Tommaso Recchioni, Alexandra Mihai, Giovanna Manzi, Carmine Dario Vizza
{"title":"TAPSE/sPAP and Inferior Vena Cava as a Risk Stratification Model in PAH: When the Pipe and Pump Are Not Enough","authors":"Tommaso Recchioni, Alexandra Mihai, Giovanna Manzi, Carmine Dario Vizza","doi":"10.1111/echo.70162","DOIUrl":"https://doi.org/10.1111/echo.70162","url":null,"abstract":"","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"What Is the Optimal Measurement Method for CT-Derived Fractional Flow Reserve?","authors":"Nobuo Tomizawa","doi":"10.1111/echo.70161","DOIUrl":"https://doi.org/10.1111/echo.70161","url":null,"abstract":"","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katy K. Tsai, Andrew Y. Chang, Christiane M. Abouzeid, Mandar A. Aras, Qizhi Fang, Dwight Bibby, Leila Haghighat, Joan F. Hilton, Adil I. Daud, Nelson B. Schiller
{"title":"Longitudinal Evaluation of Immune Checkpoint Inhibitor-Induced Fatigue Syndrome by Rest, Stress, and Speckle-Tracking Strain Echocardiography","authors":"Katy K. Tsai, Andrew Y. Chang, Christiane M. Abouzeid, Mandar A. Aras, Qizhi Fang, Dwight Bibby, Leila Haghighat, Joan F. Hilton, Adil I. Daud, Nelson B. Schiller","doi":"10.1111/echo.70158","DOIUrl":"https://doi.org/10.1111/echo.70158","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Immune checkpoint inhibitor (ICI) anti-tumor therapy is commonly associated with reports of significant fatigue. Whether ICI-induced fatigue is linked to subclinical cardiac toxicity is not well understood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We performed a prospective observational study to monitor cardiac function following initiation of ICI in cancer patients. Rest and staged exercise stress transthoracic echocardiograms (TTE) were captured at baseline, 3 and 6 months after ICI initiation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirteen patients completed baseline testing, of whom 10 completed 3 month testing and 8 completed 6 month testing. Patients had elevated fatigue as per Common Terminology Criteria for Adverse Events (CTCAE) criteria and FACIT-Fatigue subscale scores (47.5 [42.5–52] vs. 47 [38–48], <i>p</i> = 0.001). Among resting echocardiographic parameters, left ventricular (LV) outflow tract velocity time integral (VTI) was reduced at 6 months (22.6 cm [21.2–24.5] vs. 19.8 cm [17.2–21.2], <i>p</i> = 0.001), albeit still within normal range. Measures of biventricular size and systolic function, along with LV global longitudinal strain (GLS) and LA global strain, were not significantly changed. Among exercise parameters, peak heart rate was reduced at 6 months (143.4 bpm [128.5–153.5] vs. 123.5 [110.2–130.8], <i>p</i> = 0.048); of those who completed 6 month testing, two (29%) were unable to achieve the previous peak stage of exercise.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In patients starting ICI, statistically-significant reductions in cardiac systolic function (LVOT VTI) and peak HR were observed, with nearly one-third unable to achieve peak exercise at 6 months. This finding, combined with reported fatigue and lack of changes to biventricular systolic functional measures, suggests induced functional cardiac limitations are due to deconditioning, rather than cardiotoxicity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jun Li, Mingliang Dong, Zhenyun Sun, Qiao Li, Shouxiang Ni
{"title":"Tricuspid Regurgitation: Knowledge of Tricuspid Valve Morphology, Etiology of Regurgitation, and Grading of Regurgitation Severity","authors":"Jun Li, Mingliang Dong, Zhenyun Sun, Qiao Li, Shouxiang Ni","doi":"10.1111/echo.70147","DOIUrl":"https://doi.org/10.1111/echo.70147","url":null,"abstract":"<div>\u0000 \u0000 <p>With the aging of the population, the number of patients with tricuspid regurgitation (TR) is increasing. Severe TR is associated with global morbidity and mortality of cardiovascular events. In recent years, the rapid development of transcatheter interventions for tricuspid valve disease has made TR a current research hotspot. More preoperative information about the patient's tricuspid valve anatomy, the etiology leading to TR, and the severity of TR will aid in intraoperative maneuvers and postoperative prognosis assessments.</p>\u0000 </div>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Christina Karamarkou, Mehran Babady, Charalampia Maltsinioti, Oliver Bruder
{"title":"Update on Imaging in Hypertrophic Cardiomyopathy","authors":"Christina Karamarkou, Mehran Babady, Charalampia Maltsinioti, Oliver Bruder","doi":"10.1111/echo.70146","DOIUrl":"https://doi.org/10.1111/echo.70146","url":null,"abstract":"<div>\u0000 \u0000 <p>Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disorder associated with significant morbidity and mortality. This review highlights the essential role of multimodal imaging—transthoracic echocardiography (TTE), cardiac magnetic resonance (CMR), and cardiac computed tomography (CCT)—in the diagnosis, risk stratification, and management of HCM. TTE remains the first-line tool, while advanced techniques like CMR and CCT offer enhanced accuracy in tissue characterization, fibrosis detection, and procedural planning. By integrating these imaging modalities, clinicians can adopt a precision medicine approach, enabling tailored treatment strategies that address individual patient needs. This comprehensive use of imaging not only enhances clinical decision-making but also holds the potential to improve long-term outcomes for patients with HCM.</p>\u0000 </div>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unseen Window: Incidental Detection of Aortopulmonary Window in Tetralogy of Fallot: A Case Report","authors":"Omer Mohammed Mujahid, Sambhunath Das, Vishnu Anandan, Arjun Joshi, Amitabh Satsangi","doi":"10.1111/echo.70153","DOIUrl":"https://doi.org/10.1111/echo.70153","url":null,"abstract":"<div>\u0000 \u0000 <p>Aortopulmonary window with Tetralogy of Fallot is a rare cardiac defect with very few reported cases in literature. We report an incidentally detected type 1 aortopulmonary window during routine intraoperative transesophageal echocardiography, which helped to tailor the anesthetic and surgical plan for better post-operative outcome.</p>\u0000 </div>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143801310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shanshan Li, Yanxiang Wu, Jingya Li, Yawen Deng, Liyuan Xu, Jiao Yang, Ruijuan Su, Ning Ma
{"title":"Longitudinal Trajectory of Left Ventricular Systolic Function in Children During Anthracycline-Based Chemotherapy Assessed by Noninvasive Myocardial Work","authors":"Shanshan Li, Yanxiang Wu, Jingya Li, Yawen Deng, Liyuan Xu, Jiao Yang, Ruijuan Su, Ning Ma","doi":"10.1111/echo.70151","DOIUrl":"https://doi.org/10.1111/echo.70151","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Noninvasive myocardial work (MW), which incorporates myocardial deformation and blood pressure, can be used to quantitatively evaluate left ventricular (LV) systolic function in children undergoing chemotherapy. However, the trajectories of MW indices (MWIs) in children during anthracycline-based chemotherapy remain unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the longitudinal trajectories of MWIs during anthracycline-based chemotherapy and compare the relative changes between MWIs and conventional echocardiographic parameters.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and Results</h3>\u0000 \u0000 <p>We retrospectively analyzed 441 echocardiograms from 102 children (median age, 7 years; 72 boys) with cancer who received anthracycline-based treatment. Conventional echocardiographic parameters (LV ejection fraction [LVEF] and global longitudinal strain [GLS]) and MWIs (global work index [GWI], global constructive work [GCW], global work efficiency [GWE], and global wasted work [GWW]) were obtained using GE EchoPAC software. The Mantel–Haenszel Chi-squared test revealed that GLS, GWI, GCW, and GWE all worsened during chemotherapy (all <i>p</i> < 0.05 for trend), with this deterioration appearing when the cumulative dose of anthracyclines reached 30–60 mg/m<sup>2</sup>. However, no significant trends were observed for LVEF and GWW (both <i>p</i> > 0.05 for trend). The linear mixed models indicated that GLS and GWE exhibited a consistent downward trend, whereas GWI and GCW experienced a plateau phase within the cumulative anthracycline dose range of 100–250 mg/m<sup>2</sup>. The relative changes in GWI and GCW were greater than those of GLS and GWE throughout chemotherapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Echocardiographic MW could provide a more sensitive assessment of anthracycline-induced cardiotoxicity (AIC) in children, allowing timely chemotherapy adjustment or cardioprotective measures to prevent cardiac dysfunction.</p>\u0000 </section>\u0000 </div>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143786968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alejandra Robles-Nava, Gabriela Melendez-Ramirez, Xochitl A. Ortiz-Leon, Rodriguez-Zanella Hugo, Jose A. Arias-Godinez, Edith L. Posada-Martinez, Maria E. Ruiz-Esparza, Jose R. Cruz-Mendoza, Juan F. Fritche-Salazar
{"title":"Adult Patient With Systolic Murmur: An Unexpected Diagnosis of Congenital Heart Disease","authors":"Alejandra Robles-Nava, Gabriela Melendez-Ramirez, Xochitl A. Ortiz-Leon, Rodriguez-Zanella Hugo, Jose A. Arias-Godinez, Edith L. Posada-Martinez, Maria E. Ruiz-Esparza, Jose R. Cruz-Mendoza, Juan F. Fritche-Salazar","doi":"10.1111/echo.70159","DOIUrl":"https://doi.org/10.1111/echo.70159","url":null,"abstract":"<div>\u0000 \u0000 <p>We present a case of a 50-year-old male patient with shortness of breath and progressive edema. Echocardiography demonstrated dilation of the four cavities, left ventricular dysfunction, and a patent arterial duct (PDA) with systolic predominant flow due to pulmonary hypertension. Cardiac magnetic resonance imaging (MRI) confirmed the PDA. This case is of particular interest since the typical continuous heart murmur found in PDA is lost due to equalization of the diastolic pressure between the pulmonary and aortic circulation.</p>\u0000 </div>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143786969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pietro Costantini, Francesca Coraducci, Giulia De Zan, Damiano Fedele, Eleonora Ostillio, Riccardo Bertozzi, Federico Donato, Giuseppe Muscogiuri, Anna Giulia Pavon, Luca Bergamaschi, Carmine Pizzi, Astrid Hendriks, Anneline S. J. M. te Riele, Dominika Suchá, Sophie Rier, Pim van der Harst, Birgitta Velthuis, Ivo van der Bilt, Anna Colarieti, Alessandro Carriero, Marco Guglielmo
{"title":"Ablation of Ventricular and Atrial Arrhythmias in the Era of Cardiac Magnetic Resonance","authors":"Pietro Costantini, Francesca Coraducci, Giulia De Zan, Damiano Fedele, Eleonora Ostillio, Riccardo Bertozzi, Federico Donato, Giuseppe Muscogiuri, Anna Giulia Pavon, Luca Bergamaschi, Carmine Pizzi, Astrid Hendriks, Anneline S. J. M. te Riele, Dominika Suchá, Sophie Rier, Pim van der Harst, Birgitta Velthuis, Ivo van der Bilt, Anna Colarieti, Alessandro Carriero, Marco Guglielmo","doi":"10.1111/echo.70150","DOIUrl":"https://doi.org/10.1111/echo.70150","url":null,"abstract":"<p>In the past decade, cardiac magnetic resonance (CMR) has undergone remarkable progress, emerging as a pivotal tool in various cardiological scenarios. Its capacity for tissue characterization, both with and without contrast agents, makes CMR the perfect tool to study the substrate of arrhythmia. This review highlights the potential role of CMR in electrophysiology (EP) and its role in the ablation of atrial and ventricular arrhythmias. First, we will discuss the key aspects of ventricular arrhythmia ablation, while in the second part, we will review how CMR is changing the ablation of atrial arrhythmias. The potentiality of CMR in the pre-procedural, intra-procedural, and post-ablation assessment will be reviewed. In particular, CMR is capable of visualizing fibrosis and building 3D reconstruction. Furthermore, it is possible to merge a 3D-rendered shell of the heart into the EP room to guide radiation-free ablation through active or passive tracking. Finally, the accuracy of CMR in depicting ablation lesions and its ability to predict arrhythmia relapses will be discussed.</p>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/echo.70150","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143787314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Rheumatoid Inflammation Causing Aortic Valve Perforation","authors":"Neeta Bachani, Rashmi Rao, Neha Arora, Pradeep Vaideeswar, Kunal Sinkar, Jaipal Jadwani","doi":"10.1111/echo.70145","DOIUrl":"https://doi.org/10.1111/echo.70145","url":null,"abstract":"<p>An elderly woman with rheumatoid arthritis presented with progressive dyspnea. Transoesophageal echocardiography revealed severe aortic regurgitation with perforation of the non-coronary and left coronary leaflet. After stabilization and a week of antibiotic therapy, aortic valve replacement was performed. The valve histology showed palisading granulomas typical of rheumatoid etiology.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":50558,"journal":{"name":"Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques","volume":"42 4","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}