Effect of Leptin Levels of Type 2 Diabetes Mellitus and Diabetic Complications.

IF 1.2 4区 医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL
Jingzhu Nan, Xu Zhang, Diangeng Li, Meiling Jin, Guanghong Guo, Jin Dong, Xiujuan Li
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引用次数: 2

Abstract

Purpose: To investigate serum leptin levels in patients with type 2 diabetes mellitus (T2DM) and the relationship between leptin levels and T2DM complications and prevalence.

Methods: A total of 355 patients, 282 cases with T2DM and 73 normal controls, were recruited at 1st Medical Centre, Chinese PLA General Hospital (Beijing, China) between November 2013 and July 2014. Levels of serum leptin, biochemical markers and sexual hormones were measured, and clinical characteristics were retrieved through the electronic medical record system.

Results: Leptin levels in females were higher than that in males. Leptin levels in T2MD patients were positively correlated with body mass index, percent body fat, triglyceride, cystatin C homocysteine and salivary acid, and negatively correlated with glycosylated serum protein and glycosylated albumin levels. Leptin levels in males were positively correlated with systolic pressure and estradiol, and negatively correlated with testosterone and high density lipoprotein cholesterol. Sex (female) was positively correlated with the duration of disease. Leptin levels in T2DM patients with complications such as hypertension, diabetic nephropathy, diabetic peripheral neuropathy and coronary heart disease were higher than that in patients without such complications. Leptin levels in females with diabetic retinopathy and diabetic macroangiopathy were higher than that in patients without such complications, but there was no difference in males.

Conclusions: Leptin has significant gender differences. Leptin levels are related to body mass index, percent body fat and sex hormone level in T2DM patients and may affect short-term blood glucose control in T2DM patients. Leptin levels are related to complications in patients with T2DM and affect the prevalence rates of complications.

瘦素水平对2型糖尿病及其并发症的影响。
目的:探讨2型糖尿病(T2DM)患者血清瘦素水平及其与T2DM并发症及患病率的关系。方法:2013年11月至2014年7月在中国人民解放军总医院第一医疗中心招募T2DM患者355例,其中T2DM患者282例,正常人73例。测定血清瘦素、生化指标和性激素水平,并通过电子病历系统检索临床特征。结果:女性瘦素水平高于男性。T2MD患者瘦素水平与体重指数、体脂百分比、甘油三酯、胱抑素C同型半胱氨酸、唾液酸呈正相关,与糖化血清蛋白、糖化白蛋白水平负相关。男性瘦素水平与收缩压和雌二醇呈正相关,与睾酮和高密度脂蛋白胆固醇负相关。性别(女性)与病程呈正相关。伴有高血压、糖尿病肾病、糖尿病周围神经病变、冠心病等并发症的T2DM患者瘦素水平高于无此类并发症的T2DM患者。女性糖尿病视网膜病变和糖尿病大血管病变患者的瘦素水平高于无此类并发症的患者,但男性无差异。结论:瘦素具有显著的性别差异。瘦素水平与T2DM患者体重指数、体脂百分比和性激素水平相关,可能影响T2DM患者短期血糖控制。瘦素水平与2型糖尿病患者的并发症有关,并影响并发症的发生率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical and Investigative Medicine
Clinical and Investigative Medicine 医学-医学:研究与实验
CiteScore
1.50
自引率
12.50%
发文量
18
审稿时长
>12 weeks
期刊介绍: Clinical and Investigative Medicine (CIM), publishes original work in the field of Clinical Investigation. Original work includes clinical or laboratory investigations and clinical reports. Reviews include information for Continuing Medical Education (CME), narrative review articles, systematic reviews, and meta-analyses.
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