Clinical and Investigative Medicine最新文献_第10页

Screening for Immune-Related RNA Biomarkers of Aneurysmal Subarachnoid Hemorrhage. 动脉瘤性蛛网膜下腔出血免疫相关RNA生物标志物的筛选。

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2022-06-26 DOI: 10.25011/cim.v45i2.38449

Lin Cheng, Yun Zhao, Hong Ke

{"title":"Screening for Immune-Related RNA Biomarkers of Aneurysmal Subarachnoid Hemorrhage.","authors":"Lin Cheng, Yun Zhao, Hong Ke","doi":"10.25011/cim.v45i2.38449","DOIUrl":"https://doi.org/10.25011/cim.v45i2.38449","url":null,"abstract":"Purpose: Through comprehensive bioinformatics analysis based on the immune microenvironment, this study aimed to identify immune-related RNA biomarkers that indicate aneurysmal subarachnoid hemorrhage (aSAH).Methods: The GSE73378 dataset was downloaded from the National Center for Biotechnology Information GEO database, providing blood from 107 normal controls and 103 patients with aSAH. The immune infiltration types in the aSAH blood samples were assessed and RNAs that were differentially expressed (DE) between 1) the aSAH and control groups and 2) the immune infiltration groups (high and low) were identified. The intersecting genes were subjected to weighted gene co-expression network analysis followed by co-expression network construction. The aSAH-related genes and pathways were identified from the Comparative Toxicogenomics Database: update 2019.Results: A total of three DE long non-coding RNAs (lncRNAs) and 301 DE mRNAs were identified. Of the 301 mRNAs, 91 were significantly enriched in three modules. Based on the 91 mRNAs and three lncRNAs, a co-expression network related to the disease pathway was constructed. This pathway consisted of 16 factors, including the 13 mRNAs (e.g., TNFSF13B, TNFSF10, MYD88, GNA12 and NSMAF) and three lncRNAs (FAM66A, LINC00954 and CELF2-AS2), as well as six pathways, including the NF-κB, toll-like receptor, and sphingolipid signalling pathways.Conclusion: TNFSF13B, MYD88, GNA12, NSMAF, FAM66A, LINC00954 and CELF2-AS2 may serve as biomarkers for aSAH. The NF-κB, toll-like receptor and sphingolipid signalling pathways may play critical roles in the progression of aSAH.","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":"45 2","pages":"E28-38"},"PeriodicalIF":0.8,"publicationDate":"2022-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40395976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimating Disease Prevalence in Administrative Data. 估算行政数据中的疾病患病率。

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2022-06-26 DOI: 10.25011/cim.v45i2.38100

Jacek A Kopec

{"title":"Estimating Disease Prevalence in Administrative Data.","authors":"Jacek A Kopec","doi":"10.25011/cim.v45i2.38100","DOIUrl":"https://doi.org/10.25011/cim.v45i2.38100","url":null,"abstract":"Purpose: Disease prevalence estimates from population-based administrative databases are often biased due to measurement (misclassification) errors. The purpose of this article is to review the methodology for estimating disease prevalence in administrative data, with a focus on bias correction.Source: Several approaches to bias correction in administrative data were reviewed and application of these methods was demonstrated using an example from the literature: physician claims and hospitalization data were employed to estimate diabetes prevalence in Ontario, Canada.Findings: Misclassification bias in prevalence estimates from administrative data can be reduced by developing and selecting an optimal algorithm for case identification, applying a bias correction formula, or using statistical modelling. An algorithm for which sensitivity equals positive predictive value provides an unbiased estimate of prevalence. Bias reduction methods generally require information about the measurement properties of the algorithm, such as sensitivity, specificity, or predictive value. These properties depend on disease type, prevalence, algorithm definition (including the observation window), and may vary by population and time. Prevalence estimates can be improved by applying multivariable disease prediction models.Conclusion: Frequency of a positive case identification algorithm in administrative data is generally not equivalent to disease prevalence. Although prevalence estimates can be corrected for bias using known measurement properties of the algorithm, these properties may be difficult to estimate accurately; therefore, disease prevalence estimates based on administrative data must be treated with caution.","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":"45 2","pages":"E21-27"},"PeriodicalIF":0.8,"publicationDate":"2022-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40398900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Association Between ESR1 XBAI and Breast Cancer Susceptibility: A Systematic Review and Meta-Analysis. ESR1 XBAI与乳腺癌易感性之间的关系:一项系统综述和荟萃分析。

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2022-03-23 DOI: 10.25011/cim.v45i1.37842

Tongyou Sunemail, R. Lian, Xiujun Liang, Dayong Sun

{"title":"Association Between ESR1 XBAI and Breast Cancer Susceptibility: A Systematic Review and Meta-Analysis.","authors":"Tongyou Sunemail, R. Lian, Xiujun Liang, Dayong Sun","doi":"10.25011/cim.v45i1.37842","DOIUrl":"https://doi.org/10.25011/cim.v45i1.37842","url":null,"abstract":"PURPOSE\u0000Estrogen receptor 1 (ESR1) XbaI polymorphisms may affect breast cancer susceptibility; however, the results of previously published studies are inconsistent. This meta-analysis aimed to investigate the relationship between ESR1 XbaI polymorphism and breast cancer risk. Methods: Articles from the PubMed, Embase, Cochrane Library, WoS, Scopus, Wanfang Data, CNKI, CBM and CQVIP databases were systematically searched to determine the association between ESR1 XbaI polymorphism and breast cancer risk. The pooled results were assessed using odds ratios (ORs) and 95% confidence intervals (CIs), followed by subgroup analysis. Results: Twenty-two studies involving 12,821 cases and 14,739 control subjects were analyzed. The pooled results indicated that ESR1 XbaI polymorphism may decrease risk of breast cancer in AG vs. AA (co-dominant model: OR = 0.88, 95% CI = 0.79-0.97, P = 0.015) and AG + GG vs. AA models (dominant model: OR = 0.89, 95% CI = 0.80-0.98, P = 0.022). Subgroup analysis indicated significant associations between the ESR1 XbaI polymorphism and breast cancer risk were observed in Asian subjects, non-Hardy-Weinberg equilibrium study, post-menopausal status and hospital-based subgroups under the AG vs. AA and AG + GG vs. AA models (all P < 0.05). Conclusions: Our analysis of pooled data indicated that AG genotype in ESR1 XbaI may be a protective factor for breast cancer patients in some subgroups.","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":"38 1","pages":"E21-34"},"PeriodicalIF":0.8,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83000104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Discussion With Dr. Philippe Campeau, Medical Geneticist and Clinician-Scientist. 与医学遗传学家、临床科学家Philippe Campeau博士的讨论。

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2022-03-23 DOI: 10.25011/cim.v45i1.38228

Danny Jomaa, Philippe M. Campeau

引用次数: 0

Spring 2022: Clinician Investigator Trainee Association Of Canada (CITAC). 2022年春季:加拿大临床研究员培训协会(CITAC)。

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2022-03-23 DOI: 10.25011/cim.v45i1.38101

Melissa Phuong, Valera Castanov, C. Turco, Robert X. Lao, Wenxuan Wang, Amelia T Yuan, Heather T Whittaker

引用次数: 0

Long Term Prognostic Value Of SYNTAX Score II Among Stemi Patients-A Comprehensive Result From Meta-Analysis. 句法评分II在Stemi患者中的长期预后价值——来自荟萃分析的综合结果

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2022-03-23 DOI: 10.25011/cim.v45i1.38083

Changjie Yu, Qianying Xie, L. Cai, Zexin Chen, S. Qiu

{"title":"Long Term Prognostic Value Of SYNTAX Score II Among Stemi Patients-A Comprehensive Result From Meta-Analysis.","authors":"Changjie Yu, Qianying Xie, L. Cai, Zexin Chen, S. Qiu","doi":"10.25011/cim.v45i1.38083","DOIUrl":"https://doi.org/10.25011/cim.v45i1.38083","url":null,"abstract":"PURPOSE\u0000To assess the predictive value of SS II (SYNTAX score II) for long-term outcomes in ST-elevated myoarial infarction (STEMI) patients. Source: PubMed, EMBASE and Cochrane databases were searched up until September 24, 2021. Two investigators extracted data independently from the relevant articles. A random-effects model was conducted to combine the pooled hazard ratio (HR) or risk ratio (RR) for association between SS II and long term outcomes. Principal findings: A total of 12 articles (7,195 subjects) were included in the final meta-analyses. Analysis of nine of the articles showed that higher SS II predicted poor long term all-cause mortality among STEMI patients (pooled RRs=4.09,95%CI: 3.49-4.80). A similar association of SS II with poor long term mortality was observed when the crude HRs and adjusted HRs were pooled (crude HRs: pooled HR=1.07, 95%CI: 1.04-1.09; adjusted HRs: pooled HR=1.05, 95%CI:1.04-1.07). The STEMI patients with higher SS II also showed a higher associated with increased risk of long term major adverse cardiac events (pooled HR = 1.05, 95% CI: 1.02-1.07; pooled RR=2.28, 95%CI:2.02-2.57). A consistent association was found for heart failure among STEMI patients. Conclusion: Higher SS II predicted poor long term all-cause mortality, major adverse cardia events and heart failure among STEMI patients.","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":"7 1","pages":"E12-20"},"PeriodicalIF":0.8,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79208886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Young Investigator Interview With CSCI Distinguished Scientist Awardee Dr. Michael Hill. 青年研究者专访CSCI杰出科学家奖获得者Michael Hill博士。

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2022-03-23 DOI: 10.25011/cim.v45i1.38099

Wenxuan Wang, Michael D. Hill

引用次数: 0

Hats Off to the CIM Reviewers of 2021. 向2021年的CIM评审人员致敬。

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2021-12-31 DOI: 10.25011/cim.v44i4.37863

Robert Bortolussi, Alex Levit

引用次数: 0

Carotid Intima-Media Thickness in Patients with Subclinical Hypothyroidism: A Prospective Controlled Study. 亚临床甲状腺功能减退患者颈动脉内膜-中膜厚度:一项前瞻性对照研究。

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2021-12-31 DOI: 10.25011/cim.v44i4.37139

Anally J Soto-García, Guillermo Elizondo-Riojas, Rene Rodriguez-Gutiérrez, Leonardo G Mancillas-Adame, J Gerardo González-González

{"title":"Carotid Intima-Media Thickness in Patients with Subclinical Hypothyroidism: A Prospective Controlled Study.","authors":"Anally J Soto-García, Guillermo Elizondo-Riojas, Rene Rodriguez-Gutiérrez, Leonardo G Mancillas-Adame, J Gerardo González-González","doi":"10.25011/cim.v44i4.37139","DOIUrl":"https://doi.org/10.25011/cim.v44i4.37139","url":null,"abstract":"Purpose: The association between subclinical hypothyroidism (SCH) and cardiovascular risk, particularly with a TSH <10 µIU/ml, remains controversial. The objective of our study was to assess the association between SCH and cardiovascular risk through carotid intima-media thickness, and alternatively, to evaluate its change after treatment with levothyroxine.Methods: A total of 54 individuals were included in the study: 18 with SCH; 18 with overt hypothyroidism (OH); and 18 healthy controls (HC). The carotid intima-media thickness was measured in each group. In SCH, follow-up was performed at three and six months after the start of levothyroxine treatment.Results: The mean age of the total population at baseline was 35.8 years. The median TSH in SCH was 6.15 µIU/ml. The carotid intima-media thickness (mean and standard deviation) was greater in SCH in comparison to the HC group: right common carotid artery (RCCA), 0.486 ± 0.106 mm and 0.413 ± 0.075 mm in SCH and HC, respectively, p=0.01 and left common carotid artery (LCCA), 0.511 ± 0.144 mm and 0.427 mm ± 0.090 in SCH and HC, respectively, p=0.03). In patients with SCH, there was a decrease in the carotid intima-media thickness after treatment with levothyroxine (RCCA and LCCA, p <0.05 at three and six months).Conclusions: There was an association between increased carotid intima-media thickness in patients with SCH in comparison with HC, even with a TSH <10 µIU/ml. The increase was reversed with levothyroxine therapy. The association of this increased thickness with important cardiovascular outcomes remains uncertain and should be evaluated in future studies.","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":"44 4","pages":"E39-45"},"PeriodicalIF":0.8,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39781340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stress and Burnout Among Mental Health Staff During the COVID-19 Pandemic. COVID-19 大流行期间心理健康工作人员的压力和职业倦怠。

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2021-12-31 DOI: 10.25011/cim.v44i4.37753

Joseph Sadek, Ben MacDonald, Brooke Streeter

{"title":"Stress and Burnout Among Mental Health Staff During the COVID-19 Pandemic.","authors":"Joseph Sadek, Ben MacDonald, Brooke Streeter","doi":"10.25011/cim.v44i4.37753","DOIUrl":"10.25011/cim.v44i4.37753","url":null,"abstract":"Purpose: The coronavirus disease 2019 (COVID-19) pandemic has deeply altered social and working environments among health care workers. These health care workers are therefore at risk of additional psychosocial strain and ensuing metal health symptoms, which indirectly affects patient care. In this study, we aimed to assess the psychosocial and psychopathological impact of COVID-19 among acute care mental health and addictions staff.Methods: This study is a cross-sectional survey and contains a sample size of 60 mental health and addiction acute care workers recruited from within Nova Scotia Health Authority. The survey was constructed using the online survey system, Opinio, and consisted of three sections: demographic variables (gender, age group and profession); the DASS-21 Questionnaire (which provides dimensional measures of stress, anxiety and depression); and the MBI-HSS (MP) Questionnaire (which measures three dimensions of burnout-emotional exhaustion, depersonalization and personal achievement).Results: The majority of participants had at least one pathologic score on the DASS-21 and MBI-HSS (MP) sections (75.5% and 93.5%, respectively). The median severity on the DASS-21 and MBI-HSS (MP) were both moderate, with the younger age group (20-35 years) having more significant burnout scores (p = 0.0494). Simple logistic regression showed a significant relationship between burnout severity and pathologic distress, and simple linear regression showed significant correlation between DASS-21 and MBI-HSS (MP) scores, with a R2 value of 0.4633.Conclusion: More planning, programs, resources and further research are needed to support wellness and recovery of all health care professionals who work at the mental health and addictions acute care unit.","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":"44 4","pages":"E2-10"},"PeriodicalIF":0.8,"publicationDate":"2021-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39894011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0