发布求助
文献互助 智能选刊 最新文献

Clinical Journal of the American Society of Nephrology最新文献

筛选
英文 中文
Bisphosphonate Use After Kidney Transplantation Is Associated with Lower Fracture Risk. 肾移植后使用双膦酸盐可降低骨折风险
IF 8.5 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2024-11-05 DOI: 10.2215/CJN.0000000591
Joseph M Kahwaji, Su-Jau Yang, John Sim, Chong Young Parke, Roland L Lee
{"title":"Bisphosphonate Use After Kidney Transplantation Is Associated with Lower Fracture Risk.","authors":"Joseph M Kahwaji, Su-Jau Yang, John Sim, Chong Young Parke, Roland L Lee","doi":"10.2215/CJN.0000000591","DOIUrl":"https://doi.org/10.2215/CJN.0000000591","url":null,"abstract":"<p><strong>Background: </strong>Kidney transplant recipients are at higher risk of fractures compared to the general population. The use of bisphosphonates has been shown to increase bone mineral density after transplantation but has not been shown to lower fracture rates. Here, we aim to determine if exposure to bisphosphonates associates with lower incidence of non-vertebral fractures after kidney transplantation.</p><p><strong>Methods: </strong>We conducted a retrospective review for all Southern California Kaiser Permanente kidney transplant recipients with osteoporosis transplanted between 2000 and 2019. Baseline variables were collected. Those prescribed an oral bisphosphonate were compared to those who were not. The primary outcome was non-vertebral fracture. Chi square was used to evaluate categorical variables and Wilcoxson rank sum test for continuous variables. Propensity scores were generated to balance covariates in the bisphosphonate and non-bisphosphonate groups. Cause-specific hazard and sub distribution (Fine-Gray) methods were performed for competing risk analysis. Death censored graft survival was evaluated as a secondary outcome using standard Cox regression.</p><p><strong>Results: </strong>There were 489 patients included in the study, 203 of which were in the bisphosphonate group. The cause specific hazard model suggested a 64% lower risk of non-vertebral fracture in the bisphosphonate group (p=0.02). The Fine-Gray hazard model treating death as a competing risk did not show lower relative incidence of non-vertebral fracture. Bisphosphonate treatment was associated with lower death censored graft failure (p=0.002).</p><p><strong>Conclusions: </strong>Bisphosphonate use after kidney transplantation may associate with lower risk of non-vertebral fracture after transplant. Bisphosphonate use in this study was also associated with lower death censored graft failure. Caution is advised when interpreting these results given the retrospective nature of the study.</p>","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":8.5,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surrogate Endpoints in APOL1-Associated Kidney Disease: Evaluation in Three Cohorts. APOL1 相关肾病的替代终点：三个队列的评估
IF 8.5 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2024-11-05 DOI: 10.2215/CJN.0000000000000575
Alix Rosenberg, Carina Flaherty, Amanda Anderson, Lawrence J Appel, Josef Coresh, Jiang He, Jim Lash, Celina Liu, Panduranga Rao, Jonathan Taliercio, Aditya Surapaneni, Morgan Grams
{"title":"Surrogate Endpoints in APOL1-Associated Kidney Disease: Evaluation in Three Cohorts.","authors":"Alix Rosenberg, Carina Flaherty, Amanda Anderson, Lawrence J Appel, Josef Coresh, Jiang He, Jim Lash, Celina Liu, Panduranga Rao, Jonathan Taliercio, Aditya Surapaneni, Morgan Grams","doi":"10.2215/CJN.0000000000000575","DOIUrl":"https://doi.org/10.2215/CJN.0000000000000575","url":null,"abstract":"<p><strong>Background: </strong>Surrogate endpoints for the clinical outcome of kidney failure have been accepted by the United States Food and Drug Administration. However, they have not been specifically evaluated in Apolipoprotein L1 (APOL1)-associated kidney disease.</p><p><strong>Methods: </strong>This random-effects meta-analysis included African-American participants in the Atherosclerosis Risk in Communities (ARIC) study (N=3071), the Chronic Renal Insufficiency Cohort (CRIC; N=998), and the African American Study of Kidney Disease and Hypertension (AASK; N=609). Surrogate endpoints included three-year 30% and 40% decline in glomerular filtration rate (GFR), doubling of urine protein-to-creatinine ratio (UPCR), and >3 ml/min/1.73 m2 per year decline in GFR. Clinical outcomes included kidney failure requiring kidney replacement therapy, heart failure, cardiovascular disease, and death after three years.Results: 22% in AASK, 18% in CRIC, and 13% in ARIC had the APOL1 high risk genotype. Participants with the APOL1 high-risk genotype had higher risk of all three-year GFR outcomes but not doubling of UPCR, as well as kidney failure after three years. The three-year outcomes were strongly associated with kidney failure, with weaker but statistically significant associations with the development of heart failure, cardiovascular disease, and mortality. There were no differences in associations between short-term and long-term clinical outcomes by APOL1 risk status.</p><p><strong>Conclusions: </strong>Individuals with the APOL1 high risk genotype were more susceptible to three-year GFR-related endpoints and long-term kidney failure than individuals with the APOL1 low-risk genotype. There was no consistent difference in short-term-clinical outcome associations by APOL1 genotype, supporting the use of surrogates in APOL1-associated kidney disease.</p>","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":8.5,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142584828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer Screening among Patients with Kidney Failure Requiring Hemodialysis: Where We Are and Where We Are Going. 需要血液透析的肾衰竭患者的癌症筛查：我们的现状与未来。
IF 8.5 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2024-11-01 DOI: 10.2215/CJN.0000000612
Deepa Jayaram, Ladan Golestaneh
{"title":"Cancer Screening among Patients with Kidney Failure Requiring Hemodialysis: Where We Are and Where We Are Going.","authors":"Deepa Jayaram, Ladan Golestaneh","doi":"10.2215/CJN.0000000612","DOIUrl":"https://doi.org/10.2215/CJN.0000000612","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":8.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gender Differences in Citation Rate: An Analysis of Randomized Controlled Trials in Nephrology High-Impact Journals Over Two Decades. 引用率的性别差异：对二十年来肾脏病学高影响力期刊上随机对照试验的分析。
IF 8.5 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2024-11-01 Epub Date: 2024-08-06 DOI: 10.2215/CJN.0000000000000511
Qandeel H Soomro, Shuojohn Li, Angela McCarthy, Dalila Varela, Javaughn Ways, Amalya M Charytan, Colin Keane, Giana Ramos, Joey Nicholson, David M Charytan
{"title":"Gender Differences in Citation Rate: An Analysis of Randomized Controlled Trials in Nephrology High-Impact Journals Over Two Decades.","authors":"Qandeel H Soomro, Shuojohn Li, Angela McCarthy, Dalila Varela, Javaughn Ways, Amalya M Charytan, Colin Keane, Giana Ramos, Joey Nicholson, David M Charytan","doi":"10.2215/CJN.0000000000000511","DOIUrl":"10.2215/CJN.0000000000000511","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":8.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Intake of Whole Grains with Health Outcomes in the Chronic Renal Insufficiency Cohort Study. 慢性肾功能不全队列研究中全谷物摄入量与健康结果的关系
IF 8.5 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2024-11-01 Epub Date: 2024-08-14 DOI: 10.2215/CJN.0000000000000538
Dillon Winkelman, Julie Smith-Gagen, Casey M Rebholz, Orlando M Gutierrez, David E St-Jules
{"title":"Association of Intake of Whole Grains with Health Outcomes in the Chronic Renal Insufficiency Cohort Study.","authors":"Dillon Winkelman, Julie Smith-Gagen, Casey M Rebholz, Orlando M Gutierrez, David E St-Jules","doi":"10.2215/CJN.0000000000000538","DOIUrl":"10.2215/CJN.0000000000000538","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":8.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141983813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiopulmonary Exercise Testing in Patients with Chronic Kidney Disease. 慢性肾病患者的心肺运动测试
IF 8.5 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2024-11-01 DOI: 10.2215/CJN.0000000610
Marcelle Tuttle, Mark J Sarnak
{"title":"Cardiopulmonary Exercise Testing in Patients with Chronic Kidney Disease.","authors":"Marcelle Tuttle, Mark J Sarnak","doi":"10.2215/CJN.0000000610","DOIUrl":"https://doi.org/10.2215/CJN.0000000610","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":8.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cystatin C and Kidney Function Recovery in Patients Requiring Continuous KRT for Acute Kidney Injury. 胱抑素 C 与急性肾损伤需要持续肾脏替代疗法患者的肾功能恢复。
IF 8.5 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2024-11-01 Epub Date: 2024-08-21 DOI: 10.2215/CJN.0000000000000531
Sarah M Haeger, Kayo Okamura, Amy S Li, Zhibin He, Bryan D Park, Isadore M Budnick, North Foulon, Matthew Kennis, Rachel E Blaine, Makoto Miyazaki, Ruth Campbell, Diana I Jalal, James F Colbert, John T Brinton, Benjamin R Griffin, Sarah Faubel
{"title":"Cystatin C and Kidney Function Recovery in Patients Requiring Continuous KRT for Acute Kidney Injury.","authors":"Sarah M Haeger, Kayo Okamura, Amy S Li, Zhibin He, Bryan D Park, Isadore M Budnick, North Foulon, Matthew Kennis, Rachel E Blaine, Makoto Miyazaki, Ruth Campbell, Diana I Jalal, James F Colbert, John T Brinton, Benjamin R Griffin, Sarah Faubel","doi":"10.2215/CJN.0000000000000531","DOIUrl":"10.2215/CJN.0000000000000531","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":8.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142019464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Association between Residential Segregation and Access to Kidney Transplantation: Evidence from a Multistate Cohort Study. 居住地隔离与肾移植机会之间的关系--来自多州队列研究的证据》（The Association Between Residential Segregation and Access to Kidney Transplantation - Evidence from a Multi-State Cohort Study）。
IF 8.5 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2024-11-01 Epub Date: 2024-08-26 DOI: 10.2215/CJN.0000000000000565
Jasmine Berry, Aubriana Perez, Mengyu Di, Chengcheng Hu, Stephen O Pastan, Rachel E Patzer, Jessica L Harding
{"title":"The Association between Residential Segregation and Access to Kidney Transplantation: Evidence from a Multistate Cohort Study.","authors":"Jasmine Berry, Aubriana Perez, Mengyu Di, Chengcheng Hu, Stephen O Pastan, Rachel E Patzer, Jessica L Harding","doi":"10.2215/CJN.0000000000000565","DOIUrl":"10.2215/CJN.0000000000000565","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":8.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gender Equity in Academic Nephrology: Enough Talk, Now Is the Time to Act. 肾脏病学术界的性别平等：说得够多了，现在是行动的时候了。
IF 8.5 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2024-11-01 Epub Date: 2024-10-04 DOI: 10.2215/CJN.0000000585
Liz Lightstone
{"title":"Gender Equity in Academic Nephrology: Enough Talk, Now Is the Time to Act.","authors":"Liz Lightstone","doi":"10.2215/CJN.0000000585","DOIUrl":"10.2215/CJN.0000000585","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":8.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142373467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: BNT162b2 versus mRNA-1273 Third Dose COVID-19 Vaccine in Patients with CKD and Maintenance Dialysis Patients. 更正：BNT162b2 与 mRNA-1273 第三剂量 COVID-19 疫苗在慢性肾脏病患者和维持性透析患者中的应用。
IF 8.5 1区 医学
Clinical Journal of the American Society of Nephrology Pub Date : 2024-11-01 DOI: 10.2215/CJN.0000000608
{"title":"Correction: BNT162b2 versus mRNA-1273 Third Dose COVID-19 Vaccine in Patients with CKD and Maintenance Dialysis Patients.","authors":"","doi":"10.2215/CJN.0000000608","DOIUrl":"10.2215/CJN.0000000608","url":null,"abstract":"","PeriodicalId":50681,"journal":{"name":"Clinical Journal of the American Society of Nephrology","volume":null,"pages":null},"PeriodicalIF":8.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142407171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信