Current Opinion in Ophthalmology最新文献_第6页

Implementation of anterior segment ophthalmic telemedicine. 实施眼科前段远程医疗。

IF 3.7 2区医学

Current Opinion in Ophthalmology Pub Date : 2024-07-01 Epub Date: 2024-05-14 DOI: 10.1097/ICU.0000000000001052

Grayson W Armstrong, Daniel L Liebman, Helia Ashourizadeh

{"title":"Implementation of anterior segment ophthalmic telemedicine.","authors":"Grayson W Armstrong, Daniel L Liebman, Helia Ashourizadeh","doi":"10.1097/ICU.0000000000001052","DOIUrl":"10.1097/ICU.0000000000001052","url":null,"abstract":"Purpose of review: The growing push to integrate telemedicine into ophthalmic practices requires physicians to have a thorough understanding of ophthalmic telemedicine's applications, limitations, and recent advances in order to provide well tolerated and appropriate clinical care. This review aims to provide an overview of recent advancements in the use of ophthalmic telemedicine for anterior segment eye examinations.Recent findings: Virtual care for anterior segment evaluation relies on appropriate technology, novel workflows, and appropriate clinical case selection. Recent advances, particularly in the wake of the COVID-19 pandemic, have highlighted the utility of home-based assessments for visual acuity, external evaluation, tonometry, and refraction. Additionally, innovative workflows incorporating office-based testing into virtual care, termed 'hybrid telemedicine', enable high-quality ophthalmic testing to inform clinical decision-making.Summary: Novel digital tools and workflows enable high-quality anterior segment evaluation and management for select ophthalmic concerns. This review highlights the clinical tools and workflows necessary to enable anterior segment telehealth.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":"35 4","pages":"343-350"},"PeriodicalIF":3.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141176811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Limbal stem cell therapy. 瓣膜干细胞疗法

IF 3.7 2区医学

Current Opinion in Ophthalmology Pub Date : 2024-07-01 Epub Date: 2024-05-17 DOI: 10.1097/ICU.0000000000001061

Clemence Bonnet, Sheyla Gonzalez, Sophie X Deng

{"title":"Limbal stem cell therapy.","authors":"Clemence Bonnet, Sheyla Gonzalez, Sophie X Deng","doi":"10.1097/ICU.0000000000001061","DOIUrl":"https://doi.org/10.1097/ICU.0000000000001061","url":null,"abstract":"Purpose of review: To highlight the progress and future direction of limbal stem cell (LSC) therapies for the treatment of limbal stem cell deficiency (LSCD).Recent findings: Direct LSC transplantation have demonstrated good long-term outcomes. Cultivated limbal epithelial transplantation (CLET) has been an alternative to treat severe to total LSCD aiming to improve the safety and efficacy of the LSC transplant. A prospective early-stage uncontrolled clinical trial shows the feasibility and safety of CLET manufactured under xenobiotic free conditions. Other cell sources for repopulating of the corneal epithelium such as mesenchymal stem cells (MSCs) and induced pluripotent stem cells are being investigated. The first clinical trials of using MSCs showed short-term results, but long-term efficacy seems to be disappointing. A better understanding of the niche function and regulation of LSC survival and proliferation will lead to the development of medical therapies to rejuvenate the residual LSCs found in a majority of eyes with LSCD in vivo. Prior efforts have been largely focused on improving LSC transplantation. Additional effort should be placed on improving the accuracy of diagnosis and staging of LSCD, and implementing standardized outcome measures which enable comparison of efficacy of different LSCD treatments for different severity of LSCD. The choice of LSCD treatment will be customized based on the severity of LSCD in the future.Summary: New approaches for managing different stages of LSCD are being developed. This concise review summarizes the progresses in LSC therapies for LSCD, underlying mechanisms, limitations, and future areas of development.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":"35 4","pages":"309-314"},"PeriodicalIF":3.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141176812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surgical options and clinical outcomes for high myopia. 高度近视的手术方案和临床效果。

IF 3.7 2区医学

Current Opinion in Ophthalmology Pub Date : 2024-05-02 DOI: 10.1097/icu.0000000000001053

Ashley A Abing, Alyce Oh, Lauren F Ong, Amir H Marvasti, Dan B Tran, Jimmy K Lee

引用次数: 0

Implementation of optical coherence tomography in retinopathy of prematurity screening. 在早产儿视网膜病变筛查中采用光学相干断层扫描技术。

IF 3.7 2区医学

Current Opinion in Ophthalmology Pub Date : 2024-05-01 Epub Date: 2024-01-11 DOI: 10.1097/ICU.0000000000001030

Adam M Hanif, Yifan Jian, Benjamin K Young, John Peter Campbell

{"title":"Implementation of optical coherence tomography in retinopathy of prematurity screening.","authors":"Adam M Hanif, Yifan Jian, Benjamin K Young, John Peter Campbell","doi":"10.1097/ICU.0000000000001030","DOIUrl":"10.1097/ICU.0000000000001030","url":null,"abstract":"Purpose of review: In this review, we explore the investigational applications of optical coherence tomography (OCT) in retinopathy of prematurity (ROP), the insights they have delivered thus far, and key milestones for its integration into the standard of care.Recent findings: While OCT has been widely integrated into clinical management of common retinal diseases, its use in pediatric contexts has been undermined by limitations in ergonomics, image acquisition time, and field of view. Recently, investigational handheld OCT devices have been reported with advancements including ultra-widefield view, noncontact use, and high-speed image capture permitting real-time en face visualization. These developments are compelling for OCT as a more objective alternative with reduced neonatal stress compared to indirect ophthalmoscopy and/or fundus photography as a means of classifying and monitoring ROP.Summary: OCT may become a viable modality in management of ROP. Ongoing innovation surrounding handheld devices should aim to optimize patient comfort and image resolution in the retinal periphery. Future clinical investigations may seek to objectively characterize features of peripheral stage and explore novel biomarkers of disease activity.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"252-259"},"PeriodicalIF":3.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11034813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139418482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Review and analysis of history and utilization of pneumatic retinopexy after pneumatic retinopexy versus vitrectomy for the management of primary rhegmatogenous retinal detachment outcomes randomized trial (PIVOT). 在气动视网膜修复术与玻璃体切割术治疗原发性流变性视网膜脱离结果随机试验（PIVOT）之后，对气动视网膜修复术的历史和使用情况进行回顾和分析。

IF 3.7 2区医学

Current Opinion in Ophthalmology Pub Date : 2024-05-01 Epub Date: 2024-02-15 DOI: 10.1097/ICU.0000000000001039

Serena Shah, Brandon Chou, Marissa Patel, Arjun Watane, Lea Shah, Nicolas Yannuzzi, Jayanth Sridhar

{"title":"Review and analysis of history and utilization of pneumatic retinopexy after pneumatic retinopexy versus vitrectomy for the management of primary rhegmatogenous retinal detachment outcomes randomized trial (PIVOT).","authors":"Serena Shah, Brandon Chou, Marissa Patel, Arjun Watane, Lea Shah, Nicolas Yannuzzi, Jayanth Sridhar","doi":"10.1097/ICU.0000000000001039","DOIUrl":"10.1097/ICU.0000000000001039","url":null,"abstract":"Purpose of review: We describe the history and series results of pneumatic retinopexy (PnR)and provide an analysis of PnR utilization after publication of results of pneumatic retinopexy versus vitrectomy for the management of primary rhegmatogenous retinal detachment outcomes randomized trial (PIVOT).Recent findings: No significant trends were found for average number of services ( P = 0.153) of PnR after the publication of PIVOT results.Summary: PnR is a rhegmatogenous retinal detachment (RRD) repair technique that was first described in the early 1900 s and has evolved over time to become a modern-day, minimally invasive, underutilized treatment option. Other repair techniques for RRD include scleral buckling and pars plana vitrectomy (PPV), which has been compared to the use of PnR in PIVOT. Results of PIVOT concluded that PnR offered superior visual acuity and noninferiority. PnR is underutilized in the United States even after publication of results of PIVOT deemed it a noninferior treatment. Lack of a significant increase in national utilization of PnR could be associated with multifactorial clinician, systems, and financial reasons in the real-world setting.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"217-222"},"PeriodicalIF":3.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139747735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intravitreal enzyme replacement for inherited retinal diseases. 治疗遗传性视网膜疾病的玻璃体内酶替代物。

IF 3.7 2区医学

Current Opinion in Ophthalmology Pub Date : 2024-05-01 Epub Date: 2023-12-26 DOI: 10.1097/ICU.0000000000001029

Ana Catalina Rodriguez-Martinez, James Wawrzynski, Robert H Henderson

{"title":"Intravitreal enzyme replacement for inherited retinal diseases.","authors":"Ana Catalina Rodriguez-Martinez, James Wawrzynski, Robert H Henderson","doi":"10.1097/ICU.0000000000001029","DOIUrl":"10.1097/ICU.0000000000001029","url":null,"abstract":"Purpose of review: This paper provides an update on intravitreal (IVT) enzyme replacement therapy (ERT) in metabolic retinal diseases; particularly neuronal ceroid lipofuscinosis type 2 (CLN2) also known as Batten disease.Recent findings: ERT is being explored in CLN2 related Batten disease, a fatal neurodegenerative condition associated with retinopathy and blindness that is caused by the deficiency of lysosomal enzyme TPP1. Cerliponase alfa, a recombinant human tripeptidyl-peptidase1 (rhTPP1) administered by intraventricular infusions has been demonstrated to slow the rate of neurodegenerative decline but not retinopathy. A preclinical study of IVT rhTPP1 in a CLN2 canine model demonstrated efficacy in preserving retinal function and retinal morphology shown on histology. More recently, intravitreal (IVT) administration of rhTPP1 was reported in a first-in-human compassionate use study. Patients received 12-18 months of 8-weekly IVT ERT (0.2 mg rhTPP-1 in 0.05 ml) in one eye. No significant ocular adverse reactions were reported. Treatment decreased the rate of retinal thinning but modestly.Summary: The evidence suggests that IVT ERT with rhTPP1 may be a safe and effective treatment for CLN2 retinopathy. However, the optimal dosage and frequency to achieve the best possible outcomes requires further investigation as does patient selection.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"232-237"},"PeriodicalIF":3.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139089287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Weight loss, bariatric surgery, and novel antidiabetic drugs effects on diabetic retinopathy: a review. 减肥、减肥手术和新型抗糖尿病药物对糖尿病视网膜病变的影响：综述。

IF 3.7 2区医学

Current Opinion in Ophthalmology Pub Date : 2024-05-01 Epub Date: 2024-01-30 DOI: 10.1097/ICU.0000000000001038

Alejandro M Perez, Emily Neag, Jayanth Sridhar, Basil K Williams

{"title":"Weight loss, bariatric surgery, and novel antidiabetic drugs effects on diabetic retinopathy: a review.","authors":"Alejandro M Perez, Emily Neag, Jayanth Sridhar, Basil K Williams","doi":"10.1097/ICU.0000000000001038","DOIUrl":"10.1097/ICU.0000000000001038","url":null,"abstract":"Purpose of review: Diabetic retinopathy (DR) is a leading cause of visual impairment, and the increasing prevalence of diabetes and obesity will impact rates of visual impairment moving forward. Our review aims to synthesize the current body of evidence regarding the impact of lifestyle interventions, such as weight loss, bariatric surgery, and novel antidiabetic drugs, on DR.Recent findings: Literature review revealed insufficient evidence regarding the impact of weight loss on DR. Preoperative DR patients undergoing bariatric surgery were found to have similar short-term chances of improvement or worsening DR. Progression of DR with glucagon-like peptide 1 receptor agonists treatments appears unrelated to specific drugs and was also observed with traditional antidiabetic medications.Summary: Rapidly correcting HbA1c levels (≥2%) can paradoxically lead to early worsening DR. Patients considering weight loss, bariatric surgery, and novel antidiabetic drugs should be aware of the potential for DR progression, but they should not be discouraged, as achieving glycemic control is essential for reducing long-term morbidity and mortality from other diabetes-related complications. It is advisable to conduct a baseline retinal examination before treatment and continue monitoring during therapy. Further research is needed to understand the long-term effects of these treatments on DR.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"192-196"},"PeriodicalIF":3.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139652017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinal arterial and vein occlusion: is surgery ever indicated? 视网膜动静脉闭塞：是否需要手术？

IF 3.7 2区医学

Current Opinion in Ophthalmology Pub Date : 2024-05-01 Epub Date: 2024-02-28 DOI: 10.1097/ICU.0000000000001045

Kazuaki Kadonosono, Maiko Inoue, Yasuo Yanagi

{"title":"Retinal arterial and vein occlusion: is surgery ever indicated?","authors":"Kazuaki Kadonosono, Maiko Inoue, Yasuo Yanagi","doi":"10.1097/ICU.0000000000001045","DOIUrl":"10.1097/ICU.0000000000001045","url":null,"abstract":"Purpose of review: To highlight the recent progression in surgical treatments for central retinal vein occlusion (CRVO) and central retinal artery occlusion (CRAO).Recent findings: Anti-VEGF treatment, accepted as a primary treatment for CRVO, is unable to effectively treat all types of the diseases. Regarding CRAO, there are not any accepted therapies available. There have however been recent innovations in surgery, such as utilizing robotics-assisted tools in cannulation procedures for central retinal artery occlusion, or micro-cystotomy for refractory macular edema resulting from ischemic CRVO.Summary: Refractory macular edema due to CRVO can be treated with aspiration of the fluid found inside the large cysts often seen in edema. The success rate of micro-cystotomy has been reported at 78% in eyes with refractory macular edema. Recent studies have shown that cannulation with tissue plasminogen activator (tPA) is effective for eyes with CRAO due to thrombus.Recent cannulation or micro-cystotomy procedures can be enhanced with the use of robotic tools which allow us to perform this difficult procedure more easily. Newly developed technology, and consequent developments in surgical procedures, will allow us to deal with unmet needs for retinal vessel occlusive diseases.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"210-216"},"PeriodicalIF":3.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139998216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Update on corneal crosslinking for keratoconus and corneal ectasia. 角膜交联治疗角膜炎和角膜异位症的最新进展。

IF 3.7 2区医学

Current Opinion in Ophthalmology Pub Date : 2024-05-01 DOI: 10.1097/icu.0000000000001056

Steven A Greenstein, Peter S Hersh

引用次数: 0

ChatGPT enters the room: what it means for patient counseling, physician education, academics, and disease management. ChatGPT 进入病房：它对病人咨询、医生教育、学术和疾病管理的意义。

IF 3.7 2区医学

Current Opinion in Ophthalmology Pub Date : 2024-05-01 Epub Date: 2024-02-07 DOI: 10.1097/ICU.0000000000001036

Bita Momenaei, Hana A Mansour, Ajay E Kuriyan, David Xu, Jayanth Sridhar, Daniel S W Ting, Yoshihiro Yonekawa

{"title":"ChatGPT enters the room: what it means for patient counseling, physician education, academics, and disease management.","authors":"Bita Momenaei, Hana A Mansour, Ajay E Kuriyan, David Xu, Jayanth Sridhar, Daniel S W Ting, Yoshihiro Yonekawa","doi":"10.1097/ICU.0000000000001036","DOIUrl":"10.1097/ICU.0000000000001036","url":null,"abstract":"Purpose of review: This review seeks to provide a summary of the most recent research findings regarding the utilization of ChatGPT, an artificial intelligence (AI)-powered chatbot, in the field of ophthalmology in addition to exploring the limitations and ethical considerations associated with its application.Recent findings: ChatGPT has gained widespread recognition and demonstrated potential in enhancing patient and physician education, boosting research productivity, and streamlining administrative tasks. In various studies examining its utility in ophthalmology, ChatGPT has exhibited fair to good accuracy, with its most recent iteration showcasing superior performance in providing ophthalmic recommendations across various ophthalmic disorders such as corneal diseases, orbital disorders, vitreoretinal diseases, uveitis, neuro-ophthalmology, and glaucoma. This proves beneficial for patients in accessing information and aids physicians in triaging as well as formulating differential diagnoses. Despite such benefits, ChatGPT has limitations that require acknowledgment including the potential risk of offering inaccurate or harmful information, dependence on outdated data, the necessity for a high level of education for data comprehension, and concerns regarding patient privacy and ethical considerations within the research domain.Summary: ChatGPT is a promising new tool that could contribute to ophthalmic healthcare education and research, potentially reducing work burdens. However, its current limitations necessitate a complementary role with human expert oversight.","PeriodicalId":50604,"journal":{"name":"Current Opinion in Ophthalmology","volume":" ","pages":"205-209"},"PeriodicalIF":3.7,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139708420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0