Clinical and Investigative Medicine最新文献_第7页

Fall 2023: Clinician Investigator Trainee Association of Canada (CITAC). 2023年秋季：加拿大临床医生研究员实习生协会（CITAC）。

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2023-09-28 DOI: 10.25011/cim.v46i3.41655

Melissa S Phuong, Robert X Lao, Salonee V Patel, Amelia T Yuan, Wenxuan Wang

引用次数: 0

CCL2 Promotes Novel Coronavirus-Mediated Inflammatory Responses in Macrophages. CCL2在巨噬细胞中促进新型冠状病毒介导的炎症反应。

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2023-09-28 DOI: 10.25011/cim.v46i3.40273

Fang Ding, Muwei Dai, Xichun Kang, Xin Zhang, Li Li, Lei Zhao, Ping Jiang, Huixia Gao, Huimin Yan

{"title":"CCL2 Promotes Novel Coronavirus-Mediated Inflammatory Responses in Macrophages.","authors":"Fang Ding, Muwei Dai, Xichun Kang, Xin Zhang, Li Li, Lei Zhao, Ping Jiang, Huixia Gao, Huimin Yan","doi":"10.25011/cim.v46i3.40273","DOIUrl":"10.25011/cim.v46i3.40273","url":null,"abstract":"Purpose: The hyperinflammatory response is one of the main complications associated with novel coronavirus disease 2019 (COVID-19), and there is no effective treatment for cytokine storm. Therefore, it is important to investigate the key genes associated with severity of the disease.Methods: In this study, we used a microarray data set to analyze the key genes associated with severe illness in patients with COVID-19. The proportion of immune cells was determined using the CIBERSORT algorithm. The key genes were further verified by detecting the levels of cytokines and chemokines in the serum of patients. Additionally, macrophages were stimulated with SARS-CoV-2 spike protein and chemokine ligand (CCL) 2. The expression of cytokines, ERK1/2, and NF-κB in macrophages was detected.Results: Four hub genes were identified. Among them, C-C motif chemokine receptor 2 (CCR2) was an upregulated hub gene, while killer cell lectin-like receptor subfamily K member 1 (KLRK1), macrophage colony-stimulating factor receptor (CSF1R), and CD3D human recombinant protein (CD3D) were downregulated genes. Immune cell type identification found that the proportion of monocytes was higher in patients with severe COVID-19 than that in controls. Moreover, levels of CCL2 were significantly higher in patients with COVID-19. When stimulated with SARS-CoV-2 S protein and CCL2, macrophages secreted more inflammatory cytokines. The expression level of ERK1/2 was elevated.Conclusions: These results suggested that S protein and CCL2 may mediate macrophage inflammatory responses through the ERK1/2 signaling pathway. This study provides a basis for clinical treatment and improves the prognosis of critically ill patients with COVID-19.","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":"46 3","pages":"E34-45"},"PeriodicalIF":0.8,"publicationDate":"2023-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41157814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Young Investigator Interview with CSCI Distinguished Scientist Awardee Dr. Caroline Quach-Thanh. 与 CSCI 杰出科学家奖获得者 Caroline Quach-Thanh 博士的青年研究员访谈。

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2023-06-28 DOI: 10.25011/cim.v46i2.40759

Valera Castanov, Caroline Quach

{"title":"Young Investigator Interview with CSCI Distinguished Scientist Awardee Dr. Caroline Quach-Thanh.","authors":"Valera Castanov, Caroline Quach","doi":"10.25011/cim.v46i2.40759","DOIUrl":"10.25011/cim.v46i2.40759","url":null,"abstract":"Dr. Caroline Quach-Thanh is a Professor in the Departments of Microbiology, Infectious Diseases and Immunology and of Pediatrics at University of Montreal. She is in charge of Infection Prevention and Control at CHU Sainte-Justine where she works as a pediatric infectious diseases specialist and medical microbiologist. Dr. Quach is a clinician-scientist and the Canada Research Chair, Tier 1 in Infection Prevention and Control. In 2022, Dr. Quach-Thanh received the Distinguished Scientist Award 2022 from the Canadian Society for Clinical Investigation. In the same year, she received a Women of Distinction Award-for public service-from the Women's Y Foundation. Dr. Quach-Thanh is the former president from the Association for Medical Microbiology and Infectious Diseases Canada (AMMI), a past Chair of the National Advisory Committee on Immunization (NACI) and is the current chair of the Quebec Immunization Committee. She was named Fellow of the Canadian Academy of Health Sciences and of the Society for Healthcare Epidemiology of America. Dr. QuachThanh was selected as one of the 2019 most Powerful Women in Canada. In 2021, she received the Order of Merit from Université de Montréal and was made Officière de l'Ordre national du Québec in 2022.","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":"46 2","pages":"E4-6"},"PeriodicalIF":0.8,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9750397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Video Education Program for Proper use of Inhalation Devices in Elderly COPD Patients. 老年COPD患者正确使用吸入装置的视频教育计划。

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2023-06-28 DOI: 10.25011/cim.v46i2.40272

Hong Zhu, Shouquan Qin, Meng Wu

{"title":"Video Education Program for Proper use of Inhalation Devices in Elderly COPD Patients.","authors":"Hong Zhu, Shouquan Qin, Meng Wu","doi":"10.25011/cim.v46i2.40272","DOIUrl":"10.25011/cim.v46i2.40272","url":null,"abstract":"Purpose: This research investigated the utility of a QR code-based video pharmaceutical education program to guide the proper use of the inhalation device in elderly chronic obstructive pulmonary disease (COPD) patients.Methods: The patients were recruited for this prospective study during a COPD hospitalization, with 96 patients in the control group (CG) receiving conventional hospital care and 93 patients in the intervention group (IG) receiving QR code-based video pharmaceutical education from hospitalization to six months after discharge to improve proper utilization of inhalation technology The outcome measures used to assess the effectiveness of the education program were the COPD Assessment Test (CAT), inhaler use accuracy, inhaler technique score, Beliefs about Medicines Questionnaire (BMQ) score and patient satisfaction.Results: Compared with CG, inhaler use accuracy and inhaler use scores improved in the IG group, while BMQ-Concern and CAT scores were significantly lower (P<0.05). Improvements in patient quality-of-life and satisfaction were reported.Conclusions: This study revealed that the QR code-based video pharmaceutical education program can improve the quality of life and satisfaction of elderly COPD patients.","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":"46 2","pages":"E7-17"},"PeriodicalIF":0.8,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9734851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk due to Elevated Uric Acid Levels in Children With Henoch-Schonlein Purpura. 过敏性紫癜患儿尿酸水平升高的风险。

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2023-06-28 DOI: 10.25011/cim.v46i2.40274

Xiucui Han, Pengfei Xu

{"title":"Risk due to Elevated Uric Acid Levels in Children With Henoch-Schonlein Purpura.","authors":"Xiucui Han, Pengfei Xu","doi":"10.25011/cim.v46i2.40274","DOIUrl":"10.25011/cim.v46i2.40274","url":null,"abstract":"Purpose: To compare uric acid levels in children with Henoch-Schonlein purpura (HSP)without nephritis and with renal damage, and at different pathological grades.Methods: A total of 451 children were enrolled in this study, including 64 with HSP without nephritis and 387 HSP with kidney damage. Age, gender, uric acid, urea, creatinine and cystatin C levels were reviewed. Pathological findings of those with renal impairment were also reviewed.Results: Among the HSP children with renal damage, 44 were grade I, 167 were grade II and 176 were grade III. There were significant differences in age, uric acid, urea, creatinine and cystatin C levels between the two groups (p<0.05, all). Correlation analysis showed that uric acid levels in children with HSP without nephritis were positively correlated with urea and creatinine levels (p<0.05). Uric acid levels in HSP children with renal damage was positively correlated with age, urea, creatinine and cystatin C levels (p<0.05, all). Regression analysis found that, without adding any correction factors, there were significant differences in uric acid levels between the two groups; however, after adjusting for pathological grade, there was no longer a significant difference.Conclusions: There were significant differences of uric acid levels in children with HSP without nephritis and with renal impairment. Uric acid levels in the renal impairment group were significantly higher than that in the HSP without nephritis group. Uric acid levels were related to only the presence or absence of renal damage, not to the pathological grade.","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":"46 2","pages":"E18-22"},"PeriodicalIF":0.8,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9734850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interview With CSCI Joe Doupe Young Investigator Awardee, Dr. Amy Metcalfe. 采访CSCI乔·杜佩青年研究者奖获得者艾米·梅特卡夫博士。

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2023-06-28 DOI: 10.25011/cim.v46i2.40758

Zaid Al-Azzawi, Amy Metcalfe

引用次数: 0

Gender Disparities in Academic Outcomes Among Graduates of a Canadian MD-PhD Program. 加拿大医学博士项目毕业生学术成果的性别差异

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2023-03-26 DOI: 10.25011/cim.v46i1.39965

Joan Miguel Romero, Mark Sorin, Matthew Dankner, Heather Whittaker, April Rose, Jacquetta Trasler, Mark J Eisenberg

{"title":"Gender Disparities in Academic Outcomes Among Graduates of a Canadian MD-PhD Program.","authors":"Joan Miguel Romero, Mark Sorin, Matthew Dankner, Heather Whittaker, April Rose, Jacquetta Trasler, Mark J Eisenberg","doi":"10.25011/cim.v46i1.39965","DOIUrl":"https://doi.org/10.25011/cim.v46i1.39965","url":null,"abstract":"Purpose: Women have traditionally been underrepresented in MD and MD-PhD training programs. Here, we describe the changing demographics of an MD-PhD Program over three distinct time intervals.Methods: We designed a 64-question survey and sent it to 47 graduates of the McGill University MD-PhD program in Montréal, Québec, Canada, since its inception in 1985. We also sent a 23-question survey to the 24 students of the program in 2021. The surveys included questions related to demographics, physician-scientist training, research metrics, as well as academic and personal considerations.Results: We collected responses from August 2020 to August 2021 and grouped them into three intervals based on respondent graduation year: 1995-2005 (n = 17), 2006-2020 (n = 23) and current students (n = 24). Total response rate was 90.1% (n = 64/71). We found that there are more women currently in the program compared to the 1995-2005 cohort (41.7% increase, p<0.01). In addition, women self-reported as physician-scientists less frequently than men and reported less protected research time.Conclusions: Overall, recent MD-PhD alumni represent a more diverse population compared with their earlier counterparts. Identifying barriers to training remains an important step in ensuring MD-PhD trainees become successful physician-scientists.","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":"46 1","pages":"E4-14"},"PeriodicalIF":0.8,"publicationDate":"2023-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9804297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis. 氢化可的松联合维生素C和硫胺素治疗败血症/感染性休克:荟萃分析和试验序列分析的系统综述。

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2023-03-26 DOI: 10.25011/cim.v46i1.40275

Difan Lu, Wenchao Mao

{"title":"Hydrocortisone Combined with Vitamin C and Thiamine in the Treatment of Sepsis/Septic Shock: A Systematic Review with Meta-Analysis and Trial Sequential Analysis.","authors":"Difan Lu, Wenchao Mao","doi":"10.25011/cim.v46i1.40275","DOIUrl":"https://doi.org/10.25011/cim.v46i1.40275","url":null,"abstract":"Background: This study explored the efficacy of hydrocortisone combined with vitamin C and thiamine (HVT) in the treatment of sepsis/septic shock.Methods: PubMed, EMBASE and Web of Science were searched (establishment of the database to October 31, 2022). The meta-analysis included randomized controlled trials (RCTs); comparing the efficacy of HVT regimen and placebo in the treatment of sepsis/septic shock. The Cochrane Handbook for Systematic Reviews of Interventions was used to assess the risk of bias. The Review Manager 5.4 software was used for meta-analysis, and the relative risk (RR), mean difference (MD) and 95% confidence intervals (CI) were then determined. Trial sequential analysis (TSA) was then conducted.Results: Eight RCTs with 1,572 patients were identified. Meta-analysis showed that HVT regimen did not reduce all-cause (RR=0.96, 95% CI: 0.83 - 1.11, P=0.60), hospital (RR=1.03, 95% CI: 0.83 - 1.27, P=0.80) or intensive care unit (ICU) mortalities (RR=1.05, 95% CI: 0.86 - 1.28, P=0.65). Furthermore, there was no significant difference in the change of sequential organ failure assessment score, length of ICU stay, length of hospital stay, duration of the use of vasopressors, incidence of acute kidney injury and ventilator-free days between HVT and control groups. TSA showed that more trials are needed to confirm the results.Conclusions: HVT regimen did not reduce the mortality of patients with sepsis/septic shock and was not associated with a significant improvement in outcomes. The TSA result showed that more RCTs with high quality and large sample sizes are needed to further confirm the results.","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":"46 1","pages":"E36-49"},"PeriodicalIF":0.8,"publicationDate":"2023-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9804296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Efficacy of Mesenchymal Stem Cell Therapy on Lupus Nephritis and Renal Function in Systemic Lupus Erythematosus: A Meta-Analysis. 间充质干细胞治疗对系统性红斑狼疮患者狼疮肾炎和肾功能的疗效:荟萃分析。

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2023-03-26 DOI: 10.25011/cim.v46i1.39561

Yang Xia, Hua Ye, Kejia Li, Bairu Shi, Xian Sun, Jiajun Wu

{"title":"Efficacy of Mesenchymal Stem Cell Therapy on Lupus Nephritis and Renal Function in Systemic Lupus Erythematosus: A Meta-Analysis.","authors":"Yang Xia, Hua Ye, Kejia Li, Bairu Shi, Xian Sun, Jiajun Wu","doi":"10.25011/cim.v46i1.39561","DOIUrl":"https://doi.org/10.25011/cim.v46i1.39561","url":null,"abstract":"Purpose: The purpose of this meta-analysis is to determine the efficacy of mesenchymal stromal/stem cell (MSC) transplantation therapy on lupus nephritis (LN) and renal function of patients with systemic lupus erythematosus (SLE).Methods: Articles that reported the data of MSC therapy on the renal function as well as disease activity of LN in patients with SLE were searched in PubMed, Web of Science, Embase and the Cochrane Library. Mean difference for disease activity and laboratory parameters were pooled to evaluate the efficacy of MSC, and incidence was pooled for clinical remission, death and severe adverse event.Results: A total of 12 studies with 586 patients were included. The disease activity indices, including SLEDAI and BILAG, were significantly decreased within 12 months after MSC therapy (P< 0.05). Laboratory parameters for renal function and disease control including estimated glomerular filtration rate, creatinine, blood urea nitrogen, complement C3, albumin and urine protein, were also significantly improved after therapy. The pooled rate of clinical remission at 12 months was 28.1% and the total rate during follow-up was 33.7%. The pooled rate of death at 12 months was 5.2% and the total rate during follow-up was 5.5%. Severe adverse events were rare and not associated with the treatment of MSC.Conclusions: This is the first meta-analysis that focuses on the effect of MSC on LN and renal function of patients with SLE, and the results shows a favorable safety profile and encouraging results of MSC for improving the disease activity of LN as well as the renal function of SLE patients.","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":"46 1","pages":"E24-35"},"PeriodicalIF":0.8,"publicationDate":"2023-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9804294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of Adherence to Short-Course Probiotics Among Children with Gastroenteritis who are Enrolled in a Clinical Trial. 参加一项临床试验的肠胃炎儿童对短期益生菌依从性的预测因素

IF 0.8 4区医学

Clinical and Investigative Medicine Pub Date : 2023-03-26 DOI: 10.25011/cim.v46i1.39560

Katrina F Hurley, Eleanor A Fitzpatrick, Jianling Xie, Sarah Urquhart, Ken J Farion, Serge Gouin, Suzanne Schuh, Naveen Poonai, Stephen Freedman

{"title":"Predictors of Adherence to Short-Course Probiotics Among Children with Gastroenteritis who are Enrolled in a Clinical Trial.","authors":"Katrina F Hurley, Eleanor A Fitzpatrick, Jianling Xie, Sarah Urquhart, Ken J Farion, Serge Gouin, Suzanne Schuh, Naveen Poonai, Stephen Freedman","doi":"10.25011/cim.v46i1.39560","DOIUrl":"https://doi.org/10.25011/cim.v46i1.39560","url":null,"abstract":"Background: To improve our understanding of adherence to discharge medications in the ED and within research trials, we sought to quantify medication adherence and identify predictors thereof in children with acute gastroenteritis (AGE).Methods: We conducted a secondary analysis of a randomized trial of twice daily probiotic for 5 days. The population included previously healthy children aged 3-47 months with AGE. The primary outcome was patient-reported adherence to the treatment regimen, defined a priori as having received >70% of the prescribed doses. Secondary outcomes included predictors of treatment adherence and concordance between patient-reported adherence and the returned medication sachet counts.Results: After excluding participants with missing data on adherence, 760 participants were included in this analysis: 383 in the probiotic arm (50.4%); and 377 in the placebo arm (49.6%). Self-reported adherence was similar in both groups (77.0% in probiotic versus 80.3% in placebo). There was good agreement between self-reported adherence and sachet counts (87% within limits of agreement (-2.9 to 3.5 sachets) on the Bland-Altman plots). In the multivariable regression model, covariates associated with adherence were greater number of days of diarrhea post-emergency department visit, and the study site; covariates negatively associated with adherence were age 12-23 months, severe dehydration and greater total number of vomiting and diarrhea episodes after enrolment.Conclusions: Longer duration of diarrhea and study site were associated with higher probiotic adherence. Age 12-23 months, severe dehydration and greater number of vomiting and diarrhea episodes post enrolment negatively predicted treatment adherence.","PeriodicalId":50683,"journal":{"name":"Clinical and Investigative Medicine","volume":"46 1","pages":"E15-23"},"PeriodicalIF":0.8,"publicationDate":"2023-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9804295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0