Comprehensive Result From Meta-Analysis. 句法评分II在Stemi患者中的长期预后价值——来自荟萃分析的综合结果

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2022-03-23 DOI: 10.25011/cim.v45i1.38083

Changjie Yu, Qianying Xie, L. Cai, Zexin Chen, S. Qiu

{"title":"Long Term Prognostic Value Of SYNTAX Score II Among Stemi Patients-A Comprehensive Result From Meta-Analysis.","authors":"Changjie Yu, Qianying Xie, L. Cai, Zexin Chen, S. Qiu","doi":"10.25011/cim.v45i1.38083","DOIUrl":"https://doi.org/10.25011/cim.v45i1.38083","url":null,"abstract":"PURPOSE\u0000To assess the predictive value of SS II (SYNTAX score II) for long-term outcomes in ST-elevated myoarial infarction (STEMI) patients. Source: PubMed, EMBASE and Cochrane databases were searched up until September 24, 2021. Two investigators extracted data independently from the relevant articles. A random-effects model was conducted to combine the pooled hazard ratio (HR) or risk ratio (RR) for association between SS II and long term outcomes. Principal findings: A total of 12 articles (7,195 subjects) were included in the final meta-analyses. Analysis of nine of the articles showed that higher SS II predicted poor long term all-cause mortality among STEMI patients (pooled RRs=4.09,95%CI: 3.49-4.80). A similar association of SS II with poor long term mortality was observed when the crude HRs and adjusted HRs were pooled (crude HRs: pooled HR=1.07, 95%CI: 1.04-1.09; adjusted HRs: pooled HR=1.05, 95%CI:1.04-1.07). The STEMI patients with higher SS II also showed a higher associated with increased risk of long term major adverse cardiac events (pooled HR = 1.05, 95% CI: 1.02-1.07; pooled RR=2.28, 95%CI:2.02-2.57). A consistent association was found for heart failure among STEMI patients. Conclusion: Higher SS II predicted poor long term all-cause mortality, major adverse cardia events and heart failure among STEMI patients.","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79208886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Young Investigator Interview With CSCI Distinguished Scientist Awardee Dr. Michael Hill. 青年研究者专访CSCI杰出科学家奖获得者Michael Hill博士。

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2022-03-23 DOI: 10.25011/cim.v45i1.38099

Wenxuan Wang, Michael D. Hill

引用次数: 0

Hats Off to the CIM Reviewers of 2021. 向2021年的CIM评审人员致敬。

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2021-12-31 DOI: 10.25011/cim.v44i4.37863

Robert Bortolussi, Alex Levit

引用次数: 0

Carotid Intima-Media Thickness in Patients with Subclinical Hypothyroidism: A Prospective Controlled Study. 亚临床甲状腺功能减退患者颈动脉内膜-中膜厚度:一项前瞻性对照研究。

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2021-12-31 DOI: 10.25011/cim.v44i4.37139

Anally J Soto-García, Guillermo Elizondo-Riojas, Rene Rodriguez-Gutiérrez, Leonardo G Mancillas-Adame, J Gerardo González-González

{"title":"Carotid Intima-Media Thickness in Patients with Subclinical Hypothyroidism: A Prospective Controlled Study.","authors":"Anally J Soto-García, Guillermo Elizondo-Riojas, Rene Rodriguez-Gutiérrez, Leonardo G Mancillas-Adame, J Gerardo González-González","doi":"10.25011/cim.v44i4.37139","DOIUrl":"https://doi.org/10.25011/cim.v44i4.37139","url":null,"abstract":"Purpose: The association between subclinical hypothyroidism (SCH) and cardiovascular risk, particularly with a TSH <10 µIU/ml, remains controversial. The objective of our study was to assess the association between SCH and cardiovascular risk through carotid intima-media thickness, and alternatively, to evaluate its change after treatment with levothyroxine.Methods: A total of 54 individuals were included in the study: 18 with SCH; 18 with overt hypothyroidism (OH); and 18 healthy controls (HC). The carotid intima-media thickness was measured in each group. In SCH, follow-up was performed at three and six months after the start of levothyroxine treatment.Results: The mean age of the total population at baseline was 35.8 years. The median TSH in SCH was 6.15 µIU/ml. The carotid intima-media thickness (mean and standard deviation) was greater in SCH in comparison to the HC group: right common carotid artery (RCCA), 0.486 ± 0.106 mm and 0.413 ± 0.075 mm in SCH and HC, respectively, p=0.01 and left common carotid artery (LCCA), 0.511 ± 0.144 mm and 0.427 mm ± 0.090 in SCH and HC, respectively, p=0.03). In patients with SCH, there was a decrease in the carotid intima-media thickness after treatment with levothyroxine (RCCA and LCCA, p <0.05 at three and six months).Conclusions: There was an association between increased carotid intima-media thickness in patients with SCH in comparison with HC, even with a TSH <10 µIU/ml. The increase was reversed with levothyroxine therapy. The association of this increased thickness with important cardiovascular outcomes remains uncertain and should be evaluated in future studies.","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39781340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MIR-181A-5P Attenuates Ovalbumin-Induced Allergic Inflammation in Nasal Epithelial Cells by Targeting IL-33/P38 MAPK Pathway. MIR-181A-5P通过靶向IL-33/P38 MAPK通路减轻卵清蛋白诱导的鼻上皮细胞变应性炎症

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2021-12-31 DOI: 10.25011/cim.v44i4.37327

Songliang Long, Hua Zhang

{"title":"MIR-181A-5P Attenuates Ovalbumin-Induced Allergic Inflammation in Nasal Epithelial Cells by Targeting IL-33/P38 MAPK Pathway.","authors":"Songliang Long, Hua Zhang","doi":"10.25011/cim.v44i4.37327","DOIUrl":"https://doi.org/10.25011/cim.v44i4.37327","url":null,"abstract":"Purpose: Chronic inflammation of the nasal mucosal tissues plays an important role in the pathogenesis of allergic rhinitis (AR). Aberrantly-expressed micro ribonucleic acid (miRNA) has been found to have strong associations with the inflammatory reactions in allergic diseases; however, its functional significance and molecular mechanism in AR remains unclear. The purpose of this study is to determine the functional role and mechanism of miR-181a-5p in AR.Methods: Allergic inflammatory reaction was induced by ovalbumin in human nasal epithelial cell line RPMI2650. The anti-inflammatory effects of miR-181a-5p were evaluated by examining pro-inflammatory cytokines (interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α)) in the culture of RPMI-2650 cells stimulated by ovalbumin, using quantitative real-time reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay. Luciferase assay and gain-of-function assay were used to investigate the association of miR-181a-5p and IL-33/p38 MAPK axis.Results: MiR-181a-5p was significantly downregulated in mucosal tissues of AR patients and in RPMI-2650 cells treated with ovalbumin. The overexpression of miR-181a-5p showed prominent suppression of inflammatory cytokine production in RPMI-2650 cells with the stimulation of ovalbumin. MiR-181a-5p directly targeted, and negatively regulated IL-33 to suppress the activation of p38 MAPK signalling.Conclusion: The results suggest that miR-181a-5p restricted allergic inflammation through inhibition of IL-33/p38 MAPK pathway, indicating miR-181a-5p may play an anti-inflammatory role in AR.","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39781338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Trauma Care During the COVID-19 Pandemic: A Canadian Survey. COVID-19大流行期间的创伤护理:一项加拿大调查。

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2021-12-31 DOI: 10.25011/cim.v44i4.37515

Mostafa Alhabboubi, François De Champlain, Khalifa AlQaydi, Basem Algamdi, Joe Nemeth, Greg Clark

{"title":"Trauma Care During the COVID-19 Pandemic: A Canadian Survey.","authors":"Mostafa Alhabboubi, François De Champlain, Khalifa AlQaydi, Basem Algamdi, Joe Nemeth, Greg Clark","doi":"10.25011/cim.v44i4.37515","DOIUrl":"https://doi.org/10.25011/cim.v44i4.37515","url":null,"abstract":"Purpose: The coronavirus disease 2019 (COVID-19) pandemic has placed major limitations on trauma health care systems. This survey aims to identify how Canadian trauma centres altered their processes to care for injured patients and protect their staff during the pandemic.Methods: A survey was distributed to trauma directors at level 1 Canadian adult trauma centres in July 2020. Questions included changes made to the trauma service in preparation for the pandemic, modification to clinical practice and expected lasting modifications after the pandemic.Results: The response rate was 68.4%. All trauma centres modified their treatment and investigation protocols for the pandemic. Most respondents adopted online platforms for meetings and educational activities and used simulation to prepare for COVID-19-infected trauma patients. The approach to who would intubate trauma patients, which trauma patients should be tested for COVID-19 and who should use N95 ventilators, varied among the sites surveyed.Conclusion: All centres modified some of their treatment and investigation protocols for the pandemic but not all modifications were adopted universally. Knowing these steps and comparing them with other global centres will help organize disaster plans for the current and future pandemics.","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39894015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress and Burnout Among Mental Health Staff During the COVID-19 Pandemic. COVID-19 大流行期间心理健康工作人员的压力和职业倦怠。

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2021-12-31 DOI: 10.25011/cim.v44i4.37753

Joseph Sadek, Ben MacDonald, Brooke Streeter

{"title":"Stress and Burnout Among Mental Health Staff During the COVID-19 Pandemic.","authors":"Joseph Sadek, Ben MacDonald, Brooke Streeter","doi":"10.25011/cim.v44i4.37753","DOIUrl":"10.25011/cim.v44i4.37753","url":null,"abstract":"Purpose: The coronavirus disease 2019 (COVID-19) pandemic has deeply altered social and working environments among health care workers. These health care workers are therefore at risk of additional psychosocial strain and ensuing metal health symptoms, which indirectly affects patient care. In this study, we aimed to assess the psychosocial and psychopathological impact of COVID-19 among acute care mental health and addictions staff.Methods: This study is a cross-sectional survey and contains a sample size of 60 mental health and addiction acute care workers recruited from within Nova Scotia Health Authority. The survey was constructed using the online survey system, Opinio, and consisted of three sections: demographic variables (gender, age group and profession); the DASS-21 Questionnaire (which provides dimensional measures of stress, anxiety and depression); and the MBI-HSS (MP) Questionnaire (which measures three dimensions of burnout-emotional exhaustion, depersonalization and personal achievement).Results: The majority of participants had at least one pathologic score on the DASS-21 and MBI-HSS (MP) sections (75.5% and 93.5%, respectively). The median severity on the DASS-21 and MBI-HSS (MP) were both moderate, with the younger age group (20-35 years) having more significant burnout scores (p = 0.0494). Simple logistic regression showed a significant relationship between burnout severity and pathologic distress, and simple linear regression showed significant correlation between DASS-21 and MBI-HSS (MP) scores, with a R2 value of 0.4633.Conclusion: More planning, programs, resources and further research are needed to support wellness and recovery of all health care professionals who work at the mental health and addictions acute care unit.","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39894011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ICD-10 Diagnostic Coding for Identifying Hospitalizations Related to a Diabetic Foot Ulcer. 识别糖尿病足溃疡相关住院的ICD-10诊断编码

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2021-12-31 DOI: 10.25011/cim.v44i4.37592

Muzammil H Syed, Mohammed Al-Omran, Jean Jacob-Brassard, Joel G Ray, Mohamad A Hussain, Muhammad Mamdani, Charles de Mestral

{"title":"ICD-10 Diagnostic Coding for Identifying Hospitalizations Related to a Diabetic Foot Ulcer.","authors":"Muzammil H Syed, Mohammed Al-Omran, Jean Jacob-Brassard, Joel G Ray, Mohamad A Hussain, Muhammad Mamdani, Charles de Mestral","doi":"10.25011/cim.v44i4.37592","DOIUrl":"https://doi.org/10.25011/cim.v44i4.37592","url":null,"abstract":"Purpose: To estimate the positive predictive value (PPV) of Canadian ICD-10 diagnostic coding for the identification of hospitalization related to a diabetic foot ulcer (DFU).Methods: Hospitalizations related to a neuropathic and/or ischemic DFU were identified from the Discharge Abstract Database (DAD) records of a single Canadian tertiary care hospital between April 1, 2002 and March 31, 2019. The first coding approach required a most responsible diagnosis (MRDx) code for diabetes-specific foot ulceration or gangrene (DSFUG group). Three alternative coding approaches were also considered: MRDx code for lower-limb osteomyelitis (osteomyelitis group); lower-limb ulceration (LLU group); or lower-limb atherosclerotic gangrene (atherosclerosis group)-each in conjunction with a non-MRDx DSFUG code on the same DAD record. From all eligible DAD records, random samples were drawn for each coding group. DAD records were independently compared by a masked reviewer who manually abstracted data from the entire hospital record (reference standard). The PPV and 95% CI were generated.Results: Out of 1,460 hospitalizations, a total of 300, 50, 33 and seven records were included from the DSFUG, osteomyelitis, LLU and atherosclerosis samples, respectively. Compared to the reference standard, the PPV for all 390 records was 88.5% (95% CI 84.9 to 91.5). The DSFUG group had the highest PPV (90.0%, 95% CI 86.0 to 93.2), followed by the atherosclerosis (85.7%, 95% CI 42.1 to 99.6), LLU (84.9%, 95% CI 68.1 to 94.9) and osteomyelitis (82.0%, 95% CI 68.6 to 91.4) groups.Conclusion: Based on data from a Canadian tertiary care hospital, the specified coding algorithms can be used to identify and study the management and outcomes of people hospitalized with a DFU in Ontario.","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":null,"pages":null},"PeriodicalIF":0.8,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39894013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1