Critical Reviews in Therapeutic Drug Carrier Systems最新文献

Enhancing Microemulsion based Therapeutic Drug Delivery: Exploring Surfactants, Co-surfactants, and Quality by Design Strategies within Pseudo-ternary Phase Diagrams 增强基于微乳液的治疗性给药：探索伪三元相图中的表面活性剂、辅助表面活性剂和质量设计策略

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-08-01 DOI: 10.1615/critrevtherdrugcarriersyst.2024053427

Abhishek Bamanna, Anjali Rajora, Kalpana Nagpal

{"title":"Enhancing Microemulsion based Therapeutic Drug Delivery: Exploring Surfactants, Co-surfactants, and Quality by Design Strategies within Pseudo-ternary Phase Diagrams","authors":"Abhishek Bamanna, Anjali Rajora, Kalpana Nagpal","doi":"10.1615/critrevtherdrugcarriersyst.2024053427","DOIUrl":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2024053427","url":null,"abstract":"Microemulsions are thermodynamically stable, clear and homogeneous mixtures of oil, water, and surfactants that have garnered significant attention in various industrial and biomedical applications. The basic components of microemulsions are oil, water, and surfactant, and their composition ratios play a crucial role in determining their properties and stability. Factors such as the type of surfactant, oil, and water used, temperature, and the presence of cosurfactants can greatly influence the formation, stability and properties of microemulsions. These are appropriate for use in drug delivery applications because to their physicochemical characteristics, which include small droplet size, large interfacial area, and good solubilization capacity for both hydrophilic and hydrophobic drugs with significant improvement in their biological activity. The theories of microemulsion and the role of phase diagrams in microemulsion formation and various components for choice of surfactant and co-surfactant are explained. Recent advancements in the preparation and characterization techniques of microemulsion, ranging from visual inspection to the phase behaviour studies and advanced spectroscopic techniques, with a focus on potential of microemulsion in drug delivery along with microemulsion-based drug candidates that are most commonly used for its formulation are also discussed. The review helps in understanding how different excipients affect the release of the active pharmaceutical ingredient. The quality by design approach utilized for optimization of microemulsions is also discussed.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142222521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NOVEL DRUG DELIVERY TOOLS FOR BETTER PERMEATION AND SKIN CANCER TREATMENT 新型给药工具，提高渗透性和皮肤癌治疗效果

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-06-01 DOI: 10.1615/critrevtherdrugcarriersyst.2024047670

Kajal Chaudhary, Anjali Rajora

{"title":"NOVEL DRUG DELIVERY TOOLS FOR BETTER PERMEATION AND SKIN CANCER TREATMENT","authors":"Kajal Chaudhary, Anjali Rajora","doi":"10.1615/critrevtherdrugcarriersyst.2024047670","DOIUrl":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2024047670","url":null,"abstract":"Skin cancer stands as a challenging global health concern, necessitating innovative approaches to cure deficiencies within traditional therapeutic modalities. While conventional drug delivery methods through injection or oral administration have long prevailed, the emergence of topical drug administration presents a compelling alternative. The skin, aside from offering a swift and painless procedure, serves as a reservoir, maintaining drug efficacy over extended durations. This comprehensive review seeks to shed light on the potential of nanotechnology as a promising avenue for efficacious cancer treatment, with a particular emphasis on skin cancer. Additionally, it underscores the transdermal approach as a viable strategy for addressing various types of cancer. This work also explores into the delivery of peptides and proteins along with in-depth explanations of different delivery systems currently under investigation for localized skin cancer treatment. Furthermore, the review discusses the formidable challenges that must be surmounted before these innovations can find their way into clinical practice, offering a roadmap for future research and therapeutic development.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141504150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanobiocatalysts and Nanozymes: Enzyme-Inspired Nanomaterials for Industrial and Biomedical Applications 纳米生物催化剂和纳米酶：用于工业和生物医学应用的酶启发纳米材料

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-05-01 DOI: 10.1615/critrevtherdrugcarriersyst.2024051171

Sarika Gupta, Meenu Kumari, Koyel Panja, Priyanka Bajaj, Kalpana Nagpal

{"title":"Nanobiocatalysts and Nanozymes: Enzyme-Inspired Nanomaterials for Industrial and Biomedical Applications","authors":"Sarika Gupta, Meenu Kumari, Koyel Panja, Priyanka Bajaj, Kalpana Nagpal","doi":"10.1615/critrevtherdrugcarriersyst.2024051171","DOIUrl":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2024051171","url":null,"abstract":"Enzymes play a pivotal role in the human body, but their potential is not limited to just that. Scientists have successfully modified these enzymes as nanobiocatalysts or nanozymes for industrial or commercial use, either in the food, medicine, biotech, or even textile industries. These nanobiocatalysts and nanozymes offer several advantages over enzymes, like better stability, improved shelf-life, increased percentage yield, and reuse potential, which is very difficult with normal enzymes. The various techniques of NBC synthesis using immobilization techniques like adsorption, covalent binding, affinity immobilization, and entrapment methods are briefly discussed. The enzymes are either entrapped or adsorbed on the nanocarrier matrices, which can be nanofibers, nanoporous carriers, or nanocontainers as nanobiocatalysts. We also highlight the challenges the nanobiocatalyst overcomes in the industrial production of some drugs like sitagliptin, montelukast, pregabalin, and atorvastatin. Also, the inactivation of an organophosphate or opioid poisoning treating agent, SSOPOX nanohybrid, is discussed in this paper. Nanozymes are intrinsic enzyme-like compounds, and they also show wide application in themselves. Their GQD/AGNP nanohybrid shows antibacterial potential; they can also be utilized in optical sensing to detect small molecules, ions, nucleic acids, proteins, and cancer cells. In this paper, various applications of these NBCs have been discussed, and their potential applications with examples are also mentioned.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141147309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating the Challenges of 3D Printing Personalized Medicine in Space Explorations: A Comprehensive Review 在太空探索中驾驭 3D 打印个性化医疗的挑战：全面回顾

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-04-01 DOI: 10.1615/critrevtherdrugcarriersyst.2024051126

PRAKASH KATAKAM, Madhavi Lakshmi Ratna Bhavaraju, Tanniru Venkata Narayana, Koushik Bhandari, Nagarajan Sriram, Vidya Sagar Sisinty, Shanta Kumari Adiki

{"title":"Navigating the Challenges of 3D Printing Personalized Medicine in Space Explorations: A Comprehensive Review","authors":"PRAKASH KATAKAM, Madhavi Lakshmi Ratna Bhavaraju, Tanniru Venkata Narayana, Koushik Bhandari, Nagarajan Sriram, Vidya Sagar Sisinty, Shanta Kumari Adiki","doi":"10.1615/critrevtherdrugcarriersyst.2024051126","DOIUrl":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2024051126","url":null,"abstract":"Space exploration has undergone a paradigm shift in recent years, with a growing emphasis on long-duration missions and human habitation on other celestial bodies. Private aerospace businesses are at the forefront of advancing the next iteration of spacecraft, encompassing a wide range of applications such as deep space exploration (e.g., SpaceX) and cost-effective satellite deployments (e.g., Rocketlab). One of the critical challenges associated with prolonged space missions is the provision of personalized medical care. 3D printing technology has emerged as a potential solution, enabling the on-demand production of personalized medical devices and medications. However, the unique conditions of space pose substantial challenges to the successful implementation of 3D printing for personalized medicine. Tremendous scope for research exists in terms of resource utilization and waste management in space ecosystem, robotic and AI enabled tool utilization, remote operability, interplanetary travel, space education and training tools, digital twins, space tourism and in many other aspects of 3D printing for personalized medicine in space explorations.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140578703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Conventional to Novel Drug Delivery Systems for Meloxicam: A Systematic Review 美洛昔康的传统给药系统到新型给药系统：系统综述

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-02-01 DOI: 10.1615/critrevtherdrugcarriersyst.2024048988

Manjusha Annaji, Nur Mita, Jessica Heard, Xuejia Kang, Ishwor Poudel, Sai H.S. Boddu, Amit K. Tiwari, R. Jayachandra Babu

{"title":"From Conventional to Novel Drug Delivery Systems for Meloxicam: A Systematic Review","authors":"Manjusha Annaji, Nur Mita, Jessica Heard, Xuejia Kang, Ishwor Poudel, Sai H.S. Boddu, Amit K. Tiwari, R. Jayachandra Babu","doi":"10.1615/critrevtherdrugcarriersyst.2024048988","DOIUrl":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2024048988","url":null,"abstract":"Meloxicam, a selective COX-2 inhibitor, has demonstrated clinical effectiveness in managing inflammation and acute pain. Although available in oral formulations such as capsules, tablets, and suspension, frequent administration is necessary to maintain therapeutic efficacy, which can increase adverse effects and patient non-compliance. To address these issues, several sustained drug delivery strategies such as oral, transdermal, transmucosal, injectable, implantable drug delivery systems have been developed for meloxicam. These sustained drug delivery strategies have the potential to improve the therapeutic efficacy and safety profile of meloxicam by reducing the frequency of dosing and associated gastrointestinal side effects. The choice of drug delivery system will depend on the desired release profile, the target site of inflammation, and the mode of administration. Overall, meloxicam sustained delivery systems offer better patient compliance, and reduce side effects, thereby improving the clinical applications of this drug. Herein, we discuss in detail the different strategies for the sustained delivery of meloxicam.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139956067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Path of Novelty from Nanoparticles to Nanobots: Theragnostic Approach for Targeting Cancer Therapy. 从纳米粒子到纳米机器人的创新之路：癌症靶向治疗的热诊断方法。

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.2023046674

Gursharanpreet Kaur, Bhawna Khanna, Mohammed Yusuf, Akanksha Sharma, Akhil Khajuria, Hema K Alajangi, Pradeep K Jaiswal, Mandip Sachdeva, Ravi Pratap Barnwal, Gurpal Singh

{"title":"A Path of Novelty from Nanoparticles to Nanobots: Theragnostic Approach for Targeting Cancer Therapy.","authors":"Gursharanpreet Kaur, Bhawna Khanna, Mohammed Yusuf, Akanksha Sharma, Akhil Khajuria, Hema K Alajangi, Pradeep K Jaiswal, Mandip Sachdeva, Ravi Pratap Barnwal, Gurpal Singh","doi":"10.1615/CritRevTherDrugCarrierSyst.2023046674","DOIUrl":"10.1615/CritRevTherDrugCarrierSyst.2023046674","url":null,"abstract":"Pharmaceutical development of cancer therapeutics is a dynamic area of research. Even after decades of intensive work, cancer continues to be a dreadful disease with an ever-increasing global incidence. The progress of nanotechnology in cancer research has overcome inherent limitations in conventional cancer chemotherapy and fulfilled the need for target-specific drug carriers. Nanotechnology uses the altered patho-physiological microenvironment of malignant cells and offers various advantages like improved solubility, reduced toxicity, prolonged drug circulation with controlled release, circumventing multidrug resistance, and enhanced biodistribution. Early cancer detection has a crucial role in selecting the best drug regime, thus, diagnosis and therapeutics go hand in hand. Furthermore, nanobots are an amazing possibility and promising innovation with numerous significant applications, particularly in fighting cancer and cleaning out blood vessels. Nanobots are tiny robots, ranging in size from 1 to 100 nm. Moreover, the nanobots would work similarly to white blood cells, watching the bloodstream and searching for indications of distress. This review articulates the evolution of various organic and inorganic nanoparticles and nanobots used as therapeutics, along with their pros and cons. It also highlights the shift in diagnostics from conventional methods to more advanced techniques. This rapidly growing domain is providing more space for engineering desired nanoparticles that can show miraculous results in therapeutic and diagnostic trials.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67437822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanotechnology-Based Approaches for Cosmeceutical and Skin Care: A Systematic Review. 基于纳米技术的药妆和护肤方法：系统综述。

IF 3 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.v41.i5.20

Shital Rani, Piyush Dey, Kritika Pruthi, Sahajdeep Singh, Shivansh Mahajan, Hema K Alajangi, Sumeet Kapoor, Ankur Pandey, Dikshi Gupta, Ravi Pratap Barnwal, Gurpal Singh

引用次数: 0

Advances in Gold nanoparticles: Synthesis, Functionalization Strategies and Theranostic Applications in Cancer 金纳米粒子的研究进展：癌症中的合成、功能化策略和治疗应用

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-01-01 DOI: 10.1615/critrevtherdrugcarriersyst.2024046712

Mansi Damani, Mrunal Jadhav, Rashmi Joshi, Bheeshma Pratap Singh, Munira Momin, Raghumani S Ningthoujam, Tabassum Khan

{"title":"Advances in Gold nanoparticles: Synthesis, Functionalization Strategies and Theranostic Applications in Cancer","authors":"Mansi Damani, Mrunal Jadhav, Rashmi Joshi, Bheeshma Pratap Singh, Munira Momin, Raghumani S Ningthoujam, Tabassum Khan","doi":"10.1615/critrevtherdrugcarriersyst.2024046712","DOIUrl":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2024046712","url":null,"abstract":"Cancer is among the leading causes of mortality and morbidity in the world. Metallic nanoparticles, especially gold nanoparticles have emerged to be attractive systems to circumvent the associated adverse effects. By the virtue of their unique properties of tunable size, shape, composition, optical properties, biocompatibility, minimal toxicity, multivalency, fluorescence-luminescence property and surface plasmon resonance; gold nanoparticles have the potential to be used as drug delivery systems. It is vital to ensure that the drug reaches the target site of action for selective kill of cancer cells without harm to healthy cells. These nanoparticles can be easily functionalised with a wide array of ligands- peptides, oligonucleotides, polymers, carbohydrates for active targeting to ensure site specific delivery and reduced systemic effects. Gold nanoparticles have been investigated as carriers for gene delivery, drug delivery with or without photothermal therapy, in diagnosis based on radiation or spectroscopy. They have emerged as attractive theranostic approach in the overall management of cancer with superior benefit to risk features. In this review, we have discussed synthesis of different gold nanoparticles (nanorods, spherical nanoparticles, hollow gold nanoparticles), their functionalization strategies and their applications in biomedical domain. Various research studies and clinical trials on application of gold nanoparticles in diagnosis and therapeutics are highlighted.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139464838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applications of Cannabinoids in Neuropathic Pain: An Updated Review. 大麻酚类药物在神经性疼痛中的应用：最新综述。

IF 3 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.2022038592

Peggy Arthur, Anil Kumar Kalvala, Sunil Kumar Surapaneni, Mandip Sachdeva Singh

{"title":"Applications of Cannabinoids in Neuropathic Pain: An Updated Review.","authors":"Peggy Arthur, Anil Kumar Kalvala, Sunil Kumar Surapaneni, Mandip Sachdeva Singh","doi":"10.1615/CritRevTherDrugCarrierSyst.2022038592","DOIUrl":"10.1615/CritRevTherDrugCarrierSyst.2022038592","url":null,"abstract":"Neuropathic pain is experienced due to injury to the nerves, underlying disease conditions or toxicity induced by chemotherapeutics. Multiple factors can contribute to neuropathic pain such as central nervous system (CNS)-related autoimmune and metabolic disorders, nerve injury, multiple sclerosis and diabetes. Hence, development of pharmacological interventions to reduce the drawbacks of existing chemotherapeutics and counter neuropathic pain is an urgent unmet clinical need. Cannabinoid treatment has been reported to be beneficial for several disease conditions including neuropathic pain. Cannabinoids act by inhibiting the release of neurotransmitters from presynaptic nerve endings, modulating the excitation of postsynaptic neurons, activating descending inhibitory pain pathways, reducing neural inflammation and oxidative stress and also correcting autophagy defects. This review provides insights on the various preclinical and clinical therapeutic applications of cannabidiol (CBD), cannabigerol (CBG), and cannabinol (CBN) in various diseases and the ongoing clinical trials for the treatment of chronic and acute pain with cannabinoids. Pharmacological and genetic experimental strategies have well demonstrated the potential neuroprotective effects of cannabinoids and also elaborated their mechanism of action for the therapy of neuropathic pain.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11228808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41219278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting Amyloids with coated Nanoparticles: A review on lucrative combinations of Nanoparticles and its Bio-compatible coating 包被纳米颗粒靶向淀粉样蛋白:纳米颗粒及其生物相容性包被的研究进展

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-01-01 DOI: 10.1615/critrevtherdrugcarriersyst.2023046209

Oshin D. Warerkar, Niyati H. Mudliar, M. Momin, Prabhat Singh

{"title":"Targeting Amyloids with coated Nanoparticles: A review on lucrative combinations of Nanoparticles and its Bio-compatible coating","authors":"Oshin D. Warerkar, Niyati H. Mudliar, M. Momin, Prabhat Singh","doi":"10.1615/critrevtherdrugcarriersyst.2023046209","DOIUrl":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2023046209","url":null,"abstract":"Amyloidosis is the major cause of many neurodegenerative diseases, such as, Alzheimer's and Parkinson's where the misfolding and deposition of a previously functional protein make it inept for carrying out its function. The genesis of amyloid fibril formation and the strategies to inhibit it have been studied extensively, although some parts of this puzzle still remain unfathomable to date. Many classes of molecules have been explored as potential drugs in vitro, but their inability to work in vivo by crossing the blood-brain-barrier has made them an inadequate treatment option. In this regard, nanoparticles (NPs) have turned out to be an exciting alternative because they could overcome many drawbacks of previously studied molecules and provide advantages, such as, greater bioavailability of molecules and target-specific delivery of drugs. In this paper, we present an overview on several coated NPs which have shown promising efficiency in inhibiting fibril formation. A hundred and thirty papers published in the past two decades have been comprehensively reviewed, which majorly encompass NPs comprising different materials like gold, silver, iron-oxide, poly(lactic-co-glycolic acid), polymeric NP, etc., which are coated with various molecules of predominantly natural origin, such as different types of amino acids, peptides, curcumin, drugs, catechin, etc. We hope that this review will shed light on the advancement of symbiotic amalgamation of NPs with molecules from natural sources and will inspire further research on the tremendous therapeutic potential of these combinations for many amyloid-related diseases.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":null,"pages":null},"PeriodicalIF":2.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67437785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0