Ethnicity & Disease最新文献

{"title":"Physical and Psychological Burden among Caregivers of Latinx Older Adults with Stroke and Multimorbidity.","authors":"Shilpa Krishnan, Haobin Tony Chen, Sarah Caston, Seunghwa Rho","doi":"10.18865/ed.33.4.156","DOIUrl":"10.18865/ed.33.4.156","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the association between Latinx older adults' stroke, multimorbidity, and caregiver burden.</p><p><strong>Methods: </strong>For this retrospective cohort study, we used the Hispanic Established Populations for the Epidemiologic Study of the Elderly (H-EPESE) Wave-7 data set. The caregiver's physical burden was defined by using the Level of Burden Index. The caregiver's psychological burden was measured by using the Perceived Stress Scale (PSS-4). Multimorbidity was defined as the presence of 3 or more chronic conditions.</p><p><strong>Results: </strong>The average age of the Latinx adults was 86 years, and the caregivers were 56 years. Latinx older adults and caregivers were more likely to be females (66% and 75%). Most caregivers were children (71%). Twelve percent of Latinx older adults presented with stroke, and 50% presented with multimorbidity. Caregiver physical burden was stratified into 3 levels: low (43%), medium (17%), and high (40%) burden. The cumulative logit model revealed that caregivers caring for those with stroke or multimorbidity had a high physical burden. Family caregivers and caregivers with a higher household income had a low physical burden. Caregivers with multimorbidity had a higher psychological burden. Caregivers who were interviewed in Spanish and those with higher household incomes had decreased psychological burden.</p><p><strong>Conclusion: </strong>This study revealed that caregivers had a higher physical burden among caregivers of Latinx adults with stroke or multimorbidity. Future studies must investigate the relationship between Latinx adults' stroke and caregiver psychological health, and build culturally tailored policies and community interventions to support caregivers susceptible to high stress and burden.</p>","PeriodicalId":50495,"journal":{"name":"Ethnicity & Disease","volume":"33 4","pages":"156-162"},"PeriodicalIF":3.4,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11155624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141297200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Core Community Needs for School-Based Asthma Programming: A Qualitative Assessment in Colorado Communities.","authors":"Sarah E Brewer, Julia Reedy, Danielle Maestas, Lisa Ross DeCamp, Anowara Begum, Michaela Brtnikova, Lisa Cicutto, Stanley J Szefler, Amy Huebschmann","doi":"10.18865/ed.DECIPHeR.35","DOIUrl":"10.18865/ed.DECIPHeR.35","url":null,"abstract":"<p><strong>Objectives: </strong>Asthma is one of the most prevalent chronic conditions affecting approximately 8.5% of children in Colorado. Our school-based asthma program (SBAP) has effectively improved asthma control and reduced asthma disparities among children but has been largely limited to the Denver area. We interviewed community stakeholders in 5 regions of Colorado to understand community needs for broader dissemination of SBAPs.</p><p><strong>Methods: </strong>In-depth, semistructured key informant interviews were conducted with school nurses, parents, pediatric healthcare providers, public health professionals, and community resource organization representatives. Inductive and deductive analyses were informed by the practical, robust, implementation, and sustainability model, an implementation science framework.</p><p><strong>Results: </strong>Participants (n=52) identified 6 types of needs for successful future implementation of our SBAP: (1) buy-in from stakeholders; (2) asthma prioritization; (3) improved relationships, communication, and coordination among school nurses, healthcare providers, and community organizations that address social determinants of health (SDOH) and children/families; (4) resources to address healthcare and SDOH needs and awareness of existing resources; (5) asthma education for children/families, school staff, and community members; and (6) improved coordination for School Asthma Care Plan completion. These needs mapped to a 3-tiered, progressive structure of foundational, relational, and functional needs for implementation success.</p><p><strong>Conclusion: </strong>These 6 types of needs illuminate factors that will allow this SBAP to work well and program delivery approaches and implementation strategies that may need modification to be successful. Next steps should include tailoring implementation strategies to variations in local context to support fit, effectiveness, and sustainment.</p>","PeriodicalId":50495,"journal":{"name":"Ethnicity & Disease","volume":"DECIPHeR Spec","pages":"35-43"},"PeriodicalIF":3.4,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Notes From the Field: Diverse Partner Perspectives Improve the Usability and Equity Focus of Implementation Guides.","authors":"Amy G Huebschmann, Melanie Gleason, Rachel Armstrong, Amy Sheridan, Ana Kim, Christy Haas-Howard, Nichole Bobo, Nicole M Wagner, Anowara Begum","doi":"10.18865/ed.DECIPHeR.132","DOIUrl":"10.18865/ed.DECIPHeR.132","url":null,"abstract":"<p><strong>Context: </strong>School-based asthma programs (SBAPs) have improved health and educational disparities among youth with asthma.</p><p><strong>Design: </strong>To support scaling out effective SBAPs, our school partners identified a need for online implementation guides that are \"always available,\" to meet the needs of school nurses' demanding schedules. School nurses play a key role in the adoption and implementation of SBAPs, so it is important to ensure the implementation guide would be highly usable and acceptable to them.</p><p><strong>Objective: </strong>Accordingly, our research team collaborated with human-centered design experts to identify the \"user journeys\" of school nurses and co-created our online implementation guide as a public-facing website with input from local and national school nurse partners.</p><p><strong>Main results: </strong>In this perspectives article, our school nurse implementation partners and human-centered design experts reflect on challenges overcome in this process of developing a tailored implementation guide to school nurses and offer lessons from the field to others seeking to co-create implementation guides with community partners.</p>","PeriodicalId":50495,"journal":{"name":"Ethnicity & Disease","volume":"DECIPHeR Spec","pages":"132-134"},"PeriodicalIF":3.4,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Navigators to Increase Patient Portal Enrollment among Patients in a Federally Qualified Health Care System.","authors":"Alicia K Matthews, Alana D Steffen, Larisa A Burke, Geri Donenberg, Cherdsak Duangchan, Jennifer Akufo, Hope Opuada, Damilola Oyaluade, Brittany Harris Vilona, Hilda Diaz, Darcy Dodd","doi":"10.18865/ed.DECIPHeR.117","DOIUrl":"10.18865/ed.DECIPHeR.117","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the training, preliminary results, and lessons learned from using patient navigators to increase the enrollment of low-income patients in a health system-supported and electronic health record-linked patient portal.</p><p><strong>Methods: </strong>Patient navigators (n=4) were trained to assist patients in a federally qualified health center to enroll in and use patient portals. Patient navigators were stationed at 3 clinic locations. Data from the electronic health record system (Epic) were used to compare MyChart patient portal activation rates and use among patients for the 8 months before and after patient navigation services were offered.</p><p><strong>Results: </strong>Navigators offered 83% of eligible patients with activation assistance. Sixty-four percent of the patients (n=1062) offered MyChart enrollment assistance accepted help. Seventy-four percent of assisted patients with no prior MyChart enrollment activated their accounts during that clinic visit. The primary reason for declining MyChart assistance was a lack of access to or comfort with technology. Patient portal activation increased during the 8 months when navigators were at the clinics (51%) compared to the previous 8 months (44%). Most new users viewed lab results and read a message [χ²(1)=49.3, p<.001], with significant increases evident for African Americans [44% before, 49% during; χ²(1)=40.4, p<.001] and Latinx patients [52% before, 60% during; χ²(1)=6.15, p=.013].</p><p><strong>Conclusion: </strong>Study results suggest that using patient navigators is feasible and beneficial for increasing patient enrollment in the Federally Qualified Health Centers context. However, patient-, clinic-, and system-level factors were identified as barriers and should be addressed in future research studies.</p>","PeriodicalId":50495,"journal":{"name":"Ethnicity & Disease","volume":"DECIPHeR Spec","pages":"117-125"},"PeriodicalIF":3.4,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Representativeness of Seriously Ill Patient Survey Responders in a Pragmatic Clinical Trial.","authors":"Aaron J Chau, Ron Hays, Anne M Walling, Lisa Gibbs, Maryam Rahimi, Rebecca L Sudore, Neil S Wenger","doi":"10.18865/ed.33.2-3.091","DOIUrl":"10.18865/ed.33.2-3.091","url":null,"abstract":"<p><strong>Objective: </strong>Pragmatic trials often implement an intervention across a population of patients but require information unavailable at the population level that must be reported by a subset of patients. In this pragmatic clinical trial, we compared characteristics of seriously ill patients with those who completed a survey evaluating advance care planning across 3 academic health systems.</p><p><strong>Methods: </strong>A deliberate process including health system and external stakeholders and patients was used to design materials for and the approach to seriously ill patients. We developed a survey and conducted a multistep process to identify seriously ill primary care patients. We evaluated the relationships of age, gender, race and ethnicity, and vulnerability using the social vulnerability index in this population, and explored the representativeness of survey respondents compared with the underlying seriously ill population in terms of age, race and ethnicity, and vulnerability measured.</p><p><strong>Results: </strong>About 5% (8707 patients) of the primary care population was classified as seriously ill, 5351 were mailed a survey and 1100 provided survey responses. Hispanic and Black patients were younger than White patients, and Black and Hispanic patients were more vulnerable than White and Asian patients and patients of other races. Representativeness was high across age and race and ethnicity, although White and Hispanic patients were more likely to respond than Black and Asian patients and patients of other races. Vulnerability in the surveyed sample was nearly identical to the population.</p><p><strong>Conclusions: </strong>A tailored survey and recruitment strategy yielded a representative sample of seriously ill, largely older, primary care respondents in the context of a pragmatic clinical trial.</p>","PeriodicalId":50495,"journal":{"name":"Ethnicity & Disease","volume":"33 2-3","pages":"91-97"},"PeriodicalIF":3.4,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11145732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Best Practice Recommendations for Integrating Health Equity into Pragmatic Clinical Trials for Dementia Care.","authors":"Susan L Mitchell, Ellen P McCarthy, Ladson Hinton, Manka Nkimbeng, Katherine D Peak, Ana R Quiñones","doi":"10.18865/ed.33.2-3.084","DOIUrl":"10.18865/ed.33.2-3.084","url":null,"abstract":"<p><strong>Context: </strong>Minoritized populations experience higher rates of dementia and worse health outcomes than non-Hispanic white people, but they are vastly underrepresented in pragmatic clinical trials embedded in health care systems (ePCTs). Little guidance is available to consider health equity-relevant issues in ePCTs.</p><p><strong>Objective: </strong>This report describes the development, structure, and content of a guidance document developed by the National Institute on Aging Imbedded Pragmatic AD/ADRD Clinical Trials (IMPACT) Collaboratory to help investigators systematically assess the integration of health equity into all aspects of ePCT design.</p><p><strong>Design: </strong>Led by a task force of IMPACT investigators, a literature review of existing frameworks for health equity considerations in clinical trials was conducted. Next, priority health equity-relevant recommendations in the domains of ePCT design were solicited from Collaboratory experts. The 50 submitted recommendations were reduced to 36 nonoverlapping best practices and categorized into 6 domains, as follows: Getting Started, Community Stakeholder Engagement, Design and Analysis, Intervention Design and Implementation, Health Care System and Participant Selection, and Selecting Outcomes. Each domain had 6 best practice recommendations consisting of a succinctly worded main sentence, with 1 to 2 explanatory sentences. The content was finalized through an iterative process of editing and revision.</p><p><strong>Conclusions: </strong>Although specifically focused on ePCTs involving dementia care, the best practices are applicable to any ePCT and can be useful to advance health equity in traditional clinical trials. This guidance document provides a first step toward promoting holistic, structured integration of health equity into the design and conduct of ePCTs as a matter of good science.</p>","PeriodicalId":50495,"journal":{"name":"Ethnicity & Disease","volume":"33 2-3","pages":"84-90"},"PeriodicalIF":3.4,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11145731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental Health, Self-Care, and Engagement in Care among Black Women Living with HIV.","authors":"Jordan Patrick, Sannisha K Dale","doi":"10.18865/ed.33.2-3.116","DOIUrl":"10.18865/ed.33.2-3.116","url":null,"abstract":"<p><strong>Objectives: </strong>Due to sociostructural factors, Black women living with human immunodeficiency virus (HIV) in the United States represent the highest percentage of women with HIV and experience mental health struggles that impact health behaviors. This study examines associations between mental health, self-care, medication adherence, engagement with healthcare, HIV-related healthcare visits, and hospitalization.</p><p><strong>Methods: </strong>One hundred and nineteen Black women living with HIV in the Southeastern United States completed measures on scheduled visits (general and HIV-related healthcare), visits attended/missed/rescheduled, mental healthcare engagement (therapy and support groups), hospital visits (emergency room and overnight stays), medication adherence, and a clinician-administered interview assessing mental health.</p><p><strong>Results: </strong>Higher self-care was associated with fewer emergency room visits (β=-0.31, P<.001) and hospitalizations (β=-0.22, P<.05). Higher post-traumatic stress disorder symptoms were associated with hospitalization (β=0.23, P<.05) and missed HIV-related visits (β=0.20, P<.05) but higher outpatient mental healthcare visits for group psychotherapy (β=0.20, P< .05). Higher suicidality was associated with lower HIV-related healthcare visits scheduled (β=-0.26, P<.01). Higher HIV load was associated with higher HIV-related healthcare visits scheduled (β=0.45, P<.001) and hospitalization (β=0.41, P<.001). Higher Wisepill medication adherence (β=-0.28, P<.01) and self-reported adherence (β=-0.33, P<.001) were associated with fewer HIV missed visits. Higher self-reported adherence was associated with fewer emergency room visits (β=-0.38, P<.001) and hospitalizations (β=-0.27, P<.001).</p><p><strong>Conclusions: </strong>Our findings highlight the need for treating mental health symptoms and enhancing self-care among Black women living with HIV to improve engagement in care and health behaviors and decrease emergency room visits and hospitalization.</p>","PeriodicalId":50495,"journal":{"name":"Ethnicity & Disease","volume":"33 2-3","pages":"116-123"},"PeriodicalIF":3.4,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11145728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of Obesity and Metabolic Syndrome in the High Cardiovascular Risk Setting of Rural Western Honduras.","authors":"Eleazar E Montalvan-Sanchez, Aida Rodriguez-Murillo, Tiffani Carrasco-Stoval, Keila Carrera, Renato Beas, Roberto Giron, Valeria Jerez-Moreno, Roque Antonio Soriano-Turcios, Orlando Reyes-Guerra, Karla Torres, Diego Izquierdo-Veraza, Tatiana Torres, Azizullah A Beran, Daniela Montalvan-Sanchez, Dalton A Norwood","doi":"10.18865/ed.33.2-3.124","DOIUrl":"10.18865/ed.33.2-3.124","url":null,"abstract":"<p><strong>Objective: </strong>To determine the prevalence of obesity and metabolic syndrome (MS) in the population older than 45 years in rural Western Honduras and contribute to the limited literature on MS in Central America.</p><p><strong>Methods: </strong>Descriptive cross-sectional study conducted in the District of Copan. The study includes 382 men and women aged 45 to 75 years. With proper consent, anthropometric parameters, blood pressure, blood sugar, and lipid profile were evaluated. MS was diagnosed by using the National Cholesterol Education Program Criteria - Adult Panel Treatment III (NCEP-ATP III). Data were stored in REDCap (Research Electronic Data Capture) and analyzed with STATA14.</p><p><strong>Results: </strong>Data were collected on 382 patients; of these, 38% were male and 62% female. The prevalence of obesity was 24.1% for both sexes. The prevalence of MS was 64.9%. Prevalence in males and females was 54% and 71%, respectively. Notable parameters were elevated triglycerides (71%), low High-density lipoprotein cholesterol (HDL-C) (63.4%), and abdominal obesity (56.8%). In men, the distribution of MS was more homogeneous, with a mean result of 80% amongst all ages.</p><p><strong>Conclusions: </strong>The overall prevalence of obesity and MS is severely underestimated in rural Honduras. The most remarkable parameter for MS was high triglycerides (71%). Sixty-nine percent of the population has above-normal Body Mass Index (BMI). Public health efforts to control comorbidities and tackle risk factors in this population should take utmost priority.</p>","PeriodicalId":50495,"journal":{"name":"Ethnicity & Disease","volume":"33 2-3","pages":"124-129"},"PeriodicalIF":3.4,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11145726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Considerations When Designing and Implementing Pragmatic Clinical Trials That Include Older Hispanics.","authors":"Rafael Samper-Ternent, Stephanie L Silveira, Alan Stevens, Elena Volpi, Aanand D Naik","doi":"10.18865/ed.33.2-3.076","DOIUrl":"10.18865/ed.33.2-3.076","url":null,"abstract":"<p><strong>Introduction: </strong>Pragmatic clinical trials (PCTs) are designed to connect researchers with clinicians to assess the real-world effectiveness and feasibility of interventions, treatments, or health care delivery strategies in routine practice. Within PCTs larger, more representative sampling is possible to improve the external validity of the research. Older adults from underrepresented groups can benefit from PCTs given their historically lower engagement in clinical research. The current article focuses on older Hispanic adults with Alzheimer disease and related dementias (ADRDs). Older Hispanic adults represent 19% of the US population and have a higher prevalence of ADRDs than Whites. We provide data from 2 PCTs about the recruitment of older Hispanics with ADRDs and discuss unique challenges associated with conducting PCTs and propose strategies to overcome challenges.</p><p><strong>Data and methods: </strong>The first PCT outlined is the Patient Priorities Care for Hispanics with Dementia (PPC-HD) trial. PPC-HD is testing the feasibility of implementing a culturally adapted version of the Patient Priorities Care approach for older Hispanic adults with multiple chronic conditions and dementia. The second PCT is the Dementia Care (D-CARE) Study, which is a multisite pragmatic study comparing the effectiveness of a health care system-based approach and a community-based approach to dementia care to usual care in patients with ADRDs and their family caregivers.</p><p><strong>Lessons learned and recommendations for future studies: </strong>The lessons learned are summarized according to the various stakeholders that need to work together to effectively recruit diverse participants for PCTs: individuals, health care systems, research teams, and communities. Individual-level considerations include communication, priorities, and flexibility. Health care system-level considerations are grounded in 4 principles of Community-Based Participatory Research and include collaboration/partnership, available resources, priorities of the health care system, and sustainability. Research team-level considerations include team members, intentionality, and communication. Community-level considerations highlight the importance of partnerships, community members, and appropriate incentives.</p><p><strong>Discussion: </strong>PCTs provide a unique and potentially impactful opportunity to test interventions in real-world settings that must be culturally appropriate to reach underrepresented groups. Collectively, considering variables at multiple levels to address the needs of older adults with ADRDs is crucial, and the examples and suggestions provided in this report are a foundation for future research.</p>","PeriodicalId":50495,"journal":{"name":"Ethnicity & Disease","volume":"33 2-3","pages":"76-83"},"PeriodicalIF":3.4,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11145730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contributors to Early Mortality in African Americans, the Jackson Heart Study.","authors":"Katherine C Brooks, Mark J Ommerborn, Lara I Brewer, Mario Sims, Adolfo Correa, Gabriel S Tajeu, Cheryl R Clark","doi":"10.18865/ed.33.2-3.098","DOIUrl":"10.18865/ed.33.2-3.098","url":null,"abstract":"<p><strong>Introduction: </strong>In recent years, premature \"deaths of despair\" (ie, due to alcohol, drug use, and suicide) among middle-aged White Americans have received increased attention in the popular press, yet there has been less discussion on what explains premature deaths among young African Americans. In this study, we examined factors related to deaths of despair (alcohol use, drug use, smoking) and contextual factors (perceived discrimination, socioeconomic status, neighborhood conditions) as predictors of premature deaths before the age of 65 years among African Americans.</p><p><strong>Methods: </strong>The Jackson Heart Study (JHS) is a longitudinal cohort study of African Americans in the Jackson, Mississippi, metropolitan statistical area. We included participants younger than 65 years at baseline (n=4000). Participant enrollment began in 2000 and data for these analyses were collected through 2019. To examine predictors of mortality, we calculated multivariable adjusted hazard ratios (HRs; 95% CI), using Cox proportional hazard models adjusted for age, sex, ideal cardiovascular health metrics, drug use, alcohol intake, functional status, cancer, chronic kidney disease, asthma, waist circumference, depression, income, education, health insurance status, perceived neighborhood safety, and exposure to lifetime discrimination.</p><p><strong>Results: </strong>There were 230 deaths in our cohort, which spanned from 2001-2019. After adjusting for all covariates, males (HR, 1.50; 95% CI, 1.11-2.03), participants who used drugs (HR, 1.53; 95% CI, 1.13-2.08), had a heavy alcohol drinking episode (HR, 1.71; 95% CI, 1.22-2.41), reported 0-1 ideal cardiovascular health metrics (HR, 1.78; 95% CI, 1.06-3.02), had cancer (HR, 2.38; 95% CI, 1.41-4.01), had poor functional status (HR, 1.68; 95% CI, 1.19-2.37), or with annual family income less than $25,000 (HR, 1.63; 95% CI, 1.02-2.62) were more likely to die before 65 years of age.</p><p><strong>Conclusions: </strong>In our large cohort of African American men and women, clinical predictors of premature death included poor cardiovascular health and cancer, and social predictors included low income, drug use, heavy alcohol use, and being a current smoker. Clinical and social interventions are warranted to prevent premature mortality in African Americans.</p>","PeriodicalId":50495,"journal":{"name":"Ethnicity & Disease","volume":"33 2-3","pages":"98-107"},"PeriodicalIF":3.4,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11145729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141285245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}