{"title":"靶向癌症干细胞的纳米药物介导疗法:一项新兴技术。","authors":"Sana Kauser, Irzam Haroon, Saima Wajid","doi":"10.1615/CritRevTherDrugCarrierSyst.2025047123","DOIUrl":null,"url":null,"abstract":"<p><p>Cancer stem cells (CSCs) are a category of cancer cells endowed with the ability to renew themselves, undergo unregulated growth, and exhibit a differentiation capacity akin to that of normal stem cells. CSCs have been linked with tumor metastasis and cancer recurrence due to their ability to elude immune monitoring. As a result, targeting CSCs specifically may improve the efficacy of cancer therapy. Recently, the use of nanotechnology has gained substantial attention in cancer treatment. Cancer nanotechnology is an interdisciplinary field of research where nano-biotechnology fosters the combination of diagnostics and treatments, which is an important part of a personalized approach to cancer treatment. Thus, using nanoparticles against cancer cells and CSCs simultaneously may lead to the development of a better therapeutic intervention to eradicate cancer. In this review, we describe recent achievements in cancer therapy targeting CSCs of various malignancies, such as lung cancer, breast cancer, colorectal cancer, and prostate cancer, by using nanotechnology.</p>","PeriodicalId":50614,"journal":{"name":"Critical Reviews in Therapeutic Drug Carrier Systems","volume":"42 6","pages":"1-44"},"PeriodicalIF":2.5000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Nanomedicine-Mediated Therapies to Target Cancer Stem Cells: An Emerging Technology.\",\"authors\":\"Sana Kauser, Irzam Haroon, Saima Wajid\",\"doi\":\"10.1615/CritRevTherDrugCarrierSyst.2025047123\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Cancer stem cells (CSCs) are a category of cancer cells endowed with the ability to renew themselves, undergo unregulated growth, and exhibit a differentiation capacity akin to that of normal stem cells. CSCs have been linked with tumor metastasis and cancer recurrence due to their ability to elude immune monitoring. As a result, targeting CSCs specifically may improve the efficacy of cancer therapy. Recently, the use of nanotechnology has gained substantial attention in cancer treatment. Cancer nanotechnology is an interdisciplinary field of research where nano-biotechnology fosters the combination of diagnostics and treatments, which is an important part of a personalized approach to cancer treatment. Thus, using nanoparticles against cancer cells and CSCs simultaneously may lead to the development of a better therapeutic intervention to eradicate cancer. In this review, we describe recent achievements in cancer therapy targeting CSCs of various malignancies, such as lung cancer, breast cancer, colorectal cancer, and prostate cancer, by using nanotechnology.</p>\",\"PeriodicalId\":50614,\"journal\":{\"name\":\"Critical Reviews in Therapeutic Drug Carrier Systems\",\"volume\":\"42 6\",\"pages\":\"1-44\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Critical Reviews in Therapeutic Drug Carrier Systems\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2025047123\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Critical Reviews in Therapeutic Drug Carrier Systems","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1615/CritRevTherDrugCarrierSyst.2025047123","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Nanomedicine-Mediated Therapies to Target Cancer Stem Cells: An Emerging Technology.
Cancer stem cells (CSCs) are a category of cancer cells endowed with the ability to renew themselves, undergo unregulated growth, and exhibit a differentiation capacity akin to that of normal stem cells. CSCs have been linked with tumor metastasis and cancer recurrence due to their ability to elude immune monitoring. As a result, targeting CSCs specifically may improve the efficacy of cancer therapy. Recently, the use of nanotechnology has gained substantial attention in cancer treatment. Cancer nanotechnology is an interdisciplinary field of research where nano-biotechnology fosters the combination of diagnostics and treatments, which is an important part of a personalized approach to cancer treatment. Thus, using nanoparticles against cancer cells and CSCs simultaneously may lead to the development of a better therapeutic intervention to eradicate cancer. In this review, we describe recent achievements in cancer therapy targeting CSCs of various malignancies, such as lung cancer, breast cancer, colorectal cancer, and prostate cancer, by using nanotechnology.
期刊介绍:
Therapeutic uses of a variety of drug carrier systems have significant impact on the treatment and potential cure of many chronic diseases, including cancer, diabetes mellitus, psoriasis, parkinsons, Alzheimer, rheumatoid arthritis, HIV infection, infectious diseases, asthma, and drug addiction. Scientific efforts in these areas are multidisciplinary, involving the physical, biological, medical, pharmaceutical, biological materials, and engineering fields.
Articles concerning this field appear in a wide variety of journals. With the vast increase in the number of articles and the tendency to fragment science, it becomes increasingly difficult to keep abreast of the literature and to sort out and evaluate the importance and reliability of the data, especially when proprietary considerations are involved. Abstracts and noncritical articles often do not provide a sufficiently reliable basis for proper assessment of a given field without the additional perusal of the original literature. This journal bridges this gap by publishing authoritative, objective, comprehensive multidisciplinary critical review papers with emphasis on formulation and delivery systems. Both invited and contributed articles are subject to peer review.