European Journal of Internal Medicine最新文献_第2页

Clinical applicability considerations for depot-specific miRNA profiling in gastrointestinal cancer. 仓库特异性miRNA谱分析在胃肠道肿瘤中的临床适用性考虑

IF 6.1 2区医学

European Journal of Internal Medicine Pub Date : 2026-05-02 DOI: 10.1016/j.ejim.2026.106919

Xiuzhi Cao, Lu Li, Ming Zhuang

引用次数: 0

Multiple hepatic lesions and vascular lakes. 多发肝脏病变和血管湖。

IF 6.1 2区医学

European Journal of Internal Medicine Pub Date : 2026-05-02 DOI: 10.1016/j.ejim.2026.106929

Monica Rubio-Ardanaz, Miguel Sogbe, Juan Felipe Lucena

引用次数: 0

Specialist or generalist management of emergency medical admissions - immediate and long-term outcomes. 紧急医疗入院的专家或综合管理-即时和长期结果。

IF 6.1 2区医学

European Journal of Internal Medicine Pub Date : 2026-05-02 DOI: 10.1016/j.ejim.2026.106923

Richard Conway, Declan Byrne, Deirdre O'Riordan, Bernard Silke

{"title":"Specialist or generalist management of emergency medical admissions - immediate and long-term outcomes.","authors":"Richard Conway, Declan Byrne, Deirdre O'Riordan, Bernard Silke","doi":"10.1016/j.ejim.2026.106923","DOIUrl":"https://doi.org/10.1016/j.ejim.2026.106923","url":null,"abstract":"<p><strong>Aim: </strong>To study whether the admission of unselected emergency medical patients, under either a Consultant with General Medicine (GIM) or Specialist accreditation, influenced either short or longer-term all-cause mortality.</p><p><strong>Methods: </strong>We report an observational cohort study of all emergency medical admissions admitted over 14 years between January 2011 and October 2024. The 30-day in-hospital and long-term all-cause mortality (10 year), were related to Consultant primary accreditation (GIM vs. Specialist), using logistic multiple variable regression or Cox proportional hazard models.</p><p><strong>Results: </strong>There were 76,464 admissions in 42,104 unique patients over the period, with care delivered by 162 Consultants of whom 34 (21%) had a major GIM accreditation. The specialist load/on-call averaged 7.0 cases (IQR: 4.4, 9.0) in contrast to GIM at 12.1 cases (IQR: 11.7, 14.5). Over 14 years 30-day in-hospital all-cause mortality (per unique patient) declined from 2012 at 9.6% (95%CI: 8.4, 10.9) to 2024 at 2.9% (95%CI: 2.5, 3.4). Acute hospital mortality marginally favoured Specialty at 3.71% (95%CI: 3.54, 3.87) rather than GIM care GIM 4.10% (95%CI: 3.86, 4.34) with OR 1.12 (95%CI: 1.03, 1.22). Longer-term adjusted mortality was lower for the GIM admission cohort - HR 0.33 (95%CI: 0.24, 0.46) and for those admitted under Consultants with a higher volume (>5 cases) throughput - HR 0.77 (95%CI: 0.64, 0.94).</p><p><strong>Conclusion: </strong>These data suggest merits for GIM and Specialty care; short-term care favoured Specialist supervision, but overall long-term care proved better for GIM or higher volume Consultants.</p>","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":" ","pages":"106923"},"PeriodicalIF":6.1,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rethinking renal protection in patients with heart failure and reduced ejection fraction. 对心力衰竭和射血分数降低患者肾保护的再思考。

IF 6.1 2区医学

European Journal of Internal Medicine Pub Date : 2026-05-02 DOI: 10.1016/j.ejim.2026.106932

Wei Chen, Kexin Ye

引用次数: 0

Emerging evidence from combination therapy reinforces the role of β-blockers in resistant hypertension. 来自联合治疗的新证据强化了β受体阻滞剂在顽固性高血压中的作用。

IF 6.1 2区医学

European Journal of Internal Medicine Pub Date : 2026-05-02 DOI: 10.1016/j.ejim.2026.106922

Stefano Masi, Claudio Borghi

引用次数: 0

Management of ANOCA and suspected microvascular angina: integration of plaque-directed and functional strategies ANOCA和疑似微血管心绞痛的管理：斑块导向和功能策略的整合

IF 6.1 2区医学

European Journal of Internal Medicine Pub Date : 2026-05-01 Epub Date: 2026-01-27 DOI: 10.1016/j.ejim.2026.106713

Lukasz Szarpak , Zbigniew Siudak , Andrea Denegri

引用次数: 0

Optimizing cardiorenal protection in HFrEF: From pharmacological mechanisms to clinical implementation 优化HFrEF的心肾保护：从药理机制到临床实施。

IF 6.1 2区医学

European Journal of Internal Medicine Pub Date : 2026-05-01 Epub Date: 2026-01-12 DOI: 10.1016/j.ejim.2026.106699

Miao Yuan

引用次数: 0

Heart failure with preserved ejection fraction in the elderly: Clinical, imaging, and biomarker profiles according to global longitudinal strain by cardiac magnetic resonance 老年人保留射血分数的心力衰竭：根据心脏磁共振整体纵向应变的临床、成像和生物标志物概况。

IF 6.1 2区医学

European Journal of Internal Medicine Pub Date : 2026-05-01 Epub Date: 2025-12-15 DOI: 10.1016/j.ejim.2025.106653

Pau Llàcer , Marina García Melero , María Ángeles Fernández , Pedro Torres , Luis Manzano

引用次数: 0

Efficacy and harms of polypills for cardiovascular disease prevention: A systematic review and meta-analysis of randomized controlled trials 多药片预防心血管疾病的疗效和危害：随机对照试验的系统回顾和荟萃分析。

IF 6.1 2区医学

European Journal of Internal Medicine Pub Date : 2026-05-01 Epub Date: 2026-02-19 DOI: 10.1016/j.ejim.2026.106775

Brian M. Portela , Ryan M. Shan , Lahar Miriyapalli , Vinay Pasupuleti , Carlos Diaz-Arocutipa , Adrian V. Hernandez

{"title":"Efficacy and harms of polypills for cardiovascular disease prevention: A systematic review and meta-analysis of randomized controlled trials","authors":"Brian M. Portela , Ryan M. Shan , Lahar Miriyapalli , Vinay Pasupuleti , Carlos Diaz-Arocutipa , Adrian V. Hernandez","doi":"10.1016/j.ejim.2026.106775","DOIUrl":"10.1016/j.ejim.2026.106775","url":null,"abstract":"<div><h3>Background</h3><div>To systematically evaluate polypill effects on cardiovascular (CV) risk factors, CV outcomes, and adverse events in CV disease (CVD) prevention populations.</div></div><div><h3>Methods</h3><div>Systematic searches were conducted in five databases from inception to November 7, 2025, for randomized controlled trials (RCTs) that assessed the effects of polypills for prevention of primary or secondary CVD. Three reviewers independently screened articles, extracted data, assessed risk of bias (RoB) and evaluated GRADE quality of evidence (QoE). Inverse variance meta-analyses were conducted. Primary outcomes included all-cause mortality (ACM), CV death, all-cause hospitalization (ACH), and CV hospitalization (CVH).</div></div><div><h3>Results</h3><div>Thirteen RCTs (n = 27,836) were included. Seven RCTs investigated primary prevention, three secondary preventions, and three in both populations. When compared to controls, polypills had little to no effect on ACM (RR 0.93, 95 %CI 0.82-1.05, 9 RCTs), stroke (RR 0.61, 95 %CI 0.46-0.81, 4 RCTs), heart failure (RR 0.94, 95 %CI 0.57-1.53, 4 RCTs) and revascularization (RR 0.73, 95 %CI 0.49-1.10, 2 RCTs) and may slightly reduce CV death (RR 0.69, 95 %CI 0.57-0.83, 5 RCTs), CVH (RR 0.80, 95 %CI 0.60-1.06, 2 RCTs), and ACH (RR 0.89, 95 %CI 0.77-1.03, 3 RCTs). Polypills probably reduced MI slightly (RR 0.69, 95 %CI 0.50-0.95, 2 RCTs). Polypills had small, significant reductions of SBP, DBP, total cholesterol, and LDL, and small, non-significant increases of adverse events (AEs), serious AEs and adherence. Subgroup analyses were mostly consistent with main analyses.</div></div><div><h3>Conclusions</h3><div>In primary and secondary prevention settings, polypills had moderate reductions of CV outcomes, small effects on CV risk factors, and small increases of AEs.</div></div>","PeriodicalId":50485,"journal":{"name":"European Journal of Internal Medicine","volume":"147 ","pages":"Article 106775"},"PeriodicalIF":6.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146259985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond acute severity: Age as a determinant of in-hospital mortality in acute respiratory failure requiring non-invasive respiratory support in an intermediate care unit 超过急性严重程度：年龄是在中间护理病房需要无创呼吸支持的急性呼吸衰竭患者住院死亡率的决定因素。

IF 6.1 2区医学

European Journal of Internal Medicine Pub Date : 2026-05-01 Epub Date: 2026-03-09 DOI: 10.1016/j.ejim.2026.106821

Giulia Sartori, Lorenzo Calabria, Ernesto Crisafulli

引用次数: 0