Critical Reviews in Therapeutic Drug Carrier Systems最新文献

Drug Delivery Approaches for Rheumatoid Arthritis: Recent Advances and Clinical Translation Aspects. 类风湿关节炎的药物给药途径：最新进展和临床翻译方面。

IF 3 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2025-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.v42.i3.10

Madhumithra Thangadurai, Swaminathan Sethuraman, Anuradha Subramanian

{"title":"Drug Delivery Approaches for Rheumatoid Arthritis: Recent Advances and Clinical Translation Aspects.","authors":"Madhumithra Thangadurai, Swaminathan Sethuraman, Anuradha Subramanian","doi":"10.1615/CritRevTherDrugCarrierSyst.v42.i3.10","DOIUrl":"10.1615/CritRevTherDrugCarrierSyst.v42.i3.10","url":null,"abstract":"Rheumatoid arthritis (RA) is a multifactorial autoimmune disease characterized with symmetrical progression of joint deformity that is often diagnosed at a chronic condition with other associated pathological conditions such as pericarditis, keratitis, pulmonary granuloma. Despite the understanding of RA pathophysiology in disease progression, current clinical treatment options such as disease-modifying anti-rheumatic drugs (DMARDs), biologics, steroids, and non-steroidal anti-inflammatory drugs (NSAIDs) provide only palliative therapy while causing adverse side effects such as off-target multi-organ toxicity and risk of infections. Further, available drug delivery strategies to treat RA pathogenicity does not successfully reach the site of action due to various barriers such as phagocytosis and first pass effect in addition to the disease complexity and unknown etiology, thereby leading to the development of irreversible joint dysfunction. Therefore, novel and effective strategies remain an unmet need to control the disease progression and to maintain the balance between pro- and anti-inflammatory cytokines. This review provides a comprehensive outlook on the RA pathophysiology and its corresponding disease progression. Contributions of synoviocytes such as macrophages, fibroblast-like cells in increasing invasiveness to exacerbate joint damage is also outlined in this review, which could be a potential future therapeutic target to complement the existing treatment regimens in controlling RA pathogenesis. Further, various smart drug delivery approaches under research to achieve maximum therapeutic efficacy with minimal adverse side effects have been discussed, which in turn emphasize the unmet challenges and future perspectives in addressing RA complications.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"42 3","pages":"1-54"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polymeric Nanoparticles Revolutionizing Brain Cancer Therapy: A Comprehensive Review of Strategies and Advances. 聚合纳米粒子革新脑癌治疗：策略和进展的综合综述。

IF 3 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2025-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.2024051822

Gilchrist Singh Wahengbam, Sakshi Nirmal, Jai Nandwana, Swatileena Kar, Vandana Kumari, Rajeev Mishra, Abhijeet Singh

{"title":"Polymeric Nanoparticles Revolutionizing Brain Cancer Therapy: A Comprehensive Review of Strategies and Advances.","authors":"Gilchrist Singh Wahengbam, Sakshi Nirmal, Jai Nandwana, Swatileena Kar, Vandana Kumari, Rajeev Mishra, Abhijeet Singh","doi":"10.1615/CritRevTherDrugCarrierSyst.2024051822","DOIUrl":"10.1615/CritRevTherDrugCarrierSyst.2024051822","url":null,"abstract":"Brain cancer continues to be one of the most formidable malignancies to manage, mainly attributable to the presence of the blood-brain barrier (BBB) limiting the permeability of drugs and the diverse characteristics of brain tumors complicating treatment. The management of brain tumors has been hampered by many different factors, including the impermeability of the BBB, which restricts the delivery of chemotherapeutic agents to the tumor site, as well as intertumoral heterogeneity and the influence of brain tumor stem cells. In addition, small molecular weight drugs cannot specifically accumulate in malignant cells and have a limited circulation half-life. Nanoparticles (NPs) can be engineered to traverse the BBB and transport therapeutic medications directly into the brain, enhancing their efficacy compared with the conventional delivery of unbound drugs. Surface modifications of NPs can boost their efficiency by increasing their selectivity towards tumor receptors. This review covers treatment methods for malignant gliomas, associated risk factors, and improvements in brain drug administration, emphasizing the future potential of polymeric NPs and their mechanism for crossing the BBB. To surmount these obstacles, the newly formulated drug-delivery approach utilizing NPs, particularly those coated with cell membranes, has demonstrated potential in treating brain cancer. These NPs provide targeted tumor specificity, biocompatibility, extended circulation, enhanced BBB penetration, and immune evasion. This review focuses on coating strategies for PLGA NPs, particularly dual-targeting methods, to enhance BBB permeability and tumor-targeted delivery of drugs in brain cancer.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"42 2","pages":"73-106"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunotherapy in Cervical Cancer: An Evolutionary Paradigm in Women's Reproductive Health. 宫颈癌免疫治疗：妇女生殖健康的进化范式。

IF 3 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2025-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.2025044498

Mansi Damani, Akshada Mhaske, Sayali Dighe, Sujata P Sawarkar

{"title":"Immunotherapy in Cervical Cancer: An Evolutionary Paradigm in Women's Reproductive Health.","authors":"Mansi Damani, Akshada Mhaske, Sayali Dighe, Sujata P Sawarkar","doi":"10.1615/CritRevTherDrugCarrierSyst.2025044498","DOIUrl":"10.1615/CritRevTherDrugCarrierSyst.2025044498","url":null,"abstract":"Cervical cancer is the fourth most common cause of morbidity and mortality in women. The major causative factor for cervical cancer is primary prolonged infection with human papillomavirus, along with secondary factors such as immunodeficiency, smoking, low socioeconomic standards, poor hygiene, and overuse of oral contraceptives. A grave need exists to practice novel strategies to overcome existing drawbacks of conventional therapy such as chemotherapy, radiation therapy, and surgery. Cancer immunotherapy works by strengthening the immune system of the host to combat against the cancerous cells. Immunotherapy in cervical cancer treatment has demonstrated long-lasting effects; however, the response to such therapies was nominal due to its prominent limitations such as immunosuppressive behavior of the tumor. Presently plethora of nanoplatforms such as polymeric nanoparticles, micelles, liposomes, and dendrimers are being maneuvered with cancer immunotherapy. The amalgamation of nanotechnology and immunotherapy in the treatment of cervical cancer is conceivable due to the mutual association between the tumor microenvironment and immunosurveillance. Safety concerns of nanoplatforms with immunotherapeutics such as toxicity, inflammation, and unwanted accumulation in tissues could be surmounted by surface modification methods. This review highlights the benefits of the amalgamation of nanotechnology and immunotherapy to improve shortcomings applicable to the conventional delivery of cancer treatment. We also aim to outline the nanoimmunotherapy sophistications and future translational avenues in this rapidly flourishing cancer treatment modality.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"42 3","pages":"55-88"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanistic Understanding of Onychomycosis Progression and Current Advancement in the Transungual Drug Delivery System. 甲真菌病进展的机制理解和经舌给药系统的最新进展。

IF 3 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2025-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.2024053869

Gaurav S Chavan, Aarti Belgamwar, Kiran D Patil, Yogeeta O Agrawal

{"title":"Mechanistic Understanding of Onychomycosis Progression and Current Advancement in the Transungual Drug Delivery System.","authors":"Gaurav S Chavan, Aarti Belgamwar, Kiran D Patil, Yogeeta O Agrawal","doi":"10.1615/CritRevTherDrugCarrierSyst.2024053869","DOIUrl":"10.1615/CritRevTherDrugCarrierSyst.2024053869","url":null,"abstract":"Onychomycosis, a nail infection prevalent in 50 to 60% of all nail illnesses globally, caused by dermatophytes, poses significant challenges to current therapies due to their limitations in effective administration. This review explores recent advancements in novel drug delivery systems while exploring the molecular mechanisms underlying onychomycosis progression. The physicochemical properties of antifungal treatments and the intricate structure of the nail plate present challenges and can be addressed by nanotechnology-enabled solutions. Furthermore, the review extensively covers diagnostic methods crucial for accurate onychomycosis identification. This review offers insights to enhance onychomycosis management by elucidating mechanistic aspects of the disease. Emphasizing the role of nanotechnology in drug delivery systems, it addresses current treatment challenges using innovative approaches. Moreover, the evaluation of various formulations highlights opportunities to improve therapeutic efficacy. Overall, this comprehensive review explores the current status, challenges, diagnostics advances, and novel approaches for the administration of drugs for the management of onychomycosis.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"42 3","pages":"89-125"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current Review on Nanophytomedicines in the Treatment of Oral Cancer: Recent Trends and Treatment Prospects. 纳米植物药在口腔癌治疗中的应用综述：最新趋势与治疗前景》。

IF 3 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2025-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.v42.i1.30

Neha P Shukla, Giftson J Senapathy

{"title":"Current Review on Nanophytomedicines in the Treatment of Oral Cancer: Recent Trends and Treatment Prospects.","authors":"Neha P Shukla, Giftson J Senapathy","doi":"10.1615/CritRevTherDrugCarrierSyst.v42.i1.30","DOIUrl":"10.1615/CritRevTherDrugCarrierSyst.v42.i1.30","url":null,"abstract":"Cancer is one of the major life-threatening diseases in the world and oral cancer is the 8th most common type of deadly cancers in Asian countries. Despite many causes, tobacco is the main causative agent as 90% of oral cancer cases were due to daily consumption of tobacco and its products. The major drawback of the conventional therapies for oral cancer including chemotherapy, surgery and radiotherapy or combination of these is the dose limiting toxicity. Developments in technology and research led to new innovative discoveries in cancer treatments. In the past few decades, increased attention has been given to researches in alternative cancer treatment strategies using plants and plant products. Recently many anticancer drugs from natural products or phytochemicals were approved internationally. Due to the low bioavailability and poor solubility of phytochemicals, various research works on nano-carrier based drug delivery systems were exploited in the recent past to make them as promising anticancer agents. In the current review, an overview of oral cancer and its treatment, risk factors, missing links of conventional therapies, contribution of nanotechnology in cancer treatment and research on phytochemical based drug treatment and different polymeric nanoparticles were discussed briefly. The future prospects for the use of various types of polymeric nanoparticles applied in the diagnosis and treatment of oral cancer were also mentioned. The major concern of this review is to give the reader a better understanding on various types of treatment for oral cancer.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"42 1","pages":"89-118"},"PeriodicalIF":3.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing Microemulsion based Therapeutic Drug Delivery: Exploring Surfactants, Co-surfactants, and Quality by Design Strategies within Pseudo-ternary Phase Diagrams 增强基于微乳液的治疗性给药：探索伪三元相图中的表面活性剂、辅助表面活性剂和质量设计策略

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-08-01 DOI: 10.1615/critrevtherdrugcarriersyst.2024053427

Abhishek Bamanna, Anjali Rajora, Kalpana Nagpal

{"title":"Enhancing Microemulsion based Therapeutic Drug Delivery: Exploring Surfactants, Co-surfactants, and Quality by Design Strategies within Pseudo-ternary Phase Diagrams","authors":"Abhishek Bamanna, Anjali Rajora, Kalpana Nagpal","doi":"10.1615/critrevtherdrugcarriersyst.2024053427","DOIUrl":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2024053427","url":null,"abstract":"Microemulsions are thermodynamically stable, clear and homogeneous mixtures of oil, water, and surfactants that have garnered significant attention in various industrial and biomedical applications. The basic components of microemulsions are oil, water, and surfactant, and their composition ratios play a crucial role in determining their properties and stability. Factors such as the type of surfactant, oil, and water used, temperature, and the presence of cosurfactants can greatly influence the formation, stability and properties of microemulsions. These are appropriate for use in drug delivery applications because to their physicochemical characteristics, which include small droplet size, large interfacial area, and good solubilization capacity for both hydrophilic and hydrophobic drugs with significant improvement in their biological activity. The theories of microemulsion and the role of phase diagrams in microemulsion formation and various components for choice of surfactant and co-surfactant are explained. Recent advancements in the preparation and characterization techniques of microemulsion, ranging from visual inspection to the phase behaviour studies and advanced spectroscopic techniques, with a focus on potential of microemulsion in drug delivery along with microemulsion-based drug candidates that are most commonly used for its formulation are also discussed. The review helps in understanding how different excipients affect the release of the active pharmaceutical ingredient. The quality by design approach utilized for optimization of microemulsions is also discussed.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"9 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142222521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NOVEL DRUG DELIVERY TOOLS FOR BETTER PERMEATION AND SKIN CANCER TREATMENT 新型给药工具，提高渗透性和皮肤癌治疗效果

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-06-01 DOI: 10.1615/critrevtherdrugcarriersyst.2024047670

Kajal Chaudhary, Anjali Rajora

{"title":"NOVEL DRUG DELIVERY TOOLS FOR BETTER PERMEATION AND SKIN CANCER TREATMENT","authors":"Kajal Chaudhary, Anjali Rajora","doi":"10.1615/critrevtherdrugcarriersyst.2024047670","DOIUrl":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2024047670","url":null,"abstract":"Skin cancer stands as a challenging global health concern, necessitating innovative approaches to cure deficiencies within traditional therapeutic modalities. While conventional drug delivery methods through injection or oral administration have long prevailed, the emergence of topical drug administration presents a compelling alternative. The skin, aside from offering a swift and painless procedure, serves as a reservoir, maintaining drug efficacy over extended durations. This comprehensive review seeks to shed light on the potential of nanotechnology as a promising avenue for efficacious cancer treatment, with a particular emphasis on skin cancer. Additionally, it underscores the transdermal approach as a viable strategy for addressing various types of cancer. This work also explores into the delivery of peptides and proteins along with in-depth explanations of different delivery systems currently under investigation for localized skin cancer treatment. Furthermore, the review discusses the formidable challenges that must be surmounted before these innovations can find their way into clinical practice, offering a roadmap for future research and therapeutic development.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"12 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141504150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanobiocatalysts and Nanozymes: Enzyme-Inspired Nanomaterials for Industrial and Biomedical Applications 纳米生物催化剂和纳米酶：用于工业和生物医学应用的酶启发纳米材料

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-05-01 DOI: 10.1615/critrevtherdrugcarriersyst.2024051171

Sarika Gupta, Meenu Kumari, Koyel Panja, Priyanka Bajaj, Kalpana Nagpal

{"title":"Nanobiocatalysts and Nanozymes: Enzyme-Inspired Nanomaterials for Industrial and Biomedical Applications","authors":"Sarika Gupta, Meenu Kumari, Koyel Panja, Priyanka Bajaj, Kalpana Nagpal","doi":"10.1615/critrevtherdrugcarriersyst.2024051171","DOIUrl":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2024051171","url":null,"abstract":"Enzymes play a pivotal role in the human body, but their potential is not limited to just that. Scientists have successfully modified these enzymes as nanobiocatalysts or nanozymes for industrial or commercial use, either in the food, medicine, biotech, or even textile industries. These nanobiocatalysts and nanozymes offer several advantages over enzymes, like better stability, improved shelf-life, increased percentage yield, and reuse potential, which is very difficult with normal enzymes. The various techniques of NBC synthesis using immobilization techniques like adsorption, covalent binding, affinity immobilization, and entrapment methods are briefly discussed. The enzymes are either entrapped or adsorbed on the nanocarrier matrices, which can be nanofibers, nanoporous carriers, or nanocontainers as nanobiocatalysts. We also highlight the challenges the nanobiocatalyst overcomes in the industrial production of some drugs like sitagliptin, montelukast, pregabalin, and atorvastatin. Also, the inactivation of an organophosphate or opioid poisoning treating agent, SSOPOX nanohybrid, is discussed in this paper. Nanozymes are intrinsic enzyme-like compounds, and they also show wide application in themselves. Their GQD/AGNP nanohybrid shows antibacterial potential; they can also be utilized in optical sensing to detect small molecules, ions, nucleic acids, proteins, and cancer cells. In this paper, various applications of these NBCs have been discussed, and their potential applications with examples are also mentioned.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"160 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141147309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating the Challenges of 3D Printing Personalized Medicine in Space Explorations: A Comprehensive Review 在太空探索中驾驭 3D 打印个性化医疗的挑战：全面回顾

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-04-01 DOI: 10.1615/critrevtherdrugcarriersyst.2024051126

PRAKASH KATAKAM, Madhavi Lakshmi Ratna Bhavaraju, Tanniru Venkata Narayana, Koushik Bhandari, Nagarajan Sriram, Vidya Sagar Sisinty, Shanta Kumari Adiki

{"title":"Navigating the Challenges of 3D Printing Personalized Medicine in Space Explorations: A Comprehensive Review","authors":"PRAKASH KATAKAM, Madhavi Lakshmi Ratna Bhavaraju, Tanniru Venkata Narayana, Koushik Bhandari, Nagarajan Sriram, Vidya Sagar Sisinty, Shanta Kumari Adiki","doi":"10.1615/critrevtherdrugcarriersyst.2024051126","DOIUrl":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2024051126","url":null,"abstract":"Space exploration has undergone a paradigm shift in recent years, with a growing emphasis on long-duration missions and human habitation on other celestial bodies. Private aerospace businesses are at the forefront of advancing the next iteration of spacecraft, encompassing a wide range of applications such as deep space exploration (e.g., SpaceX) and cost-effective satellite deployments (e.g., Rocketlab). One of the critical challenges associated with prolonged space missions is the provision of personalized medical care. 3D printing technology has emerged as a potential solution, enabling the on-demand production of personalized medical devices and medications. However, the unique conditions of space pose substantial challenges to the successful implementation of 3D printing for personalized medicine. Tremendous scope for research exists in terms of resource utilization and waste management in space ecosystem, robotic and AI enabled tool utilization, remote operability, interplanetary travel, space education and training tools, digital twins, space tourism and in many other aspects of 3D printing for personalized medicine in space explorations.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"27 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140578703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Conventional to Novel Drug Delivery Systems for Meloxicam: A Systematic Review 美洛昔康的传统给药系统到新型给药系统：系统综述

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-02-01 DOI: 10.1615/critrevtherdrugcarriersyst.2024048988

Manjusha Annaji, Nur Mita, Jessica Heard, Xuejia Kang, Ishwor Poudel, Sai H.S. Boddu, Amit K. Tiwari, R. Jayachandra Babu

{"title":"From Conventional to Novel Drug Delivery Systems for Meloxicam: A Systematic Review","authors":"Manjusha Annaji, Nur Mita, Jessica Heard, Xuejia Kang, Ishwor Poudel, Sai H.S. Boddu, Amit K. Tiwari, R. Jayachandra Babu","doi":"10.1615/critrevtherdrugcarriersyst.2024048988","DOIUrl":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2024048988","url":null,"abstract":"Meloxicam, a selective COX-2 inhibitor, has demonstrated clinical effectiveness in managing inflammation and acute pain. Although available in oral formulations such as capsules, tablets, and suspension, frequent administration is necessary to maintain therapeutic efficacy, which can increase adverse effects and patient non-compliance. To address these issues, several sustained drug delivery strategies such as oral, transdermal, transmucosal, injectable, implantable drug delivery systems have been developed for meloxicam. These sustained drug delivery strategies have the potential to improve the therapeutic efficacy and safety profile of meloxicam by reducing the frequency of dosing and associated gastrointestinal side effects. The choice of drug delivery system will depend on the desired release profile, the target site of inflammation, and the mode of administration. Overall, meloxicam sustained delivery systems offer better patient compliance, and reduce side effects, thereby improving the clinical applications of this drug. Herein, we discuss in detail the different strategies for the sustained delivery of meloxicam.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"16 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139956067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0