{"title":"Global seroprevalence of hepatitis E among people living with HIV: a systematic review and meta-analysis.","authors":"Mariana Cavalheiro Magri, Caroline Manchiero, Bianca Peixoto Dantas, Wanderley Marques Bernardo, Edson Abdala, Fátima Mitiko Tengan","doi":"10.1093/epirev/mxag003","DOIUrl":"10.1093/epirev/mxag003","url":null,"abstract":"<p><p>Hepatitis E virus (HEV) infection can progress to chronic hepatitis in immunosuppressed individuals. The seroprevalence of hepatitis E among people living with HIV remains controversial. In this systematic review and meta-analysis, the pooled global seroprevalence of hepatitis E among people living with HIV is estimated. This study followed the Preferred Reporting Items for Systematic Review and Meta-Analysis guidelines and was registered in PROSPERO. Searches were conducted in the PubMed, Embase, and Web of Science databases. The seroprevalence of hepatitis E (anti-HEV IgG) among people living with HIV was estimated by meta-analysis using the random-effects model. Subgroup meta-analyses were performed for each continent. A total of 88 studies from 5 continents were included; most were conducted in European countries (48.9%). The pooled seroprevalence of HEV infection was 16.0% (95% CI, 13.0-18.0; I2 = 97.7%). Subgroup analyses revealed seroprevalence rates of 12.0% in Europe, 24.0% in Asia, 19.0% in Africa, and 11.0% in the Americas, and a notably high prevalence was observed in low-income countries (37.0%). Sensitivity analyses restricted to studies with sample sizes of more than 200 participants and risk of bias score ≥ 7 indicated seroprevalence estimates of 18.0% and 15.0%, respectively. In conclusion, this meta-analysis demonstrates a pooled global seroprevalence of HEV infection of 16.0% among people living with HIV, ranging from 11.0% to 24.0% across the continents.</p>","PeriodicalId":50510,"journal":{"name":"Epidemiologic Reviews","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kate Mason, Tanya Durrand, Glenda M Bishop, Alex Sully, Zoe Aitken
{"title":"Housing affordability and health in people with disability: A scoping review.","authors":"Kate Mason, Tanya Durrand, Glenda M Bishop, Alex Sully, Zoe Aitken","doi":"10.1093/epirev/mxag004","DOIUrl":"10.1093/epirev/mxag004","url":null,"abstract":"<p><p>Persistent inequities in the social determinants of health contribute to poor health outcomes among people with disability. People with disability are more likely to live in unaffordable housing, which is associated with increased risk of chronic conditions and poor mental health. However, there is limited research on how housing affordability affects health in this priority population. We undertook a scoping review to evaluate existing evidence on the health impacts of living in unaffordable housing for people with disability. Peer-reviewed literature published in English between 2004 and 2024 was considered. The MEDLINE, SocIndex, and Web of Science databases were searched to identify studies examining possible links between housing affordability and any health outcome in a population of people with disability. Two independent reviewers performed study screening and data extraction. Of the 1386 studies identified initially, 3 met the eligibility criteria. The included studies focused on individuals with acquired, psychiatric, or military-related disability. Each study provided evidence suggesting unaffordable housing negatively affected mental health in people with disability. Substantial methodological and conceptual heterogeneity limited direct comparison or synthesis. This review highlights a critical knowledge gap in the relationship between housing affordability and health for people with disability, limiting the development of evidence-informed policy and intervention. People with disability have a fundamental right to access affordable, appropriate housing, as well as the right to the highest attainable standard of health. High-quality, targeted research using consistent definitions of disability and housing affordability, as well as validated health outcome measures, is needed to inform future policy.</p>","PeriodicalId":50510,"journal":{"name":"Epidemiologic Reviews","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13082871/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147379548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniel Souza Sacramento, Samantha Adiely Alecrim Mendonça, Altair Seabra de Farias, Vanderson Sampaio
{"title":"Digital solutions for tuberculosis surveillance and control in primary health care: a scoping review.","authors":"Daniel Souza Sacramento, Samantha Adiely Alecrim Mendonça, Altair Seabra de Farias, Vanderson Sampaio","doi":"10.1093/epirev/mxag008","DOIUrl":"10.1093/epirev/mxag008","url":null,"abstract":"<p><p>Digital solutions are essential for eliminating tuberculosis as a public health problem. They can be applied across all stages of patient care, health surveillance, program management, workforce development, and community engagement. In this study, we aimed to identify and map digital solutions for tuberculosis developed and/or validated within the context of primary health care. We retrieved studies from Medline, Scopus, Embase, Web of Science, and Google Scholar that focused on digital solutions for tuberculosis, targeting managers, health professionals, or patients. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews guidelines to review, synthesize, and report the findings of articles that met our inclusion criteria. Of 3133 identified publications, 96 were included after full-text screening. Most solutions focused on treatment monitoring and adherence (n = 46 studies). There was particular emphasis on electronic directly observed therapy, smart pillboxes, and mobile applications. Artificial intelligence-based solutions also emerged that were applied to diagnosis, prediction of treatment nonadherence, and prognosis. The findings show that digital solutions have evolved from simple tools to advanced artificial intelligence models. We conclude that the systematic incorporation of these technologies into national protocols is crucial to accelerate progress toward the targets established by the End TB Strategy.</p>","PeriodicalId":50510,"journal":{"name":"Epidemiologic Reviews","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147583107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Paadukana Sairaj, Rajendra Pradeepa, Thyparambil Aravindakshan Pramodkumar, Ulagamathesan Venkatesan, Wesley Hannah, Viswanathan Mohan, Ralph Maddison, Ranjit Mohan Anjana, David W Dunstan
{"title":"Trends in prevalence of type 2 diabetes, obesity, and hypertension in urban India since 2000: a systematic review and meta-analysis.","authors":"Paadukana Sairaj, Rajendra Pradeepa, Thyparambil Aravindakshan Pramodkumar, Ulagamathesan Venkatesan, Wesley Hannah, Viswanathan Mohan, Ralph Maddison, Ranjit Mohan Anjana, David W Dunstan","doi":"10.1093/epirev/mxag012","DOIUrl":"10.1093/epirev/mxag012","url":null,"abstract":"<p><p>Rapid changes in urbanization in India have paralleled increased prevalence in noncommunicable diseases (NCDs), including type 2 diabetes (T2D), hypertension (HTN), and obesity. To examine sex-specific temporal trends in the prevalence of T2D, HTN, general obesity (GO), and abdominal obesity (AO) among urban populations in India since 2000, a systematic review and meta-analysis was conducted in accordance with a registered Prospective Register of Systematic Reviews protocol (CRD42024548962). PubMed, Global Health (via EBSCOhost), Embase, Scopus, and Web of Science were searched for studies from 2000-2025 (initial search: October 12, 2024; update: July 4, 2025). Eligible studies were cross-sectional and reported the prevalence of T2D or HTN or obesity in urban Indian populations. Screening, data extraction, and risk-of-bias assessment using the Hoy tool were performed independently by 2 reviewers, with a third resolving conflicts. Pooled prevalence was estimated via random-effects meta-analysis in R (version 4.5.3), with forest and funnel plots generated using ggplot2. Out of 3143 records screened, 57 studies were included. The pooled prevalence demonstrated upward trajectory. T2D rose from 13% in 2000-2005 to 21% in 2021-2025, and HTN from 29% to 31%. For obesity, GO increased from 24% in 2000-2005 to 36% in 2016-2020, while AO rose from 47% to 72% over the same period. Sex-stratified analyses showed greater increases among males for T2D and HTN, whereas AO increased more among females. These findings underscore increasing T2D, HTN, and obesity in urban India, highlighting the need for strengthened primary care and supportive environmental and policy measures address the urban NCD burden.</p>","PeriodicalId":50510,"journal":{"name":"Epidemiologic Reviews","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13455360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148457445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lindsay A Gaudet, Jennifer Pillay, Dianne Zakaria, Sabrina Saba, Ben Vandermeer, Maria Tan, Lisa Hartling
{"title":"Risk of new diagnoses and exacerbations of chronic conditions after SARS-CoV-2 infection: a systematic review update.","authors":"Lindsay A Gaudet, Jennifer Pillay, Dianne Zakaria, Sabrina Saba, Ben Vandermeer, Maria Tan, Lisa Hartling","doi":"10.1093/epirev/mxaf018","DOIUrl":"10.1093/epirev/mxaf018","url":null,"abstract":"<p><p>The large number of people infected by SARS-CoV-2 necessitates estimation of the future health care burdens. We updated a systematic review examining associations between SARS-CoV-2 infection and incidence of new diagnoses and exacerbations of chronic conditions. Updated searches were run September 4, 2024, in the MEDLINE and Embase databases for observational studies with a control group, adjustment by sex and comorbid conditions, and reporting age-stratified data for 1 or more chronic condition category (n = 12) or condition type (n = 46) of interest. Two human reviewers screened 50% of titles and abstracts, then DistillerAI acted as second reviewer. Two human reviewers assessed full texts of relevant studies for eligibility based on a priori criteria. One reviewer extracted data and assessed risk of bias using the JBI cohort studies checklist; a second reviewer verified results data and risk-of-bias assessments. Pooled hazard ratios (HRs) were estimated with inverse-variance weighting. Using the Grading of Recommendations, Assessment, Development, and Evaluation approach, 2 reviewers assessed certainty in conclusions of little to no association (ie, HR = 0.75-1.25), small to moderate association (ie, HR = 0.51-0.74 or 1.26-1.99), or large association (ie, HR ≤ 0.50 or ≥ 2.00). We identified 46 new studies and brought forward 23 studies from the original review. After SARS-CoV-2 infection, there is probably increased risk of new diagnoses for several chronic conditions, especially in adults. Most findings are based on data from earlier pandemic periods; their relevance to contemporary populations is uncertain due to differences in vaccination rates and circulating variants of concern. PROSPERO registration identifier CRD42024585278.</p>","PeriodicalId":50510,"journal":{"name":"Epidemiologic Reviews","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12858253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145566092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Miriam Chisholm, Sricharan Navuluri, Moronke Ogundolie, Matthew Boykin, Sakshi Chopra, Sirajbir Sodhi, Samantha Kaplan, Alexandra Gaviser, Tonia Poteat, Whitney R Robinson, Nrupen Bhavsar
{"title":"Length of look-back periods in studies using administrative data: a scoping review.","authors":"Miriam Chisholm, Sricharan Navuluri, Moronke Ogundolie, Matthew Boykin, Sakshi Chopra, Sirajbir Sodhi, Samantha Kaplan, Alexandra Gaviser, Tonia Poteat, Whitney R Robinson, Nrupen Bhavsar","doi":"10.1093/epirev/mxaf019","DOIUrl":"10.1093/epirev/mxaf019","url":null,"abstract":"<p><p>Administrative data, including electronic health record (EHR) and claims data, are increasingly used to generate real-world evidence for epidemiologic research. Unlike clinical trials, which assess baseline conditions at the initial visit, observational studies using these data must define an appropriate look-back period to identify baseline characteristics. However, to our knowledge, no established guidelines exist on the optimal length of look-back periods by clinical outcome. We conducted a scoping review, with a lens on methodological studies, to assess the frequency and variability of look-back periods used in epidemiologic studies. We searched PubMed for studies that used look-back periods using EHRs, claims data, or international registries. Our search yielded 262 studies spanning a broad range of clinical outcomes. Look-back periods varied substantially, ranging from 12 hours to 39 years, depending on the clinical outcome. The most common clinical areas included pharmacology, cardiovascular disease, cancer, and health care utilization. Our review underscores the need for tailored look-back periods based on the clinical context; we suggest a one-size-fits-all approach may be inadequate. Research should focus on the impact of look-back periods on less-studied outcomes. This review provides a resource for researchers to make informed decisions on the appropriate look-back periods in epidemiologic studies using administrative data.</p>","PeriodicalId":50510,"journal":{"name":"Epidemiologic Reviews","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145913785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jayati Khattar, Carmela Melina Albanese, Kathryn Barrett, Natalie V Scime, Hilary K Brown
{"title":"Hysterectomy in women with disabilities: a systematic review.","authors":"Jayati Khattar, Carmela Melina Albanese, Kathryn Barrett, Natalie V Scime, Hilary K Brown","doi":"10.1093/epirev/mxaf020","DOIUrl":"10.1093/epirev/mxaf020","url":null,"abstract":"<p><p>Hysterectomy is the most frequently performed nonobstetric surgery in women. Women with disabilities face barriers to reproductive health care, and little is known about their hysterectomy risk. The objective of this systematic review was to compare hysterectomy risk among women with and without disabilities. We searched the MEDLINE, Embase, PsycInfo, and CINAHL Plus databases from inception to May 2024 using validated search strategies. We included peer-reviewed observational studies that compared hysterectomy in women with physical, sensory, cognitive, and intellectual or developmental disabilities with those without disabilities. Study characteristics and data were extracted using a standardized form; the Newcastle-Ottawa Scale (NOS) was used for quality assessment. Study findings were summarized narratively following Synthesis Without Meta-analysis guidelines. The search yielded 3686 unique records, of which 5 met our criteria. These included 1 retrospective cohort and 4 cross-sectional studies, which were conducted in the United States (n = 3), Canada (n = 1), and South Korea (n = 1), and ranged in size from 881 to 42 842 participants. Evidence from 4 studies indicated hysterectomy frequency was higher among women with disabilities (range: 6.1% to 22.8%) compared with those without disabilities (range: 2.2% to 18.6%). Three studies suggested the disparity in hysterectomy was greatest among premenopausal women. Quality assessment scores on the NOS ranged from 0 to 8 (median, 3), with limitations mostly related to measurement of the exposure and outcome. The limited research on this topic points to the need for more studies on hysterectomy among women with disabilities, given historical reproductive injustices faced by this population.</p>","PeriodicalId":50510,"journal":{"name":"Epidemiologic Reviews","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12858371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145907147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gayoung Lee, Hyun-Kyung Kim, Arata Hidano, Sung-Mok Jung
{"title":"Systematic review of environmental factors associated with severe fever with thrombocytopenia syndrome occurrences.","authors":"Gayoung Lee, Hyun-Kyung Kim, Arata Hidano, Sung-Mok Jung","doi":"10.1093/epirev/mxag011","DOIUrl":"10.1093/epirev/mxag011","url":null,"abstract":"<p><p>Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne viral disease with a high fatality rate among older adults. It is posing a growing public health threat across Asia, with increasing potential for geographic spread beyond the region. Control efforts remain largely confined to individual-level tick-bite prevention, reflecting persistent gaps in understanding the ecological mechanisms that sustain SFTS transmission, particularly how environmental factors shape transmission dynamics across vectors, animal reservoirs, and human populations. We systematically reviewed 2910 studies to synthesize evidence on associations between environmental factors and SFTS occurrences across populations. Temperature, humidity, precipitation, elevation, and land cover are consistently linked to human SFTS occurrence through nonlinear, often reverse-U-shaped, relationships, underscoring the need for analytical frameworks capable of capturing the inherently nonlinear nature of environmental influences. However, we identified no quantitative assessments of how environmental factors shape SFTS occurrence in vectors or animal reservoirs, nor any stage-specific assessment of how these factors act across the transmission cycle, leaving multifaceted environmental effects acting across the tick-animal-human interface collapsed into oversimplified estimates based solely on human cases. To address these critical gaps, research must prioritize stage-specific elucidation of environmental drivers across the SFTS transmission cycle through mechanistic modeling approaches integrated with transboundary surveillance under a One Health framework. As climate and land-use changes continue to reshape vector habitats and expand regions at risk, such efforts will be essential for enhancing ecological understanding and guiding One Health-grounded surveillance and control strategies that can mitigate the growing transboundary burden of SFTS.</p>","PeriodicalId":50510,"journal":{"name":"Epidemiologic Reviews","volume":" ","pages":""},"PeriodicalIF":9.6,"publicationDate":"2026-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13291317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148018926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kerrie Gallagher, Grace Phillips, Paul Corcoran, Stephen Platt, Heather McClelland, Michelle O'Driscoll, Eve Griffin
{"title":"The social determinants of suicide: an umbrella review.","authors":"Kerrie Gallagher, Grace Phillips, Paul Corcoran, Stephen Platt, Heather McClelland, Michelle O'Driscoll, Eve Griffin","doi":"10.1093/epirev/mxaf004","DOIUrl":"10.1093/epirev/mxaf004","url":null,"abstract":"<p><p>Previous research has highlighted the role of social determinants of health on mental health, but their impact on suicide is less understood. The aim of this umbrella review was to systematically examine the association between 10 social determinants of health, as defined by the World Health Organization, and suicide mortality. A key word search of titles and abstracts was conducted in six digital databases for studies published up to August 24, 2023. Inclusion criteria were peer-reviewed systematic reviews and meta-analyses examining the association between these determinants and suicide. Methodological quality was assessed using an adapted AMSTAR-2 tool. A narrative synthesis, structured by social determinant, was conducted. A total of 49 records (n = 25 meta-analyses and 24 systematic reviews) were included in this review. Determinants with the most available evidence were housing, basic amenities and the environment (n = 21); income and social protection (n = 13); unemployment (n = 8); and early childhood development (n = 6). Limited evidence was identified for education (n = 3), social inclusion and nondiscrimination (n = 3), and working-life conditions (n = 3). No reviews examined the relationship between affordable health care services, structural conflict, or food insecurity and suicide. There was evidence of a modest effect of social determinants on suicide mortality. Most evidence related to unemployment, job insecurity, income and social protection, and childhood adversity. The methodological quality of the included reviews varied considerably. High-quality research fully exploring the relationship between social and environmental factors and suicide risk is needed.</p>","PeriodicalId":50510,"journal":{"name":"Epidemiologic Reviews","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143774742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Sex differences in the effects of dietary fiber on chronic disease risk: a meta-analysis of prospective cohort studies.","authors":"Changxiao Xie, Yujie Xu, Xiaoyu Wang, Longping Yan, Haiyou Wang, Jingyuan Xiong, Guo Cheng","doi":"10.1093/epirev/mxaf016","DOIUrl":"10.1093/epirev/mxaf016","url":null,"abstract":"<p><p>Dietary fiber plays a key role in preventing chronic diseases, but sex disparities in its health effects remain unclear. This meta-analysis examined the associations between fiber intake and chronic disease risk in men and women; cohort studies reported on in published articles found in the PubMed, Web of Science, and Embase databases were reviewed up to July 2025. Among 2 408 576 participants (n = 1 035 449 men and 1 392 820 women) from 20 studies, higher fiber intake was linked to reduced chronic disease risk in both sexes, with a pooled hazard ratio (HR) of 0.80 (95% CI, 0.75-0.84) for men and 0.83 (95% CI, 0.76-0.91) for women. Notably, fiber significantly lowered cancer risk only in men (HR = 0.81; 95% CI, 0.75-0.87). Grains and vegetable fiber reduced chronic disease risk in men (HR = 0.90 and 0.86, respectively), whereas no specific fiber source had significant benefits for women. In conclusion, although dietary fiber significantly reduced the risk of chronic diseases for both sexes, the threshold for observing beneficial effects is lower in men compared with women, in whom its impact may be more susceptible to confounding factors. More research is needed to clarify sex-specific dietary recommendations for chronic disease prevention.</p>","PeriodicalId":50510,"journal":{"name":"Epidemiologic Reviews","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145432983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}