Pietro Costantini, Francesca Coraducci, Giulia De Zan, Damiano Fedele, Eleonora Ostillio, Riccardo Bertozzi, Federico Donato, Giuseppe Muscogiuri, Anna Giulia Pavon, Luca Bergamaschi, Carmine Pizzi, Astrid Hendriks, Anneline S. J. M. te Riele, Dominika Suchá, Sophie Rier, Pim van der Harst, Birgitta Velthuis, Ivo van der Bilt, Anna Colarieti, Alessandro Carriero, Marco Guglielmo
{"title":"Ablation of Ventricular and Atrial Arrhythmias in the Era of Cardiac Magnetic Resonance","authors":"Pietro Costantini, Francesca Coraducci, Giulia De Zan, Damiano Fedele, Eleonora Ostillio, Riccardo Bertozzi, Federico Donato, Giuseppe Muscogiuri, Anna Giulia Pavon, Luca Bergamaschi, Carmine Pizzi, Astrid Hendriks, Anneline S. J. M. te Riele, Dominika Suchá, Sophie Rier, Pim van der Harst, Birgitta Velthuis, Ivo van der Bilt, Anna Colarieti, Alessandro Carriero, Marco Guglielmo","doi":"10.1111/echo.70150","DOIUrl":"https://doi.org/10.1111/echo.70150","url":null,"abstract":"<p>In the past decade, cardiac magnetic resonance (CMR) has undergone remarkable progress, emerging as a pivotal tool in various cardiological scenarios. Its capacity for tissue characterization, both with and without contrast agents, makes CMR the perfect tool to study the substrate of arrhythmia. This review highlights the potential role of CMR in electrophysiology (EP) and its role in the ablation of atrial and ventricular arrhythmias. First, we will discuss the key aspects of ventricular arrhythmia ablation, while in the second part, we will review how CMR is changing the ablation of atrial arrhythmias. The potentiality of CMR in the pre-procedural, intra-procedural, and post-ablation assessment will be reviewed. In particular, CMR is capable of visualizing fibrosis and building 3D reconstruction. Furthermore, it is possible to merge a 3D-rendered shell of the heart into the EP room to guide radiation-free ablation through active or passive tracking. Finally, the accuracy of CMR in depicting ablation lesions and its ability to predict arrhythmia relapses will be discussed.</p>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/echo.70150","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rheumatoid Inflammation Causing Aortic Valve Perforation","authors":"Neeta Bachani, Rashmi Rao, Neha Arora, Pradeep Vaideeswar, Kunal Sinkar, Jaipal Jadwani","doi":"10.1111/echo.70145","DOIUrl":"https://doi.org/10.1111/echo.70145","url":null,"abstract":"<p>An elderly woman with rheumatoid arthritis presented with progressive dyspnea. Transoesophageal echocardiography revealed severe aortic regurgitation with perforation of the non-coronary and left coronary leaflet. After stabilization and a week of antibiotic therapy, aortic valve replacement was performed. The valve histology showed palisading granulomas typical of rheumatoid etiology.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Large Subcutaneous Mass Adjacent to the Left Ventricular Apex","authors":"Tomomi Miyamoto, Michiyo Yamano, Kazuki Maeda, Mayumi Takeoka, Sakiko Honda, Tatsuya Kawasaki","doi":"10.1111/echo.70149","DOIUrl":"https://doi.org/10.1111/echo.70149","url":null,"abstract":"<p>Two-dimensional speckle tracking helped determine whether the tumor adjacent to the left ventricular apex had infiltrated the pericardium. The peak strain value remains unaffected, although the peak timing in the area adjacent to the tumor is delayed. Consequently, the tumor was determined not to have infiltrated the pericardium.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"How to Decide Right Heart Function After Left Ventricular Assist Device?","authors":"Jia-Ling Lin, Chih-Hsin Hsu","doi":"10.1111/echo.70152","DOIUrl":"https://doi.org/10.1111/echo.70152","url":null,"abstract":"","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143761884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Echocardiography and the Unmet Clinical Needs in Chronic Heart Failure","authors":"Massimo Iacoviello","doi":"10.1111/echo.70141","DOIUrl":"https://doi.org/10.1111/echo.70141","url":null,"abstract":"","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Congenital Atresia of the Left Main Coronary Artery: Multiple Imaging Diagnosis of a Rare Coronary Anomaly","authors":"Mei Wu, Juan Xia, Yafeng He, Xiaojing Ma","doi":"10.1111/echo.70142","DOIUrl":"https://doi.org/10.1111/echo.70142","url":null,"abstract":"<div>\u0000 \u0000 <p>Left main coronary artery atresia (LMCAA) is a rare congenital coronary anomaly and sometimes presents with non-specific clinical symptoms that make the diagnosis challenging. We are presenting an interesting case that required multimodality imaging to establish the diagnosis.</p>\u0000 </div>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical Study of Post-Chemotherapy Cardiotoxicity in Breast Cancer Patients Based on Ultrasound Radiomics","authors":"Caiyun Xia, Shutian Wu, Yuxin Zhong, Jiangtao Wang, Alin Yao, Biaohu Liu","doi":"10.1111/echo.70136","DOIUrl":"https://doi.org/10.1111/echo.70136","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>The aim of this study is to develop and validate a combined model based on ultrasound radiomics to detect cardiotoxicity after chemotherapy in patients with breast cancer.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this paper, we included 208 patients with breast cancer diagnosed pathologically and after chemotherapy, of whom had high-quality echocardiographic images; among them, 105 cases experienced cardiotoxicity, while 103 cases did not, which were divided into a training set and a validation set using a wholly randomized method according to a ratio of 7:3. Then, the left ventricular myocardium in the parasternal long-axis view of echocardiography was manually traced, the myocardial features of each image were extracted and filtered, and then a radiomics model was established; lastly, we plotted the receiver operating characteristic (ROC) curve; calculated the area under the curve (AUC); and assessed the diagnostic performance of the model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The AUC of the combined model in the training set was 0.88 (95%CI,0.828–0.936), which was higher than the clinical model at 0.73 (95%CI,0.646–0.807) and the radiomics model at 0.84 (95%CI,0.774–0.903). In the validation set, the AUC of the combined model was 0.87 (95%CI,0.783–0.959), which was higher than the clinical model at 0.75 (95%CI,0.631–0.877) and the radiomics model at 0.81 (95%CI,0.698–0.917). The combined model of the training group and the validation group had statistical significance compared to both the clinical model and the radiomics model (<i>Z</i> = −4.066, <i>p</i> < 0.001; <i>Z</i> = −1.977, <i>p</i> = 0.048); (<i>Z</i> = −1.986, <i>p</i> = 0.047; <i>Z</i> = −2.142, <i>p</i> = 0.032). Meanwhile, the results of Hosmer–Lemeshow goodness-of-fit test were favorable (the training group: <i>X</i><sup>2</sup> = 6.776, <i>p</i> = 0.561; the validation group: <i>X</i><sup>2</sup> = 11.949, <i>p</i> = 0.154).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The combined model based on radiomics is an effective tool for the early diagnosis of cardiac toxicity in breast cancer patients after chemotherapy. It helps to detect cardiotoxicity of breast cancer patients during chemotherapy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Li Yu, Zurong Yang, Zhang Ming, Qichang Zhou, Shi Zeng
{"title":"Impaired Aortic Biomechanical Properties in Patients With Severe Obstructive Sleep Apnea Syndrome","authors":"Li Yu, Zurong Yang, Zhang Ming, Qichang Zhou, Shi Zeng","doi":"10.1111/echo.70135","DOIUrl":"https://doi.org/10.1111/echo.70135","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Evaluating the biomechanical properties of the aorta is crucial for assessing cardiovascular risk and preventing disease progression. The aim of this study was to evaluate the biomechanical properties of the ascending aorta (AA) in severe obstructive sleep apnea syndrome (OSAS) patients with or without hypertension (HT) via velocity vector imaging (VVI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 68 patients with severe OSAS were selected, 35 of whom were included in the simple OSAS group and 33 of whom were included in the OSAS + HT group, and 40 volunteers without these two disorders who were taken as the control group. AA biomechanical properties, that is, AA longitudinal strain (ALS), AA circumferential strain (ACS), and fractional area change (FAC), were evaluated via VVI. Pulsed Doppler early transmitral peak flow velocity (E), early diastolic mitral annular velocity (e’), left ventricular (LV) global longitudinal strain (GLS), and the AA dimension (AD) were also measured.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>ALS (mean ± SD; 32.8% ± 11.9% and 19.7% ± 7.6% vs. 40.6% ± 15.6%, <i>p</i> = 0.006), ACS (mean ± SD; 11.8% ± 3.5% and 8.6% ± 2.7% vs. 16.5% ± 5.8%, <i>p</i> = 0.02), and FAC (mean ± SD; 21.0% ± 5.3% and 12.4% ± 3.8% vs. 32.8% ± 9.7%, <i>p</i> = 0.004) were significantly lower in the patient groups (OSAS and OSAS + HT, respectively) than in the control group. LV systolic and diastolic functions were also impaired in the patient groups. Compared with volunteers without OSAS and HT, these patients had a greater AD and E/e’ ratio and a lower GLS (<i>p</i> < 0.01). The aortic biomechanical properties were strongly correlated with the LV function and sleep parameters.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>AA biomechanical properties are impaired in patients with severe OSAS, especially those with HT. Impairments in these aortic biomechanical properties are associated with diminished LV function and abnormal sleep parameters. This discovery may help clinicians identify and manage potential cardiovascular risks in OSAS patients. Further large-scale longitudinal studies are needed to confirm the potential predictive value of aortic events (e.g., aortic aneurysm or dissection) in patients with OSAS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Meta-Analysis of the Association Between Left-Ventricular Late Gadolinium Enhancement on Cardiac MRI and Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy","authors":"Jiantao Song, Peng Chen, Xiangyue Pan, Bo Chen, Jianhui Zang, Junjie Zhang","doi":"10.1111/echo.70144","DOIUrl":"https://doi.org/10.1111/echo.70144","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Atrial fibrillation (AF) is a common complication in individuals with hypertrophic cardiomyopathy (HCM), associated closely with myocardial fibrosis. Late gadolinium enhancement (LGE) detected by cardiac magnetic resonance (CMR) imaging is a marker of myocardial fibrosis and may indicate an increased risk of AF. This meta-analysis was performed to investigate the relationship between left ventricular (LV)-LGE and the occurrence of AF in patients with HCM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A comprehensive search of the PubMed, Embase, and Web of Science databases was conducted to identify observational studies in which the prevalence or incidence of AF in patients with HCM with and without LV-LGE was compared. Random-effects models were employed to calculate pooled odds ratios (ORs) and mean differences (MDs), accounting for potential heterogeneity across studies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fourteen reports of 15 observational studies performed with 4 947 patients with HCM were included. The pooled results revealed that CMR-detected LV-LGE was associated with a significantly greater risk of AF (OR, 1.97; 95% confidence interval [CI] 1.41–2.75; <i>p</i> < 0.001, <i>I</i><sup>2</sup> = 60%). Subgroup analyses yielded consistent results across study designs, patient ages, sex distributions, analytical models, and study quality scores. Based on data from six studies in which it was reported, the extent of LV-LGE was greater in patients with AF than in those without AF (MD, 2.83%; 95% CI, 0.69–4.97; <i>p</i> = 0.01, <i>I</i><sup>2</sup> = 66%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>CMR-detected LV-LGE is associated with a heightened AF risk in patients with HCM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>CRD42024621359</p>\u0000 </section>\u0000 </div>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Li Li, Zhiming Jiang, Liangyi Li, Na Yi, Linlin Chen, Linzi Li
{"title":"Impact of Various Doses of Dobutamine on Myocardial Viability and the Effects of β-Blockers in Patients With Ischemic Cardiomyopathy: An Assessment Using Stress Echocardiography","authors":"Li Li, Zhiming Jiang, Liangyi Li, Na Yi, Linlin Chen, Linzi Li","doi":"10.1111/echo.70134","DOIUrl":"https://doi.org/10.1111/echo.70134","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study aimed to investigate the predictive value of dobutamine stress echocardiography (DSE) at varying doses for myocardial viability, with a particular emphasis on the impact of <i>β</i>-adrenergic blockers on myocardial viability in patients with ischemic cardiomyopathy (ICM).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>A total of 189 patients with ICM underwent DSE. Based on the dosage of dobutamine, patients were randomly divided into three groups: low-dose group (LD, 10 µg/kg/min, <i>n</i> = 63), medium-dose group (CD, 20 µg/kg/min, <i>n</i> = 63), and high-dose group (HD, 30 µg/kg/min, <i>n</i> = 63). All patients received <i>β</i>-blockers 1 min after the DSE examination. Changes in heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), radial strain (RS), and radial strain rate (RSr) during left ventricular systole (LVS) were analyzed, along with secondary effects and myocardial viability in the LD-β, CD-β, and HD-β groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>During the postoperative dobutamine injection, HR, SBP, and DBP in the LD, CD, and HD groups were significantly higher compared to pre-injection levels (<i>p </i>< 0.05), with DBP in the HD group being notably higher than in the LD and CD groups (<i>p </i>< 0.05). After intravenous injection of metoprolol, all indicators significantly decreased in the LD and CD groups (<i>p </i>< 0.05). The rates of RS and RSr in the CD and HD groups were significantly lower than those in the LD group (<i>p </i>< 0.05). The proportion of normal wall motion viability (VWM) post-injection was significantly higher than pre-injection levels (<i>p </i>< 0.05), with the CD group surpassing the LD group (<i>p </i>< 0.05). The use of <i>β</i>-adrenergic blockers demonstrated that the sensitivity, specificity, and accuracy of myocardial viability in the LD, CD, and HD groups were all superior to those of the control group (<i>p </i>< 0.05), with the CD group exhibiting the highest diagnostic performance (<i>p </i>< 0.05). The incidence of arrhythmias in the HD group was 20.3%, compared to 7.9% in the LD group (χ<sup>2</sup> = 6.78, <i>p</i> = 0.034). Additionally, the occurrence of cardiovascular events in the HD group was 17.2%, significantly higher than the 6.3% observed in the LD group (χ<sup>2</sup> = 6.21, <i>p</i> = 0.045).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Moderate-dose DSE exhibited the optimal diagnostic performance in assessing myocardial viability in patients with ICM. Furthermore, the use of <i>β</i>-blockers effectively enhances the sensitivity and ","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143726872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}