Critical Reviews in Therapeutic Drug Carrier Systems最新文献_第2页

Nanobiocatalysts and Nanozymes: Enzyme-Inspired Nanomaterials for Industrial and Biomedical Applications 纳米生物催化剂和纳米酶：用于工业和生物医学应用的酶启发纳米材料

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-05-01 DOI: 10.1615/critrevtherdrugcarriersyst.2024051171

Sarika Gupta, Meenu Kumari, Koyel Panja, Priyanka Bajaj, Kalpana Nagpal

{"title":"Nanobiocatalysts and Nanozymes: Enzyme-Inspired Nanomaterials for Industrial and Biomedical Applications","authors":"Sarika Gupta, Meenu Kumari, Koyel Panja, Priyanka Bajaj, Kalpana Nagpal","doi":"10.1615/critrevtherdrugcarriersyst.2024051171","DOIUrl":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2024051171","url":null,"abstract":"Enzymes play a pivotal role in the human body, but their potential is not limited to just that. Scientists have successfully modified these enzymes as nanobiocatalysts or nanozymes for industrial or commercial use, either in the food, medicine, biotech, or even textile industries. These nanobiocatalysts and nanozymes offer several advantages over enzymes, like better stability, improved shelf-life, increased percentage yield, and reuse potential, which is very difficult with normal enzymes. The various techniques of NBC synthesis using immobilization techniques like adsorption, covalent binding, affinity immobilization, and entrapment methods are briefly discussed. The enzymes are either entrapped or adsorbed on the nanocarrier matrices, which can be nanofibers, nanoporous carriers, or nanocontainers as nanobiocatalysts. We also highlight the challenges the nanobiocatalyst overcomes in the industrial production of some drugs like sitagliptin, montelukast, pregabalin, and atorvastatin. Also, the inactivation of an organophosphate or opioid poisoning treating agent, SSOPOX nanohybrid, is discussed in this paper. Nanozymes are intrinsic enzyme-like compounds, and they also show wide application in themselves. Their GQD/AGNP nanohybrid shows antibacterial potential; they can also be utilized in optical sensing to detect small molecules, ions, nucleic acids, proteins, and cancer cells. In this paper, various applications of these NBCs have been discussed, and their potential applications with examples are also mentioned.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"160 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141147309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Navigating the Challenges of 3D Printing Personalized Medicine in Space Explorations: A Comprehensive Review 在太空探索中驾驭 3D 打印个性化医疗的挑战：全面回顾

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-04-01 DOI: 10.1615/critrevtherdrugcarriersyst.2024051126

PRAKASH KATAKAM, Madhavi Lakshmi Ratna Bhavaraju, Tanniru Venkata Narayana, Koushik Bhandari, Nagarajan Sriram, Vidya Sagar Sisinty, Shanta Kumari Adiki

{"title":"Navigating the Challenges of 3D Printing Personalized Medicine in Space Explorations: A Comprehensive Review","authors":"PRAKASH KATAKAM, Madhavi Lakshmi Ratna Bhavaraju, Tanniru Venkata Narayana, Koushik Bhandari, Nagarajan Sriram, Vidya Sagar Sisinty, Shanta Kumari Adiki","doi":"10.1615/critrevtherdrugcarriersyst.2024051126","DOIUrl":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2024051126","url":null,"abstract":"Space exploration has undergone a paradigm shift in recent years, with a growing emphasis on long-duration missions and human habitation on other celestial bodies. Private aerospace businesses are at the forefront of advancing the next iteration of spacecraft, encompassing a wide range of applications such as deep space exploration (e.g., SpaceX) and cost-effective satellite deployments (e.g., Rocketlab). One of the critical challenges associated with prolonged space missions is the provision of personalized medical care. 3D printing technology has emerged as a potential solution, enabling the on-demand production of personalized medical devices and medications. However, the unique conditions of space pose substantial challenges to the successful implementation of 3D printing for personalized medicine. Tremendous scope for research exists in terms of resource utilization and waste management in space ecosystem, robotic and AI enabled tool utilization, remote operability, interplanetary travel, space education and training tools, digital twins, space tourism and in many other aspects of 3D printing for personalized medicine in space explorations.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"27 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140578703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Conventional to Novel Drug Delivery Systems for Meloxicam: A Systematic Review 美洛昔康的传统给药系统到新型给药系统：系统综述

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-02-01 DOI: 10.1615/critrevtherdrugcarriersyst.2024048988

Manjusha Annaji, Nur Mita, Jessica Heard, Xuejia Kang, Ishwor Poudel, Sai H.S. Boddu, Amit K. Tiwari, R. Jayachandra Babu

{"title":"From Conventional to Novel Drug Delivery Systems for Meloxicam: A Systematic Review","authors":"Manjusha Annaji, Nur Mita, Jessica Heard, Xuejia Kang, Ishwor Poudel, Sai H.S. Boddu, Amit K. Tiwari, R. Jayachandra Babu","doi":"10.1615/critrevtherdrugcarriersyst.2024048988","DOIUrl":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2024048988","url":null,"abstract":"Meloxicam, a selective COX-2 inhibitor, has demonstrated clinical effectiveness in managing inflammation and acute pain. Although available in oral formulations such as capsules, tablets, and suspension, frequent administration is necessary to maintain therapeutic efficacy, which can increase adverse effects and patient non-compliance. To address these issues, several sustained drug delivery strategies such as oral, transdermal, transmucosal, injectable, implantable drug delivery systems have been developed for meloxicam. These sustained drug delivery strategies have the potential to improve the therapeutic efficacy and safety profile of meloxicam by reducing the frequency of dosing and associated gastrointestinal side effects. The choice of drug delivery system will depend on the desired release profile, the target site of inflammation, and the mode of administration. Overall, meloxicam sustained delivery systems offer better patient compliance, and reduce side effects, thereby improving the clinical applications of this drug. Herein, we discuss in detail the different strategies for the sustained delivery of meloxicam.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"16 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139956067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Path of Novelty from Nanoparticles to Nanobots: Theragnostic Approach for Targeting Cancer Therapy. 从纳米粒子到纳米机器人的创新之路：癌症靶向治疗的热诊断方法。

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.2023046674

Gursharanpreet Kaur, Bhawna Khanna, Mohammed Yusuf, Akanksha Sharma, Akhil Khajuria, Hema K Alajangi, Pradeep K Jaiswal, Mandip Sachdeva, Ravi Pratap Barnwal, Gurpal Singh

{"title":"A Path of Novelty from Nanoparticles to Nanobots: Theragnostic Approach for Targeting Cancer Therapy.","authors":"Gursharanpreet Kaur, Bhawna Khanna, Mohammed Yusuf, Akanksha Sharma, Akhil Khajuria, Hema K Alajangi, Pradeep K Jaiswal, Mandip Sachdeva, Ravi Pratap Barnwal, Gurpal Singh","doi":"10.1615/CritRevTherDrugCarrierSyst.2023046674","DOIUrl":"10.1615/CritRevTherDrugCarrierSyst.2023046674","url":null,"abstract":"Pharmaceutical development of cancer therapeutics is a dynamic area of research. Even after decades of intensive work, cancer continues to be a dreadful disease with an ever-increasing global incidence. The progress of nanotechnology in cancer research has overcome inherent limitations in conventional cancer chemotherapy and fulfilled the need for target-specific drug carriers. Nanotechnology uses the altered patho-physiological microenvironment of malignant cells and offers various advantages like improved solubility, reduced toxicity, prolonged drug circulation with controlled release, circumventing multidrug resistance, and enhanced biodistribution. Early cancer detection has a crucial role in selecting the best drug regime, thus, diagnosis and therapeutics go hand in hand. Furthermore, nanobots are an amazing possibility and promising innovation with numerous significant applications, particularly in fighting cancer and cleaning out blood vessels. Nanobots are tiny robots, ranging in size from 1 to 100 nm. Moreover, the nanobots would work similarly to white blood cells, watching the bloodstream and searching for indications of distress. This review articulates the evolution of various organic and inorganic nanoparticles and nanobots used as therapeutics, along with their pros and cons. It also highlights the shift in diagnostics from conventional methods to more advanced techniques. This rapidly growing domain is providing more space for engineering desired nanoparticles that can show miraculous results in therapeutic and diagnostic trials.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"1 1","pages":"1-38"},"PeriodicalIF":2.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67437822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanotechnology-Based Approaches for Cosmeceutical and Skin Care: A Systematic Review. 基于纳米技术的药妆和护肤方法：系统综述。

IF 3 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.v41.i5.20

Shital Rani, Piyush Dey, Kritika Pruthi, Sahajdeep Singh, Shivansh Mahajan, Hema K Alajangi, Sumeet Kapoor, Ankur Pandey, Dikshi Gupta, Ravi Pratap Barnwal, Gurpal Singh

引用次数: 0

Advances in Gold nanoparticles: Synthesis, Functionalization Strategies and Theranostic Applications in Cancer 金纳米粒子的研究进展：癌症中的合成、功能化策略和治疗应用

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-01-01 DOI: 10.1615/critrevtherdrugcarriersyst.2024046712

Mansi Damani, Mrunal Jadhav, Rashmi Joshi, Bheeshma Pratap Singh, Munira Momin, Raghumani S Ningthoujam, Tabassum Khan

{"title":"Advances in Gold nanoparticles: Synthesis, Functionalization Strategies and Theranostic Applications in Cancer","authors":"Mansi Damani, Mrunal Jadhav, Rashmi Joshi, Bheeshma Pratap Singh, Munira Momin, Raghumani S Ningthoujam, Tabassum Khan","doi":"10.1615/critrevtherdrugcarriersyst.2024046712","DOIUrl":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2024046712","url":null,"abstract":"Cancer is among the leading causes of mortality and morbidity in the world. Metallic nanoparticles, especially gold nanoparticles have emerged to be attractive systems to circumvent the associated adverse effects. By the virtue of their unique properties of tunable size, shape, composition, optical properties, biocompatibility, minimal toxicity, multivalency, fluorescence-luminescence property and surface plasmon resonance; gold nanoparticles have the potential to be used as drug delivery systems. It is vital to ensure that the drug reaches the target site of action for selective kill of cancer cells without harm to healthy cells. These nanoparticles can be easily functionalised with a wide array of ligands- peptides, oligonucleotides, polymers, carbohydrates for active targeting to ensure site specific delivery and reduced systemic effects. Gold nanoparticles have been investigated as carriers for gene delivery, drug delivery with or without photothermal therapy, in diagnosis based on radiation or spectroscopy. They have emerged as attractive theranostic approach in the overall management of cancer with superior benefit to risk features. In this review, we have discussed synthesis of different gold nanoparticles (nanorods, spherical nanoparticles, hollow gold nanoparticles), their functionalization strategies and their applications in biomedical domain. Various research studies and clinical trials on application of gold nanoparticles in diagnosis and therapeutics are highlighted.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"58 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139464838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applications of Cannabinoids in Neuropathic Pain: An Updated Review. 大麻酚类药物在神经性疼痛中的应用：最新综述。

IF 3 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-01-01 DOI: 10.1615/CritRevTherDrugCarrierSyst.2022038592

Peggy Arthur, Anil Kumar Kalvala, Sunil Kumar Surapaneni, Mandip Sachdeva Singh

{"title":"Applications of Cannabinoids in Neuropathic Pain: An Updated Review.","authors":"Peggy Arthur, Anil Kumar Kalvala, Sunil Kumar Surapaneni, Mandip Sachdeva Singh","doi":"10.1615/CritRevTherDrugCarrierSyst.2022038592","DOIUrl":"10.1615/CritRevTherDrugCarrierSyst.2022038592","url":null,"abstract":"Neuropathic pain is experienced due to injury to the nerves, underlying disease conditions or toxicity induced by chemotherapeutics. Multiple factors can contribute to neuropathic pain such as central nervous system (CNS)-related autoimmune and metabolic disorders, nerve injury, multiple sclerosis and diabetes. Hence, development of pharmacological interventions to reduce the drawbacks of existing chemotherapeutics and counter neuropathic pain is an urgent unmet clinical need. Cannabinoid treatment has been reported to be beneficial for several disease conditions including neuropathic pain. Cannabinoids act by inhibiting the release of neurotransmitters from presynaptic nerve endings, modulating the excitation of postsynaptic neurons, activating descending inhibitory pain pathways, reducing neural inflammation and oxidative stress and also correcting autophagy defects. This review provides insights on the various preclinical and clinical therapeutic applications of cannabidiol (CBD), cannabigerol (CBG), and cannabinol (CBN) in various diseases and the ongoing clinical trials for the treatment of chronic and acute pain with cannabinoids. Pharmacological and genetic experimental strategies have well demonstrated the potential neuroprotective effects of cannabinoids and also elaborated their mechanism of action for the therapy of neuropathic pain.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"41 1","pages":"1-33"},"PeriodicalIF":3.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11228808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41219278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting Amyloids with coated Nanoparticles: A review on lucrative combinations of Nanoparticles and its Bio-compatible coating 包被纳米颗粒靶向淀粉样蛋白:纳米颗粒及其生物相容性包被的研究进展

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-01-01 DOI: 10.1615/critrevtherdrugcarriersyst.2023046209

Oshin D. Warerkar, Niyati H. Mudliar, M. Momin, Prabhat Singh

{"title":"Targeting Amyloids with coated Nanoparticles: A review on lucrative combinations of Nanoparticles and its Bio-compatible coating","authors":"Oshin D. Warerkar, Niyati H. Mudliar, M. Momin, Prabhat Singh","doi":"10.1615/critrevtherdrugcarriersyst.2023046209","DOIUrl":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2023046209","url":null,"abstract":"Amyloidosis is the major cause of many neurodegenerative diseases, such as, Alzheimer's and Parkinson's where the misfolding and deposition of a previously functional protein make it inept for carrying out its function. The genesis of amyloid fibril formation and the strategies to inhibit it have been studied extensively, although some parts of this puzzle still remain unfathomable to date. Many classes of molecules have been explored as potential drugs in vitro, but their inability to work in vivo by crossing the blood-brain-barrier has made them an inadequate treatment option. In this regard, nanoparticles (NPs) have turned out to be an exciting alternative because they could overcome many drawbacks of previously studied molecules and provide advantages, such as, greater bioavailability of molecules and target-specific delivery of drugs. In this paper, we present an overview on several coated NPs which have shown promising efficiency in inhibiting fibril formation. A hundred and thirty papers published in the past two decades have been comprehensively reviewed, which majorly encompass NPs comprising different materials like gold, silver, iron-oxide, poly(lactic-co-glycolic acid), polymeric NP, etc., which are coated with various molecules of predominantly natural origin, such as different types of amino acids, peptides, curcumin, drugs, catechin, etc. We hope that this review will shed light on the advancement of symbiotic amalgamation of NPs with molecules from natural sources and will inspire further research on the tremendous therapeutic potential of these combinations for many amyloid-related diseases.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"1 1","pages":"85-119"},"PeriodicalIF":2.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67437785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Patent Review on the Use of Cyclodextrin Inclusion Complexes to Enhance Physicochemical and Pharmacological Properties in Antidepressant Drugs. 关于使用环糊精包合物增强抗抑郁药物理化和药理特性的专利综述。

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2024-01-01

José Adão Carvalho Nascimento Júnior, Luiza Abrahão Frank, Alcimary Bispo Santos, Anamaria Mendonça Santos, Tatianny de Araújo Andrade, Paula Dos Passos Menezes, Renata Vidor Contri, Mairim Russo Serafini

{"title":"A Patent Review on the Use of Cyclodextrin Inclusion Complexes to Enhance Physicochemical and Pharmacological Properties in Antidepressant Drugs.","authors":"José Adão Carvalho Nascimento Júnior, Luiza Abrahão Frank, Alcimary Bispo Santos, Anamaria Mendonça Santos, Tatianny de Araújo Andrade, Paula Dos Passos Menezes, Renata Vidor Contri, Mairim Russo Serafini","doi":"","DOIUrl":"","url":null,"abstract":"Major depressive disorder is considered one of the most common and prevalent diseases worldwide, affecting children, adults, and the elderly. Currently, several antidepressant drugs are available on the market, but the low adherence of patients due to the slow therapeutic response is a problem to be solved. In this way, cyclodextrins become an alternative to circumvent the limitations and improve the physicochemical and pharmacological properties of this class of drugs. Thus, the objective of this work is to carry out a current review of patents associating antidepressant drugs and cyclodextrins. The patent search was performed in two patent databases, the World Intellectual Property Organization and the European Patent Office using terms in the title and abstract fields and the international patent classification code for antidepressant drugs. In the end, 27 patent documents were selected and divided into three classifications, physical-chemical characterization study, pre-clinical in vivo trials, and clinical trials. The scientific evidence found in the patents considers the use of cyclodextrins as an important alternative to improve the therapeutic and physicochemical properties of antidepressant drugs, among the main improved properties are, solubility, stability, masking taste and odor, bioavailability.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"41 6","pages":"57-88"},"PeriodicalIF":2.7,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141159181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-invasive delivery of Insulin for breaching hindrances against Diabetes 以非侵入方式输送胰岛素，打破糖尿病防治障碍

IF 2.7 4区医学

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2023-12-01 DOI: 10.1615/critrevtherdrugcarriersyst.2023048197

Manoj Sarangi, Sasmita Padhi, Goutam Rath

{"title":"Non-invasive delivery of Insulin for breaching hindrances against Diabetes","authors":"Manoj Sarangi, Sasmita Padhi, Goutam Rath","doi":"10.1615/critrevtherdrugcarriersyst.2023048197","DOIUrl":"https://doi.org/10.1615/critrevtherdrugcarriersyst.2023048197","url":null,"abstract":"Insulin is recognized as a crucial weapon in managing diabetes. Subcutaneous (s.c.) injections are the traditional approach for insulin administration, which usually have many limitations. Numerous alternative (non-invasive) slants through different routes have been explored by the researchers for making needle-free delivery of insulin for attaining its augmented absorption as well as bioavailability. The current review delineating numerous pros and cons of several novel approaches of non-invasive insulin delivery by overcoming many of their hurdles. Primary information on the topic was gathered by searching scholarly articles from PubMed added with extraction of data from auxiliary manuscripts. Many approaches (discussed in the article) are meant for the delivery of a safe, effective, stable, and patient friendly administration of insulin via buccal, oral, inhalational, transdermal, intranasal, ocular, vaginal and rectal routes. Few of them have proven their clinical efficacy for maintaining the glycemic levels, whereas others are under the investigational pipe line. The developed products are comprising of many advanced micro/nano composite technologies and few of them might be entering into the market in near future, thereby garnishing the hopes of millions of diabetics who are under the network of s.c. insulin injections.","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"3 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138561201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0