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Clinical Journal of the American Society of Nephrology最新文献

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Long-Term Exposure to Fine Particulate Matter and Kidney Function among Patients with Polycystic Kidney Disease. 多囊肾病患者长期暴露于细颗粒物与肾功能的关系
IF 9.8 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2026-04-14 DOI: 10.2215/cjn.0000001065
Youngrin Kwag,Jieun Min,Whanhee Lee,Seoyeong Ahn,Sooyoung Kim,Hyojin Ha,Minho Kim,Jongmin Oh,Duk-Hee Kang,Eunhee Ha
{"title":"Long-Term Exposure to Fine Particulate Matter and Kidney Function among Patients with Polycystic Kidney Disease.","authors":"Youngrin Kwag,Jieun Min,Whanhee Lee,Seoyeong Ahn,Sooyoung Kim,Hyojin Ha,Minho Kim,Jongmin Oh,Duk-Hee Kang,Eunhee Ha","doi":"10.2215/cjn.0000001065","DOIUrl":"https://doi.org/10.2215/cjn.0000001065","url":null,"abstract":"BACKGROUNDPolycystic kidney disease (PKD) is the fourth leading cause of end-stage kidney disease. Although the condition is primarily genetic, environmental exposures such as air pollution may influence disease progression.METHODSWe investigated whether long-term exposure to fine particulate matter (PM2.5) is associated with kidney function decline among individuals with PKD and whether this association differs by age, sex, initial kidney function, and tolvaptan use. Using the Korea National Health Information Database, we identified 18,898 adults with PKD who underwent at least two health screenings between 2016 and 2023. Annual mean PM2.5 exposure was estimated with a high-resolution (1 km2) machine learning-based model. Linear mixed-effects models were applied to assess the association between PM2.5 exposure and changes in estimated glomerular filtration rate (eGFR), adjusting for demographic, socioeconomic, and lifestyle covariates.RESULTSEach 1 µg/m3 higher lag 0-1 year PM2.5 was associated with a -0.09 mL/min/1.73 m2 change in eGFR (95% CI, -0.16 to -0.01). More evident associations were observed among younger adults (-0.26; 95% CI, -0.42 to -0.09), individuals with preserved baseline kidney function (-0.14; 95% CI, -0.21 to -0.07), male (-0.10; 95% CI, -0.21 to 0), and individuals who were not prescribed tolvaptan (-0.12; 95% CI, -0.20 to -0.04).CONCLUSIONSChronic exposure to PM2.5 appears to be an environmental modifier of kidney function decline in PKD, particularly among younger individuals and those with preserved kidney function. Environmental risk reduction strategies, together with pharmacologic therapy, may help delay the onset of end-stage kidney disease in this vulnerable population.","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":"97 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Twelve Years to a Diagnosis: The Unfinished Agenda of Equity in Kidney Disease. 12年诊断：未完成的肾脏疾病公平议程。
IF 9.8 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2026-04-13 DOI: 10.2215/cjn.0000001070
Manuel Arellano Armisen
{"title":"Twelve Years to a Diagnosis: The Unfinished Agenda of Equity in Kidney Disease.","authors":"Manuel Arellano Armisen","doi":"10.2215/cjn.0000001070","DOIUrl":"https://doi.org/10.2215/cjn.0000001070","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":"28 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Authors' Reply: Convergent Proteinuria Reduction across Distinct Therapeutic Pathways in IgA Nephropathy. 作者回复：IgA肾病不同治疗途径的趋同蛋白尿减少。
IF 9.8 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2026-04-13 DOI: 10.2215/cjn.0000001046
Hiddo J L Heerspink,Brad H Rovin,Bruce Hendry,Vladimir Tesar
{"title":"Authors' Reply: Convergent Proteinuria Reduction across Distinct Therapeutic Pathways in IgA Nephropathy.","authors":"Hiddo J L Heerspink,Brad H Rovin,Bruce Hendry,Vladimir Tesar","doi":"10.2215/cjn.0000001046","DOIUrl":"https://doi.org/10.2215/cjn.0000001046","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":"34 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimizing Home Hemodialysis Vascular Access Infection Outcomes Through Continuous Quality Improvement. 通过持续质量改进优化家庭血液透析血管通路感染结局。
IF 9.8 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2026-04-10 DOI: 10.2215/cjn.0000001056
Ryan J Chan,Daniela Arustei,Celine D'Gama,Rose Faratro,Eduardo Magtoto,Kalaivani Renganathan,Christopher T Chan
{"title":"Optimizing Home Hemodialysis Vascular Access Infection Outcomes Through Continuous Quality Improvement.","authors":"Ryan J Chan,Daniela Arustei,Celine D'Gama,Rose Faratro,Eduardo Magtoto,Kalaivani Renganathan,Christopher T Chan","doi":"10.2215/cjn.0000001056","DOIUrl":"https://doi.org/10.2215/cjn.0000001056","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":"8 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147648970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expanding Evidence for Glucagon-Like Peptide-1 Receptor Agonists in Those with Diabetes and Kidney Disease. 胰高血糖素样肽-1受体激动剂用于糖尿病和肾脏疾病的证据越来越多。
IF 9.8 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2026-04-09 DOI: 10.2215/cjn.0000001072
Michael W Holliday,Sankar D Navaneethan
{"title":"Expanding Evidence for Glucagon-Like Peptide-1 Receptor Agonists in Those with Diabetes and Kidney Disease.","authors":"Michael W Holliday,Sankar D Navaneethan","doi":"10.2215/cjn.0000001072","DOIUrl":"https://doi.org/10.2215/cjn.0000001072","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":"21 6 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147641767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hierarchical Composite End Points: The Future of Randomized Trials of Kidney Disease? 分级复合终点：肾病随机试验的未来？
IF 9.8 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2026-04-09 DOI: 10.2215/cjn.0000001057
Natalie Staplin,Parminder K Judge
{"title":"Hierarchical Composite End Points: The Future of Randomized Trials of Kidney Disease?","authors":"Natalie Staplin,Parminder K Judge","doi":"10.2215/cjn.0000001057","DOIUrl":"https://doi.org/10.2215/cjn.0000001057","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":"32 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147641760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rediscovering Motivational Interviewing Spirit: Working with Patients Receiving Hemodialysis in the HOPE Consortium Trial. 重新发现动机访谈精神：在HOPE联合试验中与接受血液透析的患者一起工作。
IF 9.8 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2026-04-08 DOI: 10.2215/cjn.0000001084
Daniel W McNeil,Heather Howell,Eshika Kalam,Kevin Payne,Blanca Contreras,Carlyn Clark,Veronica Dyer,Daniel Cukor,Martin Cheatle
{"title":"Rediscovering Motivational Interviewing Spirit: Working with Patients Receiving Hemodialysis in the HOPE Consortium Trial.","authors":"Daniel W McNeil,Heather Howell,Eshika Kalam,Kevin Payne,Blanca Contreras,Carlyn Clark,Veronica Dyer,Daniel Cukor,Martin Cheatle","doi":"10.2215/cjn.0000001084","DOIUrl":"https://doi.org/10.2215/cjn.0000001084","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":"87 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147635698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Authors' Reply: Addressing Disparity Efficacy of Finerenone-Empagliflozin Combination in Asian Patients with Diabetic Kidney Disease. 作者回复：菲纳列酮-恩帕列净联合治疗亚洲糖尿病肾病疗效差异的研究
IF 9.8 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2026-04-07 DOI: 10.2215/cjn.0000001021
Rajiv Agarwal
{"title":"Authors' Reply: Addressing Disparity Efficacy of Finerenone-Empagliflozin Combination in Asian Patients with Diabetic Kidney Disease.","authors":"Rajiv Agarwal","doi":"10.2215/cjn.0000001021","DOIUrl":"https://doi.org/10.2215/cjn.0000001021","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":"4 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147630246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessing Cardiac Fitness for Kidney Transplantation - Uses and Pitfalls of Multimodality Imaging. 评估肾移植的心脏健康-多模态成像的用途和缺陷。
IF 9.8 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2026-04-06 DOI: 10.2215/cjn.0000001081
Jun Yu Chen,Mark Thomas,Ben Holloway,Jonathan N Townend
{"title":"Assessing Cardiac Fitness for Kidney Transplantation - Uses and Pitfalls of Multimodality Imaging.","authors":"Jun Yu Chen,Mark Thomas,Ben Holloway,Jonathan N Townend","doi":"10.2215/cjn.0000001081","DOIUrl":"https://doi.org/10.2215/cjn.0000001081","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":"84 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147625822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-Volume Hemodiafiltration: Expanding the Value of KRT by Lowering Hospitalization Burden. 大容量血液滤过：通过降低住院负担扩大KRT的价值。
IF 9.8 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2026-04-02 DOI: 10.2215/cjn.0000001066
Bernard Canaud
{"title":"High-Volume Hemodiafiltration: Expanding the Value of KRT by Lowering Hospitalization Burden.","authors":"Bernard Canaud","doi":"10.2215/cjn.0000001066","DOIUrl":"https://doi.org/10.2215/cjn.0000001066","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":"41 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147599253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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