Current Proteomics最新文献

{"title":"Critical Residues in HSP70 Nucleotide Binding Domain for Challenges in Drug Design","authors":"Mustafa Ergul, F. Aktan, Yusuf Tutar","doi":"10.2174/1570164618666210413111223","DOIUrl":"https://doi.org/10.2174/1570164618666210413111223","url":null,"abstract":"\u0000\u0000The association of a drug with its target protein correlates to its medicinal activity and the microenvironment plays a key role in this association. The key challenge is to identify mutations which unlikely to respond to designed drugs. \u0000\u0000\u0000\u0000 Hsp70 is an anti-apoptotic factor and tumor cells overexpress Hsp70 to survive against anti-cancer agents. The impact of pathogenic mutations on Hsp70 is unknown. Elucidation of these alterations is essential to understand the molecular switch mechanism. Thus, critical spots on Hsp70 Nucleotide Binding Domain (NBD) are important since mutation-driven sensitivity may be useful in designing innovative inhibitors. \u0000\u0000\u0000\u0000ATP, AMP-PNP (non-hydrolyzable analog of ATP) along with commercially available compounds VER-155008 (ATP analog and competitive inhibitor) and MKT-077 (allosteric inhibitor of ADP bound form) were docked to Hsp70 NBD structure in silico to identify critical amino acids of inhibition mechanism. Site-directed mutagenesis of the determined critical residues along with ATP hydrolysis and luciferase refolding were performed. Wild-type and mutant Hsp70s were compared to determine the effect on protein functions in the presence or the absence of inhibitors.\u0000\u0000\u0000\u0000This study identified three mutants that have a loss of function for Hsp70, which may alter the drug inhibition activity as oncogenic cells have multiple mutations. \u0000\u0000\u0000\u0000Two commercial inhibitors employed here that mimic ATP and ADP states respectively are not affected by these mutational perturbations and displayed effective interference for Hsp70 functions. Designing inhibitors by considering these critical residues may improve drug design and increase drug efficiency.\u0000","PeriodicalId":50601,"journal":{"name":"Current Proteomics","volume":"13 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2021-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89402095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytotoxic and Apoptotic Effect of Iris taochia Plant Extracts on Human Breast Cancer (MCF-7) Cells","authors":"Burak Yazgan, O. Ozcelik, A. Ayar, Gülin Renda, Tuba Yıldırım","doi":"10.2174/1570164618666210402152159","DOIUrl":"https://doi.org/10.2174/1570164618666210402152159","url":null,"abstract":"\u0000\u0000Iris taochia is an endemic plant in Turkey. Iris species has many biological effects such as antibacterial, antiinflammatory, antioxidant \u0000and anticancer properties. Apoptosis is a programmed cell death and this mechanism regulates the death of cancer cells. \u0000\u0000\u0000\u0000The aim of our work is to investigate how the Iris taochia extracts affect the apoptotic activity in the MCF7 cells. \u0000\u0000\u0000\u0000Cytotoxic dose and cell viability is determined by the MTT assay. Bad, Bax, Bcl-2, Bcl-W, Bid, Bim, Caspase 3, Caspase 8, CD40, CD40L, cIAP-2, CytoC, DR6, Fas, FasL, HSP27, HSP60, HSP70, HTRA, IGF-I, IGF-II, IGFBP-1, IGFBP-2, IGFBP-3, IGFBP-4, IGFBP-5, IGFBP-6, IGF-1sR, Livin, p21, p27, p53, SMAC, Survivin, sTNF-R1, sTNF-R2, TNF-α, TNF-β, TRAILR-1, TRAILR-2, TRAILR-3, TRAILR-4 and XIAP proteins were measured by the membrane array kit.\u0000\u0000\u0000\u0000Iris taochia extracts exhibited significant cytotoxic effects on MCF7 cells and IC50 values ranging from 1.56 to 100 μg/mL. Our results indicate that MeOH extract of Iris taochia in MCF7 cells may be a regulator of cell death proteins, cell cycle and growth factors. DCM and EtOH extracts of Iris taochia have a limited effect on MCF7 cells. Especially, HSPs, which play a significant role in chemoresistance downregulating DCM and EtOH extracts of Iris taochia, whereas ligands and receptors of extrinsic apoptotic pathway are upregulated by these extracts.\u0000\u0000\u0000\u0000This is the first study to investigate the cytotoxic and apoptotic effect of Iris taochia extracts on MCF7 cells. Results also showed that Iris taochia reduced cell viability and induced apoptotic pathways as a potential regulator of cancer cell death.\u0000","PeriodicalId":50601,"journal":{"name":"Current Proteomics","volume":"38 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2021-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77651414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"RNA-Seq Data Analysis Unveils Potential Conserved Micro-RNAs in Agave Deserti","authors":"B. Jabbar, Batcho Agossa Anicet, M. Sarwar, B. Rashid, S. Hassan, T. Husnain","doi":"10.2174/1570164617999200529122637","DOIUrl":"https://doi.org/10.2174/1570164617999200529122637","url":null,"abstract":"\u0000\u0000Exploring molecular mechanism of abiotic stress tolerance in plants is needed to\u0000overcome the deterioration of yield and quality of crop plants to meet the food security challenges\u0000of the growing population.\u0000\u0000\u0000\u0000MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate target\u0000gene expression for modulating plant growth, development, and response to different stresses.\u0000Agave belonging to CAM plants’ has remarkable tolerance to extreme conditions of drought and\u0000heat; however, molecular mechanisms underlying this excellence are yet to explore.\u0000\u0000\u0000\u0000This study applies comparative genomics approach on available Transcriptome (RNA-\u0000Seq) data of Agave deserti to identify potential miRNAs, and miRNA targets.\u0000\u0000\u0000\u0000Transcriptome datasets consisting of 128,869 Agave contigs was processed to create local\u0000database, for nucleotide homology analysis with 6,028 non-redundant plant miRNAs as query\u0000sequences. Protein coding sequences were removed, and potential pre-miRNA sequences were tested\u0000for stability analysis based on a variety of factors, including but not limited to %G+C content\u0000and minimum free energy (-ΔG), as a filter to remove pseudo pre-miRNAs.\u0000\u0000\u0000\u0000This study identified 30 unique miRNAs of Agave deserti harboring 14 different categories\u0000of precursors. Phylogenetic analysis revealed evolutionary relationship between newly identified\u0000pre-miRNAs with corresponding pre-miRNA homologues. Target genes of miRNAs were\u0000predicted subsequently, and possible functions were defined by functional annotation analysis.\u0000\u0000\u0000\u0000The results of this study will pave the way for further research, exploring the molecular\u0000mechanisms in Agave deserti and the role of miRNAs in gene regulation under abiotic stresses.\u0000","PeriodicalId":50601,"journal":{"name":"Current Proteomics","volume":"40 1","pages":"248-263"},"PeriodicalIF":0.8,"publicationDate":"2021-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85044840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protein aggregation and self assembly in Health and Disease","authors":"A. Basak, S. Basak","doi":"10.2174/1570164618666210223160742","DOIUrl":"https://doi.org/10.2174/1570164618666210223160742","url":null,"abstract":"\u0000\u0000Self-attachment of proteins leading to the formation of highly insoluble protein oligomers and aggregates has become an important focus of research owing to its diverse implications in pathophysiology and diseases. This has become a more frequent phenomenon in most neurological and neurodegenerative diseases as well as in dementia. In recent years such event of protein aggregation has linked to other disease conditions, disorders or adverse health conditions. Interestingly, aggregation of protein also plays role in development, growth or metabolism. Most often physiological proteins are initially bio-synthesised in native or nascent geometrical forms or conformations but later they undergo specific folding pattern and thereby acquire a stable configuration that is biologically relevant and active. It is highly important that these proteins remain in their biologically active configuration in order to exert their functional properties. Any alteration or change to this structural configuration can be detrimental to their specific functions and may cause pathological consequences leading to the onset of diseases or disorders. Several factors such as the action of chaperones, binding partners, physiological metal ions, pH level, temperature, ionic strength, interfacial exposure (solid-liquid, liquid-liquid, gas-liquid), mutation and post translational modification, chemical changes, interaction with small molecules such as lipids, hormones, etc. and solvent environment have been either identified or proposed as important factors in conferring the ultimate status of protein structure and configuration. \u0000Among many misfolding protein conformations, self-assembly or aggregation is the most significant. It leads to the formation of highly oligomeric self-aggregates that precipitate and interfere with many biochemical processes with serious pathological consequences. The most common implication of protein aggregation leading to the formation of deposits / plaques of various morphological types is the onset of neurological and neurodegenerative diseases that include Alzheimer’s, Parkinson’s, Huntington, ALS (Amyotrophic Lateral Sclerosis), CJD (Creutzfeldt Jakob Dementia), Prion diseases, Amyloidosis and other forms of dementia. However increasingly studies revealed that protein aggregation may also be associated with other diseases such as cancer, type 2 diabetes, renal, corneal and cardiovascular diseases. Protein aggregation diseases are now considered as part of “Proteinopathy” which refers to conditions where proteins become structurally abnormal or fail to fold into stable normal configurations. In this review, we reflect on various aspects of protein self-aggregation, potential underlying causes, mechanism, role of secondary structures, pathological consequences and possible intervention strategies as reported in published literatures. \u0000\u0000","PeriodicalId":50601,"journal":{"name":"Current Proteomics","volume":"26 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2021-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74040726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of Protein Structural Classes: Features Extraction to Classification Algorithm","authors":"Xiaoqing Liu, Zhenyu Yang, Yaoxin Wang, Qi Dai","doi":"10.2174/1570164618666210218141148","DOIUrl":"https://doi.org/10.2174/1570164618666210218141148","url":null,"abstract":"\u0000\u0000The fast growing of protein sequencing and protein structure data has promoted the development of the protein structural class prediction. Several prediction methods have been proposed to study protein folding rate, DNA binding sites, as well as reducing the search of conformational space and realizing the prediction of tertiary structure. This paper introduces the current approaches of protein structural class prediction and emphasize their steps from information extraction to classification algorithms.\u0000","PeriodicalId":50601,"journal":{"name":"Current Proteomics","volume":"16 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81812076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of proteins from putative human DNA and RNA viruses.","authors":"C. Polanco, V. Uversky, G. Vargas-Alarcón, T. Buhse, A. Huberman, M. Márquez, Leire Andrés","doi":"10.2174/1570164618666210212123850","DOIUrl":"https://doi.org/10.2174/1570164618666210212123850","url":null,"abstract":"\u0000\u0000 In the vast variety of viruses known, there is a particular interest in those transmitted to humans and whose ability to disseminate represents a significant public health issue. \u0000\u0000\u0000\u0000 The present study’s objective is to bioinformatically characterize the proteins of the two main divisions of viruses, RNA-viruses and DNA-viruses. \u0000\u0000\u0000\u0000\u0000In this work, a set of in-house computational programs was used to calculate the polarity/charge profiles and intrinsic disorder predisposition profiles of the proteins of several groups of viruses representing both types extracted from UniProt database. The efficiency of these computational programs was statistically verified. \u0000\u0000\u0000\u0000It was found that the polarity/charge profile of the proteins is, in most cases, an efficient discriminant that allows the re-creation of the taxonomy known for both viral groups. Additionally, the entire set of \"reviewed\" proteins in UniProt database was analyzed to find proteins with the polarity/charge profiles similar to those obtained for each viral group. This search revealed a substantial number of proteins with such polarity-charge profiles. \u0000\u0000\u0000\u0000Polarity/charge profile represents a physicochemical metric, which is easy to calculate, and which can be used to effectively identify viral groups from their protein sequences.\u0000\u0000","PeriodicalId":50601,"journal":{"name":"Current Proteomics","volume":"32 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2021-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88856858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The epidemiological and pangenome landscape of Staphylococcus aureus and identification of conserved novel candidate vaccine antigens","authors":"Kanwal Naz, Nimat Ullah, Anam Naz, Sidra Irum, H. Dar, Tahreem Zaheer, F. Shahid, Amjad Ali","doi":"10.2174/1570164618666210212122847","DOIUrl":"https://doi.org/10.2174/1570164618666210212122847","url":null,"abstract":"\u0000\u0000 Staphylococcus aureus (S. aureus) is a gram-positive bacterium and one of the major nosocomial pathogen. It has the ability to acquire resistance against almost all available classes of antibiotics; Methicillin-Resistant S. aureus (MRSA) is a well-known antibiotic resistance. S. aureus is a globally distributed pathogen that need in-depth epidemiological and genomic level investigation for proper treatment and prevention. \u0000\u0000\u0000\u0000 To explore the genomic epidemiology of S. aureus in-silico Multi Locus Sequence Typing (MLST) was carried out for 355 complete genomes. Diversity within the species was investigated through pan-genome analysis and subtractive genomic approach was employed for identification of core immunogenic targets. \u0000\u0000\u0000\u0000 Epidemiological study identified 62 different sequence types (STs) of S. aureus distributed worldwide, in which ST-8, ST-5, ST-398, ST-239, and ST-30 are the most dominant STs comprising more than 50% of the isolates. The pan-genome of S. aureus is still open with 7,199 genes and there is a major contribution (80%) of MRSA strains in the S. aureus species pangenome. The core genome (2,025 genes) of S. aureus is almost stable (comprises of 72% of S. aureus genome size) while accessory and unique genes (28% of S. aureus genome size) are gradually increasing. Screening of 2,025 core genes identified putative vaccine candidates. The best scoring and dominant B-cell and T-cell epitopes were predicted out of the selected potential vaccine candidate proteins with the help of a multi-step screening procedure. \u0000\u0000\u0000\u0000 We believe that the current study will provide insight into the genetic epidemiology and diversity of S. aureus and the predicted epitopes against the pathogen can be tested further for its immunological responses within the host and may provide both humoral and cellular immunity against the disease.\u0000","PeriodicalId":50601,"journal":{"name":"Current Proteomics","volume":"47 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2021-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85294841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective inhibition of mitochondrial metabolism by Cryptotanshinone in MDA-MB231 cells : A Proteomic Analysis","authors":"Jiefeng Zhou, Qingcao Li, Haoran Wu, Shin-Han Tsai, Yu-Ting Yeh","doi":"10.2174/1570164618666210208144542","DOIUrl":"https://doi.org/10.2174/1570164618666210208144542","url":null,"abstract":"\u0000\u0000\u0000Triple-negative breast cancer (TNBC) is a subtype of invasive cancer in breast with the symptoms of unfavourable prognosis and limited targeted treatment options. Evidence of changes in the metabolic status of TNBC, characterised by increased glycolysis, mitochondrial oxidative phosphorylation, as well as production and utilization of tricarboxylic acid cycle intermediates.\u0000\u0000\u0000\u0000\u0000Investigate the proteins altered in cryptotanshinone treated MDA-MB-231 cells and explore the key pathways and specific molecular markers involved in cryptotanshinone treatment.\u0000\u0000\u0000\u0000\u0000We use unlabeled quantitative proteomics to gain insight into the anticancer mechanism of cryptotanshinone on MDA-MB231 triple negative breast cancer cells. And flow cytometry was used to detect apoptosis and changes in cell mitochondrial membrane potential.\u0000\u0000\u0000\u0000\u0000We show that inhibiting the expression of electron transport chain complex proteins, also inhibits mitochondrial oxidative phosphorylation. Additionally, down-regulation of the ribosime biogenesis pathway was found to inhibit cell metabolism. \u0000\u0000\u0000\u0000\u0000In summary, results show that cryptotanshinone can trigger rapid and irreversible apoptosis in MDA-MB-231 cells through effectively inhibiting cell metabolism.\u0000\u0000","PeriodicalId":50601,"journal":{"name":"Current Proteomics","volume":"18 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2021-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74116868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression Analysis of 4-Hydroxynonenal Modified Proteins in Schizophrenia Brain; Relevance to Involvement in Redox Dysregulation","authors":"S. Manzoor, A. Khan, Beena Hasan, Shamim Mushtaq, N. Ahmed","doi":"10.2174/1570164618666210121151004","DOIUrl":"https://doi.org/10.2174/1570164618666210121151004","url":null,"abstract":"Oxidative damage contributes to the pathophysiology of schizophrenia (SZ). Redox imbalance may\u0000lead to increased lipid peroxidation, which produces toxic aldehydes like 4-hydroxynonenal (4-HNE) ultimately leading to\u0000oxidative stress. Conversely, implications of oxidative stress points towards an alteration in HNE-protein adducts and\u0000activities of enzymatic and antioxidant systems in schizophrenia.\u0000\u0000\u0000\u0000Present study focuses on identification of HNE-protein adducts and its related molecular consequences in\u0000schizophrenia pathology due to oxidative stress, particularly lipid peroxidation.\u0000\u0000\u0000\u0000 Oxyblotting was performed on seven autopsied brain samples each from cortex and hippocampus\u0000region of schizophrenia patients and their respective normal healthy controls. Additionally, thiobarbituric acid substances\u0000(TBARS), reduced glutathione (GSH) levels and catalase (CAT) activities associated with oxidative stress, were also\u0000estimated.\u0000\u0000\u0000\u0000Obtained results indicates substantially higher levels of oxidative stress in schizophrenia patients than healthy\u0000control group represented by elevated expression of HNE-protein adducts. Interestingly, hippocampus region of\u0000schizophrenia brain shows increased HNE protein adducts compared to cortex. An increase in catalase activity (4.8876 ±\u00001.7123) whereas decrease in antioxidant GSH levels (0.213 ± 0.015µmol/ml) have been observed in SZ brain. Elevated\u0000TBARS level (0.3801 ± 0.0532ug/ml) were obtained in brain regions SZ patients compared with their controls that reflects\u0000an increased lipid peroxidation (LPO).\u0000\u0000\u0000\u0000Conclusion: We propose the role of HNE modified proteins possibly associated with the pathology of\u0000schizophrenia. Our data revealed increase lipid peroxidation as a consequence of increased TBARS production.\u0000Furthermore, altered cellular antioxidants pathways related to GSH and CAT also highlight the involvement of oxidative\u0000stress in schizophrenia pathology.","PeriodicalId":50601,"journal":{"name":"Current Proteomics","volume":"141 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2021-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80061153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic Technologies and their Application for Ensuring Meat Quality, Safety and Authenticity","authors":"R. Banerjee, N. B. Maheswarappa, K. Mohan, S. Biswas, S. Batabyal","doi":"10.2174/1570164618666210114113306","DOIUrl":"https://doi.org/10.2174/1570164618666210114113306","url":null,"abstract":"\u0000\u0000Proteomic tools were extensively used to understand the relationship between muscle proteome and conversion of\u0000muscle to meat, post-mortem proteolysis, meat texture, and variation in meat color. Developments in proteomic tools have\u0000also resulted in their application for addressing the safety and authenticity issues including meat species identification,\u0000detection of animal by-products, non-meat ingredients and tissues in meat products, traceability, identification of genetically\u0000modified ingredients, chemical residues and other harmful substances. Proteomic tools are also being used in some of the\u0000potential areas like understanding the effect of animal transportation, stunning, slaughter stress, halal authentication and\u0000issues related to animal welfare. Emerging advances in proteomic and peptidomic technologies and their application in\u0000traceability, meat microbiology, safety and authentication is taking a major stride as an interesting and complementary\u0000alternative to DNA based methods currently in use. Future research in meat science need to be linked to emerging\u0000metabolomic, lipidomic and other omic technologies for ensuring integrated meat quality and safety management. In this\u0000paper, a comprehensive overview of the use of proteomics for the assessment of quality and safety in meat value chain and\u0000their potential application is discussed.\u0000","PeriodicalId":50601,"journal":{"name":"Current Proteomics","volume":"96 1","pages":""},"PeriodicalIF":0.8,"publicationDate":"2021-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75238463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}