Clinical Journal of the American Society of Nephrology最新文献

{"title":"Proteinuria Remission in Recurrent Focal Segmental Glomerulosclerosis after Autologous Stem Cell Transplantation: a Patient and Clinicians' Perspectives.","authors":"Vincent Moolenaar,Rosanne H N Prins,Jarom Heijmans,Frederike J Bemelman,Rik Westland","doi":"10.2215/cjn.0000000651","DOIUrl":"https://doi.org/10.2215/cjn.0000000651","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":"41 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Relevance of Computational Pathology Analysis of Interplay Between Kidney Microvasculature and Interstitial Microenvironment.","authors":"Yijiang Chen, Bangchen Wang, Dawit Demeke, Fan Fan, Celine Berthier, Laura Mariani, Kyle Lafata, Lawrence Holzman, Jeffrey Hodgin, Andrew Janowczyk, Laura Barisoni, Anant Madabhushi","doi":"10.2215/CJN.0000000597","DOIUrl":"10.2215/CJN.0000000597","url":null,"abstract":"<p><strong>Background: </strong>Interstitial fibrosis and tubular atrophy (IFTA), and density and shape of peritubular capillaries (PTCs), are independently prognostic of disease progression. This study aimed to identify novel digital biomarkers of disease progression and assess the clinical relevance of the interplay between a variety of PTC characteristics and their microenvironment in glomerular diseases.</p><p><strong>Methods: </strong>A total of 344 NEPTUNE/CureGN participants were included: 112 minimal change disease, 134 focal segmental glomerulosclerosis, 61 membranous nephropathy, and 37 IgA nephropathy. A PAS-stained whole slide image per patient was manually segmented for cortex, pre- and mature IFTA. Interstitial fractional space (IFS) was computationally quantified. A deep-learning model was applied to segment PTCs. Spatial and shape PTC pathomic features (230) were extracted from the cortex, IFTA, and non-IFTA sub-regions. Participants were divided into training and testing datasets (1:1). Univariate models incorporating IFTA subregions, and IFS-PTC density were constructed. LASSO regression models were used to identify the top PTC features associated with disease progression stratified by IFTA and non-IFTA sub-regions. Machine learning models were built using the top PTC features in IFTA and non-IFTA sub-regions to prognosticate disease progression.</p><p><strong>Results: </strong>PTC density in pre+mature IFTA and IFS, shape features in pre+mature IFTA, and spatial architecture features in the non-IFTA regions associated with disease progression. The machine learning generated risk scores showed a significant association with disease progression on the independent testing set.</p><p><strong>Conclusion: </strong>We uncovered previously underrecognized digital biomarkers of disease progression and the clinical relevance of the complex interplay between the status of the PTCs and the interstitial microenvironment.</p>","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing the Workforce Crisis in Uronephrology: Design and Initial Observations of the Duke Paired Undergraduate Mentorship Program.","authors":"Loryn W Dass, Anna Williams, Jennifer D Varner, Terri Taylor, Holly Hough, Jessica Sperling, Matthew A Sparks, Allison McElvaine, Rasheed Gbadegesin","doi":"10.2215/CJN.0000000601","DOIUrl":"10.2215/CJN.0000000601","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing Disparities in Access to Kidney Transplantation Regional Study: A Randomized Trial in the Southeastern United States.","authors":"Rachel E Patzer, Jade Buford, Megan Urbanski, Laura McPherson, Sudeshna Paul, Mengyu Di, Jessica L Harding, Goni Katz-Greenberg, Ana Rossi, Prince Mohan Anand, Amber Reeves-Daniel, Heather Jones, Laura Mulloy, Stephen O Pastan","doi":"10.2215/CJN.0000000586","DOIUrl":"10.2215/CJN.0000000586","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling Sex Differences in Kidney Health and CKD: A Review of the Effect of Sex Hormones.","authors":"Sarah A van Eeghen, Natalie J Nokoff, Taryn G Vosters, Maartina J P Oosterom-Eijmael, David Z I Cherney, Irene G M van Valkengoed, Ye Ji Choi, Laura Pyle, Petter Bjornstad, Martin den Heijer, Daniël H van Raalte","doi":"10.2215/CJN.0000000642","DOIUrl":"10.2215/CJN.0000000642","url":null,"abstract":"<p><p>Sexual dimorphism plays an important role in the pathogenesis and progression of CKD. Men with CKD often exhibit faster kidney function decline, leading to higher rates of kidney failure and mortality compared with women. Studies suggest that sex hormones may influence this apparent dimorphism, although the mechanisms underlying these influences remain poorly understood. In this review, we first summarize recent findings on sex differences in the prevalence and progression of CKD. Subsequently, we will focus on ( 1 ) the role of sex hormones in these sex differences, ( 2 ) kidney structural and hemodynamic differences between men and women, ( 3 ) the influence of sex hormones on pathophysiological processes leading to kidney disease, including glomerular hyperfiltration and key pathways involved in kidney inflammation and fibrosis, and finally, focus on the consequences of the underrepresentation of women in clinical trials. Understanding these sex differences is critical for advancing precision medicine and improving outcomes for both men and women with CKD.</p>","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and Proportion of Primary Focal Segmental Glomerulosclerosis (FSGS) among a Racially and Ethnically Diverse Adult Patient Population between 2010 and 2021.","authors":"Mercedes A Munis, Qiaoling Chen, T Matthew Hill, Min Zhuo, Asher D Schachter, Simran K Bhandari, Aviv Hever, Teresa N Harrison, Ancilla W Fernandes, John J Sim","doi":"10.2215/CJN.0000000590","DOIUrl":"10.2215/CJN.0000000590","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":" ","pages":""},"PeriodicalIF":8.5,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142407172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of pseudo-nephrotoxicity on apparent acute kidney injury incidence and severity: a simulation study.","authors":"Todd A. Miano, Christina H.W. Brotman, Marc H. Scheetz, Michael G. S. Shashaty","doi":"10.2215/cjn.0000000623","DOIUrl":"https://doi.org/10.2215/cjn.0000000623","url":null,"abstract":"An abstract is unavailable. This article is available as a PDF only.","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":"9 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142776398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dis-impede the Achievement of Euvolemia in Kidney Failure.","authors":"Sagar U Nigwekar, Michael J Cima","doi":"10.2215/CJN.0000000615","DOIUrl":"10.2215/CJN.0000000615","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":"19 12","pages":"1518-1520"},"PeriodicalIF":8.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142802992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cancer Screening among Patients with Kidney Failure Requiring Hemodialysis: Where We Are and Where We Are Going.","authors":"Deepa Jayaram, Ladan Golestaneh","doi":"10.2215/CJN.0000000612","DOIUrl":"10.2215/CJN.0000000612","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":" ","pages":"1521-1523"},"PeriodicalIF":8.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Repeat Kidney Biopsies in Lupus Nephritis in a Largely Black and Hispanic Population.","authors":"Anitha Ramu, Rosalba Santana de Roberts, Nang San Hti Lar Seng, Gopisree Peringeth, Hana Rajevac, James M Pullman, Meryl Waldman, Ladan Golestaneh, Belinda Jim","doi":"10.2215/CJN.0000000000000556","DOIUrl":"10.2215/CJN.0000000000000556","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":" ","pages":"1643-1645"},"PeriodicalIF":8.5,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11637691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}