{"title":"Multiparametric MRI and clinical factors for predicting early recurrence of breast cancer after modified radical mastectomy","authors":"Quan-hua Chen , Chongze Yang , Lan-hui Qin , Yan-ling Liang , Wei-wei Jiang , Jin-yuan Liao","doi":"10.1016/j.clinimag.2025.110625","DOIUrl":"10.1016/j.clinimag.2025.110625","url":null,"abstract":"<div><h3>Objective</h3><div>To determine whether preoperative multiparametric MRI features and clinicopathological factors can predict early recurrence in breast cancer patients following modified radical mastectomy (MRM).</div></div><div><h3>Materials and methods</h3><div>This retrospective study included 132 patients who underwent MRM at two hospitals from January 2012 to December 2022. Patients were classified into early recurrence (disease-free survival ≤3 years, <em>n</em> = 86) or late recurrence (>3 years, <em>n</em> = 46). We collected preoperative MRI features (tumor size, morphology, enhancement patterns, apparent diffusion coefficient (ADC) values, early enhancement rate, time-signal intensity curves) and clinical/pathological factors (age, menstruation status, neoadjuvant chemotherapy, T/N/TNM stage, tumor grade, axillary nodal involvement, vascular/nerve/nipple/skin invasion, ER, PR, HER-2, Ki-67, molecular subtype, and adjuvant therapies). Univariate and multivariate analyses (binary logistic and Cox regression) identified independent predictors of early recurrence and their impact on disease-free survival. Predictive accuracy was assessed by ROC curves.</div></div><div><h3>Results</h3><div>Significant factors associated with early recurrence (<em>P</em> < 0.05) included tumor size, ADC value, early enhancement rate, axillary lymph node metastasis, T and TNM stage, vascular invasion, ER, PR, HER-2, molecular subtype, and endocrine therapy. Multivariate analysis identified early enhancement rate, lower ADC value, and larger tumor diameter as independent predictors (AUC = 0.899). These MRI factors, together with lack of endocrine therapy, also independently influenced disease-free survival.</div></div><div><h3>Conclusion</h3><div>Preoperative multiparametric MRI features, especially early enhancement rate and tumor size, combined with endocrine therapy status, can predict early recurrence, enhancing prognosis for patients undergoing MRM.</div></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"127 ","pages":"Article 110625"},"PeriodicalIF":1.5,"publicationDate":"2025-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical ImagingPub Date : 2025-09-15DOI: 10.1016/j.clinimag.2025.110619
Ji Young Jeon , So Hyun Park , Hee Young Lee
{"title":"Corrigendum to “Critical radiology results in thoracic imaging; categorization by urgency and clinical outcome” [Clin Imaging volume 126 (October 2025)/110594]","authors":"Ji Young Jeon , So Hyun Park , Hee Young Lee","doi":"10.1016/j.clinimag.2025.110619","DOIUrl":"10.1016/j.clinimag.2025.110619","url":null,"abstract":"","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"127 ","pages":"Article 110619"},"PeriodicalIF":1.5,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical ImagingPub Date : 2025-09-15DOI: 10.1016/j.clinimag.2025.110622
Andrew Kim , Sara Strauss , Gayle Salama
{"title":"CT-guided paramaxillary glossopharyngeal nerve block: A novel and potentially safer approach for diagnostic confirmation and temporary treatment of glossopharyngeal neuralgia","authors":"Andrew Kim , Sara Strauss , Gayle Salama","doi":"10.1016/j.clinimag.2025.110622","DOIUrl":"10.1016/j.clinimag.2025.110622","url":null,"abstract":"<div><div>The glossopharyngeal nerve block is an interventional technique utilized for head and neck pain management in the setting of glossopharyngeal neuralgia, dental procedures, awake endotracheal intubations, and post-pharyngeal surgery. This procedure is traditionally performed with landmark technique or ultrasound-guided techniques, all of which are associated with potential risks and complications for the patient. We report the novel technique of a CT-guided paramaxillary approach glossopharyngeal nerve block, which has not been previously reported, eliminates the trans-parotid trajectory, and reduces potential risks and complications associated with other established techniques, particularly those related to the parotid gland, including intraparotid facial nerve injury.</div></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"127 ","pages":"Article 110622"},"PeriodicalIF":1.5,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145097891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical ImagingPub Date : 2025-09-13DOI: 10.1016/j.clinimag.2025.110616
Benjamin D. Simon, Stephanie A. Harmon, Baris Turkbey
{"title":"Reply to “A critical appraisal and methodological inquiry into an automated multimodal deep learning model for predicting biochemical recurrence in prostate cancer”","authors":"Benjamin D. Simon, Stephanie A. Harmon, Baris Turkbey","doi":"10.1016/j.clinimag.2025.110616","DOIUrl":"10.1016/j.clinimag.2025.110616","url":null,"abstract":"","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"127 ","pages":"Article 110616"},"PeriodicalIF":1.5,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145082431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Common applications of noncosmetic dermatologic sonography: A comprehensive overview","authors":"Mohammadreza Tahamtan , Shahriar Rahmani , Hadi Koohi , Faezeh Khorasanizadeh , Khadijeh Shirazkeytabar , Elnaz Pourgholi , Ximena Wortsman","doi":"10.1016/j.clinimag.2025.110608","DOIUrl":"10.1016/j.clinimag.2025.110608","url":null,"abstract":"<div><h3>Purpose</h3><div>This review aims to highlight the increasing role of ultrasound in dermatology, emphasizing its utility in assessing skin and nail lesions. It focuses on the technological advancements and research driving its adoption as a safe, cost-effective, and non-invasive diagnostic tool.</div></div><div><h3>Methods</h3><div>We conducted a comprehensive review of the literature, focusing on the technical aspects of dermatologic ultrasound, including real-time visualization, color Doppler for vascularity detection, and high axial spatial resolution. The ultrasonographic patterns of common benign and malignant conditions, inflammatory diseases, vascular anomalies, and nail lesions were analyzed.</div></div><div><h3>Results</h3><div>Ultrasound provides detailed real-time imaging, enabling accurate diagnosis and treatment planning for various dermatologic conditions. Key findings include the identification of characteristic ultrasonographic patterns for skin neoplasms, inflammatory diseases, and vascular malformations, as well as its efficacy in evaluating nail lesions.</div></div><div><h3>Conclusions</h3><div>Dermatologic ultrasound is a valuable tool for early diagnosis and management of skin and nail conditions. Its ability to visualize structural and vascular features in real-time improves diagnostic accuracy, making it an essential addition to dermatologic practice. Knowledge of ultrasonographic patterns can significantly benefit patient care.</div></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"127 ","pages":"Article 110608"},"PeriodicalIF":1.5,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145097889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical ImagingPub Date : 2025-09-12DOI: 10.1016/j.clinimag.2025.110620
Caitlin Deffler, Ashkan Eighaei Sedeh, Ellen Leitman, Thomas S C Ng, David Z Chow, Umar Mahmood, Pedram Heidari, Nathaniel Mercaldo, Shadi A Esfahani
{"title":"The role of PSMA PET/CT in identifying benign and malignant intracranial lesions in patients with prostate cancer.","authors":"Caitlin Deffler, Ashkan Eighaei Sedeh, Ellen Leitman, Thomas S C Ng, David Z Chow, Umar Mahmood, Pedram Heidari, Nathaniel Mercaldo, Shadi A Esfahani","doi":"10.1016/j.clinimag.2025.110620","DOIUrl":"https://doi.org/10.1016/j.clinimag.2025.110620","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the ability of prostate-specific membrane antigen (PSMA) PET/CT to detect and characterize intracranial lesions in patients with prostate cancer (PCa), using brain MRI as a gold standard method.</p><p><strong>Methods: </strong>In this retrospective single-center study, standard-of-care <sup>18</sup>F-piflufolastat and <sup>68</sup>Ga-gozetotide PSMA PET/CT scans for PCa patients were reviewed from August 2021 to February 2023. Patients with a brain MRI taken within 6 months of their PSMA PET/CT were enrolled. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of PSMA PET/CT were calculated for the detection of brain metastases. Lesion uptake and patients' clinical information, including prostate-specific antigen (PSA) were compared between metastatic and non-metastatic brain lesions.</p><p><strong>Results: </strong>Of 1482 reviewed PCa patients, 141 with available brain MRI within six months of PSMA PET/CT were included. The estimated incidence rate of brain metastasis was 1.1 % (17/1482; Exact 95 % CI: 0.7-1.83), using brain MRI. PSMA PET/CT had a sensitivity of 81.2 % (95 % CI: 54.4-96.0), a specificity of 93.6 % (95 % CI: 87.8-97.2), a PPV of 61.9 % (95 % CI: 44.4-76.8), and an NPV of 97.5 % (95 % CI: 93.3-99.1) for detecting at least one metastatic PCa lesion as confirmed by MRI. Although not statistically significant, the mean SUV<sub>max</sub> was higher in patients with intracranial PCa metastasis than those with other etiologies (fold change: 2.88, 95 % CI: 0.88, 9.43, p = 0.077), and a similar pattern was shown for mean PSA (fold-change: 17.2, 95 % CI: 0.95-312.6, p = 0.054).</p><p><strong>Conclusion: </strong>Intracranial uptake on PSMA PET/CT may require further clinical and imaging correlation for accurate characterization.</p>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":" ","pages":"110620"},"PeriodicalIF":1.5,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145092900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clinical ImagingPub Date : 2025-09-11DOI: 10.1016/j.clinimag.2025.110617
Kennedy Sparling , Nathan Amann , Eduardo Thadeu de Oliveira Correia , Richard Barger , Navid Faraji
{"title":"From paddle to pathology: A radiologic review of common pickleball-related injuries","authors":"Kennedy Sparling , Nathan Amann , Eduardo Thadeu de Oliveira Correia , Richard Barger , Navid Faraji","doi":"10.1016/j.clinimag.2025.110617","DOIUrl":"10.1016/j.clinimag.2025.110617","url":null,"abstract":"<div><div>With pickleball's rapid rise in participation, there has been a parallel increase in pickleball-related injuries. This review focuses on a comprehensive overview of common pickleball-related injuries, emphasizing likely mechanisms of injury and corresponding radiologic manifestations. Musculoskeletal injuries make up the majority of pickleball-related afflictions, with trauma to other organ systems reported less frequently. Although not always necessary for diagnosis, imaging modalities, including plain radiography, ultrasound, and magnetic resonance imaging, can aid in identifying injury severity and guide effective treatment. Furthermore, understanding the distinct mechanisms of these injuries, including falls, sudden lateral movements, and direct contact with players or equipment, is also essential for effective and efficient recognition of these afflictions. By becoming familiar with the nature of pickleball-related injuries and their radiologic manifestations, radiologists can ultimately more accurately identify the imaging patterns amid the sport's growing popularity.</div></div>","PeriodicalId":50680,"journal":{"name":"Clinical Imaging","volume":"127 ","pages":"Article 110617"},"PeriodicalIF":1.5,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}