Clinical and Investigative Medicine最新文献

{"title":"Verifying genetic diagnoses: Hereditary hemorrhagic telangiectasia - juvenile polyposis syndrome (HHT-JPS) or familial adenomatous polyposis (FAP)?","authors":"Mitchell Wagner, Alexander Beke, Harry Wilton-Clark, Sergio Zepeda-Gomez, Dilini Vethanayagam","doi":"10.3138/CIM-2026-0004","DOIUrl":"10.3138/CIM-2026-0004","url":null,"abstract":"<p><p>A 26-year-old woman was diagnosed with hereditary hemorrhagic telangiectasia - juvenile polyposis syndrome (HHT-JPS) after an incidental finding of a pulmonary arteriovenous malformation. Molecular genetic testing confirmed the presence of a pathogenic <i>SMAD4</i> variant, later found to be present in several other family members who were all previously labelled as having familial adenomatous polyposis. This short report contrasts and compares the conditions and highlights the importance of using genetic testing to distinguish similar presentations of gastrointestinal polyps in association with genetic conditions such as HHT-JPS and FAP. We highlight that detection of <i>SMAD4</i> mutations can distinguish individuals with HHT-JPS from those with FAP who do not appear to present with arteriovenous malformations or notable criteria for HHT. This distinction may have significant implications for those with a longstanding familial diagnosis of FAP, as HHT-JPS entails different management considerations.</p>","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":" ","pages":"40-44"},"PeriodicalIF":0.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148820084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical research on ocular myasthenia gravis and related neuromuscular disorders: A systematic review and overview.","authors":"MengYu Wang, ZhaoYuan Sheng","doi":"10.3138/CIM-2025-0194","DOIUrl":"10.3138/CIM-2025-0194","url":null,"abstract":"<p><strong>Background: </strong>Ocular myasthenia gravis is an acquired autoimmune disorder primarily manifesting clinically as ptosis, diplopia, ocular muscle paralysis, and restricted ocular motility. However, its clinical presentation overlaps with multiple ocular pathologies, leading to frequent misdiagnosis in clinical practice and adversely affecting patient prognosis. Hence, we conducted a systematic review and analysis of relevant literature.</p><p><strong>Methods: </strong>From 1 January 2020 to 31 August 2025, three databases (PubMed, Web of Science and China National Knowledge Infrastructure) were searched. This study focused on ocular myasthenia gravis, incorporating neuromuscular disorders presenting with ocular abnormalities. Keywords were selected based on disease guidelines and common clinical scenarios (frequent differential diagnoses or misdiagnoses), and the keywords <i>ocular myasthenia gravis</i>, <i>myasthenia gravis</i>, <i>motor nerve paralysis</i>, <i>ptosis</i>, <i>diabetic eye muscle paralysis</i>, and <i>thyroid-associated ophthalmopathy</i> were ultimately selected. Eight studies published prior to 2020 were identified. Despite their age, these studies were included in the present review due to their relevance to the study's scope and their value for scholarly discussion.</p><p><strong>Results: </strong>Ocular myasthenia gravis is caused by autoantibody-mediated damage to the neuromuscular junction and impaired signal transmission, typically presenting with ptosis, diplopia, and restricted eye movements. Due to the lack of a diagnostic gold standard, ocular myasthenia gravis is easily confused with oculomotor nerve palsy, ptosis, diabetic ophthalmoplegia, and thyroid-associated ophthalmopathy, leading to misdiagnosis or missed diagnosis. This may delay treatment or allow progression to generalized myasthenia gravis. Additionally, personalized treatment is required for specific populations with myasthenia gravis. Adolescents with ocular myasthenia gravis require greater caution in medication use, where traditional Chinese medicine offers a potential alternative for children with drug restrictions. Pregnant patients with myasthenia gravis require assessment of delivery methods and anesthesia risks.</p><p><strong>Conclusion: </strong>The diagnosis of ocular myasthenia gravis remains challenging, requiring differentiation from multiple similar conditions to avoid misdiagnosis and disease progression. Additionally, individualized treatment for patients with myasthenia gravis in special populations, such as children and pregnant women, is crucial. For ocular myasthenia gravis, optimizing diagnostic criteria, achieving early differential diagnosis, and exploring safer and more effective therapeutic agents are urgent issues that need to be addressed.</p>","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":" ","pages":"31-39"},"PeriodicalIF":0.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148819916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Training clinician-scientists in Canada: The CANTRAIN clinical fellows program.","authors":"Cynthia Forlini, Sarah Ibrahim, Katie Bainbridge, Lisa M Goos, Jean Bourbeau, Kristian B Filion","doi":"10.3138/CIM-2026-0043","DOIUrl":"https://doi.org/10.3138/CIM-2026-0043","url":null,"abstract":"<p><p>Clinical trials are central to the advancement of evidence-based medicine. Despite the development of the Clinician Investigator Competencies, which are integrated in the CanMEDS Framework and the Royal College-accredited Clinician Investigator Program (CIP), clinical trials-specific education and training for clinician-scientists remains fragmented and inconsistently delivered and available across Canadian institutions. To address this gap, the Canadian Consortium of Clinical Trial Training Platform (CANTRAIN) has developed a national, competency-based program for clinical fellows. This approximately 40-hour, asynchronous clinical research and trials education program is grounded in adult learning principles and enriched with experiential learning. The program covers foundational knowledge in clinical research, clinical trials and methodological principles, trial planning, national and international legal and ethical principles in addition to data management, knowledge mobilization, and dissemination to diverse audiences. By offering accessible, competency-based, and standardized clinical trials education in medical training, this program complements the current existing landscape of clinician-scientist training and has the potential to reduce barriers to education (e.g., lack of protected time and financial constraints) while strengthening and diversifying the clinician-scientist pipeline in Canada. Through this program, CANTRAIN supports a more informed and intentional entry into the clinical trials ecosystem, representing a significant step toward building a proficient, equitable, and responsive clinical research workforce capable of advancing Canada's leadership in clinical trials.</p>","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":"49 3","pages":"27-30"},"PeriodicalIF":0.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148945937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum vitamin D levels and chronic refractory wounds: Unveiling of association and exploration of potential molecular mechanisms.","authors":"Guowei Zhou, Jia Fu, Qirui Xiong, Bing'e Ma, Chaoqun Ma","doi":"10.3138/CIM-2025-0211","DOIUrl":"10.3138/CIM-2025-0211","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to explore the link between serum vitamin D levels and chronic refractory wounds (CRWs) using National Health and Nutrition Examination Survey (NHANES) data, as the exact relationship and molecular mechanisms have not been fully understood.</p><p><strong>Methods: </strong>This study included a cohort of 5,415 adult participants with complete data on serum vitamin D, CRW prevalence, and other pertinent covariates. To evaluate the associations between serum vitamin D levels and CRW prevalence, weighted logistic regression analysis, restricted cubic spline (RCS) models, and subgroup analyses were applied. Network pharmacology and molecular dynamics simulation (MDS) analyses were then performed to elucidate the potential pathways and key targets involved in vitamin D-mediated wound healing.</p><p><strong>Results: </strong>After controlling for all confounding variables, a significant inverse relationship was identified between serum vitamin D levels and CRW prevalence. When stratifying serum vitamin D levels into quartiles, individuals in the highest quartile exhibited an approximately 37% reduced risk of CRW (<i>P</i> = 0.04) compared to those in the lowest quartile. RCS analysis indicated a linear dose-response relationship across serum vitamin D levels (<i>P</i> for nonlinearity = 0.328). This inverse association was consistently observed across various population subgroups. Furthermore, network pharmacology analysis suggested that vitamin D may influence wound healing through various targets and pathways, notably the AGE-RAGE, IL-17, and PI3K-Akt signalling pathways.</p><p><strong>Conclusion: </strong>Our findings underscore a significant correlation between lower serum vitamin D levels and an increased risk of developing CRW. Vitamin D intake may constitute a modifiable lifestyle factor associated with CRW.</p>","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":" ","pages":"1-16"},"PeriodicalIF":0.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148686702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression and clinical significance of <i>CA9</i> and <i>SEC61G</i> in non-small cell lung cancer.","authors":"Yu Luo, Dehe Chen, Yunxi Wu, Yi Cai, Gaoxiong Xiao, Dinghai He, Yanjun Bai, Li Jiang","doi":"10.3138/CIM-2026-0038","DOIUrl":"10.3138/CIM-2026-0038","url":null,"abstract":"<p><strong>Background: </strong>Lung cancer is the malignancy with the highest mortality rate globally. This study aimed to investigate the expression of carbonic anhydrase IX (<i>CA9</i>) and <i>SEC61G</i> in non-small cell lung cancer (NSCLC) tissues and adjacent lung tissues and to analyze the relationships of these genes with clinicopathological features to identify potential biomarkers and therapeutic targets.</p><p><strong>Methods: </strong>Bioinformatic analysis was performed using the TIMER, TCGA, and GTEx databases to evaluate the differential expression of <i>CA9</i> and <i>SEC61G</i> in NSCLC. The associations of these genes with tumour stage were further analyzed via GEPIA. For experimental validation, immunohistochemistry was conducted on 50 NSCLC tissue samples and 37 adjacent tissue samples collected from our institution.</p><p><strong>Results: </strong>The expression levels of both <i>CA9</i> and <i>SEC61G</i> were significantly higher in NSCLC tissues than in adjacent tissues. The expression of these genes was positively correlated with advanced T stage, lymph node metastasis, distant metastasis, and tumour stage. A significant positive correlation was also observed between <i>CA9</i> and <i>SEC61G</i> expression in NSCLC tissues.</p><p><strong>Conclusion: </strong><i>CA9</i> and <i>SEC61G</i> are upregulated in NSCLC, and their expression correlates with aggressive clinicopathological features, suggesting their involvement in tumour progression. The coexpression of these genes suggests a potential synergistic effect in NSCLC, adding to the existing evidence of their utility as significant indicators for predicting disease stage and prognosis.</p>","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":" ","pages":"17-26"},"PeriodicalIF":0.9,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148841709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of high-dose of vitamin C on mortality among aged patients with severe COVID-19: A systematic review and meta-analysis.","authors":"Na Li, Yixin Yan, Yongming Li, Jingmin Ni, Jingjing Gao, Xuemei Piao, Xiaolei Hou","doi":"10.3138/CIM-2024-0302","DOIUrl":"10.3138/CIM-2024-0302","url":null,"abstract":"<p><strong>Background: </strong>Critically ill patients are frequently deficient in vitamin C. Given the significant mortality rates in the elderly population associated with COVID-19, we aimed to systematically review the literature and evaluate whether high-dose vitamin C can reduce COVID-19 mortality in this population.</p><p><strong>Methods: </strong>Multiple data sources (PubMed, Web of Science, ScienceDirect, and medRxiv) were searched using the keywords \"COVID-19\" AND \"vitamin C\" up to November 2024. Randomized controlled trials (RCTs) involving COVID-19 patients with relevant data were collected. We used a random or fixed effects meta-analysis to calculate the pooling effect.</p><p><strong>Results: </strong>Eight RCTs comprising 2,104 patients were ultimately included in the meta-analysis. The pooling effect (odds ratio [OR] 0.97[95% CI 0.80-1.18, <i>P</i> = 0.76) suggested no significant difference in mortality rates between patients treated with high-dose vitamin C and those who were not.</p><p><strong>Conclusions: </strong>Vitamin C supplementation might reduce the risk of COVID-19 mortality in critically ill patients; however, this effect varied by study. Additional research is necessary to arrive at a definitive conclusion on this subject.</p>","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":"49 2","pages":"31-42"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A message from the new CSCI President, Dr. Chandrakant Tayade.","authors":"Chandrakant Tayade","doi":"10.3138/CIM-49-2-EDITORIAL","DOIUrl":"10.3138/CIM-49-2-EDITORIAL","url":null,"abstract":"<p><p>[Formula: see text] <b>Dr. Tayade</b> earned a Doctor of Veterinary Medicine, Masters, and PhD in Immunology from the Indian Veterinary Research Institute. He then completed a postdoctoral fellowship at the University of Guelph. He joined Queen's University in 2009 as an Assistant Professor and is currently working as a Vice Dean, and the Director of MD PhD Program in the Faculty of Health Sciences. The central theme of Dr. Tayade's research focusses on how immune dysfunction contributes to endometriosis pathophysiology, and identifying immune-based markers for diagnostic and therapeutic interventions. Dr. Tayade has published over 100 peer-reviewed articles in journals such as <i>JCI Insight, Journal of Immunology, American Journal of Pathology, American Journal of Obstetrics and Gynecology</i>, and<i> Trends in Molecular Medicine</i>. He has received competitive funding from the Canadian Institutes of Health Research (CIHR), the Natural Sciences and Engineering Research Council of Canada (NSERC), and the Endometriosis Foundation of America; and industrial funding from Bayer, Aurinia Pharmaceutical, and AbbVie. For his outstanding contributions to research, Dr. Tayade has received numerous special recognitions. In 2012, he won both the Early Researcher Award from the Ministry of Research and Innovation, as well as the Christian J Herr Award for Outstanding Contributions in Reproductive Immunology from the American Society for Reproductive Immunology. In 2014, he earned the Mihran and Mary Basmajian Award for Research Excellence from the Queen's Faculty of Health Sciences.</p>","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":"49 2","pages":"1-2"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What I learned in business school: Entrepreneurship as a model for building a research career.","authors":"Susan R Kahn","doi":"10.3138/CIM-2026-0086","DOIUrl":"10.3138/CIM-2026-0086","url":null,"abstract":"<p><p>[Formula: see text] <b>Dr. Kahn</b> is a clinical epidemiologist and internist based at the Jewish General Hospital in Montreal, Canada, where she is the founder and director of the Centre of Excellence in Thrombosis and Anticoagulation Care. She is appointed as Professor with Tenure in the Department of Medicine, McGill University. Dr. Kahn's research interests focus primarily on clinical trials of interventions to prevent, diagnose, treat, and improve outcomes of venous thromboembolism. She holds a Tier 1 Canada Research Chair in Venous Thromboembolism. On April 22, 2026, at the CSCI AGM, Dr. Kahn was presented with the 2026 CSCI Distinguished Scientist Award. This article is adapted from the lecture Dr. Kahn gave at that conference. It explores how principles learned in business school-particularly entrepreneurship-can be applied to the development and sustainability of a clinical research career. Drawing on personal experience and formal training in business administration, it highlights parallels between building a research program and launching a startup venture. Key concepts, such as opportunity recognition, strategic planning, financing, marketing, iteration, and mentorship, are reframed within the context of clinical research. The article posits that adopting an entrepreneurial mindset can enhance innovation, resilience, and long-term impact in academic medicine.</p>","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":"49 2","pages":"3-6"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A longitudinal study of research productivity in McGill University's MD-PhD and Clinician Investigator Program Graduates from 2000 to 2017.","authors":"Jamie Magrill, Jean-Pierre Falet, Ella Boone, Mimosa Luigi, Isabella Arthur, Paria Asadi, Anna Frumkin, Mark Sorin, Joan Miguel Romero, Julia Luo, Nathalie Johnson, Mark J Eisenberg","doi":"10.3138/CIM-2026-0009","DOIUrl":"10.3138/CIM-2026-0009","url":null,"abstract":"<p><strong>Background: </strong>Canadian MD-PhD and Clinician Investigator Program (CIP) pathways both train physician-scientists, yet longitudinal data on graduate research productivity are limited.</p><p><strong>Methods: </strong>We conducted a longitudinal study of McGill University MD-PhD and CIP graduates who completed these programs between 2000 and 2017, using sex- and year-matched MD-only graduates as controls. Outcomes were collected for publications indexed through to December 31, 2022, and included H-index, total publications, total citations, per-paper journal impact factor, per-paper citations, and authorship position (first, second, senior). Productivity was assessed across four time periods: (1) pre-medical/medical training, (2) residency, (3) post-residency/fellowship, and (4) independent practice.</p><p><strong>Results: </strong>Among 549 graduates (MD-PhD = 31; CIP = 97; MD-only = 421), research productivity, research impact, and active research involvement (defined as ≥3 first- or senior-author papers in the prior 5 years) were similar between MD-PhD and CIP graduates; both exceeded MD-only graduates across all metrics. Within-group sex differences were not significant. MD-PhD graduates were more productive during pre-medical/medical training, whereas CIP graduates were comparatively more productive during residency. Sustained productivity in independent practice correlated with research engagement during medical school, residency, and fellowship. In both programs, graduates with active research involvement had higher authorship counts in the 10 years immediately following graduation from medical school.</p><p><strong>Discussion: </strong>Research productivity and impact were comparable between MD-PhD and CIP graduates, and both groups exceeded MD-only peers across measured research metrics. Across both programs, graduates with active research involvement had higher early-career authorship counts, particularly during residency and post-residency/fellowship time periods. These findings provide descriptive benchmarking data for future studies of physician-scientist training pathways in Canada.</p>","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":"49 2","pages":"7-20"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proceedings from the 17th Annual University of Calgary Leaders in Medicine Research Symposium.","authors":"Gabrielle Dagasso, Shahoon Khan, Emily Au, Govind Peringod, Matthew Penney, Julianna Svishchuk, Zahra Goodarzi, Satish R Raj","doi":"10.3138/CIM-49-2-LIM","DOIUrl":"10.3138/CIM-49-2-LIM","url":null,"abstract":"<p><p>The 17th annual Leaders in Medicine Research Symposium was held in person at the University of Calgary Health Sciences Centre on November 5, 2025. This event is dedicated to student research and collaboration in a range of disciplines and meant to showcase the work done by the joint degree students pursuing both graduate and medical school. The event featured a keynote address by Dr. Aravind Ganesh, titled \"Finding goodness and growth while fighting dementia and stroke.\" Dr. Ganesh is a vascular and cognitive neurologist at the University of Calgary and an alumnus of the Leaders in Medicine program. Over 70 students presented either oral or poster presentations at the symposium, with 10 of those being oral presentations. The presentations covered a range of interdisciplinary fields, such as community health sciences, biomedical engineering, oncology, and physical medicine. Overall, the symposium highlighted the influential research being done by the Leaders in Medicine and medical students at the University of Calgary.</p>","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":"49 2","pages":"56-63"},"PeriodicalIF":0.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}