Computerized Medical Imaging and Graphics最新文献

{"title":"A deep learning framework for reconstructing Breast Amide Proton Transfer weighted imaging sequences from sparse frequency offsets to dense frequency offsets","authors":"Qiuhui Yang ,&nbsp;Shu Su ,&nbsp;Tianyu Zhang ,&nbsp;Meng Wang ,&nbsp;Weiqiang Dou ,&nbsp;Kefeng Li ,&nbsp;Ya Ren ,&nbsp;Yijia Zheng ,&nbsp;Mingwei Wang ,&nbsp;Yi Xu ,&nbsp;Yue Sun ,&nbsp;Zhou Liu ,&nbsp;Tao Tan","doi":"10.1016/j.compmedimag.2025.102563","DOIUrl":"10.1016/j.compmedimag.2025.102563","url":null,"abstract":"<div><div>Amide Proton Transfer (APT) technique is a novel functional MRI technique that enables quantification of protein metabolism, but its wide application is largely limited in clinical settings by its long acquisition time. One way to reduce the scanning time is to obtain fewer frequency offset images during image acquisition. However, sparse frequency offset images are not inadequate to fit the z-spectral, a curve essential to quantifying the APT effect, which might compromise its quantification. In our study, we develop a deep learning-based model that allows for reconstructing dense frequency offsets from sparse ones, potentially reducing scanning time. We propose to leverage time-series convolution to extract both short and long-range spatial and frequency features of the APT imaging sequence. Our proposed model outperforms other seq2seq models, achieving superior reconstruction with a peak signal-to-noise ratio of 45.8 (95% confidence interval (CI): [44.9 46.7]), and a structural similarity index of 0.989 (95% CI:[0.987 0.993]) for the tumor region. We have integrated a weighted layer into our model to evaluate the impact of individual frequency offset on the reconstruction process. The weights assigned to the frequency offset at ±6.5 ppm, 0 ppm, and 3.5 ppm demonstrate higher significance as learned by the model. Experimental results demonstrate that our proposed model effectively reconstructs dense frequency offsets (n = 29, from 7 to -7 with 0.5 ppm as an interval) from data with 21 frequency offsets, reducing scanning time by 25%. This work presents a method for shortening the APT imaging acquisition time, offering potential guidance for parameter settings in APT imaging and serving as a valuable reference for clinicians.</div></div>","PeriodicalId":50631,"journal":{"name":"Computerized Medical Imaging and Graphics","volume":"123 ","pages":"Article 102563"},"PeriodicalIF":5.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143943171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CALIMAR-GAN: An unpaired mask-guided attention network for metal artifact reduction in CT scans","authors":"Roberto Maria Scardigno,&nbsp;Antonio Brunetti,&nbsp;Pietro Maria Marvulli,&nbsp;Raffaele Carli,&nbsp;Mariagrazia Dotoli,&nbsp;Vitoantonio Bevilacqua,&nbsp;Domenico Buongiorno","doi":"10.1016/j.compmedimag.2025.102565","DOIUrl":"10.1016/j.compmedimag.2025.102565","url":null,"abstract":"<div><div>High-quality computed tomography (CT) scans are essential for accurate diagnostic and therapeutic decisions, but the presence of metal objects within the body can produce distortions that lower image quality. Deep learning (DL) approaches using image-to-image translation for metal artifact reduction (MAR) show promise over traditional methods but often introduce secondary artifacts. Additionally, most rely on paired simulated data due to limited availability of real paired clinical data, restricting evaluation on clinical scans to qualitative analysis. This work presents CALIMAR-GAN, a generative adversarial network (GAN) model that employs a guided attention mechanism and the linear interpolation algorithm to reduce artifacts using unpaired simulated and clinical data for targeted artifact reduction. Quantitative evaluations on simulated images demonstrated superior performance, achieving a PSNR of 31.7, SSIM of 0.877, and Fréchet inception distance (FID) of 22.1, outperforming state-of-the-art methods. On real clinical images, CALIMAR-GAN achieved the lowest FID (32.7), validated as a valuable complement to qualitative assessments through correlation with pixel-based metrics (<span><math><mrow><mi>r</mi><mo>=</mo><mo>−</mo><mn>0</mn><mo>.</mo><mn>797</mn></mrow></math></span> with PSNR, <span><math><mrow><mi>p</mi><mo>&lt;</mo><mn>0</mn><mo>.</mo><mn>01</mn></mrow></math></span>; <span><math><mrow><mi>r</mi><mo>=</mo><mo>−</mo><mn>0</mn><mo>.</mo><mn>767</mn></mrow></math></span> with MS-SSIM, <span><math><mrow><mi>p</mi><mo>&lt;</mo><mn>0</mn><mo>.</mo><mn>01</mn></mrow></math></span>). This work advances DL-based artifact reduction into clinical practice with high-fidelity reconstructions that enhance diagnostic accuracy and therapeutic outcomes. Code is available at <span><span>https://github.com/roberto722/calimar-gan</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":50631,"journal":{"name":"Computerized Medical Imaging and Graphics","volume":"123 ","pages":"Article 102565"},"PeriodicalIF":5.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of an intelligent analysis system for clinical image features of melanonychia based on deep learning image segmentation","authors":"WengIoi Mio ,&nbsp;Ruiyue Chen ,&nbsp;Jiayan Lv ,&nbsp;Sien Mai ,&nbsp;Yanqing Chen ,&nbsp;Mengwen He ,&nbsp;Xin Zhang ,&nbsp;Han Ma","doi":"10.1016/j.compmedimag.2025.102543","DOIUrl":"10.1016/j.compmedimag.2025.102543","url":null,"abstract":"<div><div>Melanonychia, a condition that can be indicative of malignant melanoma, presents a significant challenge in early diagnosis due to the invasive nature and equipment dependency of traditional diagnostic methods such as nail biopsy and dermatoscope imaging. This study introduces, non-invasive intelligent analysis and follow-up system for melanonychia using smartphone imagery, harnessing the power of deep learning to facilitate early detection and monitoring. Through a cross-sectional study, Research Group developed a comprehensive nail image dataset and a two-stage model comprising a YOLOv8-based nail detection system and a UNet-based image segmentation system. The integrated YOLOv8 and UNet model achieved high accuracy and reliability in detecting and segmenting melanonychia lesions, with performance metrics such as F1, Dice, Specificity and Sensitivity significantly outperforming traditional methods and closely aligning with dermatoscopic assessments. This Artificial Intelligence-based (AI-based) system offers a user-friendly, accessible tool for both clinicians and patients, enhancing the ability to diagnose and monitor melanonychia, and holds the potential to improve early detection and treatment outcomes.</div></div>","PeriodicalId":50631,"journal":{"name":"Computerized Medical Imaging and Graphics","volume":"123 ","pages":"Article 102543"},"PeriodicalIF":5.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143937850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A diffusion-stimulated CT-US registration model with self-supervised learning and synthetic-to-real domain adaptation","authors":"Shangxuan Li ,&nbsp;Biao Jia ,&nbsp;Weiming Huang ,&nbsp;Xiaobo Zhang ,&nbsp;Wu Zhou ,&nbsp;Cheng Wang ,&nbsp;Gaojun Teng","doi":"10.1016/j.compmedimag.2025.102562","DOIUrl":"10.1016/j.compmedimag.2025.102562","url":null,"abstract":"<div><div>In abdominal interventional procedures, achieving precise registration of 2D ultrasound (US) frames with 3D computed tomography (CT) scans presents a significant challenge. Traditional tracking methods often rely on high-precision sensors, which can be prohibitively expensive. Furthermore, the clinical need for real-time registration with a broad capture range frequently exceeds the performance of standard image-based optimization techniques. Current automatic registration methods that utilize deep learning are either heavily reliant on manual annotations for training or struggle to effectively bridge the gap between different imaging domains. To address these challenges, we propose a novel diffusion-stimulated CT-US registration model. This model harnesses the physical diffusion properties of US to generate synthetic US images from preoperative CT data. Additionally, we introduce a synthetic-to-real domain adaptation strategy using a diffusion model to mitigate the discrepancies between real and synthetic US images. A dual-stream self-supervised regression neural network, trained on these synthetic images, is then used to estimate the pose within the CT space. The effectiveness of our proposed approach is verified through validation using US and CT scans from a dual-modality human abdominal phantom. The results of our experiments confirm that our method can accurately initialize the US image pose within an acceptable range of error and subsequently refine it to achieve precise alignment. This enables real-time, tracker-independent, and robust rigid registration of CT and US images.</div></div>","PeriodicalId":50631,"journal":{"name":"Computerized Medical Imaging and Graphics","volume":"123 ","pages":"Article 102562"},"PeriodicalIF":5.4,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143921566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced glaucoma classification through advanced segmentation by integrating cup-to-disc ratio and neuro-retinal rim features","authors":"Rabia Pannu ,&nbsp;Muhammad Zubair ,&nbsp;Muhammad Owais ,&nbsp;Shoaib Hassan ,&nbsp;Muhammad Umair ,&nbsp;Syed Muhammad Usman ,&nbsp;Mousa Ahmed Albashrawi ,&nbsp;Irfan Hussain","doi":"10.1016/j.compmedimag.2025.102559","DOIUrl":"10.1016/j.compmedimag.2025.102559","url":null,"abstract":"<div><div>Glaucoma is a progressive eye condition caused by high intraocular fluid pressure, damaging the optic nerve, leading to gradual, irreversible vision loss, often without noticeable symptoms. Subtle signs like mild eye redness, slightly blurred vision, and eye pain may go unnoticed, earning it the nickname “silent thief of sight.” Its prevalence is rising with an aging population, driven by increased life expectancy. Most computer-aided diagnosis (CAD) systems rely on the cup-to-disc ratio (CDR) for glaucoma diagnosis. This study introduces a novel approach by integrating CDR with the neuro-retinal rim ratio (NRR), which quantifies rim thickness within the optic disc (OD). NRR enhances diagnostic accuracy by capturing additional optic nerve head changes, such as rim thinning and tissue loss, which were overlooked using CDR alone. A modified ResUNet architecture for OD and optic cup (OC) segmentation, combining residual learning and U-Net to capture spatial context for semantic segmentation. For OC segmentation, the model achieved Dice Coefficient (DC) scores of 0.942 and 0.872 and Intersection over Union (IoU) values of 0.891 and 0.773 for DRISHTI-GS and RIM-ONE, respectively. For OD segmentation, the model achieved DC of 0.972 and 0.950 and IoU values of 0.945 and 0.940 for DRISHTI-GS and RIM-ONE, respectively. External evaluation on ORIGA and REFUGE confirmed the model’s robustness and generalizability. CDR and NRR were calculated from segmentation masks and used to train an SVM with a radial basis function, classifying the eyes as healthy or glaucomatous. The model achieved accuracies of 0.969 on DRISHTI-GS and 0.977 on RIM-ONE.</div></div>","PeriodicalId":50631,"journal":{"name":"Computerized Medical Imaging and Graphics","volume":"123 ","pages":"Article 102559"},"PeriodicalIF":5.4,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143894871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel diagnosis method utilizing MDBO-SVM and imaging genetics for Alzheimer's disease","authors":"Yu Xin ,&nbsp;Jinhua Sheng ,&nbsp;Qiao Zhang ,&nbsp;Yan Song ,&nbsp;Luyun Wang ,&nbsp;Ze Yang","doi":"10.1016/j.compmedimag.2025.102542","DOIUrl":"10.1016/j.compmedimag.2025.102542","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is the most common neurodegenerative disorder, yet its underlying mechanisms remain elusive. Early and accurate diagnosis is crucial for timely intervention and disease management. In this paper, a multi-strategy improved dung beetle optimizer (MDBO) was proposed to establish a new framework for AD diagnosis. The unique aspect of this algorithm lies in its integration of the Osprey Optimization Algorithm, Lévy flight, and adaptive t-distribution. This combination endows MDBO with superior global search capabilities and the ability to avoid local optima. Then, we presented a novel fitness function for integrating imaging genetics data. In experiments, MDBO demonstrated outstanding performance on the CEC2017 benchmark functions, proving its effectiveness in optimization problems. Furthermore, it was used to classify individuals with AD, mild cognitive impairment (MCI), and control normal (CN) using limited features. In the multi-classification of CN, MCI, and AD, the algorithm achieved excellent results, with an average accuracy of 81.7 % and a best accuracy of 92 %. Overall, the proposed MDBO algorithm provides a more comprehensive and efficient diagnostic tool, offering new possibilities for early intervention and disease progression control.</div></div>","PeriodicalId":50631,"journal":{"name":"Computerized Medical Imaging and Graphics","volume":"123 ","pages":"Article 102542"},"PeriodicalIF":5.4,"publicationDate":"2025-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143887837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ICA-SAMv7: Internal carotid artery segmentation with coarse to fine network","authors":"Xiaotian Yan ,&nbsp;Yuting Guo ,&nbsp;Ziyi Pei ,&nbsp;Xinyu Zhang ,&nbsp;Jinghao Li ,&nbsp;Zitao Zhou ,&nbsp;Lifang Liang ,&nbsp;Shuai Li ,&nbsp;Peng Lun ,&nbsp;Aimin Hao","doi":"10.1016/j.compmedimag.2025.102555","DOIUrl":"10.1016/j.compmedimag.2025.102555","url":null,"abstract":"<div><div>Internal carotid artery (ICA) stenosis is a life-threatening occult disease. Using Computed Tomography Angiography (CTA) to examine vascular lesions such as calcified and non-calcified plaques in cases of carotid artery stenosis is a necessary clinical step in formulating the correct treatment plan. Segment Anything Model (SAM) has shown promising performance in image segmentation tasks, but it performs poorly for carotid artery segmentation. Due to the small size of the calcification and the overlapping between the lumen and calcification, these challenges lead to issues such as mislabeling and boundary fragmentation, as well as high training costs. To address these problems, we propose a two-stage Carotid Artery lesion segmentation method called ICA-SAMv7, which performs coarse and fine segmentation based on the YOLOv7 and SAM model. Specifically, in the first stage (ICA-YOLOv7), we utilize YOLOv7 for coarse vessel recognition, introducing connectivity enhancement to improve accuracy and achieve precise localization of small target carotid artery. In the second stage (ICA-SAM), we enhance SAM through data augmentation and an efficient parameter fine-tuning strategy. This improves the segmentation accuracy of fine-grained lesions in blood vessels while saving training costs. Ultimately, the accuracy of lesion segmentation under the SAM model was increased from the original 48.62% to 83.69%. Extensive comparative experiments have demonstrated the outstanding performance of our algorithm. Our codes can be found at <span><span>https://github.com/BessiePei/ICA-SAMv7</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":50631,"journal":{"name":"Computerized Medical Imaging and Graphics","volume":"123 ","pages":"Article 102555"},"PeriodicalIF":5.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143899763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of ultrafast DCE-MRI for identifying benign and malignant breast lesions","authors":"Junhui Huang ,&nbsp;Yongsheng Ao ,&nbsp;Lan Mu ,&nbsp;Jierui Zhao ,&nbsp;Hongliang Chen ,&nbsp;Long Yang ,&nbsp;Bingyu Yao ,&nbsp;Shuheng Zhang ,&nbsp;Shimin Yang ,&nbsp;Greta S.P. Mok ,&nbsp;Ke Zhang ,&nbsp;Zhanli Hu ,&nbsp;Ye Li ,&nbsp;Dong Liang ,&nbsp;Xin Liu ,&nbsp;Hairong Zheng ,&nbsp;Lihua Qiu ,&nbsp;Na Zhang","doi":"10.1016/j.compmedimag.2025.102561","DOIUrl":"10.1016/j.compmedimag.2025.102561","url":null,"abstract":"<div><h3>Objectives</h3><div>This study investigates whether the use of ultrafast DCE-MRI immediately after contrast injection is an alternative to conventional DCE-MRI for diagnosing benign and malignant breast lesions.</div></div><div><h3>Methods</h3><div>A total of 86 female patients were included in this prospective study. Each patient underwent both ultrafast DCE-MRI and conventional DCE-MRI before surgery. The Mann-Whitney U test was used to analyze whether there were significant differences in DCE-MRI parameters between benign and malignant breast lesions (p &lt; 0.05) for both conventional and ultrafast methods. The AUC value of the ROC curve was used to assess the diagnostic performance for each parameter and to determine their critical values, sensitivity, and specificity using the maximum Youden index. Delong test and support vector machine (SVM) were also used to evaluate the performance of conventional DCE-MRI and ultrafast DCE-MRI in identifying benign and malignant breast lesions.</div></div><div><h3>Results</h3><div>A total of 99 lesion areas (21 benign and 78 malignant lesions) were found in the 86 patients. Conventional DCE-MRI has only two semiquantitative parameters that can identify benign and malignant (Wash-out and SER, p &lt; 0.05), whereas ultrafast DCE-MRI is the one that can identify benign and malignant for all semiquantitative parameters except clearance, and there are more semiquantitative parameters that can be used to identify benign and malignant by ultrafast DCE-MRI than by conventional DCE-MRI. The ultrafast DCE-MRI parameters (AUC=0.8626) had a greater AUC than the conventional DCE-MRI parameters (AUC=0.7552) for distinguishing between benign and malignant breast lesions.</div></div><div><h3>Conclusions</h3><div>Ultrafast DCE-MRI is effective in identifying benign and malignant breast lesions at the early stage of contrast injection; therefore, it is feasible to use Ultrafast DCE-MRI instead of conventional DCE-MRI to diagnose benign and malignant breast tumor lesions.</div></div><div><h3>Advances in knowledge</h3><div>We evaluated ultrafast DCE-MRI's quantitative parameters in distinguishing benign from malignant breast lesions. SVM was used to assess the performance of conventional and ultrafast DCE-MRI in breast malignancy discrimination.</div></div>","PeriodicalId":50631,"journal":{"name":"Computerized Medical Imaging and Graphics","volume":"123 ","pages":"Article 102561"},"PeriodicalIF":5.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomy-guided slice-description interaction for multimodal brain disease diagnosis based on 3D image and radiological report","authors":"Xin Gao ,&nbsp;Meihui Zhang ,&nbsp;Junjie Li ,&nbsp;Shanbo Zhao ,&nbsp;Zhizheng Zhuo ,&nbsp;Liying Qu ,&nbsp;Jinyuan Weng ,&nbsp;Li Chai ,&nbsp;Yunyun Duan ,&nbsp;Chuyang Ye ,&nbsp;Yaou Liu","doi":"10.1016/j.compmedimag.2025.102556","DOIUrl":"10.1016/j.compmedimag.2025.102556","url":null,"abstract":"<div><div>Accurate brain disease diagnosis based on radiological images is desired in clinical practice as it can facilitate early intervention and reduce the risk of damage. However, existing unimodal image-based models struggle to process high-dimensional 3D brain imaging data effectively. Multimodal disease diagnosis approaches based on medical images and corresponding radiological reports achieved promising progress with the development of vision-language models. However, most multimodal methods handle 2D images and cannot be directly applied to brain disease diagnosis that uses 3D images. Therefore, in this work we develop a multimodal brain disease diagnosis model that takes 3D brain images and their radiological reports as input. Motivated by the fact that radiologists scroll through image slices and write important descriptions into the report accordingly, we propose a slice-description cross-modality interaction mechanism to realize fine-grained multimodal data interaction. Moreover, since previous medical research has demonstrated potential correlation between anatomical location of anomalies and diagnosis results, we further explore the use of brain anatomical prior knowledge to improve the multimodal interaction. Based on the report description, the prior knowledge filters the image information by suppressing irrelevant regions and enhancing relevant slices. Our method was validated with two brain disease diagnosis tasks. The results indicate that our model outperforms competing unimodal and multimodal methods for brain disease diagnosis. In particular, it has yielded an average accuracy improvement of 15.87% and 7.39% compared with the image-based and multimodal competing methods, respectively.</div></div>","PeriodicalId":50631,"journal":{"name":"Computerized Medical Imaging and Graphics","volume":"123 ","pages":"Article 102556"},"PeriodicalIF":5.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal recurrent intervention for cross-modal cardiac image segmentation","authors":"Qixin Lin ,&nbsp;Saidi Guo ,&nbsp;Heye Zhang ,&nbsp;Zhifan Gao","doi":"10.1016/j.compmedimag.2025.102549","DOIUrl":"10.1016/j.compmedimag.2025.102549","url":null,"abstract":"<div><div>Cross-modal cardiac image segmentation is essential for cardiac disease analysis. In diagnosis, it enables clinicians to obtain more precise information about cardiac structure or function for potential signs by leveraging specific imaging modalities. For instance, cardiovascular pathologies such as myocardial infarction and congenital heart defects require precise cross-modal characterization to guide clinical decisions. The growing adoption of cross-modal segmentation in clinical research underscores its technical value, yet annotating cardiac images with multiple slices is time-consuming and labor-intensive, making it difficult to meet clinical and deep learning demands. To reduce the need for labels, cross-modal approaches could leverage general knowledge from multiple modalities. However, implementing a cross-modal method remains challenging due to cross-domain confounding. This challenge arises from the intricate effects of modality and view alterations between images, including inconsistent high-dimensional features. The confounding complicates the causality between the observation (image) and the prediction (label), thereby weakening the domain-invariant representation. Existing disentanglement methods face difficulties in addressing the confounding due to the insufficient depiction of the relationship between latent factors. This paper proposes the causal recurrent intervention (CRI) method to overcome the above challenge. It establishes a structural causal model that allows individual domains to maintain causal consistency through interventions. The CRI method integrates diverse high-dimensional variations into a singular causal relationship by embedding image slices into a sequence. This approach further distinguishes stable and dynamic factors from the sequence, subsequently separating the stable factor into modal and view factors and establishing causal connections between them. It then learns the dynamic factor and the view factor from the observation to obtain the label. Experimental results on cross-modal cardiac images of 1697 examples show that the CRI method delivers promising and productive cross-modal cardiac image segmentation performance.</div></div>","PeriodicalId":50631,"journal":{"name":"Computerized Medical Imaging and Graphics","volume":"123 ","pages":"Article 102549"},"PeriodicalIF":5.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}