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Clinical Journal of the American Society of Nephrology最新文献

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Metabolomic Signature of Dietary Potassium Intake: A Novel Approach to Understanding CKD Onset? 膳食钾摄入的代谢组学特征：了解慢性肾病发病的新途径？
IF 8.5 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2025-05-01 Epub Date: 2025-04-14 DOI: 10.2215/CJN.0000000720
Laetitia Koppe, Sandra Wagner
{"title":"Metabolomic Signature of Dietary Potassium Intake: A Novel Approach to Understanding CKD Onset?","authors":"Laetitia Koppe, Sandra Wagner","doi":"10.2215/CJN.0000000720","DOIUrl":"10.2215/CJN.0000000720","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":"20 5","pages":"595-597"},"PeriodicalIF":8.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Addressing the Workforce Crisis in Uronephrology: Design and Initial Observations of the Duke Paired Undergraduate Mentorship Program. 解决泌尿学中的劳动力危机：配对本科生指导计划（PUMP）的设计和初步观察。
IF 8.5 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2025-05-01 Epub Date: 2024-12-18 DOI: 10.2215/CJN.0000000601
Loryn W Dass, Anna Williams, Jennifer D Varner, Terri Taylor, Holly Hough, Jessica Sperling, Matthew A Sparks, Allison McElvaine, Rasheed Gbadegesin
{"title":"Addressing the Workforce Crisis in Uronephrology: Design and Initial Observations of the Duke Paired Undergraduate Mentorship Program.","authors":"Loryn W Dass, Anna Williams, Jennifer D Varner, Terri Taylor, Holly Hough, Jessica Sperling, Matthew A Sparks, Allison McElvaine, Rasheed Gbadegesin","doi":"10.2215/CJN.0000000601","DOIUrl":"10.2215/CJN.0000000601","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":" ","pages":"733-735"},"PeriodicalIF":8.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and Safety of Phosphate-Lowering Agents for Adult Patients with CKD Requiring Dialysis: A Network Meta-Analysis. 降磷酸盐药物治疗成人慢性肾病透析患者的疗效和安全性：一项网络荟萃分析
IF 8.5 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2025-05-01 Epub Date: 2025-03-14 DOI: 10.2215/CJN.0000000665
Masatoshi Nishimoto, Takeshi Hasegawa, Miho Murashima, Hisashi Noma, Hiroki Nishiwaki, Shunsuke Yamada, Aya Mizukami, Hirotaka Saito, Hiroshi Kimura, Masatomo Taniguchi, Takayuki Hamano, Masafumi Fukagawa
{"title":"Efficacy and Safety of Phosphate-Lowering Agents for Adult Patients with CKD Requiring Dialysis: A Network Meta-Analysis.","authors":"Masatoshi Nishimoto, Takeshi Hasegawa, Miho Murashima, Hisashi Noma, Hiroki Nishiwaki, Shunsuke Yamada, Aya Mizukami, Hirotaka Saito, Hiroshi Kimura, Masatomo Taniguchi, Takayuki Hamano, Masafumi Fukagawa","doi":"10.2215/CJN.0000000665","DOIUrl":"10.2215/CJN.0000000665","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":" ","pages":"676-696"},"PeriodicalIF":8.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introduction to the Lifestyle Medicine and Kidney Health Series. 生活方式医学与肾脏健康丛书》简介。
IF 8.5 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2025-05-01 Epub Date: 2025-03-10 DOI: 10.2215/CJN.0000000703
Mona Boaz, Jaimon T Kelly, Donald E Wesson
{"title":"Introduction to the Lifestyle Medicine and Kidney Health Series.","authors":"Mona Boaz, Jaimon T Kelly, Donald E Wesson","doi":"10.2215/CJN.0000000703","DOIUrl":"10.2215/CJN.0000000703","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":" ","pages":"739-741"},"PeriodicalIF":8.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143587847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hydrochlorothiazide and Bone Mineral Density in Patients with Kidney Stones: Post Hoc Analysis of the NOSTONE Trial. 氢氯噻嗪和肾结石患者的骨矿物质密度：NOSTONE试验的事后分析。
IF 8.5 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2025-05-01 Epub Date: 2025-03-10 DOI: 10.2215/CJN.0000000659
Andreas Christe, Elias Primetis, Grazia M Cereghetti, Dionysios Drakopoulos, Nasser A Dhayat, Olivier Bonny, Alexander Ritter, Nilufar Mohebbi, Nicolas Faller, Lisa Pellegrini, Giulia Bedino, Reto M Venzin, Philipp Grosse, Carina Hüsler, Irene Koneth, Christian Bucher, Rosaria Del Giorno, Luca Gabutti, Michael Mayr, Urs Odermatt, Florian Buchkremer, Thomas Ernandez, Catherine Stoermann-Chopard, Daniel Teta, Luca Tamò, Sven Trelle, Beat Roth, Matteo Bargagli, Daniel G Fuster
{"title":"Hydrochlorothiazide and Bone Mineral Density in Patients with Kidney Stones: Post Hoc Analysis of the NOSTONE Trial.","authors":"Andreas Christe, Elias Primetis, Grazia M Cereghetti, Dionysios Drakopoulos, Nasser A Dhayat, Olivier Bonny, Alexander Ritter, Nilufar Mohebbi, Nicolas Faller, Lisa Pellegrini, Giulia Bedino, Reto M Venzin, Philipp Grosse, Carina Hüsler, Irene Koneth, Christian Bucher, Rosaria Del Giorno, Luca Gabutti, Michael Mayr, Urs Odermatt, Florian Buchkremer, Thomas Ernandez, Catherine Stoermann-Chopard, Daniel Teta, Luca Tamò, Sven Trelle, Beat Roth, Matteo Bargagli, Daniel G Fuster","doi":"10.2215/CJN.0000000659","DOIUrl":"10.2215/CJN.0000000659","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":" ","pages":"706-718"},"PeriodicalIF":8.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143598362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defining Kidney Health Dimensions and Their Associations with Adverse Outcomes in Persons with Diabetes and CKD. 糖尿病和慢性肾病患者肾脏健康维度的定义及其与不良结局的关联
IF 8.5 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2025-05-01 Epub Date: 2025-03-14 DOI: 10.2215/CJN.0000000676
Vanessa-Giselle Peschard, Rebecca Scherzer, Michelle M Estrella, Mark J Sarnak, Simon B Ascher, James Lash, Joseph V Bonventre, Jason H Greenberg, Orlando M Gutierrez, Jeffrey R Schelling, Ronit Katz, Katharine L Cheung, Emily B Levitan, Sarah J Schrauben, Mary Cushman, Titilayo O Ilori, Chirag R Parikh, Paul L Kimmel, Panduranga S Rao, Jonathan J Taliercio, James Sondheimer, Rachel Shulman, Steven G Coca, Jing Chen, Vasan S Ramachandran, Joachim H Ix, Michael G Shlipak
{"title":"Defining Kidney Health Dimensions and Their Associations with Adverse Outcomes in Persons with Diabetes and CKD.","authors":"Vanessa-Giselle Peschard, Rebecca Scherzer, Michelle M Estrella, Mark J Sarnak, Simon B Ascher, James Lash, Joseph V Bonventre, Jason H Greenberg, Orlando M Gutierrez, Jeffrey R Schelling, Ronit Katz, Katharine L Cheung, Emily B Levitan, Sarah J Schrauben, Mary Cushman, Titilayo O Ilori, Chirag R Parikh, Paul L Kimmel, Panduranga S Rao, Jonathan J Taliercio, James Sondheimer, Rachel Shulman, Steven G Coca, Jing Chen, Vasan S Ramachandran, Joachim H Ix, Michael G Shlipak","doi":"10.2215/CJN.0000000676","DOIUrl":"10.2215/CJN.0000000676","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":" ","pages":"665-675"},"PeriodicalIF":8.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Obesity and Metabolic Health in CKD. 慢性肾脏病患者的肥胖和代谢健康。
IF 8.5 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2025-05-01 Epub Date: 2025-03-14 DOI: 10.2215/CJN.0000000704
Csaba P Kovesdy
{"title":"Obesity and Metabolic Health in CKD.","authors":"Csaba P Kovesdy","doi":"10.2215/CJN.0000000704","DOIUrl":"10.2215/CJN.0000000704","url":null,"abstract":"<p><p>Obesity is a worldwide epidemic with a future projected growth of 40% over 10 years. Obesity increases the risk of diabetes, hypertension, and cardiovascular disease, and it also leads to higher risk of CKD, through both direct and indirect mechanisms. Although obesity is a feature of overnutrition and is associated with poor outcomes in the general population, obese individuals with CKD often display complex metabolic patterns such as sarcopenic obesity, and obesity can be associated with better survival in individuals with advanced CKD. Weight loss interventions are proven to improve glycemic control and cardiovascular risk factors, and successful weight loss is associated with improved albuminuria in patients with preexisting CKD. The long-term effects of weight loss interventions on kidney function and on survival in patients with CKD are less well studied, and hence, such interventions should be individualized.</p>","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":" ","pages":"742-754"},"PeriodicalIF":8.5,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143631022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intermuscular Adipose Tissue in Chronic Kidney Disease: A Window into Muscle Quality and Health? 慢性肾脏疾病的肌间脂肪组织：肌肉质量与健康的窗口？
IF 9.8 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2025-04-30 DOI: 10.2215/cjn.0000000745
Mert Demirci,R Gulsah Dilaver,Baback Roshanravan,T Alp Ikizler,Jorge L Gamboa
{"title":"Intermuscular Adipose Tissue in Chronic Kidney Disease: A Window into Muscle Quality and Health?","authors":"Mert Demirci,R Gulsah Dilaver,Baback Roshanravan,T Alp Ikizler,Jorge L Gamboa","doi":"10.2215/cjn.0000000745","DOIUrl":"https://doi.org/10.2215/cjn.0000000745","url":null,"abstract":"Patients with chronic kidney disease (CKD) often experience loss of muscle mass, altered muscle function, and low physical functionality, all of which contribute to increased mortality and morbidity. Mitochondrial dysfunction emerges early in the progression of CKD and may play a central role in physical dysfunction. Factors such as uremia, systemic inflammation, oxidative stress, and inappropriate activation of the renin-angiotensin-aldosterone system may play are role on mitochondrial dysfunction. On the other hand, the accumulation of ectopic adipose tissue in skeletal muscle, also known as intermuscular adipose tissue (IMAT), is a newly recognized factor in muscle function and physical performance. IMAT is a marker of muscle quality, adversely affecting local muscle function, and is associated with insulin resistance and systemic inflammation, conditions commonly observed in CKD. Nevertheless, the exact composition of IMAT and its relationship with mitochondria and muscle energetics in CKD is not fully understood. Evaluating the relationship between IMAT accumulation and mitochondrial dysfunction in CKD may unveil potential interventions to improve physical function and the quality of life of patients with CKD.","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":"36 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding Natural Language Processing and Large Language Models in Kidney Health. 肾脏健康中的自然语言处理解码和大语言模型。
IF 9.8 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2025-04-30 DOI: 10.2215/cjn.0000000746
Hailey Yetman,Lili Chan
{"title":"Decoding Natural Language Processing and Large Language Models in Kidney Health.","authors":"Hailey Yetman,Lili Chan","doi":"10.2215/cjn.0000000746","DOIUrl":"https://doi.org/10.2215/cjn.0000000746","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":"10 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143897463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Cardiovascular-Kidney-Metabolic Health Framework: Implications for Nephrology. 心血管-肾脏-代谢健康框架：对肾脏病学的启示
IF 9.8 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2025-04-28 DOI: 10.2215/cjn.0000000744
Janani Rangaswami,Michael G Shlipak,Roy O Mathew,Chiadi E Ndumele
{"title":"The Cardiovascular-Kidney-Metabolic Health Framework: Implications for Nephrology.","authors":"Janani Rangaswami,Michael G Shlipak,Roy O Mathew,Chiadi E Ndumele","doi":"10.2215/cjn.0000000744","DOIUrl":"https://doi.org/10.2215/cjn.0000000744","url":null,"abstract":"Metabolic risk factors, chronic kidney disease, and cardiovascular disease are highly prevalent, frequently co-exist, and adversely impact lifespan and health span globally. The American Heart Association (AHA) recently defined Cardiovascular-Kidney-Metabolic (CKM) syndrome to highlight the interconnectedness between these conditions, across biological and socio-ecological domains. The CKM health initiative of the AHA seeks to improve cardiovascular and kidney health at a population level by providing a holistic approach to the management of individuals with CKM syndrome, emphasizing CKM health across the lifespan with priority for primordial/primary prevention, improving short and long-term cardiovascular risk prediction, and presenting an implementation framework for multidisciplinary health care models across diverse healthcare settings. Chronic kidney disease is a key risk factor, mediator, and therapeutic target to reduce cardiovascular disease burden, and is represented across all aspects of the AHA CKM health framework. This review article highlights the major take-aways for nephrologists from the AHA CKM health initiative. It outlines the areas where nephrologists can impact the delivery of holistic CKM care as part of the multidisciplinary team. Finally, it describes a potential future role for nephrology to guide and implement screening and early interventions for kidney disease, to move the needle towards kidney health at a population level.","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":"30 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143889268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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