{"title":"来自汇总分析的证据:CD4+和CD8+ T细胞表达减少可能反映COVID-19患者感染的严重程度并预测更差的预后","authors":"Daojun Hu, Li Li, Wenjie Shi, Li Zhang","doi":"10.1016/j.cca.2020.06.040","DOIUrl":null,"url":null,"abstract":"<p><p>This study mainly focused on the very serious COVID-19 epidemic situation at present and provided a new insight for the treatment and monitor of patients with COVID-19. Through this meta-analysis, we could draw a conclusion that less expression of blood CD4<sup>+</sup> and CD8<sup>+</sup> T cells count might reflect the severity of infection and often accompanied by a poor prognosis. Hence, we inferred blood CD4+ and CD8+ T cells count could be a promising biomarker for disease assessment and monitor of patients with COVID-19.</p>","PeriodicalId":504940,"journal":{"name":"Clinica chimica acta; international journal of clinical chemistry","volume":" ","pages":"1-4"},"PeriodicalIF":0.0000,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.cca.2020.06.040","citationCount":"13","resultStr":"{\"title\":\"Less expression of CD4<sup>+</sup> and CD8<sup>+</sup> T cells might reflect the severity of infection and predict worse prognosis in patients with COVID-19: Evidence from a pooled analysis.\",\"authors\":\"Daojun Hu, Li Li, Wenjie Shi, Li Zhang\",\"doi\":\"10.1016/j.cca.2020.06.040\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This study mainly focused on the very serious COVID-19 epidemic situation at present and provided a new insight for the treatment and monitor of patients with COVID-19. Through this meta-analysis, we could draw a conclusion that less expression of blood CD4<sup>+</sup> and CD8<sup>+</sup> T cells count might reflect the severity of infection and often accompanied by a poor prognosis. Hence, we inferred blood CD4+ and CD8+ T cells count could be a promising biomarker for disease assessment and monitor of patients with COVID-19.</p>\",\"PeriodicalId\":504940,\"journal\":{\"name\":\"Clinica chimica acta; international journal of clinical chemistry\",\"volume\":\" \",\"pages\":\"1-4\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1016/j.cca.2020.06.040\",\"citationCount\":\"13\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinica chimica acta; international journal of clinical chemistry\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.cca.2020.06.040\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2020/6/27 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinica chimica acta; international journal of clinical chemistry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.cca.2020.06.040","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/6/27 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
Less expression of CD4+ and CD8+ T cells might reflect the severity of infection and predict worse prognosis in patients with COVID-19: Evidence from a pooled analysis.
This study mainly focused on the very serious COVID-19 epidemic situation at present and provided a new insight for the treatment and monitor of patients with COVID-19. Through this meta-analysis, we could draw a conclusion that less expression of blood CD4+ and CD8+ T cells count might reflect the severity of infection and often accompanied by a poor prognosis. Hence, we inferred blood CD4+ and CD8+ T cells count could be a promising biomarker for disease assessment and monitor of patients with COVID-19.
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