Mechanistic Understanding of Onychomycosis Progression and Current Advancement in the Transungual Drug Delivery System.

IF 3 4区医学 Q2 PHARMACOLOGY & PHARMACY

Critical Reviews in Therapeutic Drug Carrier Systems Pub Date : 2025-01-01 DOI:10.1615/CritRevTherDrugCarrierSyst.2024053869

Gaurav S Chavan, Aarti Belgamwar, Kiran D Patil, Yogeeta O Agrawal

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引用次数: 0

Abstract

Onychomycosis, a nail infection prevalent in 50 to 60% of all nail illnesses globally, caused by dermatophytes, poses significant challenges to current therapies due to their limitations in effective administration. This review explores recent advancements in novel drug delivery systems while exploring the molecular mechanisms underlying onychomycosis progression. The physicochemical properties of antifungal treatments and the intricate structure of the nail plate present challenges and can be addressed by nanotechnology-enabled solutions. Furthermore, the review extensively covers diagnostic methods crucial for accurate onychomycosis identification. This review offers insights to enhance onychomycosis management by elucidating mechanistic aspects of the disease. Emphasizing the role of nanotechnology in drug delivery systems, it addresses current treatment challenges using innovative approaches. Moreover, the evaluation of various formulations highlights opportunities to improve therapeutic efficacy. Overall, this comprehensive review explores the current status, challenges, diagnostics advances, and novel approaches for the administration of drugs for the management of onychomycosis.

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甲真菌病进展的机制理解和经舌给药系统的最新进展。

甲真菌病是一种指甲感染，在全球所有指甲疾病中占50%至60%，由皮肤真菌引起，由于其有效给药的局限性，对目前的治疗提出了重大挑战。本文综述了新型药物传递系统的最新进展，同时探讨了甲真菌病进展的分子机制。抗真菌治疗的物理化学性质和指甲板的复杂结构提出了挑战，可以通过纳米技术解决。此外，审查广泛涵盖诊断方法至关重要的准确鉴定甲真菌病。这篇综述提供了见解，以加强甲真菌病的管理，阐明了机制方面的疾病。它强调纳米技术在药物输送系统中的作用，使用创新方法解决当前的治疗挑战。此外，各种配方的评估强调了提高治疗效果的机会。总的来说，这篇全面的综述探讨了目前的现状，挑战，诊断的进展，以及治疗甲真菌病的新方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Reviews in Therapeutic Drug Carrier Systems 医学-药学

CiteScore

5.50

自引率

18.50%

发文量

审稿时长

>12 weeks

期刊介绍： Therapeutic uses of a variety of drug carrier systems have significant impact on the treatment and potential cure of many chronic diseases, including cancer, diabetes mellitus, psoriasis, parkinsons, Alzheimer, rheumatoid arthritis, HIV infection, infectious diseases, asthma, and drug addiction. Scientific efforts in these areas are multidisciplinary, involving the physical, biological, medical, pharmaceutical, biological materials, and engineering fields. Articles concerning this field appear in a wide variety of journals. With the vast increase in the number of articles and the tendency to fragment science, it becomes increasingly difficult to keep abreast of the literature and to sort out and evaluate the importance and reliability of the data, especially when proprietary considerations are involved. Abstracts and noncritical articles often do not provide a sufficiently reliable basis for proper assessment of a given field without the additional perusal of the original literature. This journal bridges this gap by publishing authoritative, objective, comprehensive multidisciplinary critical review papers with emphasis on formulation and delivery systems. Both invited and contributed articles are subject to peer review.