肠道电阻体对自闭症谱系障碍患者的影响

Dalia Abuljadayel, Ahmed Bahieldin, Budur Alotaibi, Wafa M. Aresh, Reem M. Farsi
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引用次数: 0

摘要

最近的研究揭示了肠道抗原组与自闭症谱系障碍(ASD)患者之间的联系。早产和子宫内接触药物等环境因素会对自闭症谱系障碍儿童产生重大影响。废水、医院和动物生产废水中的微生物已被发现含有各种抗生素耐药基因 (ARG),这些基因编码了对多种抗生素的耐药性。目前,环境变量被认为是这种病症的潜在病因,因为仅靠遗传学无法解释其主要起源。肠道微生物群(GM)中的许多细菌都对人体健康有影响。此外,肠道中还存在一种受出生方式、生活方式和遗传影响的微生物。例如,要产生影响宿主的不同化合物、训练宿主的免疫力、改变药物作用和新陈代谢、调节肠道内分泌功能以及消除毒素,肠道微生物群对实现预期治疗目标至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Influence of Gut Resistome on Humans with Autism Spectrum Disorder
Recent studies have shed light on the connection between the gut resistome and individuals with autism spectrum disorder (ASD). Environmental factors such as premature birth and exposure to drugs in utero can have a significant impact on children with ASD. Microorganisms present in wastewater, hospitals, and animal production wastewaters have been found to contain various antibiotic-resistant genes (ARGs) that encode resistance to a broad spectrum of antibiotics. Environmental variables are currently considered potential etiological agents of this condition, as genetics alone cannot explain its primary origin. Numerous bacteria found in the gut microbiota (GM) have an impact on human health. Furthermore, a microbe impacted by birth mode, lifestyle, and genetics is present in the intestine. To produce different compounds that affect the host, train the host's immunity, modify drug action and metabolism, regulate gut endocrine function, and eliminate toxins, for example, GM is essential to achieving the intended target for treatment application.
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