靶向癌症干细胞的纳米药物介导疗法:一项新兴技术。

IF 2.5 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Sana Kauser, Irzam Haroon, Saima Wajid
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引用次数: 0

摘要

癌症干细胞(CSCs)是一类具有自我更新能力的癌细胞,可以进行不受调节的生长,并表现出与正常干细胞相似的分化能力。由于CSCs能够逃避免疫监测,因此与肿瘤转移和癌症复发有关。因此,特异性靶向CSCs可能会提高癌症治疗的疗效。近年来,纳米技术在癌症治疗中的应用受到了广泛关注。癌症纳米技术是一个跨学科的研究领域,其中纳米生物技术促进了诊断和治疗的结合,这是个性化癌症治疗方法的一个重要组成部分。因此,同时使用纳米颗粒对抗癌细胞和csc可能会导致更好的治疗干预措施的发展,以根除癌症。在这篇综述中,我们描述了利用纳米技术治疗各种恶性肿瘤(如肺癌、乳腺癌、结直肠癌和前列腺癌)的csc的最新进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Nanomedicine-Mediated Therapies to Target Cancer Stem Cells: An Emerging Technology.

Cancer stem cells (CSCs) are a category of cancer cells endowed with the ability to renew themselves, undergo unregulated growth, and exhibit a differentiation capacity akin to that of normal stem cells. CSCs have been linked with tumor metastasis and cancer recurrence due to their ability to elude immune monitoring. As a result, targeting CSCs specifically may improve the efficacy of cancer therapy. Recently, the use of nanotechnology has gained substantial attention in cancer treatment. Cancer nanotechnology is an interdisciplinary field of research where nano-biotechnology fosters the combination of diagnostics and treatments, which is an important part of a personalized approach to cancer treatment. Thus, using nanoparticles against cancer cells and CSCs simultaneously may lead to the development of a better therapeutic intervention to eradicate cancer. In this review, we describe recent achievements in cancer therapy targeting CSCs of various malignancies, such as lung cancer, breast cancer, colorectal cancer, and prostate cancer, by using nanotechnology.

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来源期刊
CiteScore
5.50
自引率
18.50%
发文量
27
审稿时长
>12 weeks
期刊介绍: Therapeutic uses of a variety of drug carrier systems have significant impact on the treatment and potential cure of many chronic diseases, including cancer, diabetes mellitus, psoriasis, parkinsons, Alzheimer, rheumatoid arthritis, HIV infection, infectious diseases, asthma, and drug addiction. Scientific efforts in these areas are multidisciplinary, involving the physical, biological, medical, pharmaceutical, biological materials, and engineering fields. Articles concerning this field appear in a wide variety of journals. With the vast increase in the number of articles and the tendency to fragment science, it becomes increasingly difficult to keep abreast of the literature and to sort out and evaluate the importance and reliability of the data, especially when proprietary considerations are involved. Abstracts and noncritical articles often do not provide a sufficiently reliable basis for proper assessment of a given field without the additional perusal of the original literature. This journal bridges this gap by publishing authoritative, objective, comprehensive multidisciplinary critical review papers with emphasis on formulation and delivery systems. Both invited and contributed articles are subject to peer review.
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