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Clinica chimica acta; international journal of clinical chemistry最新文献

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Vancomycin-induced hypokalemia: A proof-of-concept case report. 万古霉素引起的低钾血症:一个概念验证病例报告。
IF 5
Clinica chimica acta; international journal of clinical chemistry Pub Date : 2020-11-01 Epub Date: 2020-07-17 DOI: 10.1016/j.cca.2020.07.028
Candida Driemeyer, José A T Poloni, Luiza M T Ulysséa, Alessandro C Pasqualotto
{"title":"Vancomycin-induced hypokalemia: A proof-of-concept case report.","authors":"Candida Driemeyer,&nbsp;José A T Poloni,&nbsp;Luiza M T Ulysséa,&nbsp;Alessandro C Pasqualotto","doi":"10.1016/j.cca.2020.07.028","DOIUrl":"https://doi.org/10.1016/j.cca.2020.07.028","url":null,"abstract":"<p><strong>Background: </strong>Vancomycin is used on a large scale in medical practice, mostly for the treatment of serious gram-positive bacterial infection. Many adverse effects have been linked to vancomycin use with nephrotoxicity being one of its most prevalent side effects.</p><p><strong>Case report: </strong>We present the case of an 81 years-old woman who had sustained vancomycin-induced hypokalemia while treating an infected surgical wound. She was under chronic use of losartan for high blood pressure but she was not diabetic. Potassium in serum reached critically low levels during the use of this antibiotic - despite intravenous reposition - and returned to normal right after the drug was stopped, in two different occasions. Elevated urinary potassium levels indicated renal potassium wasting, though serum creatinine levels remained within the normal range throughout hospitalization.</p><p><strong>Conclusions: </strong>Vancomycin must be considered as a possible cause for hypokalemia of unknown etiology and physicians should be aware of this potential severe adverse effect.</p>","PeriodicalId":504940,"journal":{"name":"Clinica chimica acta; international journal of clinical chemistry","volume":" ","pages":"232-234"},"PeriodicalIF":5.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cca.2020.07.028","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38167408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Clinical performances of an ELISA for SARS-CoV-2 antibody assay and correlation with neutralization activity. ELISA检测SARS-CoV-2抗体的临床性能及与中和活性的相关性
IF 5
Clinica chimica acta; international journal of clinical chemistry Pub Date : 2020-11-01 Epub Date: 2020-08-18 DOI: 10.1016/j.cca.2020.08.024
Andrea Padoan, Silvia Zuin, Chiara Cosma, Daniela Basso, Mario Plebani, Francesco Bonfante
{"title":"Clinical performances of an ELISA for SARS-CoV-2 antibody assay and correlation with neutralization activity.","authors":"Andrea Padoan,&nbsp;Silvia Zuin,&nbsp;Chiara Cosma,&nbsp;Daniela Basso,&nbsp;Mario Plebani,&nbsp;Francesco Bonfante","doi":"10.1016/j.cca.2020.08.024","DOIUrl":"https://doi.org/10.1016/j.cca.2020.08.024","url":null,"abstract":"","PeriodicalId":504940,"journal":{"name":"Clinica chimica acta; international journal of clinical chemistry","volume":" ","pages":"654-655"},"PeriodicalIF":5.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cca.2020.08.024","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38281570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Saliva for use with a point of care assay for the rapid diagnosis of COVID-19. 用于快速诊断COVID-19的护理点检测的唾液。
IF 5
Clinica chimica acta; international journal of clinical chemistry Pub Date : 2020-11-01 Epub Date: 2020-09-08 DOI: 10.1016/j.cca.2020.09.001
Jeffrey A SoRelle, Lenin Mahimainathan, Clare McCormick-Baw, Dominick Cavuoti, Francesca Lee, Abey Thomas, Ravi Sarode, Andrew E Clark, Alagarraju Muthukumar
{"title":"Saliva for use with a point of care assay for the rapid diagnosis of COVID-19.","authors":"Jeffrey A SoRelle,&nbsp;Lenin Mahimainathan,&nbsp;Clare McCormick-Baw,&nbsp;Dominick Cavuoti,&nbsp;Francesca Lee,&nbsp;Abey Thomas,&nbsp;Ravi Sarode,&nbsp;Andrew E Clark,&nbsp;Alagarraju Muthukumar","doi":"10.1016/j.cca.2020.09.001","DOIUrl":"https://doi.org/10.1016/j.cca.2020.09.001","url":null,"abstract":"","PeriodicalId":504940,"journal":{"name":"Clinica chimica acta; international journal of clinical chemistry","volume":" ","pages":"685-686"},"PeriodicalIF":5.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cca.2020.09.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38366078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Less expression of CD4+ and CD8+ T cells might reflect the severity of infection and predict worse prognosis in patients with COVID-19: Evidence from a pooled analysis. 来自汇总分析的证据:CD4+和CD8+ T细胞表达减少可能反映COVID-19患者感染的严重程度并预测更差的预后
IF 5
Clinica chimica acta; international journal of clinical chemistry Pub Date : 2020-11-01 Epub Date: 2020-06-27 DOI: 10.1016/j.cca.2020.06.040
Daojun Hu, Li Li, Wenjie Shi, Li Zhang
{"title":"Less expression of CD4<sup>+</sup> and CD8<sup>+</sup> T cells might reflect the severity of infection and predict worse prognosis in patients with COVID-19: Evidence from a pooled analysis.","authors":"Daojun Hu,&nbsp;Li Li,&nbsp;Wenjie Shi,&nbsp;Li Zhang","doi":"10.1016/j.cca.2020.06.040","DOIUrl":"https://doi.org/10.1016/j.cca.2020.06.040","url":null,"abstract":"<p><p>This study mainly focused on the very serious COVID-19 epidemic situation at present and provided a new insight for the treatment and monitor of patients with COVID-19. Through this meta-analysis, we could draw a conclusion that less expression of blood CD4<sup>+</sup> and CD8<sup>+</sup> T cells count might reflect the severity of infection and often accompanied by a poor prognosis. Hence, we inferred blood CD4+ and CD8+ T cells count could be a promising biomarker for disease assessment and monitor of patients with COVID-19.</p>","PeriodicalId":504940,"journal":{"name":"Clinica chimica acta; international journal of clinical chemistry","volume":" ","pages":"1-4"},"PeriodicalIF":5.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cca.2020.06.040","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38101703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
"One-gate" design should be used for the study of the diagnostic efficacy of biological markers. 生物标志物的诊断效能研究应采用“一门”设计。
IF 5
Clinica chimica acta; international journal of clinical chemistry Pub Date : 2020-11-01 Epub Date: 2020-07-06 DOI: 10.1016/j.cca.2020.07.004
Xu-Xiao Guo, Shu-Mei Bai
{"title":"\"One-gate\" design should be used for the study of the diagnostic efficacy of biological markers.","authors":"Xu-Xiao Guo,&nbsp;Shu-Mei Bai","doi":"10.1016/j.cca.2020.07.004","DOIUrl":"https://doi.org/10.1016/j.cca.2020.07.004","url":null,"abstract":"<p><p>1. The first draft of this article proposes \"Please authors answer a question: was there only 43 patients with diagnosed gastric cancer from April 2018 to July 2018?\" Is it to know whether the researchers chose 43 patients because of fewer cases or intentionally fewer? The reviewer's \"response reviewers\" admitted \"it's better to add a benign disease group\" and \"chose 43 patients with diagnosed gastric cancer randomly for our validation,\" which confirmed my opinion \"have design flaws both in enroll subjects and the number of cases\". So after getting the reply from the original author, I deleted the above sentence. This time amend \"43 patients\" on line 43 to \"43 patients which random selection rather than all patients in the study time window\". 2. Some revision has been highlighted in red. 3. We re-edit the article sentence by sentence in English to make it more in line with the English expression.</p>","PeriodicalId":504940,"journal":{"name":"Clinica chimica acta; international journal of clinical chemistry","volume":" ","pages":"11"},"PeriodicalIF":5.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cca.2020.07.004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38135825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detailed analysis of lipolytic enzymes in a Japanese woman of familial lipoprotein lipase deficiency - Effects of pemafibrate treatment. 一名日本女性家族性脂蛋白脂肪酶缺乏症中脂溶酶的详细分析-帕玛菲特治疗的效果。
IF 5
Clinica chimica acta; international journal of clinical chemistry Pub Date : 2020-11-01 Epub Date: 2020-07-17 DOI: 10.1016/j.cca.2020.07.031
Takuya Minamizuka, Junji Kobayashi, Hayato Tada, Kazuya Miyashita, Masaya Koshizaka, Yoshiro Maezawa, Hiraku Ono, Koutaro Yokote
{"title":"Detailed analysis of lipolytic enzymes in a Japanese woman of familial lipoprotein lipase deficiency - Effects of pemafibrate treatment.","authors":"Takuya Minamizuka,&nbsp;Junji Kobayashi,&nbsp;Hayato Tada,&nbsp;Kazuya Miyashita,&nbsp;Masaya Koshizaka,&nbsp;Yoshiro Maezawa,&nbsp;Hiraku Ono,&nbsp;Koutaro Yokote","doi":"10.1016/j.cca.2020.07.031","DOIUrl":"https://doi.org/10.1016/j.cca.2020.07.031","url":null,"abstract":"<p><strong>Background: </strong>We present here a 72-y-old Japanese woman with lipoprotein lipase (LPL) deficiency and analyzed her lipolytic enzymes in detail before and after pemafibrate treatment.</p><p><strong>Methods: </strong>She had a serum triglycerides (TG) of 22.6 mmol/l at a medical checkup at the age of 52 y. She was referred to our hospital at the age of 61 y. Her serum lipoprotein lipase (LPL) concentration was extremely low, suggesting the clinical diagnosis of LPL deficiency. She experienced an event of acute pancreatitis at the age of 65 y.</p><p><strong>Results: </strong>Next-generation sequencing analysis revealed a homozygous nonsense mutation in the LPL gene, c.1277G > A (p.Trp409Ter). Her serum TG, LPL and hepatic lipase (HL) concentrations were 15.0 mmol/l, 23 ng/ml and 66 ng/ml, respectively. Fifteen minutes after intravenous heparin injection (30 U/kg), her serum TG, LPL and HL concentrations turned to 14.1 mmol/l, 20 ng/ml and 660 ng/ml, respectively. Eight weeks of pemafibrate treatment (0.2 mg/day) caused a modest reductions in serum TG (15.02 → 13.58 mmol/l) and considerable increases in preheparin HL (66 → 76 ng/ml) and PHP-HL (660 → 1118 ng/ml) concentrations and PHP-HL activities (253 → 369U/l) despite almost no effect on LPL concentrations and activities.</p><p><strong>Conclusions: </strong>These findings suggest that HL may contribute to the reduction of plasma TG in LPL deficiency.</p>","PeriodicalId":504940,"journal":{"name":"Clinica chimica acta; international journal of clinical chemistry","volume":" ","pages":"216-219"},"PeriodicalIF":5.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cca.2020.07.031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38167410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Prognostic role of preoperative fibrinogen to albumin ratio in breast cancer. 术前纤维蛋白原/白蛋白比值对乳腺癌预后的影响。
IF 5
Clinica chimica acta; international journal of clinical chemistry Pub Date : 2020-11-01 Epub Date: 2020-07-31 DOI: 10.1016/j.cca.2020.07.055
Yanwen Wang, Wenying Xu, Yan Wang
{"title":"Prognostic role of preoperative fibrinogen to albumin ratio in breast cancer.","authors":"Yanwen Wang,&nbsp;Wenying Xu,&nbsp;Yan Wang","doi":"10.1016/j.cca.2020.07.055","DOIUrl":"https://doi.org/10.1016/j.cca.2020.07.055","url":null,"abstract":"","PeriodicalId":504940,"journal":{"name":"Clinica chimica acta; international journal of clinical chemistry","volume":" ","pages":"360-362"},"PeriodicalIF":5.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cca.2020.07.055","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38215238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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