Two-Dimensional Speckle Tracking During Dobutamine Stress Echocardiography Versus Myocardial Perfusion Imaging by Single Photon Emission Computed Tomography in Patients With Suspected Coronary Artery Disease

IF 1.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques Pub Date : 2025-06-17 DOI:10.1111/echo.70221

Mostafa El Mokadem, Mohammad Noureldin, Talaat Saeed Badr, Yasser A. Abdelhady

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引用次数: 0

Abstract

Background

Coronary artery disease (CAD) is one of the causes of morbidity and death worldwide. Recently, speckle tracking technologies allowed the assessment of the strain of each myocardial segment in an automated method that may decrease inter-operator variability.

Objective

To compare the effectiveness of two-dimensional speckle tracking global longitudinal strain (GLS) during dobutamine stress echocardiography (DSE) with myocardial perfusion imaging (MPI) using single photon emission computed tomography (MPI SPECT) in the diagnosis of CAD.

Methods

A cross-sectional study was conducted involving 103 patients with CAD suspicion. Each participant underwent MPI SPECT and GLS measurements at rest and during peak dobutamine stress. The outcomes from GLS-DSE and MPI SPECT were then compared against the results of ICA as the reference standard for diagnosis.

Results

The mean age of included patients was 57.79 ± 8.08 years. The MPI-SPECT defect size results demonstrated a highly significant (p value < 0.001) and strong positive correlation with the number of affected vessels in invasive coronary angiography (ICA). The sensitivity and specificity of the MPI SPECT were 90.62% and 92.96%, respectively, with a PPV of 85.29% and an NPV of 95.65%. Additionally, a highly significant (p value < 0.001) and strong negative correlation was observed between GLS values at peak DSE and the number of affected vessels in ICA. GLS at peak DSE had 78.12% sensitivity and 88.73% specificity with PPV 75.76% and NPV 90%.

Conclusion

GLS at peak DSE looks to be another noninvasive tool for the assessment of patients with suspected CAD, with the benefits of being a quick, non-expensive, and radiation-free test.

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疑似冠状动脉疾病患者多巴酚丁胺应激超声心动图与单光子发射计算机断层扫描心肌灌注成像的二维斑点跟踪

冠状动脉疾病（CAD）是世界范围内发病率和死亡率最高的疾病之一。最近，斑点跟踪技术允许在自动化方法中评估每个心肌节段的应变，这可能会减少操作员之间的可变性。目的比较多巴酚丁胺应激超声心动图（DSE）二维散斑跟踪全局纵向应变（GLS）与单光子发射计算机断层扫描（MPI SPECT）心肌灌注成像（MPI）对冠心病的诊断价值。方法对103例疑似冠心病患者进行横断面研究。每个参与者在休息和多巴酚丁胺应激峰值时进行MPI SPECT和GLS测量。然后将GLS-DSE和MPI SPECT的结果与ICA的结果作为诊断的参考标准进行比较。结果患者平均年龄57.79±8.08岁。MPI-SPECT缺陷尺寸结果显示出高度显著(p值<；0.001)，且与有创冠状动脉造影（ICA）中受累血管的数量呈正相关。MPI SPECT的敏感性和特异性分别为90.62%和92.96%，PPV为85.29%，NPV为95.65%。此外，p值<；0.001)， DSE峰值GLS值与ICA病变血管数量呈显著负相关。DSE峰值GLS的敏感性为78.12%，特异性为88.73%，PPV为75.76%，NPV为90%。结论DSE峰值GLS是评估疑似CAD患者的另一种无创工具，具有快速、不昂贵和无辐射的优点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques 医学-心血管系统

CiteScore

2.40

自引率

6.70%

发文量

211

审稿时长

3-6 weeks

期刊介绍： Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques is the official publication of the International Society of Cardiovascular Ultrasound. Widely recognized for its comprehensive peer-reviewed articles, case studies, original research, and reviews by international authors. Echocardiography keeps its readership of echocardiographers, ultrasound specialists, and cardiologists well informed of the latest developments in the field.