Journal of Pharmaceutical Research International最新文献_第2页

Exploring the Potential of Momordica charantia Fruits Mucilage as a Novel Pharmaceutical Excipient 探索 Momordica charantia 果实黏液作为新型药用辅料的潜力

Journal of Pharmaceutical Research International Pub Date : 2024-04-24 DOI: 10.9734/jpri/2024/v36i67520

Tahamina Momtaz Chowdhury, Md Rabiul Hossain, Rashadul Hossain, R. Sultana

{"title":"Exploring the Potential of Momordica charantia Fruits Mucilage as a Novel Pharmaceutical Excipient","authors":"Tahamina Momtaz Chowdhury, Md Rabiul Hossain, Rashadul Hossain, R. Sultana","doi":"10.9734/jpri/2024/v36i67520","DOIUrl":"https://doi.org/10.9734/jpri/2024/v36i67520","url":null,"abstract":"Background: The discovery and developments of new drug formulations are inspired by medicinal plants. Polysaccharides, such as mucilage or gum from medicinal plants, have a variety of physicochemical properties and are commonly used in pharmaceutical applications.\u0000Objectives: The current study's objectives are to construct and assess Metformin HCl tablets employing Momordica charantia (MC) natural mucilage as a binder and release modifier.\u0000Methods: The mucilage was isolated from the fruits of MC. The tablet was made using a wet granulation process, and the formulation included several mucilage ratios (1%, 2.5%, 5%, and 10%).\u0000Results: It was found that the granules and tablets had good flow qualities based on results of the pre- and post-compression parameters. The release kinetic study showed that F4 showed the first order release kinetics and F8 showed the zero and the higuchi’s release kinetics. In low concentration of mucilage tablets showed good binding properties with immediate release properties. As the concentration was increased, tablets showed good binding properties with sustained release properties.\u0000Conclusion: The isolated mucilage from Momordica charantias has the potential to be used as a tablet binder and as an intermediary in the development of a sustained-release drug","PeriodicalId":506675,"journal":{"name":"Journal of Pharmaceutical Research International","volume":"54 43","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140662095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causes and Therapy of Depression Posing Risk to Alzheimer's: A Comprehensive Review 导致阿尔茨海默氏症风险的抑郁症的原因与治疗：全面回顾

Journal of Pharmaceutical Research International Pub Date : 2024-04-22 DOI: 10.9734/jpri/2024/v36i67518

N.V.L. Suvarchala Reddy V, M. G. Raju, P. Shrivani, D. P. Sudha, P. Anusha

{"title":"Causes and Therapy of Depression Posing Risk to Alzheimer's: A Comprehensive Review","authors":"N.V.L. Suvarchala Reddy V, M. G. Raju, P. Shrivani, D. P. Sudha, P. Anusha","doi":"10.9734/jpri/2024/v36i67518","DOIUrl":"https://doi.org/10.9734/jpri/2024/v36i67518","url":null,"abstract":"Depression is a complex mental disorder that not only affects mood but also poses a significant risk factor for the development of Alzheimer’s disease. Key findings unravel a bilateral relationship where depression not only emerges as a precursor but also as a consequence of Alzheimer's pathology, thereby creating a vicious cycle that exacerbates the cognitive decay. The review article traverses the landscape of both disorders, elucidating the pathological and biochemical links that interlace their neuropathological signatures. It further reviews the current landscape of treatment modalities and management strategies, positioning non-pharmacological interventions like lifestyle modifications and cognitive therapies at the forefront, alongside conventional pharmacotherapy. A novel angle is provided by the exploration of herbal plants used in treatment, gauging their efficacy and potential as alternative or adjunct therapies. Recent advancements in the therapeutic domain, such as personalized medicine and innovative drug targets, are also highlighted, offering a roadmap for translational research and clinical practice.","PeriodicalId":506675,"journal":{"name":"Journal of Pharmaceutical Research International","volume":"78 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140675306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review of Revolutionizing Green Synthesis of Nanoparticles in Pharmacy and Healthcare 纳米粒子在制药和医疗保健领域的绿色合成革命综述

Journal of Pharmaceutical Research International Pub Date : 2024-04-17 DOI: 10.9734/jpri/2024/v36i57515

K. Geetha, Mounika Yekkala, R. S. Kiran

{"title":"A Review of Revolutionizing Green Synthesis of Nanoparticles in Pharmacy and Healthcare","authors":"K. Geetha, Mounika Yekkala, R. S. Kiran","doi":"10.9734/jpri/2024/v36i57515","DOIUrl":"https://doi.org/10.9734/jpri/2024/v36i57515","url":null,"abstract":"Science's newest and fastest-growing field is nanotechnology. The foundation of nanotechnology is made up of nanoparticles. The sizes of nanoparticles range from 1 to 100 nm. A variety of classes, including inorganic, organic, ceramic, and carbon-based nanoparticles, are used to categorise the nanoparticles. Nanoparticles are becoming a more widely used material like electronic devices to medicine in industries. Green synthesis is a feasible and environmentally acceptable alternative that produces nanoparticles using natural resources and biological processes. In addition to using environmentally friendly reducing and stabilising agents, the green synthesis approach makes use of a variety of biological resources, including bacteria, fungus, plants, and algae. The synthesis of nanoparticles has grown in importance as a means of promoting targeted drug delivery, imaging, diagnostics, and therapeutic interventions in the pharmaceutical and healthcare industries. These natural resources guarantee the biocompatibility and stability of the final nanoparticles by acting as capping agents in addition to reducing agents The creation of safer and more effective medical solutions through green synthesis has great potential to transform the nanoparticle manufacturing process. Green nanotechnology for pharmacy and healthcare is experiencing innovation which is usefulness as a resource for researchers, practitioners, and policymakers. Additionally, nanoparticles can be categorised into one, two, or three methods. The synthesis of nanoparticles using chemical, physical, and environmentally friendly methods is covered in this review. To make the nanoparticles, a variety of qualitative and quantitative techniques are applied. FTIR, SEM, and TEM are examples of qualitative techniques.","PeriodicalId":506675,"journal":{"name":"Journal of Pharmaceutical Research International","volume":" 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140693316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Comprehensive Analysis of Risk Factors of Diabetic Nephropathy and Exploring the Treatment Pattern 糖尿病肾病风险因素综合分析及治疗模式探讨

Journal of Pharmaceutical Research International Pub Date : 2024-04-17 DOI: 10.9734/jpri/2024/v36i57516

Aritra Pal, Asish Bhanja, Joy Williams, Vineesha Geddam, Chandana Bendurthi, Bipin Sah, Bashongdor Marwein, Arka Ghosh, Anurag Rajkonwar, Praveen Sana, Ratna Kumari

{"title":"A Comprehensive Analysis of Risk Factors of Diabetic Nephropathy and Exploring the Treatment Pattern","authors":"Aritra Pal, Asish Bhanja, Joy Williams, Vineesha Geddam, Chandana Bendurthi, Bipin Sah, Bashongdor Marwein, Arka Ghosh, Anurag Rajkonwar, Praveen Sana, Ratna Kumari","doi":"10.9734/jpri/2024/v36i57516","DOIUrl":"https://doi.org/10.9734/jpri/2024/v36i57516","url":null,"abstract":"Aims: The study aims to comprehensively analyze diabetic nephropathy's risk factors and treatment patterns, exploring diverse factors for enhanced prevention and personalized management. \u0000Study Design: Prospective study design. \u0000Place and Duration of Study: The study was conducted for 5 months at Trust Multispeciality Hospital, Kakinada. \u0000Methodology: This retroactive chart analysis of non-critical outpatients folders of Trust Hospital that refers to the mentioned period (11/2022 -04/2023) will use Excel software. \u0000Results: A variety of risk factors promote the development and progression of diabetic nephropathy, including elevated glucose levels, high blood pressure, obesity, the long duration of diabetes, and dyslipidemia. These risk factors are modifiable by hyperglycemic agents, anti-hypertensives, and lipid-lowering agents. Most of the people who are prone to diabetic nephropathy are between 40 and 70 years of age. Males are most affected (80%) compared to females (20%). Oral hypoglycemic agents (97%) and calcium channel blockers (50%) play a major role in reducing the progression of diabetic nephropathy by controlling blood pressure and glucose levels in the subject. Obesity is also a notable risk factor for end-stage renal disease patients.","PeriodicalId":506675,"journal":{"name":"Journal of Pharmaceutical Research International","volume":" 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140691570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic Values of Pyridine Molecules from Natural Sources: A Comprehensive Review 天然来源吡啶分子的治疗价值：全面回顾

Journal of Pharmaceutical Research International Pub Date : 2024-04-17 DOI: 10.9734/jpri/2024/v36i57517

V.E. Ida Christi, J. S. Chowdary, S. S. Kumar, R. Jubilee, Blessy Victa N.I., G. S. Nachiar

{"title":"Therapeutic Values of Pyridine Molecules from Natural Sources: A Comprehensive Review","authors":"V.E. Ida Christi, J. S. Chowdary, S. S. Kumar, R. Jubilee, Blessy Victa N.I., G. S. Nachiar","doi":"10.9734/jpri/2024/v36i57517","DOIUrl":"https://doi.org/10.9734/jpri/2024/v36i57517","url":null,"abstract":"Reason for the Study: Many commercial pharmacologically interesting medicinal plant species and their formulations are used in more communities and often in more countries around the world, for their multiple uses of Active compounds from the natural sources. It should be need to extensively explored to get their properties and their benefits. The costs of drugs for resistance of common infective diseases are increased especially bacterial infections and sexually transmitted diseases. The therapeutic approach of herbal medicines is an option for concerted search for new chemical entities for new drugs development. So searching of valuable medicinal plants with their longest track record for their use and their location and distribution is must and essential. \u0000Aim: This study aims to provide an overview and documentation about pyridine alkaloids and their phytopharmacological activity related some medicinal plants. \u0000Methodology: By using the key words, the literatures were collected from Science Direct, PubMed and Google Scholar search engines. This review will create a platform to harmonizing the traditional medicine practice in the country, create a synergy between herbal medicines and modern medicine and more harmonized integrated traditional medicine practices in future. It gives an insight into the strategic plan and route map for the development of new formulations and research platform for the practice and development of herbal medicines. The pharmaceutical industry has come to consider traditional medicine as a source for identification of bio-active agents that can be used in the preparation of semi synthetic medicine in different novel formulations. \u0000Conclusion: This article focused some medicinal plants which contain different types and derivatives of pyridine alkaloids with their therapeutic applications. Further research needs to be done to make Novel pharmaceutical preparations with patent drugs and appropriate therapeutic documentation.","PeriodicalId":506675,"journal":{"name":"Journal of Pharmaceutical Research International","volume":"75 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140693846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Characterization of Gold Nanoparticles Conjugates to Increase Bioavailability of 6-Gingerol 提高 6-姜酚生物利用率的金纳米颗粒共轭物的开发与表征

Journal of Pharmaceutical Research International Pub Date : 2024-04-16 DOI: 10.9734/jpri/2024/v36i57513

G. Kumar, Ujjwal Nautiyal, Meenakshi Bhatt, Archana Dhyani

{"title":"Development and Characterization of Gold Nanoparticles Conjugates to Increase Bioavailability of 6-Gingerol","authors":"G. Kumar, Ujjwal Nautiyal, Meenakshi Bhatt, Archana Dhyani","doi":"10.9734/jpri/2024/v36i57513","DOIUrl":"https://doi.org/10.9734/jpri/2024/v36i57513","url":null,"abstract":"6-Gingerol, an abundant component of Zingiber officinale, acts as a cardiotonic and is also used in the treatment of cancer disease, but its low solubility makes it very challenging in therapeutic applications. As we are all aware of the metal toxicity of nanoparticles, here we are using gold metal because gold nanoparticles are found to have lower toxicity than other metals. In this study, we prepared optimized conjugated gold nanoparticles of 6-Gingerol (Au-6G-PVP-NPs) by chemical reduction method using polyvinylpyrrolidone, a biocompatible and biodegradable polymer, to increase the bioavailability and solubility of 6-Gingerol. The prepared nanoparticle conjugate was evaluated on different parameters such as pH, solubility, Zeta potential, TEM, DLS, polydispersity index, in vitro release, and stability studies to meet the criteria. The study concluded that gold nanoparticles conjugated with 6-Gingerol showed good solubility in gastric pH, effective drug release, and were more stable than free 6-Gingerol. Hence, it can be concluded that these conjugates can be used for cardiac disease as well as cancer treatment due to their good bioavailability, drug release, improved biocompatibility, stability, and decreased cytotoxicity.","PeriodicalId":506675,"journal":{"name":"Journal of Pharmaceutical Research International","volume":"20 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140697544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Challenges and Outcomes of Chronic Dialysis in Children: A Narrative Review 儿童慢性透析的挑战与结果：叙述性综述

Journal of Pharmaceutical Research International Pub Date : 2024-04-13 DOI: 10.9734/jpri/2024/v36i57512

Bader Osama Sager, Fahad Beshr Alkaleb, Ibrahim Abdullah Alhariqi, Aseel Abdulhafez Alharbi, M. A. Alahmadi, Faris M Elmahdi

引用次数: 0

Diagnosis of Acute Bulbar Palsy Plus Syndrome: A Rare Variant of Guillain–barre Syndrome 诊断急性球麻痹加综合征：格林-巴利综合征的罕见变种

Journal of Pharmaceutical Research International Pub Date : 2024-04-11 DOI: 10.9734/jpri/2024/v36i47511

Stuti Sharma, Neha Rajpal

引用次数: 0

Influence of Gut Resistome on Humans with Autism Spectrum Disorder 肠道电阻体对自闭症谱系障碍患者的影响

Journal of Pharmaceutical Research International Pub Date : 2024-04-08 DOI: 10.9734/jpri/2024/v36i47510

Dalia Abuljadayel, Ahmed Bahieldin, Budur Alotaibi, Wafa M. Aresh, Reem M. Farsi

引用次数: 0

A Comparison and Evaluation of Loop Diuretic Frusemide Generic vs Brand Tablets 环形利尿剂非专利药片与品牌药片的比较与评估

Journal of Pharmaceutical Research International Pub Date : 2024-03-30 DOI: 10.9734/jpri/2024/v36i47509

Tamilveeran T, Karthikeyan B, Balamurugan K.

引用次数: 0